Clostridioides difficile is an opportunistic spore-forming pathogen responsible for antibiotic-associated diarrhea in humans. C. difficile produces two main toxins: TcdA and TcdB as well as a third toxin named binary toxin (CDT) that is also involved in virulence. The present study aimed at characte …

Clinical Microbiomics. Heidi Hau, PhD, leads business and scientific activities in the US including development strategies, external partnerships and CRO organi...

New research from the University of Virginia School of Medicine and collaborators shows that microorganisms found in our guts can worsen dangerous Clostridioides difficile infections, a discovery that could help doctors identify patients at risk for

Clostridioides difficile (Clostridium difficile) infection (CDI) is one of the main public health concerns in adults, while children under 2 years of age are often colonized asymptomatically. In both adults and children, CDI is strongly associated with disturbances in gut microbiota. In this …

C. difficile-targeted antibiotics disrupt the #microbiome, which can produce a favorable environment for the unaffected dormant #Cdiff spores to germinate and grow. #MicrobiomeMonday pic.twitter.com/L08ltfiVjt— Microbiome Science (@MbiomeScience) January 2, 2023

The gut mycobiome (fungi) is a small but crucial component of the gut microbiome in humans. Intestinal fungi regulate host homoeostasis, pathophysiological and physiological processes, and the assembly of the co-residing gut bacterial microbiome. Over the past decade, accumulating studies have characterised the gut mycobiome in health and several pathological conditions. We review the compositional and functional diversity of the gut mycobiome in healthy populations from birth to adulthood. We describe factors influencing the gut mycobiome and the roles of intestinal fungi—especially Candida and Saccharomyces spp—in diseases and therapies with a particular focus on their synergism with the gut bacterial microbiome and host immunity.

The results show similar rates o colonized C difficile among pediatric patients and adult patients with cystic fibrosis.

We report a patient case with pseudomembranous colitis associated with a mono-toxin producing Clostridioides difficile belonging to the very rarely di…

In summary: we confirmed plasmid co-carriage in a single isolate, confirmed two new replicons, and added a new complete genome #cdiff to GBK. Thanks to @EicJrood for handling our submission and the anonymous reviewers for comments that improved the work! (11/11)— Wiep Klaas Smits (@SmitsLab) December 27, 2022

This work goes back to the initial in silico identification of extrachromosomal elements of #cdiff, by Bastian Hornung in our lab (https://t.co/ZjbAuaSoD0). We used the same method here, on a new set of strains. (2/11)— Wiep Klaas Smits (@SmitsLab) December 27, 2022

What does a leaky gut mean, how can it be diagnosed and what available dietary strategies work for managing it?

Deadly bacteria has an ally lurking in our guts • Earth.com

Evaluating Clostridioides difficile infection in lung cancer patients receiving EGFR-TKIs.

Multiple studies have demonstrated abnormalities in the contents of the fecal microbiota in patients with a variety of forms of arthritis. This has pr…

A subset of clinical isolates of Clostridioides difficile contains one or more plasmids and these plasmids can harbor virulence and antimicrobial resistance determinants. Despite their potential importance, C. difficile plasmids remain poorly characterized. Here, we provide the complete genome seque …

A subset of clinical isolates of Clostridioides difficile contains one or more plasmids and these plasmids can harbor virulence and antimicrobial resistance determinants. Despite their potential importance, C. difficile plasmids remain poorly characterized. Here, we provide the complete genome seque …

Clostridioides difficile (Clostridium difficile) infection (CDI) is one of the main public health concerns in adults, while children under 2 years of age are often colonized asymptomatically. In both adults and children, CDI is strongly associated with disturbances in gut microbiota. In this …

During the study period, the sentinel #surveillance scheme included ca 14–15% of all Danish cases of #Cdiff infections Binary toxin-negative strains accounted for 75% and 16 of the 20 most prevalent types⬇️https://t.co/AKfrYzexu7#antibiotic #AMR #AntimicrobialResistance pic.twitter.com/6B5zfAs4wY— 𝘌𝘶𝘳𝘰𝘴𝘶𝘳𝘷𝘦𝘪𝘭𝘭𝘢𝘯𝘤𝘦 (@Eurosurveillanc) December 14, 2022

Nature Reviews Microbiology - In this Review, Caballero-Flores, Pickard and Núñez explore how the microbiota limits colonization by pathogens and the strategies used by pathogens to...

New research from the University of Virginia School of Medicine and collaborators reveals how microorganisms found in our guts can worsen dangerous C

Clostridioides difficile causes the highest number of nosocomial infections. Currently, treatment options for C. difficile infection (CDI) are very limited, resulting in poor treatment outcomes and high recurrence rates. Although the disease caused by CDI is inflammatory in nature, the …

#Gutbacteria put people at risk for severe #Cdifficile, a #bacterium that can cause potentially deadly infections, particularly among #elderly and people on long-term #antibiotics. #Antibioticresistant #pathogens in #gut make #Cdiff more dangerous. https://t.co/7mXNcPfNLP— Greg Slabodkin (@Slabodkin) December 21, 2022

Clostridia are a polyphyletic group of Gram-positive, spore-forming anaerobes in the Firmicutes phylum that significantly impact metabolism and functioning of the human gastrointestinal tract. Recently, Clostridia were divided into two separate classes, Clostridia and …

Images in Clinical Medicine from The New England Journal of Medicine — Toxic Megacolon Due to Fulminant Clostridioides difficile Infection

Pain-sensing neurons detect environmental insults and tissue injury, driving avoidance behavior and the local release of neuropeptides. Two related papers in this issue of Cell report that gut-innervating pain neurons sense bacterial presence to both shape the constituents of the gut microbiome and protect against excessive inflammation.

Studies have demonstrated that the amount of Clostridioides difficile toxin found in stool correlates with disease severity #Cdiff #guthealth #FridayMicrobiomeFeels pic.twitter.com/WMWgCp0CKN— Microbiome Science (@MbiomeScience) December 16, 2022

Our study findings suggest no delay in transition to the updated CDI-related codes. Treatment patterns for rCDI vs nrCDI encounters were consistent with Infectious Diseases Society of America guidelines, regardless of concordance status.

Nature Communications - Here, the authors analyze the relation of fecal microbiota diversity and composition with depressive symptoms in 1,054 participants from the Rotterdam Study cohort and in...

Rhabdomyolysis (RBD) occurs secondary to tissue injury, resulting in (muscle) cell lysis and release of intracellular electrolytes and proteins into circulation. An elevation in the muscle enzyme, creatine kinase (CK), is a diagnostic marker and indicates muscle breakdown. Symptoms include dark urin …