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Glycine fermentation by C. difficile promotes virulence and spore formation, and is induced by host cathelicidin | Infection and Immunity
Glycine fermentation by C. difficile promotes virulence and spore formation, and is induced by host cathelicidin | Infection and Immunity
Clostridioides difficile is an anaerobic, Gram-positive, spore-forming gastrointestinal pathogen that causes severe diarrheal disease which can lead to death (1). To cause disease, C. difficile spores must be ingested and germinate in the intestine upon exposure to bile salts and glycine (2). Upon the outgrowth of spores into vegetative cells, C. difficile colonizes the colon, using the available nutrients to replicate within the host. As the population increases and nutrients become scarce, C. difficile produces toxins (TcdA and TcdB), releasing additional nutrients and further altering the metabolic environment (3). In turn, host inflammation is induced, resulting in the release of immune effectors and the characteristic pathologies associated with C. difficile infections (4).
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Glycine fermentation by C. difficile promotes virulence and spore formation, and is induced by host cathelicidin | Infection and Immunity
Liberation of host heme by Clostridioides difficile- mediated damage enhances Enterococcus faecalis fitness during infection - PubMed
Liberation of host heme by Clostridioides difficile- mediated damage enhances Enterococcus faecalis fitness during infection - PubMed
Clostridioides difficile and Enterococcus faecalis are two pathogens of great public health importance. Both bacteria colonize the human gastrointestinal tract where they are known to interact in ways that worsen disease outcomes. We show that the damage associated with C. difficile …
·pubmed.ncbi.nlm.nih.gov·
Liberation of host heme by Clostridioides difficile- mediated damage enhances Enterococcus faecalis fitness during infection - PubMed
The role of gut fungi in Clostridioides difficile infection - PubMed
The role of gut fungi in Clostridioides difficile infection - PubMed
Clostridioides difficile, the etiological agent of C. difficile infection (CDI), elicits a spectrum of diarrheal symptoms with varying severity and the potential to result in severe complications such as colonic perforation, pseudomembranous colitis, and toxic megacolon. The perturbation of gut micr …
·pubmed.ncbi.nlm.nih.gov·
The role of gut fungi in Clostridioides difficile infection - PubMed
Predictive value of fecal calprotectin and lactoferrin levels for negative outcomes in Clostridioides difficile infection - PubMed
Predictive value of fecal calprotectin and lactoferrin levels for negative outcomes in Clostridioides difficile infection - PubMed
By modifying the thresholds for assay positivity, the measurement of FC and FL at diagnosis is useful to predict recurrence and severity in CDI. Adding these biomarkers to current clinical scores may help to individualize CDI management.
·pubmed.ncbi.nlm.nih.gov·
Predictive value of fecal calprotectin and lactoferrin levels for negative outcomes in Clostridioides difficile infection - PubMed
Occult bacteremia in living donor liver transplantation: a prospective observational study of recipients and donors - PubMed
Occult bacteremia in living donor liver transplantation: a prospective observational study of recipients and donors - PubMed
Occult bacteremia is a common condition that occurs in both donors and recipients. While occult bacteremia generally remains subclinical in the healthy population, there is potential risk of the development of an apparent post-LT infection in recipients who are highly immunosuppressed.
