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C difficile—a rose by any other name…
C difficile—a rose by any other name…
The twists and turns of bacterial taxonomy occasionally throw up complications for the infectious diseases community. Long established and familiar organisms are, from the perspective of many medical practitioners, suddenly renamed for what might seem to be arcane reasons that have little relevance to the management of disease. However, if a name change is hastily adopted by medical practitioners there is the potential for unintended consequences. For this reason, and a strong conservative instinct, taxonomic changes can take a while to filter through to medical practice.
·thelancet.com·
C difficile—a rose by any other name…
Defined microbial communities and their soluble products protect mice from Clostridioides difficile infection - PubMed
Defined microbial communities and their soluble products protect mice from Clostridioides difficile infection - PubMed
Clostridioides difficile is the leading cause of antibiotic-associated infectious diarrhea. The development of C.difficile infection is tied to perturbations of the bacterial community in the gastrointestinal tract, called the gastrointestinal microbiota. Repairing the gastrointestinal microbiota by …
·pubmed.ncbi.nlm.nih.gov·
Defined microbial communities and their soluble products protect mice from Clostridioides difficile infection - PubMed
Starvation helps transition to abundance - a ferrosome story - PubMed
Starvation helps transition to abundance - a ferrosome story - PubMed
Iron is an essential nutrient for bacterial pathogenesis. In their study, Skaar and colleagues (Pi et al.) discovered and determined the detailed structure of ferrosomes within Clostridioides difficile, the iron-storage organelles that form under iron-limited conditions in anticipation of future iro …
·pubmed.ncbi.nlm.nih.gov·
Starvation helps transition to abundance - a ferrosome story - PubMed
Phase variation of flagella and toxins in Clostridioides difficile is mediated by selective Rho-dependent termination - PubMed
Phase variation of flagella and toxins in Clostridioides difficile is mediated by selective Rho-dependent termination - PubMed
Clostridioides difficile is an intestinal pathogen that exhibits phase variation of flagella and toxins though inversion of the flagellar (flg) switch controlling flagellar and toxin gene expression. The transcription termination factor Rho preferentially inhibits swimming motility of bacteria with …
·pubmed.ncbi.nlm.nih.gov·
Phase variation of flagella and toxins in Clostridioides difficile is mediated by selective Rho-dependent termination - PubMed
Animal and In Vitro Models as Powerful Tools to Decipher the Effects of Enteric Pathogens on the Human Gut Microbiota - PubMed
Animal and In Vitro Models as Powerful Tools to Decipher the Effects of Enteric Pathogens on the Human Gut Microbiota - PubMed
Examining the interplay between intestinal pathogens and the gut microbiota is crucial to fully comprehend the pathogenic role of enteropathogens and their broader impact on human health. Valid alternatives to human studies have been introduced in laboratory practice to evaluate the effects of infec …
·pubmed.ncbi.nlm.nih.gov·
Animal and In Vitro Models as Powerful Tools to Decipher the Effects of Enteric Pathogens on the Human Gut Microbiota - PubMed
Platelets promote human macrophages-mediated macropinocytosis of Clostridioides difficile - PubMed
Platelets promote human macrophages-mediated macropinocytosis of Clostridioides difficile - PubMed
Clostridioides difficile is the main causative agent of hospital-acquired diarrhea and the potentially lethal disease, C. difficile infection. The cornerstone of the current therapy is the use of antibiotics, which is not fully effective. The molecular mechanisms, inflammatory conditio …
·pubmed.ncbi.nlm.nih.gov·
Platelets promote human macrophages-mediated macropinocytosis of Clostridioides difficile - PubMed
Commensal antimicrobial resistance mediates microbiome resilience to antibiotic disruption - PubMed
Commensal antimicrobial resistance mediates microbiome resilience to antibiotic disruption - PubMed
Despite their therapeutic benefits, antibiotics exert collateral damage on the microbiome and promote antimicrobial resistance. However, the mechanisms governing microbiome recovery from antibiotics are poorly understood. Treatment of Mycobacterium tuberculosis, the world's most common infect …
·pubmed.ncbi.nlm.nih.gov·
Commensal antimicrobial resistance mediates microbiome resilience to antibiotic disruption - PubMed
Another iron in C. difficile's fire - PubMed
Another iron in C. difficile's fire - PubMed
Iron is arguably the most important nutrient in the ongoing battle between hosts and bacteria. Recently in Nature, a unique iron storage organelle, the ferrosome, was discovered in the human pathogen Clostridioides difficile.1 But what is the role of ferrosomes and how do they affect bact …
·pubmed.ncbi.nlm.nih.gov·
Another iron in C. difficile's fire - PubMed
Prophage Carriage and Genetic Diversity within Environmental Isolates of Clostridioides difficile - PubMed
Prophage Carriage and Genetic Diversity within Environmental Isolates of Clostridioides difficile - PubMed
Clostridioides difficile is an important human pathogen causing antibiotic-associated diarrhoea worldwide. Besides using antibiotics for treatment, the interest in bacteriophages as an alternative therapeutic option has increased. Prophage abundance and genetic diversity are well-documented i …
·pubmed.ncbi.nlm.nih.gov·
Prophage Carriage and Genetic Diversity within Environmental Isolates of Clostridioides difficile - PubMed
The microbial-derived bile acid lithocholate and its epimers inhibit Clostridioides difficile growth and pathogenicity while sparing members of the gut microbiota | Journal of Bacteriology
The microbial-derived bile acid lithocholate and its epimers inhibit Clostridioides difficile growth and pathogenicity while sparing members of the gut microbiota | Journal of Bacteriology
In the search for a novel therapeutic that targets Clostridioides difficile, bile acids have become a viable solution. Epimers of bile acids are particularly attractive as they may provide protection against C. difficile while leaving the indigenous gut ...
