C Diff Molecular

C Diff Molecular

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Meta-analysis of predictors of healthcare-associated Clostridioides difficile infection - PubMed
Meta-analysis of predictors of healthcare-associated Clostridioides difficile infection - PubMed
Our systematic review and meta-analysis of 40 studies (n = 3,905,559) identified gastric acid suppressants, recent hospitalization, antibiotic exposure, and certain comorbidities as independent predictors of healthcare-associated Clostridioides difficile infection (HA-CDI) among adult …
·pubmed.ncbi.nlm.nih.gov·
Meta-analysis of predictors of healthcare-associated Clostridioides difficile infection - PubMed
Gut microbiota-derived 3-indoleacetic acid confers a protection against sepsis-associated encephalopathy through microglial aryl hydrocarbon receptors - PubMed
Gut microbiota-derived 3-indoleacetic acid confers a protection against sepsis-associated encephalopathy through microglial aryl hydrocarbon receptors - PubMed
Gut microbiota-derived IAA confers a protection against SAE by activating AhR in microglia, improving neuronal and cognitive impairments. Thus, IAA holds the promise as a potential therapeutic agent for managing SAE.
·pubmed.ncbi.nlm.nih.gov·
Gut microbiota-derived 3-indoleacetic acid confers a protection against sepsis-associated encephalopathy through microglial aryl hydrocarbon receptors - PubMed
Synergistic Interplay of Diet, Gut Microbiota, and Insulin Resistance: Unraveling the Molecular Nexus - PubMed
Synergistic Interplay of Diet, Gut Microbiota, and Insulin Resistance: Unraveling the Molecular Nexus - PubMed
This comprehensive review explores the intricate relationship between gut microbiota, diet, and insulin resistance, emphasizing the novel roles of diet-induced microbial changes in influencing metabolic health. It highlights how diet significantly influences gut microbiota composition, with differen …
·pubmed.ncbi.nlm.nih.gov·
Synergistic Interplay of Diet, Gut Microbiota, and Insulin Resistance: Unraveling the Molecular Nexus - PubMed
Gut Microbiome Tied to Chronic Disease Outcomes
Gut Microbiome Tied to Chronic Disease Outcomes
The gut microbiome, an ecosystem of trillions of microorganisms in the human digestive tract, has been increasingly linked to chronic diseases
·miragenews.com·
Gut Microbiome Tied to Chronic Disease Outcomes
Early COVID-19 Infections Linked With Higher Heart Attack, Stroke Risk
Early COVID-19 Infections Linked With Higher Heart Attack, Stroke Risk
People who contracted COVID-19 during the early stages of the pandemic had an increased risk of myocardial infarction (heart attack), stroke, and death for the next 3 years, according to a study sponsored by the National Institutes of Health (NIH).
·jamanetwork.com·
Early COVID-19 Infections Linked With Higher Heart Attack, Stroke Risk
Regulatory Networks: Linking Toxin Production and Sporulation in Clostridioides difficile - PubMed
Regulatory Networks: Linking Toxin Production and Sporulation in Clostridioides difficile - PubMed
Clostridioides difficile has been recognized as an important nosocomial pathogen that causes diarrheal disease as a consequence of antibiotic exposure and costs the healthcare system billions of dollars every year. C. difficile enters the host gut as dormant spores, germinates into vegetative cells, …
·pubmed.ncbi.nlm.nih.gov·
Regulatory Networks: Linking Toxin Production and Sporulation in Clostridioides difficile - PubMed
Reduced Vancomycin Susceptibility in Clostridioides difficile Is Associated With Specific Ribotypes - PubMed
Reduced Vancomycin Susceptibility in Clostridioides difficile Is Associated With Specific Ribotypes - PubMed
Certain ribotypes, including RT 027, were the sole independent risk factors for reduced VAN susceptibility. Increased clinical surveillance of these strains, especially RT 027, and their antibiotic susceptibly is warranted to inform prescribing practices.
