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Gut microbial metabolome in inflammatory bowel disease: From association to therapeutic perspectives
Gut microbial metabolome in inflammatory bowel disease: From association to therapeutic perspectives
Inflammatory bowel disease (IBD), comprising Crohn's disease (CD) and ulcerative colitis (UC), is a set of clinically chronic, relapsing gastrointestinal inflammatory disease and lacks of an absolute cure. Although the precise etiology is unknown, developments in high-throughput microbial genomic se …
·pubmed.ncbi.nlm.nih.gov·
Gut microbial metabolome in inflammatory bowel disease: From association to therapeutic perspectives
Establishment of a gnotobiotic pig model of Clostridioides difficile infection and disease
Establishment of a gnotobiotic pig model of Clostridioides difficile infection and disease
Clostridioides difficile (C. difficile) is a gram-positive, spore-forming, anaerobic bacterium known to be the most common cause of hospital-acquired and antibiotic-associated diarrhea. C. difficile infection rates are on the rise worldwide and treatment options are limited, indicating a clear need …
·pubmed.ncbi.nlm.nih.gov·
Establishment of a gnotobiotic pig model of Clostridioides difficile infection and disease
Molecular Epidemiology and Genetic Relatedness of Clostridioides difficile Isolates in Pediatric Oncology and Transplant Patients using Whole Genome Sequencing
Molecular Epidemiology and Genetic Relatedness of Clostridioides difficile Isolates in Pediatric Oncology and Transplant Patients using Whole Genome Sequencing
WGS identified a highly diverse group of C. difficile isolates among POTP with CDI. Although WGS identified clusters of closely related isolates in multiple patients, epidemiologic investigation of shared inpatient exposures identified potential transmission in only two clusters. C. difficile transm …
·pubmed.ncbi.nlm.nih.gov·
Molecular Epidemiology and Genetic Relatedness of Clostridioides difficile Isolates in Pediatric Oncology and Transplant Patients using Whole Genome Sequencing
Hospitalization with Clostridioides difficile in pediatric inflammatory bowel disease: a population-based study
Hospitalization with Clostridioides difficile in pediatric inflammatory bowel disease: a population-based study
Children with IBD have a markedly higher incidence of CDI identified during a hospitalization relative to children without IBD. Consequently, symptomatic children with IBD who are hospitalized should be screened for CDI.An infographic is available for this article at: http://links.lww.com/MPG/C842.
·pubmed.ncbi.nlm.nih.gov·
Hospitalization with Clostridioides difficile in pediatric inflammatory bowel disease: a population-based study
Human colon cancer-derived Clostridioides difficile strains drive colonic tumorigenesis in mice
Human colon cancer-derived Clostridioides difficile strains drive colonic tumorigenesis in mice
Defining the complex role of the microbiome in colorectal cancer (CRC) and the discovery of novel, pro-tumorigenic microbes are areas of active investigation. In the present study, culturing and reassociation experiments revealed that toxigenic strains of Clostridioides difficile drove the tumorigen …
·pubmed.ncbi.nlm.nih.gov·
Human colon cancer-derived Clostridioides difficile strains drive colonic tumorigenesis in mice
Seres Therapeutics Presents Microbiome Therapeutic Research at the 2022 American Society of Clinical Oncology (ASCO) Annual Meeting - Yahoo Finance
Seres Therapeutics Presents Microbiome Therapeutic Research at the 2022 American Society of Clinical Oncology (ASCO) Annual Meeting - Yahoo Finance
CAMBRIDGE, Mass., June 01, 2022--Seres Therapeutics, Inc. (Nasdaq: MCRB), a leading microbiome therapeutics company, announced the presentation of preclinical data supporting further investigation of a rationally designed microbial consortium candidate (DE486) to prevent or treat gastrointestinal (GI) mucositis – a common and often painful complication of radiation and chemotherapy involving the breakdown of the rapidly-dividing epithelial cells lining the GI tract. These results are available o
·finance.yahoo.com·
Seres Therapeutics Presents Microbiome Therapeutic Research at the 2022 American Society of Clinical Oncology (ASCO) Annual Meeting - Yahoo Finance
C Diff Molecular
C Diff Molecular
Excellent thread @AvrahamCooperMD! We recently performed a large scale meta-analysis (42k+ metagenomic samples) looking the gut #microbiome associated with #Cdiff, especially in healthy infants! You can check out the preprint: https://t.co/DGoRN6QJJv https://t.co/o6JK7BzzWh— Pamela Ferretti (@pam_ferretti) May 30, 2022
·twitter.com·
C Diff Molecular
Iron Effects on Clostridioides difficile Toxin Production and Antimicrobial Susceptibilities
Iron Effects on Clostridioides difficile Toxin Production and Antimicrobial Susceptibilities
Despite the benefits of red blood cell (RBC) transfusion therapy, it can render patients vulnerable to iron overload. The excess iron deposits in various body tissues cause severe complications and organ damage such as cardiotoxicity and mold infections. Clostridioides difficile infection (CD …
·pubmed.ncbi.nlm.nih.gov·
Iron Effects on Clostridioides difficile Toxin Production and Antimicrobial Susceptibilities
An Update on Clostridioides difficile Binary Toxin - PubMed
An Update on Clostridioides difficile Binary Toxin - PubMed
Infection with Clostridioides difficile (CDI), a common healthcare-associated infection, includes symptoms ranging from mild diarrhea to severe cases of pseudomembranous colitis. Toxin A (TcdA) and toxin B (TcdB) cause cytotoxicity and cellular detachment from intestinal epithelium and are re …
