C Diff Molecular

C Diff Molecular

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Genomic and phenotypic characterization of a Clostridioides difficile strain of the epidemic ST37 type from China - PubMed
Genomic and phenotypic characterization of a Clostridioides difficile strain of the epidemic ST37 type from China - PubMed
Clostridioides difficile strains of sequence type (ST) 37, primarily including PCR ribotype (RT) 017, are prevalent in mainland China. Our study aimed to compare the major virulence factors of an epidemic C. difficile isolate of ST37 type (Xy06) from China with the well-characterized …
·pubmed.ncbi.nlm.nih.gov·
Genomic and phenotypic characterization of a Clostridioides difficile strain of the epidemic ST37 type from China - PubMed
Gut microbiota in gastrointestinal diseases: Insights and therapeutic strategies - PubMed
Gut microbiota in gastrointestinal diseases: Insights and therapeutic strategies - PubMed
Considering the bidirectional crosstalk along the gut-liver axis, gut-derived microorganisms and metabolites can be released into the liver, potentially leading to liver injury. In this editorial, we comment on several studies published in the recent issue of the World Journal of Gastroenterology …
·pubmed.ncbi.nlm.nih.gov·
Gut microbiota in gastrointestinal diseases: Insights and therapeutic strategies - PubMed
Unraveling Cecal Alterations in Clostridioides difficile Colonized Mice through Comprehensive Metabolic Profiling - PubMed
Unraveling Cecal Alterations in Clostridioides difficile Colonized Mice through Comprehensive Metabolic Profiling - PubMed
The disruption of gut microbiota caused by antibiotics favors the intestinal colonization of Clostridioides difficile - a Gram-positive, spore-forming anaerobic bacterium that causes potentially fatal gastrointestinal infections. In an endeavor to elucidate the complexities of the gut-brain a …
·pubmed.ncbi.nlm.nih.gov·
Unraveling Cecal Alterations in Clostridioides difficile Colonized Mice through Comprehensive Metabolic Profiling - PubMed
Multiple variables influence the finely calibrated antioxidant defenses of Clostridioides difficile - PubMed
Multiple variables influence the finely calibrated antioxidant defenses of Clostridioides difficile - PubMed
The obligate anaerobe Clostridioides difficile encodes multiple reductases to detoxify molecular oxygen and reactive oxygen species. Caulat and colleagues have characterized the activity and regulation of four such reductases (L. C. Caulat, A. Lotoux, M. C. Martins, N. Kint, et al., mBio 15:e …
·pubmed.ncbi.nlm.nih.gov·
Multiple variables influence the finely calibrated antioxidant defenses of Clostridioides difficile - PubMed
Mice colonized with the defined microbial community OMM19.1 are susceptible to Clostridioides difficile infection without prior antibiotic treatment - PubMed
Mice colonized with the defined microbial community OMM19.1 are susceptible to Clostridioides difficile infection without prior antibiotic treatment - PubMed
Diverse gut microorganisms present in humans and mice are essential for the prevention of microbial pathogen colonization. However, antibiotic-induced dysbiosis of the gut microbiome reduces microbial diversity and allows Clostridioides difficile (C. difficile) to colonize the intestin …
·pubmed.ncbi.nlm.nih.gov·
Mice colonized with the defined microbial community OMM19.1 are susceptible to Clostridioides difficile infection without prior antibiotic treatment - PubMed
Epidemiology of Clostridioides difficile PCR ribotype 181 after the COVID-19 pandemic in Northern Greece - PubMed
Epidemiology of Clostridioides difficile PCR ribotype 181 after the COVID-19 pandemic in Northern Greece - PubMed
Clostridioides difficile infection (CDI) is one of the most significant causes of diarrhea in hospitalized patients. The aim of this study was to investigate the incidence and epidemiology of CDI after the COVID-19 pandemic in hospitalized patients in a rehabilitation center in Thessaloniki, Greece. …
·pubmed.ncbi.nlm.nih.gov·
Epidemiology of Clostridioides difficile PCR ribotype 181 after the COVID-19 pandemic in Northern Greece - PubMed
A Mouse Model of Mild Clostridioides difficile Infection for the Characterization of Natural Immune Responses - PubMed
A Mouse Model of Mild Clostridioides difficile Infection for the Characterization of Natural Immune Responses - PubMed
(1) Background: We describe a model of primary mild-Clostridioides difficile infection (CDI) in a naïve host, including gut microbiota analysis, weight loss, mortality, length of colonization. This model was used in order to describe the kinetics of humoral (IgG, IgM) and mucosal (IgA) immune …
