C Diff Molecular

C Diff Molecular

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Penicillin-binding proteins exhibit catalytic redundancy during asymmetric cell division in Clostridioides difficile - PubMed
Penicillin-binding proteins exhibit catalytic redundancy during asymmetric cell division in Clostridioides difficile - PubMed
Peptidoglycan synthesis is an essential driver of bacterial growth and division. The final steps of this crucial process involve the activity of SEDS family glycosyltransferases that polymerize glycan strands and class B penicillin-binding protein (bPBP) transpeptidases that cross-link them. While m …
·pubmed.ncbi.nlm.nih.gov·
Penicillin-binding proteins exhibit catalytic redundancy during asymmetric cell division in Clostridioides difficile - PubMed
Characterization of the Clostridioides difficile 630Δerm putative Pro-Pro endopeptidase CD1597 - PubMed
Characterization of the Clostridioides difficile 630Δerm putative Pro-Pro endopeptidase CD1597 - PubMed
Clostridioides difficile is the leading cause of antibiotic-associated infections worldwide. Within the host, C. difficile can transition from a sessile to a motile state by secreting PPEP-1, which releases the cells from the intestinal epithelium by cleaving adhesion proteins. PPEP-1 …
·pubmed.ncbi.nlm.nih.gov·
Characterization of the Clostridioides difficile 630Δerm putative Pro-Pro endopeptidase CD1597 - PubMed
Flagellar switch inverted repeat impacts flagellar invertibility and varies Clostridioides difficile RT027/MLST1 virulence - PubMed
Flagellar switch inverted repeat impacts flagellar invertibility and varies Clostridioides difficile RT027/MLST1 virulence - PubMed
Clostridioides difficile RT027 strains cause infections that vary in severity from asymptomatic to lethal, but the molecular basis for this variability is poorly understood. Through comparative analyses of RT027 clinical isolates, we determined that isolates that exhibit greater variability i …
·pubmed.ncbi.nlm.nih.gov·
Flagellar switch inverted repeat impacts flagellar invertibility and varies Clostridioides difficile RT027/MLST1 virulence - PubMed
Characterization of the Clostridioides difficile 630Δerm putative Pro-Pro endopeptidase CD1597 - PubMed
Characterization of the Clostridioides difficile 630Δerm putative Pro-Pro endopeptidase CD1597 - PubMed
Clostridioides difficile is the leading cause of antibiotic-associated infections worldwide. Within the host, C. difficile can transition from a sessile to a motile state by secreting PPEP-1, which releases the cells from the intestinal epithelium by cleaving adhesion proteins. PPEP-1 …
·pubmed.ncbi.nlm.nih.gov·
Characterization of the Clostridioides difficile 630Δerm putative Pro-Pro endopeptidase CD1597 - PubMed
Clostridioides difficile toxin B suppresses human neutrophil migration - PubMed
Clostridioides difficile toxin B suppresses human neutrophil migration - PubMed
We investigated the effects of Clostridioides difficile toxin B (TcdB), a major virulence factor in C. difficile infection (CDI), on human neutrophils. TcdB inhibits neutrophil migration via loss of polarity of F-actin polymerization in response to interleukin-8. TcdB facilitates CDI by allowing C. …
·pubmed.ncbi.nlm.nih.gov·
Clostridioides difficile toxin B suppresses human neutrophil migration - PubMed
Clostridioides difficile toxin B suppresses human neutrophil migration - PubMed
Clostridioides difficile toxin B suppresses human neutrophil migration - PubMed
We investigated the effects of Clostridioides difficile toxin B (TcdB), a major virulence factor in C. difficile infection (CDI), on human neutrophils. TcdB inhibits neutrophil migration via loss of polarity of F-actin polymerization in response to interleukin-8. TcdB facilitates CDI by allowing C. …
·pubmed.ncbi.nlm.nih.gov·
Clostridioides difficile toxin B suppresses human neutrophil migration - PubMed
The sympathetic nervous system drives hyperinflammatory responses to Clostridioides difficile infection - PubMed
The sympathetic nervous system drives hyperinflammatory responses to Clostridioides difficile infection - PubMed
Clostridioides difficile infection (CDI) is a leading cause of hospital-acquired infections in the United States, known for triggering severe disease by hyperactivation of the host response. In this study, we determine the impact of the sympathetic nervous system (SNS) on CDI disease severity. Mouse …
·pubmed.ncbi.nlm.nih.gov·
The sympathetic nervous system drives hyperinflammatory responses to Clostridioides difficile infection - PubMed
Chemistry Associate Professor Pursues Research on Potentially Fatal Human Pathogen
Chemistry Associate Professor Pursues Research on Potentially Fatal Human Pathogen
By Tiffany Whitfield and Isaiah Hudson   Curiosity is the engine that drives research amongst faculty in the College of Sciences, and uncovering new ways to fight one of the world’s most antibiotic-resistant pathogens is what drives Associate Professor Erin Purcell. At Old Dominion University, Purcell's area of research focuses on signal transduction pathways in Clostridoides difficile (C. difficile) which is a human pathogen that causes damage to the colon and can be fatal.