·pubmed.ncbi.nlm.nih.gov·
Occult bacteremia in living donor liver transplantation: a prospective observational study of recipients and donors - PubMed
Periodontitis salivary microbiota exacerbates colitis-induced anxiety-like behavior via gut microbiota - PubMed
Periodontitis salivary microbiota exacerbates colitis-induced anxiety-like behavior via gut microbiota - PubMed
The gut-brain axis is a bidirectional communication system between the gut and central nervous system. Many host-related factors can affect gut microbiota, including oral bacteria, making the brain a vulnerable target via the gut-brain axis. Saliva contains a large number of oral bacteria, and perio …
·pubmed.ncbi.nlm.nih.gov·
Periodontitis salivary microbiota exacerbates colitis-induced anxiety-like behavior via gut microbiota - PubMed
Associations of motility and auto-aggregation with biofilm-formation capacity levels in Clostridioidesdifficile - PubMed
Associations of motility and auto-aggregation with biofilm-formation capacity levels in Clostridioidesdifficile - PubMed
Clostridioides difficile (C. difficile) is responsible for one of the most common nosocomial infections worldwide. This work assessed associations between biofilm-formation capacity levels of C. difficile and cell viability, motility, flagella, motility and auto-aggregation in 118 clinical isolates. …
·pubmed.ncbi.nlm.nih.gov·
Associations of motility and auto-aggregation with biofilm-formation capacity levels in Clostridioidesdifficile - PubMed
Gut liver brain axis in diseases: the implications for therapeutic interventions - PubMed
Gut liver brain axis in diseases: the implications for therapeutic interventions - PubMed
Gut-liver-brain axis is a three-way highway of information interaction system among the gastrointestinal tract, liver, and nervous systems. In the past few decades, breakthrough progress has been made in the gut liver brain axis, mainly through understanding its formation mechanism and increasing tr …
·pubmed.ncbi.nlm.nih.gov·
Gut liver brain axis in diseases: the implications for therapeutic interventions - PubMed
Longitudinal dynamics of gut microbiota in the pathogenesis of acute graft-versus-host disease - PubMed
Longitudinal dynamics of gut microbiota in the pathogenesis of acute graft-versus-host disease - PubMed
Dynamic changes in gut microbiota composition and related cytokines were found to be related to aGvHD, including pathogenic or protective changes. These findings suggested that manipulation of gut microbiota at different timepoints might be a promising avenue for preventing or treating this common c …
·pubmed.ncbi.nlm.nih.gov·
Longitudinal dynamics of gut microbiota in the pathogenesis of acute graft-versus-host disease - PubMed
Engraftment of essential functions through multiple fecal microbiota transplants in chronic antibiotic-resistant pouchitis-a case study using metatranscriptomics - PubMed
Engraftment of essential functions through multiple fecal microbiota transplants in chronic antibiotic-resistant pouchitis-a case study using metatranscriptomics - PubMed
Our study demonstrates the clear but short-lived activity engraftment of donor microbiota, particularly the butyrate biosynthesis after each FMT. The data suggest that FMT triggers shifts in the activity of patient microbiota towards health which need to be repeated to reach critical thresholds. As …
·pubmed.ncbi.nlm.nih.gov·
Engraftment of essential functions through multiple fecal microbiota transplants in chronic antibiotic-resistant pouchitis-a case study using metatranscriptomics - PubMed
Gut microbiome-associated predictors as biomarkers of response to advanced therapies in inflammatory bowel disease: a systematic review - PubMed
Gut microbiome-associated predictors as biomarkers of response to advanced therapies in inflammatory bowel disease: a systematic review - PubMed
Loss of response to therapy in inflammatory bowel disease (IBD) has led to a surge in research focusing on precision medicine. Three systematic reviews have been published investigating the associations between gut microbiota and disease activity or IBD therapy. We performed a systematic review to i …
·pubmed.ncbi.nlm.nih.gov·
Gut microbiome-associated predictors as biomarkers of response to advanced therapies in inflammatory bowel disease: a systematic review - PubMed
The Relationship Between the Microbiome and Antimicrobial Resistance - PubMed
