New Data Suggest Machine Learning Algorithms Can Accurately Predict C. Diff Infection in Hospitalized Patients

The Microbiome Health Index for post-Antibiotic dysbiosis was developed to improve the understanding of and manage the risks associated with antibiotic administration.

So you can start feeling better ASAP.

Current assays for Clostridioides difficile in nonhospital settings are outsourced and time-intensive, resulting in both delayed diagnosis and quarantining of infected individuals. We designed a more rapid point-of-care assay featuring a "turn-on" bioluminescent readout of a C. difficile …

DNA fingerprinting studies represent a powerful tool in surveying hypervirulent C. difficile strains in clinical settings. Resistance to vancomycin and metronidazole, as first-line antibiotics, necessitate accomplishment of proper control strategies and also prescription of tigecycline as a m …

Clostridioides difficile is the most common cause of antibiotic-associated gastrointestinal infections. Capillary-electrophoresis (CE)-PCR ribotyping is currently the gold standard for C. difficile typing but lacks discriminatory power to study transmission and outbreaks in detail. New …

The GI-PCR's results impacted the medical management of gastroenteritis for almostone-fourth of the children, and especially the prescription of appropriate antibiotic treatment before stool culture results.

Acute gastroenteritis (AGE) are leading causes of morbidity and mortality in children. Therefore, rapid pathogens identification is needed. The AGE aetiology was investigated from 2018 to 2020 in 2,066 children in Parma (Italy) by FilmArray Gastrointestinal Panel and Enterovirus-targeting RT-PCR. Pa …

The two qPCR methodologies evaluated could offer an adequate tool as part of an algorithm in the laboratory diagnosis of CDI.

Comprehensive discussion on the identification of Clostridioides difficile infection, the spectrum of disease, and overall epidemiology.

Comprehensive discussion on the identification of Clostridioides difficile infection, the spectrum of disease, and overall epidemiology.

Although the pathogenesis of Clostridioides difficile infection (CDI) is complex and incompletely understood, it is believed that the elaboration of C. difficile toxins is necessary for disease. There are a variety of tests available for the detection of both the C. difficile organism and its toxins …

Clostridioides difficile can cause colitis and is associated with hospital acquired infections. The C. difficile infection (CDI) is due to production of toxins A and B which bind to epithelial cell surface receptors and triggers signaling pathways, leading to loss of epithelial barrier function, apo …

[patent] Genetic Analysis AS awarded an important US #patent covering a #companiondiagnostics method for optimizing #IBS interventions.A #diagnostic method to be used to determine the likelihood that a patient with IBS will respond to treatment with a low-#FODMAP diet or #FMT pic.twitter.com/gm8Kl4246g— Genetic Analysis AS (@GeneticAnalysis) October 29, 2021

Researchers used a novel, highly sensitive test to measure the amount of toxin produced by C. difficile in the stool of patients with suspected infections.

The median time to negative PCR in CDI was 9 days from treatment initiation. The PCR positivity during or after treatment may be useful for recurrence prediction; larger studies are needed to validate these results.

Background: Quantitative (q) polymerase chain reaction (PCR) cycle threshold (Ct) values represent the number of amplification cycles required for a positive PCR result and are a proxy of pathogen quantity in the tested sample. The clinical utility of Ct values remains unclear for gastrointes …

Clostridium difficile (C. diff) infection is one of the most contagious diseases associated with high morbidity and mortality rates in hospitalised patients. Accurate diagnosis can slow its spread by determining the most effective treatment. Herein, we report a novel testing platform as a proof-of-c

The extensive use of the urinalysis for screening and monitoring in diverse clinical settings usually identifies abnormal urinalysis parameters in patients with no suspicion of urinary tract infection, which in turn triggers urine cultures, inappropriate antimicrobial use, and associated harms like …

Here, we assessed the utility of a polymerase chain reaction-based open reading frame typing assay for investigating the clonality of Clostridioides difficile isolates. This assay has a higher discriminatory power than multi-locus sequence typing for molecular epidemiological analysis of C. difficil …

The results of PCR capillary-based electrophoresis ribotyping in the studied samples showed a high prevalence of RT176 and 001.

Healthcare provider knowledge on fecal microbiota transplantation as a treatment for inflammatory bowel disease is still lacking.

The companies plan to combine testing for infectious diseases and cancers in one multiplex instrument targeted toward decentralized settings.

C. difficile is a leading cause of hospital-acquired diarrhea and in some cases can be dangerous. VOCs produced metabolically and exhaled on breath could be useful to diagnose this infection.

Thread by @Darcy_ID_doc: #IDTwitter DarcyDoesC.diff Or #Cdiff pearls Or how I approach C. diff in light of new guidelines PCR tests are very sensitive but specificity stinks Be sure of appropriate clinical context ...…

This study aimed to evaluate an immunochromatographic test used to detect glutamate dehydrogenase (GDH) for the diagnosis of Clostridium difficile infection (CDI) in dogs. Fecal samples of 119 diarrheic dogs were subjected to toxigenic culture as the "gold standard" method and to GDH detection (Ecod …

Kicking off #IBDBoston with @DrJessicaA talking about how to diagnose #cdiff in the #IBD patient: first GDH or PCR test and if positive, c diff +; if not, another organism needs to be identified. pic.twitter.com/SxKhaR7vLy— Tina ✨ Own Your Crohn’s (@ownyourcrohns) September 24, 2021

Clostridium difficile: The Story Continues Globally, Clostridium difficile is one of the most common causes of healthcare-associated infections in hospitals. Recently, focus of C. difficile testing has moved from identification of the organism to detecting the toxins that cause the disease. This webinar will review the updated 2017 C.difficile guidelines and recommendations from the Infectious Disease Society of America (IDSA) and the Society for Healthcare Epidemiology of America (SHEA) and describe how these updates apply to the microbiology laboratory. Speaker: Margie Morgan, PhD D(ABMM) Director Microbiology, Professor of Pathology and Laboratory Medicine Cedars-Sinai Medical Center