·odu.edu·
Chemistry Associate Professor Pursues Research on Potentially Fatal Human Pathogen
Crystal structure of a Clostridioides difficile multiple antibiotic resistance regulator (MarR) CD0473 suggests a potential redox-regulated function - PubMed
Crystal structure of a Clostridioides difficile multiple antibiotic resistance regulator (MarR) CD0473 suggests a potential redox-regulated function - PubMed
Clostridioides difficile may constitute a small part of normal gut microbiota in humans without causing any symptoms, but an uncontrolled growth common to hospitalized patients can cause Clostridioides difficile infection (CDI) leading to severe colonic symptoms. As the bacteria are attaining resist …
·pubmed.ncbi.nlm.nih.gov·
Crystal structure of a Clostridioides difficile multiple antibiotic resistance regulator (MarR) CD0473 suggests a potential redox-regulated function - PubMed
Impact of Clostridium difficile Infection Versus Colonization on Postoperative Outcomes After Oncological Colorectal Surgery: An Observational Single-Center Study With Propensity Score Analysis - PubMed
Impact of Clostridium difficile Infection Versus Colonization on Postoperative Outcomes After Oncological Colorectal Surgery: An Observational Single-Center Study With Propensity Score Analysis - PubMed
HA-CDI is associated with a higher risk of anastomotic leak after oncological colorectal surgery, while asymptomatic CDC do not have higher morbidity and may be operated electively, under standard CD treatment.
·pubmed.ncbi.nlm.nih.gov·
Impact of Clostridium difficile Infection Versus Colonization on Postoperative Outcomes After Oncological Colorectal Surgery: An Observational Single-Center Study With Propensity Score Analysis - PubMed
Clostridium difficile in Patients With Cystic Fibrosis
Clostridium difficile in Patients With Cystic Fibrosis
• One hundred seven patients with cystic fibrosis (CF) and 54 other patients with risk factors for Clostridium difficile–associated disease were entered into a bacteriologic study to compare the rate of recovery of C difficile and cytotoxin in feces with occurrence of diarrhea and to investigate...
·jamanetwork.com·
Clostridium difficile in Patients With Cystic Fibrosis
Gut Microbial and Metabolic Features Associated With Clostridioides difficile Infection Recurrence in Children - PubMed
Gut Microbial and Metabolic Features Associated With Clostridioides difficile Infection Recurrence in Children - PubMed
Our study suggests that the differing gut microbiota profiles in pediatric CDI patients may contribute to disease recurrence by modulating SCFA concentrations and bile acid profiles. The gut microbiota and metabolite signatures may be used to predict disease recurrence in children with CDI.
·pubmed.ncbi.nlm.nih.gov·
Gut Microbial and Metabolic Features Associated With Clostridioides difficile Infection Recurrence in Children - PubMed
Diverse Genotypes of Clostridioides difficile Revealed
Diverse Genotypes of Clostridioides difficile Revealed
Cross-regional strains may spread more effectively in the community, highlighting the need for ongoing molecular surveillance to monitor their prevalence and detect potential changes.
·contagionlive.com·
Diverse Genotypes of Clostridioides difficile Revealed
[Molecular characteristics and antibiotic resistance of Clostridioides difficile isolated from children in China] - PubMed
[Molecular characteristics and antibiotic resistance of Clostridioides difficile isolated from children in China] - PubMed
Objective: To understand molecular characteristics and antibiotic resistance of Clostridioides (C.) difficile isolated from children in China, and provide data support the development of disease risk assessment and burden studies. Methods: A total of 155 strains of …
·pubmed.ncbi.nlm.nih.gov·
[Molecular characteristics and antibiotic resistance of Clostridioides difficile isolated from children in China] - PubMed
Comparison of toxin gene expression levels and molecular typing of Clostridioides difficile strains isolated from patients with diarrhea - PubMed
Comparison of toxin gene expression levels and molecular typing of Clostridioides difficile strains isolated from patients with diarrhea - PubMed
We encountered toxigenic C. difficile strains with various toxin expression levels, ribotypes, and rep types based on the findings of this study. This indicated that various clones from various sources circulate in the hospitals and among patients.
