C Diff Molecular

C Diff Molecular

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Flagellin is essential for initial attachment to mucosal surfaces by Clostridioides difficile - PubMed
Flagellin is essential for initial attachment to mucosal surfaces by Clostridioides difficile - PubMed
Mucins are glycoproteins which can be found in host cell membranes and as a gelatinous surface formed from secreted mucins. Mucosal surfaces in mammals form a barrier to invasive microbes, particularly bacteria, but are a point of attachment for others. Clostridioides difficile is an anaerobi …
·pubmed.ncbi.nlm.nih.gov·
Flagellin is essential for initial attachment to mucosal surfaces by Clostridioides difficile - PubMed
A genomic survey of Clostridioides difficile isolates from hospitalized patients in Melbourne, Australia - PubMed
A genomic survey of Clostridioides difficile isolates from hospitalized patients in Melbourne, Australia - PubMed
There has been a decrease in healthcare-associated Clostridioides difficile infection (CDI) in Australia, coupled with an increase in the genetic diversity of strains isolated in these settings, and an increase in community-associated cases. To explore this changing epidemiology, we studied t …
·pubmed.ncbi.nlm.nih.gov·
A genomic survey of Clostridioides difficile isolates from hospitalized patients in Melbourne, Australia - PubMed
Microbiome profile and calprotectin levels as markers of risk of recurrent Clostridioides difficile infection - PubMed
Microbiome profile and calprotectin levels as markers of risk of recurrent Clostridioides difficile infection - PubMed
Calprotectin levels and abundance of microbial genera such as Fusobacterium and Prevotella in primary episodes could be useful as early markers of R-CDI. We propose a readily available model for prediction of R-CDI that can be applied at the initial CDI episode. The use of this tool could help to be …
·pubmed.ncbi.nlm.nih.gov·
Microbiome profile and calprotectin levels as markers of risk of recurrent Clostridioides difficile infection - PubMed
Clostridioides difficile infection in the allogeneic hematopoietic cell transplant recipient - PubMed
Clostridioides difficile infection in the allogeneic hematopoietic cell transplant recipient - PubMed
Clostridioides difficile (CD) is one of the most important causes of diarrhea in hospitalized patients, in particular those who undergo an allogeneic hematopoietic cell transplant (allo-HCT) and who are more at risk of developing a CD infection (CDI) due to frequent hospitalizations, iatrogenic immu …
·pubmed.ncbi.nlm.nih.gov·
Clostridioides difficile infection in the allogeneic hematopoietic cell transplant recipient - PubMed
Microbial ecology between Clostridioides difficile and gut microbiota - PubMed
Microbial ecology between Clostridioides difficile and gut microbiota - PubMed
Clostridioides difficile colonizes a polymicrobial environment in the intestine and is a causative agent for antibiotic-associated diarrhea (AAD) and pseudomembranous colitis (PMC). The most important virulence factors of C. difficile are bacterial toxins, and three toxins (toxin A, to …
·pubmed.ncbi.nlm.nih.gov·
Microbial ecology between Clostridioides difficile and gut microbiota - PubMed
Antisense inhibition of RNA polymerase α subunit of Clostridioides difficile - PubMed
Antisense inhibition of RNA polymerase α subunit of Clostridioides difficile - PubMed
Clostridioides difficile, the causative agent of antibiotic-associated diarrhea and pseudomembranous colitis, has emerged as a major enteric pathogen in recent years. Antibiotic treatment perturbs the gut microbiome homeostasis, which facilitates the colonization and proliferation of the path …
·pubmed.ncbi.nlm.nih.gov·
Antisense inhibition of RNA polymerase α subunit of Clostridioides difficile - PubMed
Prevalence of Non-Toxigenic Clostridioides difficile in Diarrhoea Patients and Their Clinical Characteristics - PubMed
Prevalence of Non-Toxigenic Clostridioides difficile in Diarrhoea Patients and Their Clinical Characteristics - PubMed
Non-toxigenic Clostridioides difficile (NTCD) has been shown to decrease the risk of recurrent C. difficile infection (CDI) in patients following metronidazole or vancomycin treatment for CDI. Limited data on the prevalence of NTCD strains in symptomatic patients and their clinical cha …
·pubmed.ncbi.nlm.nih.gov·
Prevalence of Non-Toxigenic Clostridioides difficile in Diarrhoea Patients and Their Clinical Characteristics - PubMed
Prevalence of Non-Toxigenic Clostridioides difficile in Diarrhoea Patients and Their Clinical Characteristics - PubMed
Prevalence of Non-Toxigenic Clostridioides difficile in Diarrhoea Patients and Their Clinical Characteristics - PubMed
Non-toxigenic Clostridioides difficile (NTCD) has been shown to decrease the risk of recurrent C. difficile infection (CDI) in patients following metronidazole or vancomycin treatment for CDI. Limited data on the prevalence of NTCD strains in symptomatic patients and their clinical cha …