The Relationship Between the Microbiome and Antimicrobial Resistance - PubMed
Antibiotics have benefitted human health since their introduction nearly a century ago. However, the rise of antibiotic resistance may portend the dawn of the "post-antibiotic age." With the narrow pipeline for novel antimicrobials, we need new approaches to deal with the rise of multidrug resistant …
·pubmed.ncbi.nlm.nih.gov·
The Relationship Between the Microbiome and Antimicrobial Resistance - PubMed
Clostridioides difficile canonical L,D-transpeptidases catalyse a novel type of peptidoglycan cross-links and are not required for beta-lactam resistance - PubMed
Clostridioides difficile canonical L,D-transpeptidases catalyse a novel type of peptidoglycan cross-links and are not required for beta-lactam resistance - PubMed
Clostridioides difficile is the leading cause of antibiotic-associated diarrhoea worldwide with significant morbidity and mortality. This organism is naturally resistant to several beta-lactam antibiotics that inhibit the polymerisation of peptidoglycan, an essential component of the bacteria cell e …
·pubmed.ncbi.nlm.nih.gov·
Clostridioides difficile canonical L,D-transpeptidases catalyse a novel type of peptidoglycan cross-links and are not required for beta-lactam resistance - PubMed
Gut microbiota signatures and modulation in irritable bowel syndrome - PubMed
Gut microbiota signatures and modulation in irritable bowel syndrome - PubMed
Irritable bowel syndrome (IBS) affects approximately one tenth of the general population and is characterized by abdominal pain associated with abnormalities in bowel habits. Visceral hypersensitivity, abnormal intestinal motor function, mucosal immune activation, and increased intestinal permeabili …
·pubmed.ncbi.nlm.nih.gov·
Gut microbiota signatures and modulation in irritable bowel syndrome - PubMed
Modeling microbiota-associated human diseases: from minimal models to complex systems - PubMed
Modeling microbiota-associated human diseases: from minimal models to complex systems - PubMed
Alterations in the intestinal microbiota are associated with various human diseases of the digestive system, including obesity and its associated metabolic diseases, inflammatory bowel diseases (IBD), and colorectal cancer (CRC). All three diseases are characterized by modifications of the richness, …
·pubmed.ncbi.nlm.nih.gov·
Modeling microbiota-associated human diseases: from minimal models to complex systems - PubMed
Diversification of division mechanisms in endospore-forming bacteria revealed by analyses of peptidoglycan synthesis in Clostridioides difficile
Diversification of division mechanisms in endospore-forming bacteria revealed by analyses of peptidoglycan synthesis in Clostridioides difficile
Nature Communications - The enzymes FtsW and FtsI are thought to be essential for the synthesis of septal peptidoglycan (PG) during bacterial cell division. Here, Shrestha et al. show that the...
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Diversification of division mechanisms in endospore-forming bacteria revealed by analyses of peptidoglycan synthesis in Clostridioides difficile
Clostridioides difficile infection leading to fulminant colitis with toxic megacolon - PubMed
Clostridioides difficile infection leading to fulminant colitis with toxic megacolon - PubMed
Clostridioidesdifficile infection (CDI) is the culprit of millions of nosocomial infections in the United States. Programs that successfully decrease its incidence, therefore, render cost savings for the healthcare system. Toxic megacolon and perforation are two of the most significant compli …
·pubmed.ncbi.nlm.nih.gov·
Clostridioides difficile infection leading to fulminant colitis with toxic megacolon - PubMed
Unveiling the inhibition mechanism of Clostridioides difficile by Bifidobacterium longum via multiomics approach - PubMed
Unveiling the inhibition mechanism of Clostridioides difficile by Bifidobacterium longum via multiomics approach - PubMed
Antibiotic-induced gut microbiota disruption constitutes a major risk factor for Clostridioides difficile infection (CDI). Further, antibiotic therapy, which is the standard treatment option for CDI, exacerbates gut microbiota imbalance, thereby causing high recurrent CDI incidence. Consequen …
·pubmed.ncbi.nlm.nih.gov·