·pubmed.ncbi.nlm.nih.gov·
A Mouse Model of Mild Clostridioides difficile Infection for the Characterization of Natural Immune Responses - PubMed
Clostridioides difficile bacteria, which was seen in news, causes an infection in which part of body
Clostridioides difficile bacteria, which was seen in news, causes an infection in which part of body
Large intestine Researchers are developing an mRNA-based vaccine for Clostridioides difficile (C. difficile), a highly contagious bacterium. C. difficile causes an infection of the colon, the longest part of the large intestine, with symptoms ranging from diarrhea to life-threatening colon damag
·gktoday.in·
Clostridioides difficile bacteria, which was seen in news, causes an infection in which part of body
Genetic insight into the relationship between inflammatory bowel disease and Clostridioides difficile infection - PubMed
Genetic insight into the relationship between inflammatory bowel disease and Clostridioides difficile infection - PubMed
Patients with inflammatory bowel disease (IBD) are at increased risk of Clostridioides difficile infection (CDI). Herein, we aimed to determine if genetic risk contributes to this observed association. We carried out a genome-wide association study (GWAS) analysis in the Michigan Genomics Ini …
·pubmed.ncbi.nlm.nih.gov·
Genetic insight into the relationship between inflammatory bowel disease and Clostridioides difficile infection - PubMed
Examining the impact of the COVID-19 pandemic on hospital-associated Clostridioides difficile infection - PubMed
Examining the impact of the COVID-19 pandemic on hospital-associated Clostridioides difficile infection - PubMed
Despite large increases in several CDI risk factors, we did not observe the expected corresponding changes in HA-CDI rate during the first two years of the COVID-19 pandemic. We hypothesize that infection prevention measures responding to COVID-19 played a role in CDI prevention.
·pubmed.ncbi.nlm.nih.gov·
Examining the impact of the COVID-19 pandemic on hospital-associated Clostridioides difficile infection - PubMed
Whole-genome sequencing of toxigenic Clostridioides difficile reveals multidrug resistance and virulence genes in strains of environmental and animal origin - PubMed
Whole-genome sequencing of toxigenic Clostridioides difficile reveals multidrug resistance and virulence genes in strains of environmental and animal origin - PubMed
The results of this study demonstrated significant genetic similarity between ST11 strains isolated from environmental sampling and from animal origin; these strains may represent a reservoir for community-acquired C. difficile infection, which is becoming a growing public health threat due to the d …
·pubmed.ncbi.nlm.nih.gov·
Whole-genome sequencing of toxigenic Clostridioides difficile reveals multidrug resistance and virulence genes in strains of environmental and animal origin - PubMed
Genetic insight into the relationship between inflammatory bowel disease and Clostridioides difficile infection - PubMed
Genetic insight into the relationship between inflammatory bowel disease and Clostridioides difficile infection - PubMed
Patients with inflammatory bowel disease (IBD) are at increased risk of Clostridioides difficile infection (CDI). Herein, we aimed to determine if genetic risk contributes to this observed association. We carried out a genome-wide association study (GWAS) analysis in the Michigan Genomics Ini …
·pubmed.ncbi.nlm.nih.gov·
Genetic insight into the relationship between inflammatory bowel disease and Clostridioides difficile infection - PubMed
Bacterial metabolites influence the autofluorescence of Clostridioides difficile - PubMed
Bacterial metabolites influence the autofluorescence of Clostridioides difficile - PubMed
Clostridioides difficile is a bacterial pathogen that has been implicated in severe gastrointestinal infections. C. difficile has intrinsic green autofluorescence and the level of this autofluorescence is known to be increased by growth time and oxygen. Currently, it is unclear if diet …
·pubmed.ncbi.nlm.nih.gov·
Bacterial metabolites influence the autofluorescence of Clostridioides difficile - PubMed
Unveiling the impact of antibiotic stress on biofilm formation and expression of toxin-antitoxin system genes in Clostridium difficile clinical isolates - PubMed
Unveiling the impact of antibiotic stress on biofilm formation and expression of toxin-antitoxin system genes in Clostridium difficile clinical isolates - PubMed
Our study suggests that toxin and antitoxin genes may impact C. difficile biofilm formation, while antibiotics could signal biofilm strengthening and gene expression increase.