·pubmed.ncbi.nlm.nih.gov·
Prevalence of Non-Toxigenic Clostridioides difficile in Diarrhoea Patients and Their Clinical Characteristics - PubMed
Mining Autoimmune-Disorder-Linked Molecular-Mimicry Candidates in Clostridioides difficile and Prospects of Mimic-Based Vaccine Design: An In Silico Approach - PubMed
Mining Autoimmune-Disorder-Linked Molecular-Mimicry Candidates in Clostridioides difficile and Prospects of Mimic-Based Vaccine Design: An In Silico Approach - PubMed
Molecular mimicry, a phenomenon in which microbial or environmental antigens resemble host antigens, has been proposed as a potential trigger for autoimmune responses. In this study, we employed a bioinformatics approach to investigate the role of molecular mimicry in Clostridioides difficile …
·pubmed.ncbi.nlm.nih.gov·
Mining Autoimmune-Disorder-Linked Molecular-Mimicry Candidates in Clostridioides difficile and Prospects of Mimic-Based Vaccine Design: An In Silico Approach - PubMed
One size does not fit all - Trehalose metabolism by Clostridioides difficile is variable across the five phylogenetic lineages - PubMed
One size does not fit all - Trehalose metabolism by Clostridioides difficile is variable across the five phylogenetic lineages - PubMed
Clostridioides difficile, the leading cause of antibiotic-associated diarrhoea worldwide, is a genetically diverse species which can metabolise a number of nutrient sources upon colonising a dysbiotic gut environment. Trehalose, a disaccharide sugar consisting of two glucose molecules bonded …
·pubmed.ncbi.nlm.nih.gov·
One size does not fit all - Trehalose metabolism by Clostridioides difficile is variable across the five phylogenetic lineages - PubMed
A computational method to dissect colonization resistance of the gut microbiota against pathogens - PubMed
A computational method to dissect colonization resistance of the gut microbiota against pathogens - PubMed
The mammalian gut microbiome protects the host through colonization resistance (CR) against the incursion of exogenous and often harmful microorganisms, but identifying the exact microbes responsible for the gut microbiota-mediated CR against a particular pathogen remains a challenge. To address thi …
·pubmed.ncbi.nlm.nih.gov·
A computational method to dissect colonization resistance of the gut microbiota against pathogens - PubMed
Glycine fermentation by C. difficile promotes virulence and spore formation, and is induced by host cathelicidin - PubMed
Glycine fermentation by C. difficile promotes virulence and spore formation, and is induced by host cathelicidin - PubMed
Clostridioides difficile is a leading cause of antibiotic-associated diarrheal disease. C. difficile colonization, growth, and toxin production in the intestine is strongly associated with its ability to use amino acids to generate energy, but little is known about the impact of specif …
·pubmed.ncbi.nlm.nih.gov·
Glycine fermentation by C. difficile promotes virulence and spore formation, and is induced by host cathelicidin - PubMed
Nectin-3 and shed forms of CSPG4 can serve as epithelial cell receptors for Clostridioides difficile TcdB - PubMed
Nectin-3 and shed forms of CSPG4 can serve as epithelial cell receptors for Clostridioides difficile TcdB - PubMed
Clostridioides difficile is a Gram-positive bacterium that can cause mild to severe diarrhea, inflammation, and colonic tissue damage in animal hosts. Symptoms of the disease can be attributed to the activity of toxin B (TcdB) secreted by C. difficile during infection. TcdB can engage …
·pubmed.ncbi.nlm.nih.gov·
Nectin-3 and shed forms of CSPG4 can serve as epithelial cell receptors for Clostridioides difficile TcdB - PubMed
Clostridium scindens secretome suppresses virulence gene expression of Clostridioides difficile in a bile acid-independent manner - PubMed
Clostridium scindens secretome suppresses virulence gene expression of Clostridioides difficile in a bile acid-independent manner - PubMed
Clostridioides difficile infection (CDI) is a major health concern and one of the leading causes of hospital-acquired diarrhea in many countries. C. difficile infection is challenging to treat as C. difficile is resistant to multiple antibiotics. Alternative solutions are needed …
·pubmed.ncbi.nlm.nih.gov·
Clostridium scindens secretome suppresses virulence gene expression of Clostridioides difficile in a bile acid-independent manner - PubMed
Nectin-3 and shed forms of CSPG4 can serve as epithelial cell receptors for Clostridioides difficile TcdB - PubMed
Nectin-3 and shed forms of CSPG4 can serve as epithelial cell receptors for Clostridioides difficile TcdB - PubMed
Clostridioides difficile is a Gram-positive bacterium that can cause mild to severe diarrhea, inflammation, and colonic tissue damage in animal hosts. Symptoms of the disease can be attributed to the activity of toxin B (TcdB) secreted by C. difficile during infection. TcdB can engage …
·pubmed.ncbi.nlm.nih.gov·
Nectin-3 and shed forms of CSPG4 can serve as epithelial cell receptors for Clostridioides difficile TcdB - PubMed
