Body mass index and risk of clostridioides difficile infection: a systematic review and meta-analysis
This meta-analysis revealed a significant negative association between BMI and CDI.
Clostridioides difficile Phosphoproteomics Shows an Expansion of Phosphorylated Proteins in Stationary Growth Phase
Phosphorylation is a posttranslational modification that can affect both housekeeping functions and virulence characteristics in bacterial pathogens. In the Gram-positive enteropathogen Clostridioides difficile, the extent and nature of phosphorylation events are poorly characterized, though a prote …
Lower BMI Increased Risk of C Diff Infection in Elderly Pneumonia Patients - Contagionlive.com
C Difficile Infection Rates Low in Stroke Patients - MD Magazine
A positive CDI test was more common in patients with suffered an aneurysmal subarachnoid hemorrhage than it was in patients with intracerebral hemorrhage or ischemic stroke.
Impact of Phage CDHS-1 on the Transcription, Physiology and Pathogenicity of a Clostridioides difficile Ribotype 027 Strain, R20291
All known Clostridioides difficile phages encode integrases rendering them potentially able to lyse or lysogenise bacterial strains. Here, we observed the infection of the siphovirus, CDHS-1 on a ribotype 027 strain, R20291 and determined the phage and bacterial gene expression profiles, and …
Studies on the Importance of the 7α-, and 12α- hydroxyl groups of N-Aryl-3α,7α,12α-trihydroxy-5β-cholan-24-amides on their Antigermination Activity Against a Hypervirulent Strain of Clostridioides (Clostridium) difficile
Chenodeoxycholic acid (CDCA) is a natural germination inhibitor for C. difficile spores. In our previous study (J. Med. Chem., 2018, 61, 6759-6778), we identified N-phenyl-3α,7α,12α-trihydroxy-5β-cholan-24-amide as an inhibitor of C. difficile strain R20291 with an IC50 of 1.8 μM. Studies …
c-di-GMP Inhibits Early Sporulation in Clostridioides difficile
The formation of dormant spores is essential for the anaerobic pathogen Clostridioides difficile to survive outside the host gastrointestinal tract. The regulatory pathways and environmental signals that initiate C. difficile spore formation within the host are not well understood. One second-messen …
A worldwide systematic review and meta-analysis of bacteria related to antibiotic-associated diarrhea in hospitalized patients
The results of this study emphasize the need for a surveillance program, as well as timely public and hospital health measures in order to control and treat AAD infections.
Clostridioides difficile peptidoglycan modifications
The cortex and peptidoglycan of Clostridioides difficile have been poorly investigated. This last decade, the interest increased because these two structures are highly modified and these modifications may be involved in antimicrobial resistance. For example, C. difficile peptidoglycan deacetylation …
Activation of the extracytoplasmic function σ factor σ V by lysozyme in Clostridioides difficile
Clostridioides difficile is naturally resistant to high levels of lysozyme an important component of the innate immune defense system. C. difficile encodes both constitutive as well as inducible lysozyme resistance genes. The inducible lysozyme resistance genes are controlled by an alternative σ fac …
Clostridioides difficile strain-dependent and strain-independent adaptations to a microaerobic environment
Clostridioides difficile (formerly Clostridium difficile) colonizes the gastrointestinal tract following disruption of the microbiota and can initiate a spectrum of clinical manifestations ranging from asymptomatic to life-threatening colitis. Following antibiotic treatment, luminal ox …
Gut microbiota features associated with Clostridioides difficile colonization in dairy calves
Diarrheal disease, a major cause of morbidity and mortality in dairy calves, is strongly associated with the health and composition of the gut microbiota. Clostridioides difficile is an opportunistic pathogen that proliferates and can produce enterotoxins when the host experiences gut dysbiosis. How …
Antimicrobial-resistant Bacteroides fragilis in Thailand and their inhibitory effect in vitro on the growth of Clostridioides difficile
Antimicrobial resistance was seen in Thai B. fragils isolates, which may help protect the host against C. difficile infection.
