Evaluating Clostridioides difficile infection in lung cancer patients receiving EGFR-TKIs.

Multiple studies have demonstrated abnormalities in the contents of the fecal microbiota in patients with a variety of forms of arthritis. This has pr…

A subset of clinical isolates of Clostridioides difficile contains one or more plasmids and these plasmids can harbor virulence and antimicrobial resistance determinants. Despite their potential importance, C. difficile plasmids remain poorly characterized. Here, we provide the complete genome seque …

A subset of clinical isolates of Clostridioides difficile contains one or more plasmids and these plasmids can harbor virulence and antimicrobial resistance determinants. Despite their potential importance, C. difficile plasmids remain poorly characterized. Here, we provide the complete genome seque …

Clostridioides difficile (Clostridium difficile) infection (CDI) is one of the main public health concerns in adults, while children under 2 years of age are often colonized asymptomatically. In both adults and children, CDI is strongly associated with disturbances in gut microbiota. In this …

During the study period, the sentinel #surveillance scheme included ca 14–15% of all Danish cases of #Cdiff infections Binary toxin-negative strains accounted for 75% and 16 of the 20 most prevalent types⬇️https://t.co/AKfrYzexu7#antibiotic #AMR #AntimicrobialResistance pic.twitter.com/6B5zfAs4wY— 𝘌𝘶𝘳𝘰𝘴𝘶𝘳𝘷𝘦𝘪𝘭𝘭𝘢𝘯𝘤𝘦 (@Eurosurveillanc) December 14, 2022

Nature Reviews Microbiology - In this Review, Caballero-Flores, Pickard and Núñez explore how the microbiota limits colonization by pathogens and the strategies used by pathogens to...

New research from the University of Virginia School of Medicine and collaborators reveals how microorganisms found in our guts can worsen dangerous C

Clostridioides difficile causes the highest number of nosocomial infections. Currently, treatment options for C. difficile infection (CDI) are very limited, resulting in poor treatment outcomes and high recurrence rates. Although the disease caused by CDI is inflammatory in nature, the …

#Gutbacteria put people at risk for severe #Cdifficile, a #bacterium that can cause potentially deadly infections, particularly among #elderly and people on long-term #antibiotics. #Antibioticresistant #pathogens in #gut make #Cdiff more dangerous. https://t.co/7mXNcPfNLP— Greg Slabodkin (@Slabodkin) December 21, 2022

Clostridia are a polyphyletic group of Gram-positive, spore-forming anaerobes in the Firmicutes phylum that significantly impact metabolism and functioning of the human gastrointestinal tract. Recently, Clostridia were divided into two separate classes, Clostridia and …

Images in Clinical Medicine from The New England Journal of Medicine — Toxic Megacolon Due to Fulminant Clostridioides difficile Infection

Pain-sensing neurons detect environmental insults and tissue injury, driving avoidance behavior and the local release of neuropeptides. Two related papers in this issue of Cell report that gut-innervating pain neurons sense bacterial presence to both shape the constituents of the gut microbiome and protect against excessive inflammation.

Studies have demonstrated that the amount of Clostridioides difficile toxin found in stool correlates with disease severity #Cdiff #guthealth #FridayMicrobiomeFeels pic.twitter.com/WMWgCp0CKN— Microbiome Science (@MbiomeScience) December 16, 2022

Our study findings suggest no delay in transition to the updated CDI-related codes. Treatment patterns for rCDI vs nrCDI encounters were consistent with Infectious Diseases Society of America guidelines, regardless of concordance status.

Nature Communications - Here, the authors analyze the relation of fecal microbiota diversity and composition with depressive symptoms in 1,054 participants from the Rotterdam Study cohort and in...

Rhabdomyolysis (RBD) occurs secondary to tissue injury, resulting in (muscle) cell lysis and release of intracellular electrolytes and proteins into circulation. An elevation in the muscle enzyme, creatine kinase (CK), is a diagnostic marker and indicates muscle breakdown. Symptoms include dark urin …

Nature Communications - Here, by studying a multi-ethnic cross-sectional urban cohort (N = 3211, 6 ethnic groups), the authors show that depressive symptom levels are related to the gut...

This article focuses on the factors that predict long-term complications of C. difficile infection and what can be done in clinical practice to minimize them.

There is growing appreciation of key roles of the gut microbiota in maintaining homeostasis and influencing brain and behaviour at critical windows ac…

This study shows that RT151 encompasses both typical and cryptic clades and provides conclusive evidence for CDI due to clade C-II isolates that was hitherto lacking. Vigilance towards CDI as a result of cryptic clade isolates is warranted.

As in vitro models continue to evolve, they become more physiologically relevant, offering improved simulations of CDI, and extending their applicability.

We also found published #CDI due to C-II isolates that were not classified as such, or misclassified; a toxinotype XXXII #cdiff strain with similar #paloc (https://t.co/HME0bqzPlV) and RA09-70, previously suggested to be clade 5 (https://t.co/bzQtfYRQFf) #settingtherecordstraight— Wiep Klaas Smits (@SmitsLab) December 12, 2022

An ANI analysis (thanks to @DanRJKnight for suggesting this) confirms our phylogenetic placement and supports the notion that C-II #cdiff isolates are indeed a separate genomospecies - https://t.co/wfv7DKfLXo pic.twitter.com/C3rr22pfCD— Wiep Klaas Smits (@SmitsLab) December 12, 2022

As the world’s population ages, neurodegenerative diseases (NDs) have brought a great burden to the world. However, effective treatment measures have not been found to alleviate the occurrence and development of NDs. Abnormal accumulation of pathogenic proteins is an important cause of NDs. Therefore, effective inhibition of the accumulation of pathogenic proteins has become a priority. As the second brain of human, the gut plays an important role in regulate emotion and cognition functions. Recent studies have reported that the disturbance of gut microbiota (GM) is closely related to accumulation of pathogenic proteins in NDs. On the one hand, pathogenic proteins directly produced by GM are transmitted from the gut to the central center via vagus nerve. On the other hand, The harmful substances produced by GM enter the peripheral circulation through intestinal barrier and cause inflammation, or cross the blood–brain barrier into the central center to cause inflammation, and cytokines produced by the central center cause the production of pathogenic proteins. These pathogenic proteins can produced by the above two aspects can cause the activation of central microglia and further lead to NDs development. In addition, certain GM and metabolites have been shown to have neuroprotective effects. Therefore, modulating GM may be a potential clinical therapeutic approach for NDs. In this review, we summarized the possible mechanism of NDs caused by abnormal accumulation of pathoge...

Clostridioides difficile causes antibiotic-associated diseases in humans, ranging from mild diarrhea to severe pseudomembranous colitis and death. A major clinical challenge is the prevention of disease recurrence, which affects nearly ~20 to 30% of the ...

Editorial: the acid test-can bile acids predict recurrence of Clostridioides difficile infection? Authors' reply

Understanding the metabolic consequences of microbial interactions that occur during infection presents a unique challenge to the field of biomedical imaging. Matrix-assisted laser desorption/ionization (MALDI) imaging mass spectrometry represents a label-free, in situ imaging modality capable of ge …

Editorial: The acid test - can bile acids predict recurrence of Clostridioides difficile infection?

Toxin A (TcdA) and toxin B (TcdB) are two key virulence factors secreted by Clostridioides difficile, which is listed as an urgent threat by the CDC. These two large homologous exotoxins are mainly responsible for diseases associated with C. difficile infection (CDI) with symptoms rang …