·news.google.com·
The microbial-derived bile acid lithocholate and its epimers inhibit Clostridioides difficile growth and pathogenicity while sparing members of the gut microbiota | Journal of Bacteriology
Flagellin is essential for initial attachment to mucosal surfaces by Clostridioides difficile | Microbiology Spectrum
Flagellin is essential for initial attachment to mucosal surfaces by Clostridioides difficile | Microbiology Spectrum
Clostridioides difficile is one of the leading causes of hospital-acquired infections worldwide and presents challenges in treatment due to recurrent gastrointestinal disease after treatment with antimicrobials. The mechanisms by which C. difficile ...
·news.google.com·
Flagellin is essential for initial attachment to mucosal surfaces by Clostridioides difficile | Microbiology Spectrum
Clostridioides difficile infection after extracorporeal membrane oxygenation support for acute myocardial infarction: a case report - PubMed
Clostridioides difficile infection after extracorporeal membrane oxygenation support for acute myocardial infarction: a case report - PubMed
In this case, temporary application of ECMO was applied, and the anti-infective treatment relied on the use of antibiotics at short-term, low-dose, and low CDI risk. Hence, the occurrence of CDI was considered an uncommon event, which may serve as a reference for future cases.
·pubmed.ncbi.nlm.nih.gov·
Clostridioides difficile infection after extracorporeal membrane oxygenation support for acute myocardial infarction: a case report - PubMed
Membrane Vesicles of Clostridioides difficile and Other Clostridial Species - PubMed
Membrane Vesicles of Clostridioides difficile and Other Clostridial Species - PubMed
Membrane vesicles are secreted by growing bacterial cells and are important components of the bacterial secretome, with a role in delivering effector molecules that ultimately enable bacterial survival. Membrane vesicles of Clostridioides difficile likely contribute to pathogenicity and is a new are …
·pubmed.ncbi.nlm.nih.gov·
Membrane Vesicles of Clostridioides difficile and Other Clostridial Species - PubMed
Antibiotic Resistances of Clostridioides difficile - PubMed
Antibiotic Resistances of Clostridioides difficile - PubMed
The rapid evolution of antibiotic resistance in Clostridioides difficile and the consequent effects on prevention and treatment of C. difficile infections (CDIs) are a matter of concern for public health. Antibiotic resistance plays an important role in driving C. difficile epidemiology. Emergence o …
·pubmed.ncbi.nlm.nih.gov·
Antibiotic Resistances of Clostridioides difficile - PubMed
Comparative Genomics of Clostridioides difficile - PubMed
Comparative Genomics of Clostridioides difficile - PubMed
Clostridioides difficile, a Gram-positive spore-forming anaerobic bacterium, has rapidly emerged as the leading cause of nosocomial diarrhoea in hospitals. The availability of large numbers of genome sequences, mainly due to the use of next-generation sequencing methods, has undoubtedly shown their …
·pubmed.ncbi.nlm.nih.gov·
Comparative Genomics of Clostridioides difficile - PubMed
An Updated View on the Cellular Uptake and Mode-of-Action of Clostridioides difficile Toxins - PubMed
An Updated View on the Cellular Uptake and Mode-of-Action of Clostridioides difficile Toxins - PubMed
Research on the human gut pathogen Clostridioides (C.) difficile and its toxins continues to attract much attention as a consequence of the threat to human health posed by hypervirulent strains. Toxin A (TcdA) and Toxin B (TcdB) are the two major virulence determinants of C. difficile. Both are sing …
·pubmed.ncbi.nlm.nih.gov·
An Updated View on the Cellular Uptake and Mode-of-Action of Clostridioides difficile Toxins - PubMed
Clostridioides difficile Biofilm - PubMed
Clostridioides difficile Biofilm - PubMed
Clostridioides difficile infection (CDI), previously Clostridium difficile infection, is a symptomatic infection of the large intestine caused by the spore-forming anaerobic, gram-positive bacterium Clostridioides difficile. CDI is an important healthcare-associated disease worldwide, characterized …