Clostridioides difficile and Vancomycin-Resistant Enterococci in COVID-19 Patients with Severe Pneumonia https://t.co/RH9JBdiuMC #cdi #cdiff
Clostridioides difficile and Vancomycin-Resistant Enterococci in COVID-19 Patients with Severe Pneumonia https://t.co/RH9JBdiuMC #cdi #cdiff— Dave Roberts (@CDifficile1) January 1, 2022
Clostridioides difficile and Vancomycin-Resistant Enterococci in COVID-19 Patients with Severe Pneumonia
Broad-spectrum antibiotics administered to patients with severe COVID-19 pneumonia pose a risk of infection caused by Clostridioides difficile. This risk is reduced mainly by strict hygiene measures and early de-escalation of antibiotic therapy. Recently, oral vancomycin prophylaxis (OVP) has …
Incidence of Clostridioides difficile in patients post loop ileostomy reversal in an Australian tertiary hospital: a retrospective study
The study confirmed that the incidence of CDI was higher in those who underwent ileostomy reversal when compared with an otherwise comparable hospital population (elective colorectal surgery patients). Additionally, those patients who underwent ileostomy reversal and had CDI experienced an increased …
CKD and Risk of Incident Hospitalization With Clostridioides Difficile Infection: Findings From the Atherosclerosis Risk in Communities (ARIC) Study
Clostridium innocuum Infection in Hospitalized Patients with Inflammatory Bowel Disease: A Retrospective Cohort Study
CI infection may lead to a poorer clinical remission in ulcerative colitis. should take it into consideration in IBD patents with active inflamamtion or refractory diarrhea with or without CD infection. Precise identification of CI is imperative to guide approproate antimicrobial therapy because of …
Dave Roberts on Twitter
Understanding How Disruption of the Gut Microbiome Leads to CDI - Pharmacy Times https://t.co/b7jlv7xXdO #cdi #cdiff— Dave Roberts (@CDifficile1) November 30, 2021
Computational approaches to understanding Clostridioides difficile metabolism and virulence - ScienceDirect
The progress of infection by Clostridioides difficile is strongly influenced by metabolic cues it encounters as it colonizes the gastrointestinal trac…
A species-wide genetic atlas of antimicrobial resistance in Clostridioides difficile | Microbiology Society
Antimicrobial resistance (AMR) plays an important role in the pathogenesis and spread of   Clostridioides difficile   infection (CDI), the leading healthcare-related gastrointestinal infection in the world. An association between AMR and CDI outbreaks is well documented, however, data is limited to a few ‘epidemic’ strains in specific geographical regions. Here, through detailed analysis of 10 330 publicly-available   C. difficile   genomes from strains isolated worldwide (spanning 270 multilocus sequence types (STs) across all known evolutionary clades), this study provides the first species-wide snapshot of AMR genomic epidemiology in   C. difficile  . Of the 10 330   C  .   difficile   genomes, 4532 (43.9 %) in 89 STs across clades 1–5 carried at least one genotypic AMR determinant, with 901 genomes (8.7 %) carrying AMR determinants for three or more antimicrobial classes (multidrug-resistant, MDR). No AMR genotype was identified in any strains belonging to the cryptic clades.   C. difficile   from Australia/New Zealand had the lowest AMR prevalence compared to strains from Asia, Europe and North America (P
Superbug warning over 'unexpected consequences' of common sugar alternative - Daily Express
A COMMON sugar additive used in popular foods may be the driving force behind the growth of one of the most aggressive superbugs, according to experts.
Considerations for Antimicrobial Selection in Clostridioides difficile Infection - OverView
Wiep Klaas Smits on Twitter
Evolution of plasmid mobility: origin and fate of non-conjugative plasmids https://t.co/WEzbeQTLCG from the @epcrocha lab. Interesting as most #cdiff #plasmids appear to be non-conjugative.— Wiep Klaas Smits (@SmitsLab) December 13, 2021
Investigating the relationship between inflammatory bowel disease and C. diff
Research into the relationship between C. diff and IBD reveals inflammation creates a more conducive environment for harmful bacteria to thrive in the gut.
From Cause to Cure: Brigham Investigators Pursue C. diff
The bacterium Clostridioides difficile (C. diff) may be smaller than a pinhead, but it presents a massive issue for hospitals.…
How Does COVID-19 Pandemic Impact on Incidence of Clostridioides difficile Infection and Exacerbation of Its Gastrointestinal Symptoms?
Coronavirus disease 2019 (COVID-19) has rapidly spread all over the world with a very high rate of mortality. Different symptoms developed by COVID-19 infection and its impacts on various organs of the human body have highlighted the importance of both coinfections and superinfections with other pat …
CLOSTRIDIOIDES DIFFICILE INFECTION IN PATIENTS WITH IBD | JIR - Dove Medical Press
Patients affected by IBD's, this infection might be facilitated by a derangement of the enteric glial cell network caused by the of proinflammatory cytokines.
New Research Confirms High Toxin Levels Linked to More Severe C. Difficile Infection - Pharmacy Times
The concentration of C. diff toxins in the stool was linked to how sick patients were at the time of diagnosis and was associated with adverse outcomes, including the risk of infection returning after treatment.
C Difficile Infection: What Causes Disruption of the Gut Microbiome? - MD Magazine
Shared insight on how disruption of the gut microbiome may occur based on antibiotic exposure, environmental factors, and diet.