Clostridioides difficile infection (CDI) is the leading cause of nosocomial diarrhea and pseudomembranous colitis in the USA. In addition to these symptoms, patients with CDI can develop severe inflammation and tissue damage, resulting in life-threatening toxic megacolon. CDI is mediated by two larg …

@AJMC_Journal and #Cdiff experts recently discussed the impact #rCDI can have on a #patient. Click here to watch their discussion: https://t.co/1zABGYbYGK pic.twitter.com/Nq6xYqmxXp— Rebiotix Inc. (@Rebiotix) February 15, 2022

Clostridioides difficile is a pathogen often associated with hospital-acquired infection or antimicrobial-induced disease; however, increasing evidence indicates infections can result from community or environmental sources. Most genomic sequencing of C. difficile has focused on clinic …

The gastrointestinal tract (GIT) is considered the largest immunological organ, with a diverse gut microbiota, that contributes to combatting pathogens and maintaining human health. Under physiological conditions, the crosstalk between gut microbiota and intestinal epithelial cells (IECs) plays a cr …

Clostridioides difficile, an intestinal pathogen and leading cause of nosocomial infection, exhibits extensive phenotypic heterogeneity through phase variation. The signal transduction system CmrRST, which encodes two response regulators (CmrR and CmrT) and a sensor kinase (CmrS), impacts C. diffici …

The gut microbiome is an ecosystem of hundreds to thousands of microbial species living within the human body. These populations affect our health, fertility, and even our longevity. But how do they

Patients with fecal samples that were positive for CDT had increased disease severity and worse clinical outcomes. Utilization of PCR and testing for C. difficile toxins A and B may not reveal the entire picture when diagnosing CDI; detection of CDT-expressing strains is valuable in identifyi …

The partners hope that metabolic profiles of carriers of disease-associated genetic variants may offer insights into the basic biology of disease processes.

The first time I had a Clostridioides difficile infection, I was 37 years old. After a sequential antibiotic cocktail of amoxicillin, penicillin, metronidazole, and clindamycin prescribed to combat an infection in my jaw, I had the first wave of symptoms. Even having a long history of stomach-related issues dating back to my childhood, these new symptoms were like nothing I had ever experienced. Anything I consumed quickly traversed my gastrointestinal system within an impressively short timeframe, leaving me with a feeling of perpetual emptiness and exhaustion, a heightened awareness of the nearest restroom facilities, and an existential appreciation for saltine crackers.

The Microbiome Health Index for post-Antibiotic dysbiosis was a promising biomarker for predicting antibiotic dysbiosis and subsequent microbiome restoration, according to research published in Frontiers of Microbiology. “It’s very important that we maintain a healthy microbiome, but there are things that can disrupt or perturb a healthy microbiome to a less healthy state, which we

In COVID-19 there is bacterial and fungal dysbiosis that correlates with systemic and pulmonary inflammation, and illness severity. Further investigations are warranted to determine the efficacy of bacteriotherapy and FMT for modulating gut dysbiosis in COVID-19.

Clostridioides difficile is a leading cause of the healthcare-associated disease C. difficile infection (CDI), which has an annual US burden of over 200 000 cases. CDI mitigation strategies have been complicated by the emergence, and widespread distribution, of phylogenetically diverse lineages, as …

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Investigators conducted a study that assessed disease severity and outcomes in patients with Clostridioides difficile infection with C difficile binary toxin-expressing strains.

Infections by the pathogenic gut bacterium Clostridioides difficile cause severe diarrheas up to a toxic megacolon and are currently among the major causes of lethal bacterial infections. Successful bacterial propagation in the gut is strongly associated with the adaptation to changing nutrition-cau …

Both single-donor and multiple-donor fecal microbiota transplantation had clinical cure rates over 80%.

Background: Within eight weeks of primary Clostridioides difficile infection (CDI), as many as 30% of patients develop recurrent disease with the associated risks of multiple relapses, morbidity, and economic burden. There are no clear clinical correlates or validated biomarkers …

We found no association between obesity and death among patients with CDI, in contrast to most other infections. Obesity is not likely to be useful for risk-stratifying hospitalized patients with CDI.

CDI in pediatric patients with AP is associated with adverse clinical outcomes and increased healthcare resource utilization. Further studies are needed to elucidate this association to prevent the development of CDI and to improve outcomes.

In a Healio video exclusive, Ruchi Mathur, MD, of the Medically Associated Science and Technology Program at Cedars-Sinai in Los Angeles, discussed how the aging process is associated with changes to the small intestinal microbiome. Mathur and colleagues studied duodenal aspirates in 251 patients, aged 18 to 80 years, and observed decreased microbial diversity in older patients, driven by

Clostridioides difficile infection (CDI) imposes a substantial burden on the health care system in the United States. Understanding the biological basis for the spectrum of C. difficile-related disease manifestations is imperative to improving treatment and prevention of CDI. Here, we …

The composition of the gut microbiome is "strongly" linked with long-COVID symptoms months after a person recovers from their initial infection, a new study shows.

The evolution of antimicrobial resistance in Clostridioides difficile has markedly shaped its epidemiology and detrimentally impacted patient care. C. difficile exhibits resistance to multiple classes of antimicrobials, due to accumulation of horizontally acquired resistance genes and de novo mutati …

We isolated a rare strain of C. difficile producing only toxin B and lacking a complete tcdA gene herein Japan. The possibility of a false negative needs to be considered with a genetic method for a diagnose of C. difficile infection.

The switch from commensal to pathogenic is considered to be an important switch that has direct consequences on human health.

Gut microbiota composition during the first years of life is variable, dynamic and influenced by both prenatal and postnatal factors, such as maternal antibiotics administered during labor, delivery mode, maternal diet, breastfeeding, and/or antibiotic consumption during infancy. Furthermore, the mi …

The type A glycan modification found in human pathogen Clostridioides difficile consists of a monosaccharide (GlcNAc) that is linked to an N-methylated threonine through a phosphodiester bond. This structure has previously been described on the flagellar protein flagellin C of several C. difficile s …

The patient has been healthy for two months now after receiving the transplant in November.