·pubmed.ncbi.nlm.nih.gov·
Comparison of toxin gene expression levels and molecular typing of Clostridioides difficile strains isolated from patients with diarrhea - PubMed
Genomic epidemiology of Clostridioides difficile Sequence Type 35 reveals intraspecies and interspecies clonal transmission - PubMed
Genomic epidemiology of Clostridioides difficile Sequence Type 35 reveals intraspecies and interspecies clonal transmission - PubMed
Clostridioides difficile sequence type (ST) 35 has been found in humans and animals worldwide. However, its genomic epidemiology and clonal transmission have not been explored in detail. In this study, 176 C. difficile ST35 isolates from six countries were sequenced. Genomic diversity, …
·pubmed.ncbi.nlm.nih.gov·
Genomic epidemiology of Clostridioides difficile Sequence Type 35 reveals intraspecies and interspecies clonal transmission - PubMed
[Molecular characteristics and antibiotic resistance of Clostridioides difficile isolated from children in China] - PubMed
[Molecular characteristics and antibiotic resistance of Clostridioides difficile isolated from children in China] - PubMed
Objective: To understand molecular characteristics and antibiotic resistance of Clostridioides (C.) difficile isolated from children in China, and provide data support the development of disease risk assessment and burden studies. Methods: A total of 155 strains of …
·pubmed.ncbi.nlm.nih.gov·
[Molecular characteristics and antibiotic resistance of Clostridioides difficile isolated from children in China] - PubMed
Genomic epidemiology of Clostridioides difficile Sequence Type 35 reveals intraspecies and interspecies clonal transmission - PubMed
Genomic epidemiology of Clostridioides difficile Sequence Type 35 reveals intraspecies and interspecies clonal transmission - PubMed
Clostridioides difficile sequence type (ST) 35 has been found in humans and animals worldwide. However, its genomic epidemiology and clonal transmission have not been explored in detail. In this study, 176 C. difficile ST35 isolates from six countries were sequenced. Genomic diversity, …
·pubmed.ncbi.nlm.nih.gov·
Genomic epidemiology of Clostridioides difficile Sequence Type 35 reveals intraspecies and interspecies clonal transmission - PubMed
Pangenome analysis of Clostridium scindens : a collection of diverse bile acid and steroid metabolizing commensal gut bacterial strains - PubMed
Pangenome analysis of Clostridium scindens : a collection of diverse bile acid and steroid metabolizing commensal gut bacterial strains - PubMed
Clostridium scindens is a commensal gut bacterium capable of forming the secondary bile acids deoxycholic acid and lithocholic acid from the primary bile acids cholic acid and chenodeoxycholic acid, respectively, as well as converting glucocorticoids to androgens. Historically, only two strai …
·pubmed.ncbi.nlm.nih.gov·
Pangenome analysis of Clostridium scindens : a collection of diverse bile acid and steroid metabolizing commensal gut bacterial strains - PubMed
Clostridioides difficile infection: an update - PubMed
Clostridioides difficile infection: an update - PubMed
Clostridioides difficile (C. difficile) is a Gram-positive, spore-forming anaerobic bacterium emerged as a leading cause of diarrhea globally. CDI's (Clostridioides difficile infection) impact on healthcare systems is concerning due to high treatment cost and increased hospitalisation …
·pubmed.ncbi.nlm.nih.gov·
Clostridioides difficile infection: an update - PubMed
Adaptation mechanisms of Clostridioides difficile to auranofin and its impact on human gut microbiota - PubMed
Adaptation mechanisms of Clostridioides difficile to auranofin and its impact on human gut microbiota - PubMed
Auranofin (AF), a former rheumatoid polyarthritis treatment, gained renewed interest for its use as an antimicrobial. AF is an inhibitor of thioredoxin reductase (TrxB), a thiol and protein repair enzyme, with an antibacterial activity against several bacteria including C. difficile, an enteropathog …
·pubmed.ncbi.nlm.nih.gov·
Adaptation mechanisms of Clostridioides difficile to auranofin and its impact on human gut microbiota - PubMed
Regional and temporal genotype profiling of Clostridioides difficile in a multi-institutional study in Japan - PubMed