Unveiling the inhibition mechanism of Clostridioides difficile by Bifidobacterium longum via multiomics approach - PubMed
Endoscopic and histopathological hints on infections in patients of common variable immunodeficiency disorder with gastrointestinal symptoms - BMC Gastroenterology
Endoscopic and histopathological hints on infections in patients of common variable immunodeficiency disorder with gastrointestinal symptoms - BMC Gastroenterology
Background and aims Common variable immunodeficiency disorder (CVID) patients may have gastrointestinal (GI) involvement and suffer from infections, which are poorly understood. This study aimed to evaluate the clinical, endoscopic, and histopathological features of CVID patients with GI symptoms and determine their correlation with infections. Methods We performed a retrospective study on 21 CVID patients with GI symptoms who underwent endoscopic examination in Peking Union Medical College Hospital from 2000 to 2020. The clinical, infectious, endoscopic, and histopathological features were reassessed. Results Chronic diarrhea was the most prevalent GI symptom, observed in 95.2% of our CVID cohort. Over 85% of patients had low body weight and malabsorption. Small bowel villous atrophy was found in 90.5% of patients under endoscopy and mostly confirmed by histopathology. GI infections were identified in 9 (42.9%) patients. Of these, 7 patients with diffuse and obvious nodular lymphoid hyperplasia (NLH) of small bowel under endoscopy had significantly higher infection rate (85.7% vs 21.4%, p
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Endoscopic and histopathological hints on infections in patients of common variable immunodeficiency disorder with gastrointestinal symptoms - BMC Gastroenterology
Identification of an anti-CRISPR protein that inhibits the CRISPR-Cas type I-B system in Clostridioides difficile - PubMed
Identification of an anti-CRISPR protein that inhibits the CRISPR-Cas type I-B system in Clostridioides difficile - PubMed
Clostridioides difficile is the widespread anaerobic spore-forming bacterium that is a major cause of potentially lethal nosocomial infections associated with antibiotic therapy worldwide. Due to the increase in severe forms associated with a strong inflammatory response and higher recurrence …
·pubmed.ncbi.nlm.nih.gov·
Identification of an anti-CRISPR protein that inhibits the CRISPR-Cas type I-B system in Clostridioides difficile - PubMed
Multi-omics analysis of hospital-acquired diarrhoeal patients reveals biomarkers of enterococcal proliferation and Clostridioides difficile infection
Multi-omics analysis of hospital-acquired diarrhoeal patients reveals biomarkers of enterococcal proliferation and Clostridioides difficile infection
Nature Communications - Antibiotics can cause hospital-acquired diarrhoea, resulting in gut microbiota and metabolome changes. Here, the authors study the faecal microbiota and metabolome of 169...
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Multi-omics analysis of hospital-acquired diarrhoeal patients reveals biomarkers of enterococcal proliferation and Clostridioides difficile infection
Trauma-toxicology: concepts, causes, complications - PubMed
Trauma-toxicology: concepts, causes, complications - PubMed
Trauma and toxic substances are connected in several aspects. On the one hand, toxic substances can be the reason for traumatic injuries in the context of accidental or violent and criminal circumstances. Examples for the first scenario is the release of toxic gases, chemicals, and particles during …
·pubmed.ncbi.nlm.nih.gov·
Trauma-toxicology: concepts, causes, complications - PubMed
A Colonic Organoid Model Challenged with the Large Toxins of Clostridioides difficile TcdA and TcdB Exhibit Deregulated Tight Junction Proteins - PubMed
A Colonic Organoid Model Challenged with the Large Toxins of Clostridioides difficile TcdA and TcdB Exhibit Deregulated Tight Junction Proteins - PubMed
Adult stem cell-derived human colonic organoid monolayers were applicable as a colon infection model for electrophysiological measurements. The TJ changes noted can explain the epithelial barrier dysfunction and diarrhea in patients, as well as increased entry of luminal antigens triggering inflamma …
·pubmed.ncbi.nlm.nih.gov·
A Colonic Organoid Model Challenged with the Large Toxins of Clostridioides difficile TcdA and TcdB Exhibit Deregulated Tight Junction Proteins - PubMed