·pubmed.ncbi.nlm.nih.gov·
An Update on Clostridioides difficile Binary Toxin - PubMed
Higher in vivo fecal concentrations of Clostridioides difficile toxins A and B in patients with NAP-1/027 strain infection
Higher in vivo fecal concentrations of Clostridioides difficile toxins A and B in patients with NAP-1/027 strain infection
Ultrasensitive, quantitative Clostridioides difficile stool toxin measurement demonstrated significantly higher concentrations of toxins A and B in patients infected with the NAP-1/027 strain compared to patients infected with other strains. These data provide in vivo confirmation of the in vitro as …
·pubmed.ncbi.nlm.nih.gov·
Higher in vivo fecal concentrations of Clostridioides difficile toxins A and B in patients with NAP-1/027 strain infection
Effects of broad-spectrum antibiotics on the colonisation of probiotic yeast Saccharomyces boulardii in the murine gastrointestinal tract | Scientific Reports - Nature.com
Effects of broad-spectrum antibiotics on the colonisation of probiotic yeast Saccharomyces boulardii in the murine gastrointestinal tract | Scientific Reports - Nature.com
Scientific Reports - Effects of broad-spectrum antibiotics on the colonisation of probiotic yeast Saccharomyces boulardii in the murine gastrointestinal tract
·nature.com·
Effects of broad-spectrum antibiotics on the colonisation of probiotic yeast Saccharomyces boulardii in the murine gastrointestinal tract | Scientific Reports - Nature.com
Identification of functional Spo0A residues critical for sporulation in Clostridioides difficile - PubMed
Identification of functional Spo0A residues critical for sporulation in Clostridioides difficile - PubMed
Clostridioides difficile is an anaerobic, Gram-positive pathogen that is responsible for C. difficile infection (CDI). To survive in the environment and spread to new hosts, C. difficile must form metabolically dormant spores. The formation of spores requires activation of the transcription factor S …
·pubmed.ncbi.nlm.nih.gov·
Identification of functional Spo0A residues critical for sporulation in Clostridioides difficile - PubMed
Infectious complications in acute graft-versus-host disease after Liver transplantation
Infectious complications in acute graft-versus-host disease after Liver transplantation
Our study reiterates that despite prophylaxis, infectious complications in GVHD following LT are common and lead to exceptionally high mortality. Individualized antimicrobial treatment, prophylaxis and monitoring strategies remain a critical component of GVHD management. Further study to optimize th …
·pubmed.ncbi.nlm.nih.gov·
Infectious complications in acute graft-versus-host disease after Liver transplantation
Highly Efficient Genome Editing in Clostridium difficile Using the CRISPR-Cpf1 System
Highly Efficient Genome Editing in Clostridium difficile Using the CRISPR-Cpf1 System
Clostridium difficile is often the primary cause of nosocomial diarrhea, leading to thousands of deaths annually worldwide. The availability of an efficient genome editing tool for C. difficile is essential to understanding its pathogenic mechanism and physiological behavior. Here, we describe a str …
·pubmed.ncbi.nlm.nih.gov·
Highly Efficient Genome Editing in Clostridium difficile Using the CRISPR-Cpf1 System
Notes from the Field: Escherichia coli O157:H7 Outbreak in Children with Clostridioides difficile Colonization Associated with an Improperly Treated Swimming Pool - Pennsylvania, June 2021
Notes from the Field: Escherichia coli O157:H7 Outbreak in Children with Clostridioides difficile Colonization Associated with an Improperly Treated Swimming Pool - Pennsylvania, June 2021
Notes from the Field: Escherichia coli O157:H7 Outbreak in Children with Clostridioides difficile Colonization Associated with an Improperly Treated Swimming Pool - Pennsylvania, June 2021
·pubmed.ncbi.nlm.nih.gov·
Notes from the Field: Escherichia coli O157:H7 Outbreak in Children with Clostridioides difficile Colonization Associated with an Improperly Treated Swimming Pool - Pennsylvania, June 2021
The WalRK Two-Component System Is Essential for Proper Cell Envelope Biogenesis in Clostridioides difficile
The WalRK Two-Component System Is Essential for Proper Cell Envelope Biogenesis in Clostridioides difficile
The WalR-WalK two-component regulatory system (TCS) is found in all Firmicutes, in which it regulates the expression of multiple genes required for remodeling the cell envelope during growth and division. Unlike most TCSs, WalRK is essential for viability, so it has attracted interest as a po …
·pubmed.ncbi.nlm.nih.gov·
The WalRK Two-Component System Is Essential for Proper Cell Envelope Biogenesis in Clostridioides difficile
Structurally investigating a niche pathway for chemical reversal of proline hydroxylation in the pathogen Clostridioides difficile - PubMed
Structurally investigating a niche pathway for chemical reversal of proline hydroxylation in the pathogen Clostridioides difficile - PubMed
The glycyl radical enzyme (GRE) family utilizes a glycyl radical cofactor, installed by AdoMet radical activating enzymes, to catalyze difficult chemical reactions in a variety of microbial metabolic pathways. Although GREs are widely encoded and expressed by bacteria found in the gut microbiome, th …
·pubmed.ncbi.nlm.nih.gov·
Structurally investigating a niche pathway for chemical reversal of proline hydroxylation in the pathogen Clostridioides difficile - PubMed