Regional and temporal genotype profiling of Clostridioides difficile in a multi-institutional study in Japan - PubMed
Clostridioides difficile, a cause of healthcare-associated infections, poses a significant global health threat. This multi-institutional retrospective study focuses on epidemic dynamics, emphasizing minor and toxin-negative clinical isolates through high-resolution genotyping. The genotype of the C …
·pubmed.ncbi.nlm.nih.gov·
Regional and temporal genotype profiling of Clostridioides difficile in a multi-institutional study in Japan - PubMed
Decreased phagocytosis and intracellular killing of bacteria in leukocytes of geriatric patients with Clostridioides difficile infections - PubMed
Decreased phagocytosis and intracellular killing of bacteria in leukocytes of geriatric patients with Clostridioides difficile infections - PubMed
Blood phagocytes from patients with C. difficile enteritis exhibited a reduced capacity to phagocytose and kill bacteria in comparison to blood phagocytes from age- and sex-matched control patients. Patients with C. difficile infection may have a higher disposition to develop infectious diseases tha …
·pubmed.ncbi.nlm.nih.gov·
Decreased phagocytosis and intracellular killing of bacteria in leukocytes of geriatric patients with Clostridioides difficile infections - PubMed
Purified CDT toxins and a clean deletion within the CDT locus provide novel insights into the contribution of binary toxin in cellular inflammation and Clostridioides difficile infection - PubMed
Purified CDT toxins and a clean deletion within the CDT locus provide novel insights into the contribution of binary toxin in cellular inflammation and Clostridioides difficile infection - PubMed
Clostridioides difficile is a spore-forming pathogen and the most common cause of healthcare-associated diarrhea and colitis in the United States. Besides producing the main virulence factors, toxin A (TcdA) and toxin B (TcdB), many of the common clinical strains encode the C. difficile transferase …
·pubmed.ncbi.nlm.nih.gov·
Purified CDT toxins and a clean deletion within the CDT locus provide novel insights into the contribution of binary toxin in cellular inflammation and Clostridioides difficile infection - PubMed
Decreased phagocytosis and intracellular killing of bacteria in leukocytes of geriatric patients with Clostridioides difficile infections - PubMed
Decreased phagocytosis and intracellular killing of bacteria in leukocytes of geriatric patients with Clostridioides difficile infections - PubMed
Blood phagocytes from patients with C. difficile enteritis exhibited a reduced capacity to phagocytose and kill bacteria in comparison to blood phagocytes from age- and sex-matched control patients. Patients with C. difficile infection may have a higher disposition to develop infectious diseases tha …
·pubmed.ncbi.nlm.nih.gov·
Decreased phagocytosis and intracellular killing of bacteria in leukocytes of geriatric patients with Clostridioides difficile infections - PubMed
Positive Intervention of Distinct Peptides in Clostridioides difficile Infection in a Mouse Model - PubMed
Positive Intervention of Distinct Peptides in Clostridioides difficile Infection in a Mouse Model - PubMed
Clostridioides difficile infection (CDI) is a common healthcare-associated infection and the leading cause of gastroenteritis-related deaths worldwide. To investigate the effects of peptide composition of different protein products on CDI, we analyzed and compared the peptide sequences and compositi …
·pubmed.ncbi.nlm.nih.gov·
Positive Intervention of Distinct Peptides in Clostridioides difficile Infection in a Mouse Model - PubMed
Adaptation mechanisms of Clostridioides difficile to auranofin and its impact on human gut microbiota - PubMed
Adaptation mechanisms of Clostridioides difficile to auranofin and its impact on human gut microbiota - PubMed
Auranofin (AF), a former rheumatoid polyarthritis treatment, gained renewed interest for its use as an antimicrobial. AF is an inhibitor of thioredoxin reductase (TrxB), a thiol and protein repair enzyme, with an antibacterial activity against several bacteria including C. difficile, an enteropathog …
·pubmed.ncbi.nlm.nih.gov·
Adaptation mechanisms of Clostridioides difficile to auranofin and its impact on human gut microbiota - PubMed