·pubmed.ncbi.nlm.nih.gov·
Unveiling the impact of antibiotic stress on biofilm formation and expression of toxin-antitoxin system genes in Clostridium difficile clinical isolates - PubMed
Relationships between Gut Microbiota and Autism Spectrum Disorders: Development and Treatment - PubMed
Relationships between Gut Microbiota and Autism Spectrum Disorders: Development and Treatment - PubMed
Many studies have demonstrated the impact of intestinal microbiota on normal brain development. Moreover, the gut microbiota (GM) is impacted by multiple endogenous and environmental factors that may promote gut dysbiosis (GD). An increasing number of studies are investigating the possible role of t …
·pubmed.ncbi.nlm.nih.gov·
Relationships between Gut Microbiota and Autism Spectrum Disorders: Development and Treatment - PubMed
Unravelling the Role of Gut and Oral Microbiota in the Pediatric Population with Type 1 Diabetes Mellitus - PubMed
Unravelling the Role of Gut and Oral Microbiota in the Pediatric Population with Type 1 Diabetes Mellitus - PubMed
Type 1 Diabetes Mellitus (T1DM) is a chronic autoimmune disease that results in the destruction of pancreatic β cells, leading to hyperglycaemia and the need for lifelong insulin therapy. Although genetic predisposition and environmental factors are considered key contributors to T1DM, the exact cau …
·pubmed.ncbi.nlm.nih.gov·
Unravelling the Role of Gut and Oral Microbiota in the Pediatric Population with Type 1 Diabetes Mellitus - PubMed
Unveiling the impact of antibiotic stress on biofilm formation and expression of toxin-antitoxin system genes in Clostridium difficile clinical isolates - PubMed
Unveiling the impact of antibiotic stress on biofilm formation and expression of toxin-antitoxin system genes in Clostridium difficile clinical isolates - PubMed
Our study suggests that toxin and antitoxin genes may impact C. difficile biofilm formation, while antibiotics could signal biofilm strengthening and gene expression increase.
·pubmed.ncbi.nlm.nih.gov·
Unveiling the impact of antibiotic stress on biofilm formation and expression of toxin-antitoxin system genes in Clostridium difficile clinical isolates - PubMed
Exploring the role of gut microbiome in autoimmune diseases: A comprehensive review - PubMed
Exploring the role of gut microbiome in autoimmune diseases: A comprehensive review - PubMed
As the industrialized society advances, there has been a gradual increase in the prevalence of autoimmune disorders. A probe into the fundamental causes has disclosed several factors in modern society that have an influence on the gut microbiome. These dramatic shifts in the gut microbiome are likel …
·pubmed.ncbi.nlm.nih.gov·
Exploring the role of gut microbiome in autoimmune diseases: A comprehensive review - PubMed
Ulcerative colitis: molecular insights and intervention therapy - PubMed
Ulcerative colitis: molecular insights and intervention therapy - PubMed
Ulcerative colitis (UC) is a chronic inflammatory bowel disease characterized by abdominal pain, diarrhea, rectal bleeding, and weight loss. The pathogenesis and treatment of UC remain key areas of research interest. Various factors, including genetic predisposition, immune dysregulation, and altera …
·pubmed.ncbi.nlm.nih.gov·
Ulcerative colitis: molecular insights and intervention therapy - PubMed
Influence of microbiota on the growth and gene expression of Clostridioides difficile in an in vitro coculture model - PubMed
Influence of microbiota on the growth and gene expression of Clostridioides difficile in an in vitro coculture model - PubMed
Clostridioides difficile is an anaerobic, spore-forming, Gram-positive pathogenic bacterium. This study aimed to analyze the effect of two samples of healthy fecal microbiota on C. difficile gene expression and growth using an in vitro coculture model. The inner compartment was cocultured with spore …
