A gastroenterologist reviews the long-term impact of dysbiosis and Clostridioides difficile infection.

Since birth, the human body gets colonized by various communities of symbiotic or commensal microorganisms and they persist till the death of an individual. The human microbiome is comprised of the genomes of microorganisms such as viruses, archaea, eukaryotes, protozoa, and, most remarkably, bacter …

Clostridioides difficile is a Gram-positive anaerobic bacterium that is the leading cause of hospital-acquired gastroenteritis in the US. In the gut milieu, C. difficile encounters microbiota-derived, growth-inhibiting bile acids that are thought to be a significant mechanism of coloni …

Our study found no difference in clinical outcomes between nCP-CRE and CSE infections. Application of this study with future studies would help in determining optimal regimens for these infections.

The clinical symptoms of an immune checkpoint inhibitor (ICI)-induced colitis are similar to those of ulcerative colitis. ICI-induced colitis, like ulcerative colitis, may be complicated by other colitis, such as Clostridioides difficile infection (CDI). A 72-year-old man was admitted because …

The relative abundance of gram-negative Bacteroidetes to other phyla, such as gram-positive Firmicutes, is essential to maintain biodiversity and human gut health.

Did you know: On our official YouTube channel you can find previous meetings of our webinar series on #cdifficile and all episodes of our new format "ESNM inside" where you can get to know leading experts in the wide field of #Neurogastroenterology 👉 https://t.co/Nqrl8nPZ62 👈 pic.twitter.com/agxmGZTlsN— ESNM.eu (@esnm_eu) July 27, 2022

4/ ⏰ 10:30-10:45📍 Stool #CDiff Toxin Concentrations in Children1st Author: @tomsandoraSenior Author:@NiraPollock ⭐️ https://t.co/Kpa8FS1Htg— Pratik ‘Tik’ Patel, MD (@DrPHO_ID) October 18, 2022

In this #MicrobiomeMonday we will be talking about one of the many factors that can affect the composition of the microbiota.Is there a significant association between an increased body mass index and alteration of the gut microbiome community composition?— Ferring Microbiome (@FerringMBiome) October 17, 2022

#Microbiome therapeutics have the potential to revolutionize the treatment of several diseases and medical conditions including #CDiff, IBD, #AlzheimersDisease, #cancer, #diabetes. Learn more here: https://t.co/UaYhHR2WMp— MTIG (@MTIG_News) October 17, 2022

Paper alert! - our work on #plasmid-mediated metronidazole resistance in #cdiff continues. https://t.co/faaJPRbWTl A small 🧵thread to highlight key points 👇 1/6— Wiep Klaas Smits (@SmitsLab) October 17, 2022

Metronidazole-Resistant emClostridioides difficile/em

Fecal microbiota transplantation (FMT) is a new and adequate route to modify the microbial ecosystem in gastrointestinal tract of the hosts. Intestina…

Some bacteria express a binary toxin translocation system, consisting of an enzymatic subunit and translocation pore, that delivers enzymes into host cells through endocytosis. The most clinically important bacterium with such a system is Clostridioides difficile (formerly Clostridium). The CDTa and …

Assessing the clinical value of faecal bile acid profiling to predict recurrence in primary Clostridioides difficile infection.

Nature Reviews Microbiology - The gut microbiota metabolizes bile acids, thereby influencing human health and diseases including obesity, colitis and cancer. In this Review, Patterson and...

Gut BA metabolism dynamics differ in primary CDI patients between those developing recurrence and those who do not. Individual BAs show promise as potential novel biomarkers to predict CDI recurrence.

Clostridioides difficile is the leading cause of post-antibiotic diarrhrea in adults. During infection, the bacterium must rapidly adapt to the host environment by using survival strategies. Protein phosphorylation is a reversible post-translational modification employed ubiquitously for signal tran …

Nature Communications - Binary toxin translocation system consists of an enzymatic subunit and translocation pore. Here, the authors report the high-resolution cryo-EM structure of Clostridioides...

Monique BrouilletteA flurry of microbiome research over the past two decades has led to many insights about the link between the microbes and health, but now the race to the clinic is on.

Accumulating evidence indicates that gut transit time is a key factor in shaping the gut microbiota composition and activity, which are linked to human health. Both population-wide and small-scale studies have identified transit time as a top covariate contributing to the large interindividual variation in the faecal microbiota composition. Despite this, transit time is still rarely being considered in the field of the human gut microbiome. Here, we review the latest research describing how and why whole gut and segmental transit times vary substantially between and within individuals, and how variations in gut transit time impact the gut microbiota composition, diversity and metabolism. Furthermore, we discuss the mechanisms by which the gut microbiota may causally affect gut motility. We argue that by taking into account the interindividual and intraindividual differences in gut transit time, we can advance our understanding of diet–microbiota interactions and disease-related microbiome signatures, since these may often be confounded by transient or persistent alterations in transit time. Altogether, a better understanding of the complex, bidirectional interactions between the gut microbiota and transit time is required to better understand gut microbiome variations in health and disease.

Iqbal: Severe C. difficile infection is defined by high white blood cell count, increased serum creatinine, pyrexia and radiological evidence of severe colitis and leaky gut @esnm_eu #GMFHCoverage pic.twitter.com/5cVc1Duih9— GutMicrobiota Health (@GMFHx) October 12, 2022

C. difficile Patient Journey C. difficile infection (CDI) occurs when Clostridioides difficile bacteria grow out of control in the digestive tract. The bacteria and their spores are resistant to many common cleaning methods so they can transfer easily between surfaces if people do not wash their hands adequately

Registration for the FENS Friday webinar on “The microbiome, immunity, and neurodevelopment trialogue: from womb to adulthood” is now open. The microbiome topic has emerged as a field of great…

Despite brain physiological functions or pathological dysfunctions relying on the activity of neuronal/non-neuronal populations, over the last decades a plethora of evidence unraveled the essential contribution of the microbial populations living and residing within the gut, called gut microbiota. T …

Selected findings about Clostridioides difficile (formerly Clostridium difficile) toxins are presented in a narrative review. Starting with a personal view on research about G proteins, adenylyl cyclase, and ADP-ribosylating toxins in the laboratory of Günter Schultz in Heidelberg, milestones of C. …

Elevated MICs to antibiotics used for treatment of C. difficile infection were rare and there was no increase in MICs over time. The lack of vanA/B genes or mutations consistently associated with elevated vancomycin MICs suggests there are multifactorial mechanisms of resistance. Ongoing surveillanc …

Despite brain physiological functions or pathological dysfunctions relying on the activity of neuronal/non-neuronal populations, over the last decades a plethora of evidence unraveled the essential contribution of the microbial populations living and residing within the gut, called gut microbiota. T …