ST 17 is most prominent sequence type. This is the first report of MLST based study of C. difficile from India. Further studies from diverse geographical regions can help better understand the epidemiology of CDI in India.

The recurrent CDI cohort were nearly 10 times likelier to suffer from a CDI-associated death than the primary CDI cohort.

The Papin Lab makes it possible to apply the understanding of the nature of the bacteria to new treatment options for C. difficile bacterial infection. 

A wide range of bacteria can synthesize surface-associated nanoparticles (SANs) through exogenous metal ions reacting with sulfide produced via cysteine metabolism, resulting in the emergence of a biological-nanoparticle hybrid (bionanohybrid). The attached nanoparticles may couple to extracellular …

This study describe a large nosocomial outbreak of Clostridioides difficile infections (CDI) dominated by ribotype (RT) 046 in a Swedish hospital. The aim of the present study was to examine the pathogenicity of this RT, explore epidemiological links by whole genome sequencing (WGS) and evalu …

With an annual incidence of 250-300 per 100,000 inhabitants, reactive arthritis is not uncommon. However, the fact that Clostridioides difficile infection (CDI) can also lead to this complication is largely unknown. We report on a 69-years-old man who developed reactive arthritis of his right …

The "magic spot" alarmones (pp)pGpp, previously implicated in Clostridioides difficile antibiotic survival, are synthesized by the RelA-SpoT homolog (RSH) of C. difficile (RSHCd) and RelQCd. These enzymes are transcriptionally activated by diverse environmental stresses. RSH …

Original Article from The New England Journal of Medicine — Duodenal Infusion of Donor Feces for Recurrent Clostridium difficile

The incidence of rec CDI is ⬆️. After an initial episode, ⤴️35% have recurrence. ⤴️60% who have a recurrence have another one. Exposure to antibiotics is a critical modifiable risk factor. Most cases occur within 2 wks of antibiotic Rx. #CDiff #antibiotics #antibioticstewardship pic.twitter.com/NTgwYohGZ0— Satyendra Dhar MD FHM🕊(𑆱𑆠𑇀𑆪𑆼𑆁𑆢𑇀𑆫 𑆣𑆫) (@DharSaty) March 2, 2022

BACKGROUND There are many causes of chronic colitis and diarrhea, including the effects of chemotherapy. Mutations in the UGT1A1 gene can be associated with increased toxicity from irinotecan-based chemotherapy. This report is of a case of delayed diagnosis of Clostridium difficile (C. difficile) co …

Clostridioides difficile (CD) is the most frequent cause of healthcare related diarrhea and its severity has increased in the last decade by the spread of hypervirulent strains. Most important CD virulence factor is toxin production; however, not only toxins are responsible for Clostridioides virule …

Growth rates and relative cytotoxicity of isolates were significantly higher and lower, respectively, in bovine-derived isolates compared to pediatric- and canine-derived isolates. Analysis of core genes showed clustering by host species, though in a few cases, human strains co-clustered with canine …

Antimicrobial resistance to treatments for Clostridioides difficile infection (CDI) poses a significant threat to global health. C. difficile is widely thought to be susceptible to oral vancomycin, which is increasingly the mainstay of CDI treatment. However, clinical labs do not condu …

Clostridioides Difficile is a well-known pathogen causing diarrhea of various degrees of severity through associated infectious colitis. However, there have been reports of infectious enteritis mainly in patients with ileostomy, causing dehydration through high-output volume; Case presentatio …

The FDA has issued a clinical hold letter to Finch Therapeutics Group Inc's (NASDAQ: FNCH) PRISM4 Phase 3 trial of CP101 in recurrent C. difficile...

A specific microbiome therapy successfully prevents C. difficile recurrences in people prone to relapse. 

The clostridial diseases of horses can be divided into three major groups: enteric/enterotoxic, histotoxic, and neurotoxic. The main enteric/enterotoxic diseases include those produced by Clostridium perfringens type C and Clostridioides difficile, both of which are characterized by en …

Many bacteria and archaea possess a two-dimensional protein array, or S-layer, that covers the cell surface and plays crucial roles in cell physiology. Here, we report the crystal structure of SlpA, the main S-layer protein of the bacterial pathogen Clostridioides difficile, and use electron microsc …

Relative high resistance was detected towards metronidazole and vancomycin, although, still have acceptable activity for CDI treatment. However, a proper plan for the use of antibiotics and more regular screening of C. difficile antibiotic resistance seems necessary.

7. The #Cdiff #BugSlayer is very tightly packed, with pores of only about 11A, so only small ions can diffuse through #SlayerStructure 9/n pic.twitter.com/3dThsJw109— Bug Slayers (@BugS_layers) February 25, 2022

Nature Communications - The S-layer is a two-dimensional protein array that covers the cell surface of many bacteria and archaea. Here, the authors use high-resolution X-ray crystallography and...

Can the immune response to COVID-19 trigger inflammatory bowel disease?

The outer coat of the antibiotic-resistant bacterium Clostridium difficile has a structure similar to chain mail that stops drugs and immune system cells from killing it

The spectacular structure of the protective armor of superbug C.difficile has been revealed for the first time showing the close-knit yet flexible outer layer – like chain mail.

Clostridioides difficile is a major nosocomial pathogen that can cause severe, toxin-mediated diarrhea and pseudomembranous colitis. Recent work has shown that C. difficile exhibits heterogeneity in swimming motility and toxin production in vitro through phase variation by site- …

“#Cdiff is considered to be a #pathogen, but our data suggests that it is a common #commensal in healthy #infants. How we label cdiff matters, because it can affect our perception of the species 🦠 and how we decide to investigate it 🔎“

Clostridioides difficile is a Gram-positive, spore-forming obligate anaerobe and a major threat to the healthcare system world-wide. Because of its strict anaerobic requirements, the infectious and transmissible morphotype is the dormant spore. During infection, C. difficile produces spores that can …