C. difficile is a leading cause of hospital-acquired diarrhea and in some cases can be dangerous. VOCs produced metabolically and exhaled on breath could be useful to diagnose this infection.
Thread by @Darcy_ID_doc on Thread Reader App – Thread Reader App
Thread by @Darcy_ID_doc: #IDTwitter DarcyDoesC.diff Or #Cdiff pearls Or how I approach C. diff in light of new guidelines PCR tests are very sensitive but specificity stinks Be sure of appropriate clinical context ...…
Evaluation of an immunochromatographic test for the detection of glutamate dehydrogenase for the diagnosis of Clostridioides (Clostridium) difficile infection in dogs
This study aimed to evaluate an immunochromatographic test used to detect glutamate dehydrogenase (GDH) for the diagnosis of Clostridium difficile infection (CDI) in dogs. Fecal samples of 119 diarrheic dogs were subjected to toxigenic culture as the "gold standard" method and to GDH detection (Ecod …
Kicking off #IBDBoston with @DrJessicaA talking about how to diagnose #cdiff in the #IBD patient: first GDH or PCR test and if positive, c diff +; if not, another organism needs to be identified.
Kicking off #IBDBoston with @DrJessicaA talking about how to diagnose #cdiff in the #IBD patient: first GDH or PCR test and if positive, c diff +; if not, another organism needs to be identified. pic.twitter.com/SxKhaR7vLy— Tina ✨ Own Your Crohn’s (@ownyourcrohns) September 24, 2021
Clostridium difficile: The Story Continues on Vimeo
Clostridium difficile: The Story Continues
Globally, Clostridium difficile is one of the most common causes of healthcare-associated infections in hospitals. Recently, focus of C. difficile testing has moved from identification of the organism to detecting the toxins that cause the disease. This webinar will review the updated 2017 C.difficile guidelines and recommendations from the Infectious Disease Society of America (IDSA) and the Society for Healthcare Epidemiology of America (SHEA) and describe how these updates apply to the microbiology laboratory.
Speaker: Margie Morgan, PhD D(ABMM)
Director Microbiology, Professor of Pathology and Laboratory Medicine Cedars-Sinai Medical Center
The future of Clostridioides difficile diagnostics
As rates of C. difficile infection decline, emphasis is now on improving test utilization and a quest for improved diagnostic approaches. These approaches may involve implementation of technologies that improve toxin testing, predict patients likely to have disease and/or a severe outcome, and harne …
Pragmatic Strategy for Fecal Specimen Storage and the Corresponding Test Methods for Clostridioides difficile Diagnosis
The quality of fecal specimens is one of the factors responsible for successful Clostridioides difficile infection (CDI) diagnosis. The quality depends largely on the storage conditions, including the temperature and time period. In this study, we organized the outputs of previous studies, fi …
@IbukunMD @JessieSeidelman @beckyasmith79 and team in pursuit of the holy grail -- improving #cdiff testing. pic.twitter.com/Lz98EIHsf1— DICON (@DICON_duke) June 8, 2021
Diagnosis of Clostridioides difficile infection by analysis of volatile organic compounds in breath, plasma, and stool: A cross-sectional proof-of-concept study
Clostridioides difficile infection (CDI) is an important infectious cause of antibiotic-associated diarrhea, with significant morbidity and mortality. Current diagnostic algorithms are based on identifying toxin by enzyme immunoassay (EIA) and toxin gene by real-time polymerase chain reaction (PCR) …
New discovery provides insight into diagnostics and treatment for severe C. difficile infection | VCH Research Institute
Clostridioides difficile (C. diff) is the leading cause of gastroenteritis-associated death in North America, and infects around half a million Americans annually. While most people affected will
Association between Clostridioides difficile infection testing results and decision to treat
We sought to determine how often patients with a negative toxin enzyme immunoassay following a positive nucleic acid amplification test for Clostridioides difficile infection (CDI) were treated for CDI in Veterans Affairs facilities. From October 2018 through March 2021, 702 (29.5%) of 2,374 unique …
Development and clinical validation of an automated cell cytotoxicity neutralization assay for detecting Clostridioides difficile toxins in clinically relevant stools samples
Overall, the automated CCNA provides a specific, sensitive, and reproducible tool to support determination of CDI epidemiology or the efficacy of interventions such as vaccines.
First Light Diagnostics Receives FDA Clearance for its Rapid Clostridiodes difficile Test on the MultiPath® Analyzer - Yahoo Finance
First Light Diagnostics is developing and commercializing breakthrough automated diagnostic products for rapidly detecting infections and determining optimal treatment. The company announced today that the US Food and Drug Administration (FDA) has cleared its SensiTox™ C. difficile Toxin Test along with its proprietary MultiPath Analyzer to be marketed in the US.
Genomic Analysis of Clostridioides difficile in 2 Regions of the United States Reveals a Diversity... Whole-genome sequencing of 422 Clostridioides difficile strains from healthcare and community settings across 2 sites over a 3-month period demonstrated a diver academic.oup.com
CDI Risk Factors Identified for Geriatric Patients Renal failure, anemia, malnutrition and the presence of infection at the time of hospital admission are all risk factors for the development of Clostridioides difficile infection in older patients. idse.net
Calprotectin Stool Test: Uses, Procedure, Results & More - Healthline
The calprotectin stool test is a noninvasive test that can help determine if you have an inflammatory or noninflammatory bowel condition. Learn more about what this test measures and when it's used.
Using a nurse-initiated bedside tool to decrease inappropriate testing for Clostridioides difficile in hospital settings
Overdiagnosis of Clostridioides difficile (C. difficile) is associated with increased hospital length of stay, antibiotic overuse, unnecessary infection prevention efforts and excess costs. This study evaluated a paper-based bedside C. difficile screening tool on the number of …