·pubmed.ncbi.nlm.nih.gov·
Reduced Vancomycin Susceptibility in Clostridioides difficile Is Associated With Specific Ribotypes - PubMed
Bacterial toxins induce non-canonical migracytosis to aggravate acute inflammation - PubMed
Bacterial toxins induce non-canonical migracytosis to aggravate acute inflammation - PubMed
Migracytosis is a recently described cellular process that generates and releases membrane-bound pomegranate-like organelles called migrasomes. Migracytosis normally occurs during cell migration, participating in various intercellular biological functions. Here, we report a new type of migracytosis …
·pubmed.ncbi.nlm.nih.gov·
Bacterial toxins induce non-canonical migracytosis to aggravate acute inflammation - PubMed
Genomic and phenotypic characterization of a Clostridioides difficile strain of the epidemic ST37 type from China - PubMed
Genomic and phenotypic characterization of a Clostridioides difficile strain of the epidemic ST37 type from China - PubMed
Clostridioides difficile strains of sequence type (ST) 37, primarily including PCR ribotype (RT) 017, are prevalent in mainland China. Our study aimed to compare the major virulence factors of an epidemic C. difficile isolate of ST37 type (Xy06) from China with the well-characterized …
·pubmed.ncbi.nlm.nih.gov·
Genomic and phenotypic characterization of a Clostridioides difficile strain of the epidemic ST37 type from China - PubMed
Gut microbiota in gastrointestinal diseases: Insights and therapeutic strategies - PubMed
Gut microbiota in gastrointestinal diseases: Insights and therapeutic strategies - PubMed
Considering the bidirectional crosstalk along the gut-liver axis, gut-derived microorganisms and metabolites can be released into the liver, potentially leading to liver injury. In this editorial, we comment on several studies published in the recent issue of the World Journal of Gastroenterology …
·pubmed.ncbi.nlm.nih.gov·
Gut microbiota in gastrointestinal diseases: Insights and therapeutic strategies - PubMed
Unraveling Cecal Alterations in Clostridioides difficile Colonized Mice through Comprehensive Metabolic Profiling - PubMed
Unraveling Cecal Alterations in Clostridioides difficile Colonized Mice through Comprehensive Metabolic Profiling - PubMed
The disruption of gut microbiota caused by antibiotics favors the intestinal colonization of Clostridioides difficile - a Gram-positive, spore-forming anaerobic bacterium that causes potentially fatal gastrointestinal infections. In an endeavor to elucidate the complexities of the gut-brain a …
·pubmed.ncbi.nlm.nih.gov·
Unraveling Cecal Alterations in Clostridioides difficile Colonized Mice through Comprehensive Metabolic Profiling - PubMed
Multiple variables influence the finely calibrated antioxidant defenses of Clostridioides difficile - PubMed
Multiple variables influence the finely calibrated antioxidant defenses of Clostridioides difficile - PubMed
The obligate anaerobe Clostridioides difficile encodes multiple reductases to detoxify molecular oxygen and reactive oxygen species. Caulat and colleagues have characterized the activity and regulation of four such reductases (L. C. Caulat, A. Lotoux, M. C. Martins, N. Kint, et al., mBio 15:e …
·pubmed.ncbi.nlm.nih.gov·
Multiple variables influence the finely calibrated antioxidant defenses of Clostridioides difficile - PubMed
Mice colonized with the defined microbial community OMM19.1 are susceptible to Clostridioides difficile infection without prior antibiotic treatment - PubMed
Mice colonized with the defined microbial community OMM19.1 are susceptible to Clostridioides difficile infection without prior antibiotic treatment - PubMed
Diverse gut microorganisms present in humans and mice are essential for the prevention of microbial pathogen colonization. However, antibiotic-induced dysbiosis of the gut microbiome reduces microbial diversity and allows Clostridioides difficile (C. difficile) to colonize the intestin …
·pubmed.ncbi.nlm.nih.gov·
Mice colonized with the defined microbial community OMM19.1 are susceptible to Clostridioides difficile infection without prior antibiotic treatment - PubMed
Epidemiology of Clostridioides difficile PCR ribotype 181 after the COVID-19 pandemic in Northern Greece - PubMed
Epidemiology of Clostridioides difficile PCR ribotype 181 after the COVID-19 pandemic in Northern Greece - PubMed
Clostridioides difficile infection (CDI) is one of the most significant causes of diarrhea in hospitalized patients. The aim of this study was to investigate the incidence and epidemiology of CDI after the COVID-19 pandemic in hospitalized patients in a rehabilitation center in Thessaloniki, Greece. …
·pubmed.ncbi.nlm.nih.gov·
Epidemiology of Clostridioides difficile PCR ribotype 181 after the COVID-19 pandemic in Northern Greece - PubMed
A Mouse Model of Mild Clostridioides difficile Infection for the Characterization of Natural Immune Responses - PubMed
A Mouse Model of Mild Clostridioides difficile Infection for the Characterization of Natural Immune Responses - PubMed
(1) Background: We describe a model of primary mild-Clostridioides difficile infection (CDI) in a naïve host, including gut microbiota analysis, weight loss, mortality, length of colonization. This model was used in order to describe the kinetics of humoral (IgG, IgM) and mucosal (IgA) immune …
·pubmed.ncbi.nlm.nih.gov·
A Mouse Model of Mild Clostridioides difficile Infection for the Characterization of Natural Immune Responses - PubMed
Clostridioides difficile bacteria, which was seen in news, causes an infection in which part of body
Clostridioides difficile bacteria, which was seen in news, causes an infection in which part of body
Large intestine Researchers are developing an mRNA-based vaccine for Clostridioides difficile (C. difficile), a highly contagious bacterium. C. difficile causes an infection of the colon, the longest part of the large intestine, with symptoms ranging from diarrhea to life-threatening colon damag
·gktoday.in·
Clostridioides difficile bacteria, which was seen in news, causes an infection in which part of body
Genetic insight into the relationship between inflammatory bowel disease and Clostridioides difficile infection - PubMed
Genetic insight into the relationship between inflammatory bowel disease and Clostridioides difficile infection - PubMed
Patients with inflammatory bowel disease (IBD) are at increased risk of Clostridioides difficile infection (CDI). Herein, we aimed to determine if genetic risk contributes to this observed association. We carried out a genome-wide association study (GWAS) analysis in the Michigan Genomics Ini …
·pubmed.ncbi.nlm.nih.gov·
Genetic insight into the relationship between inflammatory bowel disease and Clostridioides difficile infection - PubMed
Examining the impact of the COVID-19 pandemic on hospital-associated Clostridioides difficile infection - PubMed
Examining the impact of the COVID-19 pandemic on hospital-associated Clostridioides difficile infection - PubMed
Despite large increases in several CDI risk factors, we did not observe the expected corresponding changes in HA-CDI rate during the first two years of the COVID-19 pandemic. We hypothesize that infection prevention measures responding to COVID-19 played a role in CDI prevention.
