An intervention requiring that infectious diseases approve testing for Clostridioides difficile infection increased the appropriateness of testing for hospital-onset C. difficile and lowered the positive testing rate by more than 50%.

Researchers sought to determine a method of testing hematopoietic stem cell transplantation recipients for Clostridioides difficile as a cause of diarrhea.

Clostridioides difficile infection (CDI) is a major healthcare-associated infection that leads to a significant health economic burden in Japan. Using a decision tree model, we evaluated the budget impact of adopting a one-step nucleic acid amplification test (NAAT) alone pathway compared to …

Clostridioides difficile infection (CDI) is a major healthcare-associated infection that leads to a significant health economic burden in Japan. Using a decision tree model, we evaluated the budget impact of adopting a one-step nucleic acid amplification test (NAAT) alone pathway compared to …

A new study published today in the American Journal of Infection Control suggests that allowing bedside nurses to independently order testing for C. difficile significantly decreased the amount of time to receive test results as compared to requiring physician approval.

Allowing nurses to order Clostridioides difficile testing without a physician's approval could help hospitals lower infection rates, a new study suggests.

Researchers sought to determine a method of testing hematopoietic stem cell transplantation recipients for Clostridium difficile as a cause of diarrhea.

Hospital policies allowing nurses to independently initiate testing for the bacterium C. difficile could reduce infection spread and associated morbidity.

Findings suggest policy change expedites availability of test results, and could help decrease clinical and economic burden of C. difficile infections.

An infectious disease-led C. difficile testing approval process was feasible and associated with a 50% decrease in HO-CDI rates, due to enforcement of appropriate testing.

Introduction. Environmental surveillance for Clostridioides difficile is challenging. There are no internationally agreed recommendations on which method should be used when environmental surveillance is undertaken. Aim. To compare the detection of C. difficile by RT-PCR to culture-based methods and to determine which is more sensitive and specific in the clinical environment. Methods. Forty-four near-patient areas of C. difficile -positive patients were sampled using contact plates and moistened flocked swabs. Results. Detection using moistened flocked swabs followed by RT-PCR or culture detected more C. difficile than contact plates. The sensitivity and specificity of a RT-PCR assay for tcdB compared to the culture methods was 76 and 91 %, respectively. Conclusion. Despite the lower sensitivity and specificity, RT-PCR could potentially offer a more rapid and practical alternative.

Joseph Reilly, BS, PharmD, BCGP; Candace Cotto, RN; and Andrew Skinner, MD, review C. difficile infection (CDI), its risk factors, symptoms, and quality of life for the patient.

A stringent order-approval process reduced clinically nonindicated testing for C. difficile but did not significantly decrease HAIs.

A stringent order-approval process reduced clinically nonindicated testing for C. difficile but did not significantly decrease HAIs.

Use of an algorithm defining criteria for C. difficile testing, diagnosis, and treatment was associated with significantly decreased CDI diagnoses on a HSCT inpatient unit without apparent adverse effects.

Although Clostridioides difficile infection (CDI) incidence is high in the United States, standard-of-care (SOC) stool collection and testing practices might result in incidence overestimation or underestimation. We conducted diarrhea surveillance among inpatients 50 years of age in Louisville, …

A-two-step-algorithm-for-Clostridioides-difficile-infection-CDI-testing-may-reduce-unnecessary-treatment-and-improve-detection-according-to-data-presented-at

Excellent presentation @kerrieanndavies @ESCMID #ECCMID23 #ECCMID2023 lactoferrin may help tease out the significance of GDH positive /EIA negative #cdiff samples - 40min turn around - quantitative version pic.twitter.com/6J05b12NEN— Prof. Fidelma Fitzpatrick (@FfitzP) April 18, 2023

Misdiagnosis of Clostridioides difficile Infections

So proud of our former ID PGY2 (and 🦸‍♀️super steward) @LinezoLiv who just presented one of her residency projects here at #ECCMID2023 finding a two-step method for C diff testing led to a reduction in unnecessary treatment 🙌 #Cdiff #DiagnosticStewardship #IDtwitter pic.twitter.com/9eUH3iOS34— Bug Pharmacist 💊🧫 Tim Gauthier (@IDstewardship) April 15, 2023

null

The global Clostridium Diagnostics Market is anticipated to grow at a 12.2% CAGR from 2022 to 2032, from US$ 2.5 billion to US$ 7.8 billion. The market saw a 13.6% CAGR between 2015 and 2021. The market is expanding as a result of increased awareness-raising activities for clostridium-related ill...

The global Clostridium Diagnostics Market is anticipated to grow at a 12.2% CAGR from 2022 to 2032, from US$ 2.5 billion to US$ 7.8 billion. The market saw a 13.6% CAGR between 2015 and 2021. The market is expanding as a result of increased awareness-raising activities for clostridium-related illnesses and their rising prevalence. There has been an increased focus of […]

Neither PCT nor CRP helped discriminate bacterial colitis from nonbacterial colitis.

Among 1660 cases with only PCR data, the cycle threshold was significantly associated with recurrence-free survival.

VisualDx is a platform that can provide clinicians with assistive technology and burgeoning providers with patient education.

The laboratory diagnosis of Clostridioides difficile infection (CDI) is challenging since this bacteria may be detected in healthy people and toxin production detection is not sensitive enough to be used alone. Thus, there is no single test with adequate sensitivity and specificity to be used in lab …