·pubmed.ncbi.nlm.nih.gov·
Influence of microbiota on the growth and gene expression of Clostridioides difficile in an in vitro coculture model - PubMed
The current riboswitch landscape in Clostridioides difficile - PubMed
The current riboswitch landscape in Clostridioides difficile - PubMed
Riboswitches are 5' RNA regulatory elements that are capable of binding to various ligands, such as small metabolites, ions and tRNAs, leading to conformational changes and affecting gene transcription or translation. They are widespread in bacteria and frequently control genes that are essential fo …
·pubmed.ncbi.nlm.nih.gov·
The current riboswitch landscape in Clostridioides difficile - PubMed
Impact of Gut Microbiota and SCFAs in the Pathogenesis of PCOS and the Effect of Metformin Therapy - PubMed
Impact of Gut Microbiota and SCFAs in the Pathogenesis of PCOS and the Effect of Metformin Therapy - PubMed
Polycystic ovary syndrome (PCOS) is a complex disorder that impacts both the endocrine and metabolic systems, often resulting in infertility, obesity, insulin resistance, and cardiovascular complications. The aim of this study is to investigate the role of intestinal flora and its metabolites, parti …
·pubmed.ncbi.nlm.nih.gov·
Impact of Gut Microbiota and SCFAs in the Pathogenesis of PCOS and the Effect of Metformin Therapy - PubMed
Risk of Intestinal Complications, Extraintestinal Morbidity, and Mortality in Patients with Crohn's Disease and Ocular Involvement - PubMed
Risk of Intestinal Complications, Extraintestinal Morbidity, and Mortality in Patients with Crohn's Disease and Ocular Involvement - PubMed
Patients who have CD and subsequent ocular involvement have an increased risk of local intestinal complications, extraintestinal morbidity, and cardiovascular complications when compared to patients with CD without ocular involvement.
·pubmed.ncbi.nlm.nih.gov·
Risk of Intestinal Complications, Extraintestinal Morbidity, and Mortality in Patients with Crohn's Disease and Ocular Involvement - PubMed
TcdB from Hypervirulent Clostridioides difficile Induces Neuronal Loss and Neurotransmitter Alterations in the Intrinsic Enteric Nervous System - PubMed
TcdB from Hypervirulent Clostridioides difficile Induces Neuronal Loss and Neurotransmitter Alterations in the Intrinsic Enteric Nervous System - PubMed
Clostridioides difficile infection (CDI) is a predominant cause of intestinal infections. The intrinsic enteric nervous system (ENS) occupies the intestinal tissue in large numbers and intricately regulates various aspects of intestinal function. Nonetheless, the specific effects of CDI on the intri …
·pubmed.ncbi.nlm.nih.gov·
TcdB from Hypervirulent Clostridioides difficile Induces Neuronal Loss and Neurotransmitter Alterations in the Intrinsic Enteric Nervous System - PubMed
Normalization of short-chain fatty acid concentration by bacterial count of stool samples improves discrimination between eubiotic and dysbiotic gut microbiota caused by Clostridioides difficile infection - PubMed
Normalization of short-chain fatty acid concentration by bacterial count of stool samples improves discrimination between eubiotic and dysbiotic gut microbiota caused by Clostridioides difficile infection - PubMed
Short-chain fatty acids (SCFAs) represent a cornerstone of gut health, serving as critical mediators of immune modulation and overall host homeostasis. Patients with dysbiosis caused by Clostridioides difficile infection (CDI) typically exhibit lower SCFAs levels compared to healthy stool don …
·pubmed.ncbi.nlm.nih.gov·
Normalization of short-chain fatty acid concentration by bacterial count of stool samples improves discrimination between eubiotic and dysbiotic gut microbiota caused by Clostridioides difficile infection - PubMed