C Diff Molecular

C Diff Molecular

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Unveiling the impact of antibiotic stress on biofilm formation and expression of toxin-antitoxin system genes in Clostridium difficile clinical isolates - PubMed
Unveiling the impact of antibiotic stress on biofilm formation and expression of toxin-antitoxin system genes in Clostridium difficile clinical isolates - PubMed
Our study suggests that toxin and antitoxin genes may impact C. difficile biofilm formation, while antibiotics could signal biofilm strengthening and gene expression increase.
·pubmed.ncbi.nlm.nih.gov·
Unveiling the impact of antibiotic stress on biofilm formation and expression of toxin-antitoxin system genes in Clostridium difficile clinical isolates - PubMed
Exploring the role of gut microbiome in autoimmune diseases: A comprehensive review - PubMed
Exploring the role of gut microbiome in autoimmune diseases: A comprehensive review - PubMed
As the industrialized society advances, there has been a gradual increase in the prevalence of autoimmune disorders. A probe into the fundamental causes has disclosed several factors in modern society that have an influence on the gut microbiome. These dramatic shifts in the gut microbiome are likel …
·pubmed.ncbi.nlm.nih.gov·
Exploring the role of gut microbiome in autoimmune diseases: A comprehensive review - PubMed
Ulcerative colitis: molecular insights and intervention therapy - PubMed
Ulcerative colitis: molecular insights and intervention therapy - PubMed
Ulcerative colitis (UC) is a chronic inflammatory bowel disease characterized by abdominal pain, diarrhea, rectal bleeding, and weight loss. The pathogenesis and treatment of UC remain key areas of research interest. Various factors, including genetic predisposition, immune dysregulation, and altera …
·pubmed.ncbi.nlm.nih.gov·
Ulcerative colitis: molecular insights and intervention therapy - PubMed
Influence of microbiota on the growth and gene expression of Clostridioides difficile in an in vitro coculture model - PubMed
Influence of microbiota on the growth and gene expression of Clostridioides difficile in an in vitro coculture model - PubMed
Clostridioides difficile is an anaerobic, spore-forming, Gram-positive pathogenic bacterium. This study aimed to analyze the effect of two samples of healthy fecal microbiota on C. difficile gene expression and growth using an in vitro coculture model. The inner compartment was cocultured with spore …
·pubmed.ncbi.nlm.nih.gov·
Influence of microbiota on the growth and gene expression of Clostridioides difficile in an in vitro coculture model - PubMed
The current riboswitch landscape in Clostridioides difficile - PubMed
The current riboswitch landscape in Clostridioides difficile - PubMed
Riboswitches are 5' RNA regulatory elements that are capable of binding to various ligands, such as small metabolites, ions and tRNAs, leading to conformational changes and affecting gene transcription or translation. They are widespread in bacteria and frequently control genes that are essential fo …
·pubmed.ncbi.nlm.nih.gov·
The current riboswitch landscape in Clostridioides difficile - PubMed
Impact of Gut Microbiota and SCFAs in the Pathogenesis of PCOS and the Effect of Metformin Therapy - PubMed
Impact of Gut Microbiota and SCFAs in the Pathogenesis of PCOS and the Effect of Metformin Therapy - PubMed
Polycystic ovary syndrome (PCOS) is a complex disorder that impacts both the endocrine and metabolic systems, often resulting in infertility, obesity, insulin resistance, and cardiovascular complications. The aim of this study is to investigate the role of intestinal flora and its metabolites, parti …
·pubmed.ncbi.nlm.nih.gov·
Impact of Gut Microbiota and SCFAs in the Pathogenesis of PCOS and the Effect of Metformin Therapy - PubMed
Risk of Intestinal Complications, Extraintestinal Morbidity, and Mortality in Patients with Crohn's Disease and Ocular Involvement - PubMed
Risk of Intestinal Complications, Extraintestinal Morbidity, and Mortality in Patients with Crohn's Disease and Ocular Involvement - PubMed
Patients who have CD and subsequent ocular involvement have an increased risk of local intestinal complications, extraintestinal morbidity, and cardiovascular complications when compared to patients with CD without ocular involvement.