·pubmed.ncbi.nlm.nih.gov·
Examining the impact of the COVID-19 pandemic on hospital-associated Clostridioides difficile infection - PubMed
Whole-genome sequencing of toxigenic Clostridioides difficile reveals multidrug resistance and virulence genes in strains of environmental and animal origin - PubMed
Whole-genome sequencing of toxigenic Clostridioides difficile reveals multidrug resistance and virulence genes in strains of environmental and animal origin - PubMed
The results of this study demonstrated significant genetic similarity between ST11 strains isolated from environmental sampling and from animal origin; these strains may represent a reservoir for community-acquired C. difficile infection, which is becoming a growing public health threat due to the d …
·pubmed.ncbi.nlm.nih.gov·
Whole-genome sequencing of toxigenic Clostridioides difficile reveals multidrug resistance and virulence genes in strains of environmental and animal origin - PubMed
Genetic insight into the relationship between inflammatory bowel disease and Clostridioides difficile infection - PubMed
Genetic insight into the relationship between inflammatory bowel disease and Clostridioides difficile infection - PubMed
Patients with inflammatory bowel disease (IBD) are at increased risk of Clostridioides difficile infection (CDI). Herein, we aimed to determine if genetic risk contributes to this observed association. We carried out a genome-wide association study (GWAS) analysis in the Michigan Genomics Ini …
·pubmed.ncbi.nlm.nih.gov·
Genetic insight into the relationship between inflammatory bowel disease and Clostridioides difficile infection - PubMed
Bacterial metabolites influence the autofluorescence of Clostridioides difficile - PubMed
Bacterial metabolites influence the autofluorescence of Clostridioides difficile - PubMed
Clostridioides difficile is a bacterial pathogen that has been implicated in severe gastrointestinal infections. C. difficile has intrinsic green autofluorescence and the level of this autofluorescence is known to be increased by growth time and oxygen. Currently, it is unclear if diet …
·pubmed.ncbi.nlm.nih.gov·
Bacterial metabolites influence the autofluorescence of Clostridioides difficile - PubMed
Unveiling the impact of antibiotic stress on biofilm formation and expression of toxin-antitoxin system genes in Clostridium difficile clinical isolates - PubMed
Unveiling the impact of antibiotic stress on biofilm formation and expression of toxin-antitoxin system genes in Clostridium difficile clinical isolates - PubMed
Our study suggests that toxin and antitoxin genes may impact C. difficile biofilm formation, while antibiotics could signal biofilm strengthening and gene expression increase.
·pubmed.ncbi.nlm.nih.gov·
Unveiling the impact of antibiotic stress on biofilm formation and expression of toxin-antitoxin system genes in Clostridium difficile clinical isolates - PubMed
Relationships between Gut Microbiota and Autism Spectrum Disorders: Development and Treatment - PubMed
Relationships between Gut Microbiota and Autism Spectrum Disorders: Development and Treatment - PubMed
Many studies have demonstrated the impact of intestinal microbiota on normal brain development. Moreover, the gut microbiota (GM) is impacted by multiple endogenous and environmental factors that may promote gut dysbiosis (GD). An increasing number of studies are investigating the possible role of t …
·pubmed.ncbi.nlm.nih.gov·
Relationships between Gut Microbiota and Autism Spectrum Disorders: Development and Treatment - PubMed
Unravelling the Role of Gut and Oral Microbiota in the Pediatric Population with Type 1 Diabetes Mellitus - PubMed
Unravelling the Role of Gut and Oral Microbiota in the Pediatric Population with Type 1 Diabetes Mellitus - PubMed
Type 1 Diabetes Mellitus (T1DM) is a chronic autoimmune disease that results in the destruction of pancreatic β cells, leading to hyperglycaemia and the need for lifelong insulin therapy. Although genetic predisposition and environmental factors are considered key contributors to T1DM, the exact cau …
·pubmed.ncbi.nlm.nih.gov·
Unravelling the Role of Gut and Oral Microbiota in the Pediatric Population with Type 1 Diabetes Mellitus - PubMed