·pubmed.ncbi.nlm.nih.gov·
Clostridioides difficile Biofilm - PubMed
Clostridioides difficile Sporulation - PubMed
Clostridioides difficile Sporulation - PubMed
Some members of the Firmicutes phylum, including many members of the human gut microbiota, are able to differentiate a dormant and highly resistant cell type, the endospore (hereinafter spore for simplicity). Spore-formers can colonize virtually any habitat and, because of their resistance to a wide …
·pubmed.ncbi.nlm.nih.gov·
Clostridioides difficile Sporulation - PubMed
Characterization of community-acquired Clostridioides difficile strains in Israel, 2020-2022 - PubMed
Characterization of community-acquired Clostridioides difficile strains in Israel, 2020-2022 - PubMed
C. difficile isolates in Israel community exhibit high ST diversity, with no dominant strain. Other factors may influence the clinical outcomes of CDI such as toxin production, antibiotic resistance and biofilm production. Further studies are needed to better understand the dynamics and influ …
·pubmed.ncbi.nlm.nih.gov·
Characterization of community-acquired Clostridioides difficile strains in Israel, 2020-2022 - PubMed
Gut microbiota facilitate chronic spontaneous urticaria - PubMed
Gut microbiota facilitate chronic spontaneous urticaria - PubMed
Chronic spontaneous urticaria (CSU) comes with gut dysbiosis, but its relevance remains elusive. Here we use metagenomics sequencing and short-chain fatty acids metabolomics and assess the effects of human CSU fecal microbial transplantation, Klebsiella pneumoniae, Roseburia hominis, and metabolites …
·pubmed.ncbi.nlm.nih.gov·
Gut microbiota facilitate chronic spontaneous urticaria - PubMed
Hyperbaric oxygen augments susceptibility to C. difficile infection by impairing gut microbiota ability to stimulate the HIF-1α-IL-22 axis in ILC3 - PubMed
Hyperbaric oxygen augments susceptibility to C. difficile infection by impairing gut microbiota ability to stimulate the HIF-1α-IL-22 axis in ILC3 - PubMed
Hyperbaric oxygen (HBO) therapy is a well-established method for improving tissue oxygenation and is typically used for the treatment of various inflammatory conditions, including infectious diseases. However, its effect on the intestinal mucosa, a microenvironment known to be physiologically hypoxi …
·pubmed.ncbi.nlm.nih.gov·
Hyperbaric oxygen augments susceptibility to C. difficile infection by impairing gut microbiota ability to stimulate the HIF-1α-IL-22 axis in ILC3 - PubMed
Host Immune Responses to Clostridioides difficile Infection and Potential Novel Therapeutic Approaches - PubMed
Host Immune Responses to Clostridioides difficile Infection and Potential Novel Therapeutic Approaches - PubMed
Clostridioides difficile infection (CDI) is a leading nosocomial infection, posing a substantial public health challenge within the United States and globally. CDI typically occurs in hospitalized elderly patients who have been administered antibiotics; however, there has been a rise in the o …
·pubmed.ncbi.nlm.nih.gov·
Host Immune Responses to Clostridioides difficile Infection and Potential Novel Therapeutic Approaches - PubMed
The impact of gut microbiome enterotypes on ulcerative colitis: identifying key bacterial species and revealing species co-occurrence networks using machine learning - PubMed
The impact of gut microbiome enterotypes on ulcerative colitis: identifying key bacterial species and revealing species co-occurrence networks using machine learning - PubMed
Ulcerative colitis (UC) is a chronic inflammatory intestinal disease affecting the colon and rectum, with its pathogenesis attributed to genetic background, environmental factors, and gut microbes. This study aimed to investigate the role of enterotypes in UC by conducting a hierarchical analysis, d …
·pubmed.ncbi.nlm.nih.gov·
The impact of gut microbiome enterotypes on ulcerative colitis: identifying key bacterial species and revealing species co-occurrence networks using machine learning - PubMed