·pubmed.ncbi.nlm.nih.gov·
Risk of Intestinal Complications, Extraintestinal Morbidity, and Mortality in Patients with Crohn's Disease and Ocular Involvement - PubMed
TcdB from Hypervirulent Clostridioides difficile Induces Neuronal Loss and Neurotransmitter Alterations in the Intrinsic Enteric Nervous System - PubMed
TcdB from Hypervirulent Clostridioides difficile Induces Neuronal Loss and Neurotransmitter Alterations in the Intrinsic Enteric Nervous System - PubMed
Clostridioides difficile infection (CDI) is a predominant cause of intestinal infections. The intrinsic enteric nervous system (ENS) occupies the intestinal tissue in large numbers and intricately regulates various aspects of intestinal function. Nonetheless, the specific effects of CDI on the intri …
·pubmed.ncbi.nlm.nih.gov·
TcdB from Hypervirulent Clostridioides difficile Induces Neuronal Loss and Neurotransmitter Alterations in the Intrinsic Enteric Nervous System - PubMed
Normalization of short-chain fatty acid concentration by bacterial count of stool samples improves discrimination between eubiotic and dysbiotic gut microbiota caused by Clostridioides difficile infection - PubMed
Normalization of short-chain fatty acid concentration by bacterial count of stool samples improves discrimination between eubiotic and dysbiotic gut microbiota caused by Clostridioides difficile infection - PubMed
Short-chain fatty acids (SCFAs) represent a cornerstone of gut health, serving as critical mediators of immune modulation and overall host homeostasis. Patients with dysbiosis caused by Clostridioides difficile infection (CDI) typically exhibit lower SCFAs levels compared to healthy stool don …
·pubmed.ncbi.nlm.nih.gov·
Normalization of short-chain fatty acid concentration by bacterial count of stool samples improves discrimination between eubiotic and dysbiotic gut microbiota caused by Clostridioides difficile infection - PubMed
Penicillin-binding proteins exhibit catalytic redundancy during asymmetric cell division in Clostridioides difficile - PubMed
Penicillin-binding proteins exhibit catalytic redundancy during asymmetric cell division in Clostridioides difficile - PubMed
Peptidoglycan synthesis is an essential driver of bacterial growth and division. The final steps of this crucial process involve the activity of SEDS family glycosyltransferases that polymerize glycan strands and class B penicillin-binding protein (bPBP) transpeptidases that cross-link them. While m …
·pubmed.ncbi.nlm.nih.gov·
Penicillin-binding proteins exhibit catalytic redundancy during asymmetric cell division in Clostridioides difficile - PubMed
Characterization of the Clostridioides difficile 630Δerm putative Pro-Pro endopeptidase CD1597 - PubMed
Characterization of the Clostridioides difficile 630Δerm putative Pro-Pro endopeptidase CD1597 - PubMed
Clostridioides difficile is the leading cause of antibiotic-associated infections worldwide. Within the host, C. difficile can transition from a sessile to a motile state by secreting PPEP-1, which releases the cells from the intestinal epithelium by cleaving adhesion proteins. PPEP-1 …
·pubmed.ncbi.nlm.nih.gov·
Characterization of the Clostridioides difficile 630Δerm putative Pro-Pro endopeptidase CD1597 - PubMed
Flagellar switch inverted repeat impacts flagellar invertibility and varies Clostridioides difficile RT027/MLST1 virulence - PubMed
Flagellar switch inverted repeat impacts flagellar invertibility and varies Clostridioides difficile RT027/MLST1 virulence - PubMed
Clostridioides difficile RT027 strains cause infections that vary in severity from asymptomatic to lethal, but the molecular basis for this variability is poorly understood. Through comparative analyses of RT027 clinical isolates, we determined that isolates that exhibit greater variability i …
·pubmed.ncbi.nlm.nih.gov·
Flagellar switch inverted repeat impacts flagellar invertibility and varies Clostridioides difficile RT027/MLST1 virulence - PubMed
Characterization of the Clostridioides difficile 630Δerm putative Pro-Pro endopeptidase CD1597 - PubMed
Characterization of the Clostridioides difficile 630Δerm putative Pro-Pro endopeptidase CD1597 - PubMed
