Drs. Abraham, Chopra and Feuerstadt discuss importance of timely referral and diagnostic methods to discern C. difficile infection (CDI).

The study aimed to identify colonized patients as a possible source of eventual VRE (vancomycin-resistant enterococci) infection from stool samples positive for glutamate dehydrogenase antigen, as well as for Clostridioides difficile toxins A and B. The study was carried out from 7/2020 to 9/2021. S …

Advances in Therapy - Irritable bowel syndrome with diarrhea (IBS-D) is a chronic disorder of gut–brain interaction, characterized by recurrent abdominal pain in association with more...

Diagnostic stewardship has proven effective in reducing C diff infections. We need diagnostic stewardship for other hospital acquired infections as well.

Stool concentrations of the inflammasome pathway, pro-inflammatory cytokine IL-1β can accurately differentiate CDI from asymptomatic carriage and non-CDI diarrhea, making it a promising biomarker for CDI diagnosis. Significant positive correlations exist between stool toxins and stool IL-1β in CDI b …

The epidemiology of Clostridioides difficile infection (CDI) has changed over the last two decades, due to the emergence of C. difficile strains with clinical relevance and responsible for nosocomial outbreaks with severe outcomes. This study reports an outbreak occurred in a Long-term …

Researchers assessed whether the COVID-19 pandemic influenced the annual incidence of Clostridioides difficile infections among patients in the Netherlands.

Why microbiome tests are currently of limited value for your clinical practice https://t.co/uwwd1LHrKl— GutMicrobiota Health (@GMFHx) July 19, 2022

This is the first study examining tetM gene in C. difficile strains cultured from feces by LAMP. Its high specificity and sensitivity, as well as visual detection, make the new assay a powerful diagnostic tool for rapid testing.

This article focuses on the diagnosis and treatment of C. difficile infection and includes an updated summary of literature on the latest guidelines (Part 2).

Clinical picture and testing of CDI Chair: Aonghus Lavelle, Ireland - Clostridioides difficile infection laboratory investigations: When and how, Frédéric Barbut, Paris, France Followed by Q&A with all chairs and speakers

In hospitalized LT recipients with diarrhea, GI PCR pathogen identification was associated with the use of targeted antimicrobial therapy and a shorter length of stay. GI PCR testing should be considered early during admission and later in the post-LT period. This article is protected by copyright. …

Infections caused by bacteria have a major impact on public health-related morbidity and mortality. Despite major advances in the prevention and treatment of bacterial infections, the latter continue to represent a significant economic and social burden worldwide. The WHO compiled a list of six high …

Infections caused by bacteria have a major impact on public health-related morbidity and mortality. Despite major advances in the prevention and treatment of bacterial infections, the latter continue to represent a significant economic and social burden worldwide. The WHO compiled a list of six high …

Restrictive CPOE for CDI in pediatrics was successfully implemented and sustained. Diagnostic stewardship for CDI is likely cost-saving and could decrease misdiagnosis, unnecessary antibiotic therapy, and overestimation of HO-CDI rates.

Ever confused by #Cdiff testing options? 🙋🏻‍♀️@DrJessicaA Cdiff 👑 #AIBDRegionals PCR does NOT detect the PRESENCE of active toxin (ie infection) tells you that there is an organism present that CAN produce toxin2 stage testing:1.PCR testing 2.If ➕ Reflex toxin test pic.twitter.com/CfTzf178vo— Jami Kinnucan, MD, FACG (@ibdgijami) June 11, 2022

The EMR and EMR with phone call interventions were associated with a significant decrease in the HO-CDI rate and an increase in provider adherence to the algorithm.

Healthcare-associated infections can occur in different care units and can affect both patients and healthcare professionals. Bacteria represent the most common cause of nosocomial infections and, due to the excessive and irrational use of antibiotics, resistant organisms have appeared. The most imp …

After Teresa Zurberg experienced a C. difficile infection, she trained her dog to sniff and detect the bacteria in a Vancouver hospital.

Rapid, accurate detection of Clostridioides difficile toxin may potentially be predicted by toxin B PCR cycle threshold (tcdB Ct). We investigated the validity of this approach in an inpatient adult population. Patients who tested positive by C. difficile PCR (Cepheid …

Toxigenic Clostridioides difficile infection (CDI) is a high concern because of its increasing prevalence, among both nosocomial infection and community-acquired infection contexts. A total of 1320 prospective stool samples collected on FecalSwab™ (Cary-Blair medium) were screened using BD Max™ CDIF …

“RT @DrJessicaA: There is no test for #CDI. Clinical judgement is important! #DDW…”

A South Korea in-hospital assessment found that approximately half of all ordered CDI tests did not meet recommendation standards.

Epitopes are portions of a protein that are recognized by antibodies. These small amino acid sequences represent a significant breakthrough in a branch of bioinformatics called immunoinformatics. Various software are available for linear B-cell epitope (BCE) prediction such as ABCPred, SVM …

Almost half of the C. difficile tests were performed inappropriately. The patient being located in the emergency room and intensive care unit increased and decreased the risk of inappropriate testing, respectively. In a questionnaire survey, we showed that internal medicine physicians were more know …