The models achieve high discrimination performance (AUROC 0.83). There is a general consensus among different analysis approaches regarding predictors that impact patients' chances of having a positive test, which may influence iClostridioides difficile/i risk, including features clinically …

Bioaerosols, a subset of aerosols released from the biosphere, can carry pathogens, and include particles with diameters from nanometres to a few micrometres. They can remain suspended indoors and travel significant distances. Bioaerosol studies play a vital role in public health, as bioaerosols are …

Concern has emerged about the high number of people in Ireland who are being diagnosed with a potentially fatal superbug outside of hospitals.

Inclusion of hypotension, defined as SBP ≤90 mm Hg or MAP ≤65 mm Hg, was an important component of FCDI severity criteria, significantly improving the predictive ability to identify FCDI patients at risk for poor outcomes.

Cyclospora cayetanensis, a parasite causing human enteritis, has been rarely reported from healthcare laboratories despite its universal presence. While it is usually responsible for self-limiting diarrhea in immunocompetent individuals, we present a case where the patient suffered from severe, unre …

This study shows medium-dependent differences in C. difficile MICs for at least two antimicrobials across two sites. We suggest the use of FAA-HB to align with general EUCAST recommendations for susceptibility testing of anaerobic bacteria and deposited reference strains for standard susceptibility …

A diverse and well-functioning gut microbiota normally serves as a protective shield against the invasion of harmful bacteria or the proliferation of opportunistic pathogens. iClostridioides difficile/i infection (CDI) is predominantly associated with the overuse of antibiotics, resulting in a s …

Concurrent CDI intensifies systemic inflammation and adverse clinical trajectories in hospitalized COVID-19 patients. Elevations in inflammatory markers and severity scores predict worse outcomes, especially in high-risk subgroups. Early recognition and targeted interventions, including infection co …

Among adults tested for C. difficile, nucleic acid amplification test positive/toxin negative status was associated with later toxin positivity, though abs

Whole genome sequencing (WGS) of pathogens allows tracking of mutations across populations, enabling mapping of isolate relatedness and supporting detailed u...

spaniClostridioides difficile/i (iC. difficile/i) was a gram-positive anaerobic ibacterium/i in the gut, exhibiting clinical manifestations ranging from mild diarrhoea to fatal pseudomembranous colitis. iC. difficile/i infection (CDI) remains a serious public health problem and accounted/span …

spaniClostridioides difficile/i is a common etiological factor of hospital infections, which, in extreme cases, can lead to the death of patients. Most strains belonging to this bacterium species synthesize very dangerous toxins: toxin A (TcdA) and B (TcdB) and binary toxin (CDT). The aim of this st/span …

Clostridioides difficile is a Gram-positive, spore-forming anaerobic enteropathogen responsible for a wide spectrum of clinical diseases ranging from mild diarrhoea to pseudomembranous colitis. It is the first cause of healthcare-associated diarrhoeas, but community-associated Clostridioides diffici …

Nature Communications - In this study, authors introduce small molecular taxon-specific markers for bacterial detection directly in complex matrices using MS-based (spatial) metabolomics. This...

Request PDF | Adding Virome Capture Metagenomic Sequencing to Conventional Laboratory Testing Increases Unknown Fever Etiology Determination in Bamako, Mali | Unexplained fever poses significant diagnostic challenges in resource-limited settings like Bamako, Mali, where overlapping endemic diseases... | Find, read and cite all the research you need on ResearchGate

Significant variations in CDI and testing rates were observed across the three hospitals. An increase in CDI rates was noted at all centres during the 2020 SARS-CoV-2 outbreak. Advanced age was not prevalent in the cohort, and rCDI rates were relatively low. These findings highlight the need for sys …

For Clostridioides difficile infections, highly sensitive rapid diagnostic test kits are necessary for prompt diagnose and infection control. In this study, we evaluated "Quick Chaser CD GDH/TOX" (evaluation kit), a rapid diagnostic kit for C. difficile, using 65 clinical stool specime …

Clostridioides difficile (C. difficile) was a gram-positive anaerobic bacterium in the gut, exhibiting clinical manifestations ranging from mild diarrhoea to fatal pseudomembranous colitis. C. difficile infection (CDI) remains a serious public health problem and accounted …

This study shows the possibility of rapid discrimination of relevant C. difficile ribotypes by using MALDI-TOF MS. This methodology reduces the time, costs and laboriousness of current reference methods.

This rapid review identified and summarised evidence of the accuracy of new diagnostic tests for Clostridioides difficile (C. difficile).

The laboratory diagnosis of iClostridioides difficile/i infection (CDI) is controversial. Nucleic acid amplification tests (NAAT) and toxin enzyme immunoassays (EIA) are most widely used, often in combination. However, the interpretation of a positive NAAT and negative toxin immunoassay (NAAT+/E …

The German firm said that it plans to launch its AltoStar Parvovirus B19 PCR Kit 1.5 in January and other unspecified tests through spring of 2025.

spaniClostridioides difficile/i species lacking toxin genes (non-toxigenic iC. difficile/i or NTCD) may confer protection against CDI. However, current diagnostic tests detect either toxin proteins or toxin genes and cannot detect NTCD. This study developed a molecular testing method that unique/span …

ClinicalTrials.gov Identifier: NCT04078594.

Reimbursement for molecular syndromic panel testing for UTI may continue to face uncertainty.

TEHRAN (ANA)- Iranian researchers from University of Tehran succeeded in developing and designing an electrochemical genosensor to identify different strains of the C. difficile bacteria with high sensitivity and accuracy.

The gut microbiota might perhaps one day become a routine tool for the early diagnosis of many diseases and to guide treatment, but at present there

Researchers found that removing Clostridioides difficile from gastrointestinal pathogen panels reduced unnecessary treatment without causing delays in diagnosis.

Diagnosis of Clostridioides difficile infection (CDI) remains challenging as it involves in the first instance recognition (clinical awareness) of the patients' symptoms for clinical suspicion of CDI to warrant testing, and secondly, different laboratory tests have been described for CDI. Due …