Clostridioides difficile is the leading cause of antibiotic-associated infections worldwide. Within the host, C. difficile can transition from a sessile to a motile state by secreting PPEP-1, which releases the cells from the intestinal epithelium by cleaving adhesion proteins. PPEP-1 …
·pubmed.ncbi.nlm.nih.gov·
Characterization of the Clostridioides difficile 630Δerm putative Pro-Pro endopeptidase CD1597 - PubMed
Clostridioides difficile toxin B suppresses human neutrophil migration - PubMed
Clostridioides difficile toxin B suppresses human neutrophil migration - PubMed
We investigated the effects of Clostridioides difficile toxin B (TcdB), a major virulence factor in C. difficile infection (CDI), on human neutrophils. TcdB inhibits neutrophil migration via loss of polarity of F-actin polymerization in response to interleukin-8. TcdB facilitates CDI by allowing C. …
·pubmed.ncbi.nlm.nih.gov·
Clostridioides difficile toxin B suppresses human neutrophil migration - PubMed
Clostridioides difficile toxin B suppresses human neutrophil migration - PubMed
Clostridioides difficile toxin B suppresses human neutrophil migration - PubMed
We investigated the effects of Clostridioides difficile toxin B (TcdB), a major virulence factor in C. difficile infection (CDI), on human neutrophils. TcdB inhibits neutrophil migration via loss of polarity of F-actin polymerization in response to interleukin-8. TcdB facilitates CDI by allowing C. …
·pubmed.ncbi.nlm.nih.gov·
Clostridioides difficile toxin B suppresses human neutrophil migration - PubMed
The sympathetic nervous system drives hyperinflammatory responses to Clostridioides difficile infection - PubMed
The sympathetic nervous system drives hyperinflammatory responses to Clostridioides difficile infection - PubMed
Clostridioides difficile infection (CDI) is a leading cause of hospital-acquired infections in the United States, known for triggering severe disease by hyperactivation of the host response. In this study, we determine the impact of the sympathetic nervous system (SNS) on CDI disease severity. Mouse …
·pubmed.ncbi.nlm.nih.gov·
The sympathetic nervous system drives hyperinflammatory responses to Clostridioides difficile infection - PubMed
Chemistry Associate Professor Pursues Research on Potentially Fatal Human Pathogen
Chemistry Associate Professor Pursues Research on Potentially Fatal Human Pathogen
By Tiffany Whitfield and Isaiah Hudson   Curiosity is the engine that drives research amongst faculty in the College of Sciences, and uncovering new ways to fight one of the world’s most antibiotic-resistant pathogens is what drives Associate Professor Erin Purcell. At Old Dominion University, Purcell's area of research focuses on signal transduction pathways in Clostridoides difficile (C. difficile) which is a human pathogen that causes damage to the colon and can be fatal.
·odu.edu·
Chemistry Associate Professor Pursues Research on Potentially Fatal Human Pathogen
Crystal structure of a Clostridioides difficile multiple antibiotic resistance regulator (MarR) CD0473 suggests a potential redox-regulated function - PubMed
Crystal structure of a Clostridioides difficile multiple antibiotic resistance regulator (MarR) CD0473 suggests a potential redox-regulated function - PubMed
Clostridioides difficile may constitute a small part of normal gut microbiota in humans without causing any symptoms, but an uncontrolled growth common to hospitalized patients can cause Clostridioides difficile infection (CDI) leading to severe colonic symptoms. As the bacteria are attaining resist …
·pubmed.ncbi.nlm.nih.gov·
Crystal structure of a Clostridioides difficile multiple antibiotic resistance regulator (MarR) CD0473 suggests a potential redox-regulated function - PubMed
Impact of Clostridium difficile Infection Versus Colonization on Postoperative Outcomes After Oncological Colorectal Surgery: An Observational Single-Center Study With Propensity Score Analysis - PubMed
Impact of Clostridium difficile Infection Versus Colonization on Postoperative Outcomes After Oncological Colorectal Surgery: An Observational Single-Center Study With Propensity Score Analysis - PubMed
HA-CDI is associated with a higher risk of anastomotic leak after oncological colorectal surgery, while asymptomatic CDC do not have higher morbidity and may be operated electively, under standard CD treatment.
·pubmed.ncbi.nlm.nih.gov·
Impact of Clostridium difficile Infection Versus Colonization on Postoperative Outcomes After Oncological Colorectal Surgery: An Observational Single-Center Study With Propensity Score Analysis - PubMed
Clostridium difficile in Patients With Cystic Fibrosis
Clostridium difficile in Patients With Cystic Fibrosis
• One hundred seven patients with cystic fibrosis (CF) and 54 other patients with risk factors for Clostridium difficile–associated disease were entered into a bacteriologic study to compare the rate of recovery of C difficile and cytotoxin in feces with occurrence of diarrhea and to investigate...
·jamanetwork.com·
Clostridium difficile in Patients With Cystic Fibrosis
Gut Microbial and Metabolic Features Associated With Clostridioides difficile Infection Recurrence in Children - PubMed
Gut Microbial and Metabolic Features Associated With Clostridioides difficile Infection Recurrence in Children - PubMed
Our study suggests that the differing gut microbiota profiles in pediatric CDI patients may contribute to disease recurrence by modulating SCFA concentrations and bile acid profiles. The gut microbiota and metabolite signatures may be used to predict disease recurrence in children with CDI.
·pubmed.ncbi.nlm.nih.gov·
Gut Microbial and Metabolic Features Associated With Clostridioides difficile Infection Recurrence in Children - PubMed
Diverse Genotypes of Clostridioides difficile Revealed
Diverse Genotypes of Clostridioides difficile Revealed
Cross-regional strains may spread more effectively in the community, highlighting the need for ongoing molecular surveillance to monitor their prevalence and detect potential changes.
·contagionlive.com·
Diverse Genotypes of Clostridioides difficile Revealed
[Molecular characteristics and antibiotic resistance of Clostridioides difficile isolated from children in China] - PubMed
[Molecular characteristics and antibiotic resistance of Clostridioides difficile isolated from children in China] - PubMed
Objective: To understand molecular characteristics and antibiotic resistance of Clostridioides (C.) difficile isolated from children in China, and provide data support the development of disease risk assessment and burden studies. Methods: A total of 155 strains of …
·pubmed.ncbi.nlm.nih.gov·
[Molecular characteristics and antibiotic resistance of Clostridioides difficile isolated from children in China] - PubMed
Comparison of toxin gene expression levels and molecular typing of Clostridioides difficile strains isolated from patients with diarrhea - PubMed
Comparison of toxin gene expression levels and molecular typing of Clostridioides difficile strains isolated from patients with diarrhea - PubMed
We encountered toxigenic C. difficile strains with various toxin expression levels, ribotypes, and rep types based on the findings of this study. This indicated that various clones from various sources circulate in the hospitals and among patients.
·pubmed.ncbi.nlm.nih.gov·
Comparison of toxin gene expression levels and molecular typing of Clostridioides difficile strains isolated from patients with diarrhea - PubMed
Genomic epidemiology of Clostridioides difficile Sequence Type 35 reveals intraspecies and interspecies clonal transmission - PubMed
Genomic epidemiology of Clostridioides difficile Sequence Type 35 reveals intraspecies and interspecies clonal transmission - PubMed
Clostridioides difficile sequence type (ST) 35 has been found in humans and animals worldwide. However, its genomic epidemiology and clonal transmission have not been explored in detail. In this study, 176 C. difficile ST35 isolates from six countries were sequenced. Genomic diversity, …
·pubmed.ncbi.nlm.nih.gov·
Genomic epidemiology of Clostridioides difficile Sequence Type 35 reveals intraspecies and interspecies clonal transmission - PubMed
[Molecular characteristics and antibiotic resistance of Clostridioides difficile isolated from children in China] - PubMed
[Molecular characteristics and antibiotic resistance of Clostridioides difficile isolated from children in China] - PubMed
Objective: To understand molecular characteristics and antibiotic resistance of Clostridioides (C.) difficile isolated from children in China, and provide data support the development of disease risk assessment and burden studies. Methods: A total of 155 strains of …
·pubmed.ncbi.nlm.nih.gov·
[Molecular characteristics and antibiotic resistance of Clostridioides difficile isolated from children in China] - PubMed