A high-throughput structural system biology approach to increase structure representation of proteins from Clostridioides difficile - PubMed
A high-throughput structural system biology approach to increase structure representation of proteins from Clostridioides difficile - PubMed
Clostridioides difficile causes life-threatening gastrointestinal infections. It is a high-risk pathogen due to a lack of effective treatments, antimicrobial resistance, and a poorly conserved genomic core. Herein, we report 30 X-ray structures from a structure genomics pipeline spanning 13 y …
·pubmed.ncbi.nlm.nih.gov·
A high-throughput structural system biology approach to increase structure representation of proteins from Clostridioides difficile - PubMed
The TcdE holin drives toxin secretion and virulence in Clostridioides difficile - PubMed
The TcdE holin drives toxin secretion and virulence in Clostridioides difficile - PubMed
Clostridioides difficile is the leading cause of healthcare associated infections. The Pathogenicity Locus (PaLoc) toxins TcdA and TcdB promote host disease. These toxins lack canonical N-terminal signal sequences for translocation across the bacterial membrane, suggesting alternate mechanism …
·pubmed.ncbi.nlm.nih.gov·
The TcdE holin drives toxin secretion and virulence in Clostridioides difficile - PubMed
Expanding our grasp of two-component signaling in Clostridioides difficile - PubMed
Expanding our grasp of two-component signaling in Clostridioides difficile - PubMed
The intestinal pathogen Clostridioides difficile encodes roughly 50 TCS, but very few have been characterized in terms of their activating signals or their regulatory roles. A. G. Pannullo, B. R. Zbylicki, and C. D. Ellermeier (J Bacteriol 205:e00164-23, 2023, https://doi.org/10.1128/jb.00164 …
·pubmed.ncbi.nlm.nih.gov·
Expanding our grasp of two-component signaling in Clostridioides difficile - PubMed
Novel ribotype/sequence type associations and diverse CRISPR-Cas systems in environmental Clostridioides difficile strains from Northern Iraq - PubMed
Novel ribotype/sequence type associations and diverse CRISPR-Cas systems in environmental Clostridioides difficile strains from Northern Iraq - PubMed
The environment is a natural reservoir of Clostridioides difficile and here, we aimed to isolate the pathogen from seven locations in Northern Iraq. Four of the sites yielded thirty-one isolates (ten from soils, twenty-one from sediments) which together represent ribotypes 001 (five), 010 (five), 01 …
·pubmed.ncbi.nlm.nih.gov·
Novel ribotype/sequence type associations and diverse CRISPR-Cas systems in environmental Clostridioides difficile strains from Northern Iraq - PubMed
Discrimination between hypervirulent and non-hypervirulent ribotypes of Clostridioides difficile by MALDI-TOF mass spectrometry and machine learning - PubMed
Discrimination between hypervirulent and non-hypervirulent ribotypes of Clostridioides difficile by MALDI-TOF mass spectrometry and machine learning - PubMed
Hypervirulent ribotypes (HVRTs) of Clostridioides difficile such as ribotype (RT) 027 are epidemiologically important. This study evaluated whether MALDI-TOF can distinguish between strains of HVRTs and non-HVRTs commonly found in Europe. Obtained spectra of clinical C. difficile isolates (training …
·pubmed.ncbi.nlm.nih.gov·
Discrimination between hypervirulent and non-hypervirulent ribotypes of Clostridioides difficile by MALDI-TOF mass spectrometry and machine learning - PubMed
Novel ribotype/sequence type associations and diverse CRISPR-Cas systems in environmental Clostridioides difficile strains from Northern Iraq - PubMed
Novel ribotype/sequence type associations and diverse CRISPR-Cas systems in environmental Clostridioides difficile strains from Northern Iraq - PubMed
The environment is a natural reservoir of Clostridioides difficile and here, we aimed to isolate the pathogen from seven locations in Northern Iraq. Four of the sites yielded thirty-one isolates (ten from soils, twenty-one from sediments) which together represent ribotypes 001 (five), 010 (five), 01 …
·pubmed.ncbi.nlm.nih.gov·
Novel ribotype/sequence type associations and diverse CRISPR-Cas systems in environmental Clostridioides difficile strains from Northern Iraq - PubMed
Uncommon Presentation of Clostridioides difficile in the Small Bowel: A Case Report and Review of Literature - PubMed
Uncommon Presentation of Clostridioides difficile in the Small Bowel: A Case Report and Review of Literature - PubMed
Clostridioides difficile infection (CDI) is a prevalent source of hospital-acquired diarrhea. The most common presentation of CDI is colitis. In cases of fulminant colitis/toxic megacolon, a colectomy and end ileostomy are part of the treatment plan. There is evidence to suggest that it may b …
·pubmed.ncbi.nlm.nih.gov·
Uncommon Presentation of Clostridioides difficile in the Small Bowel: A Case Report and Review of Literature - PubMed
Ischemic Colitis in a Young Female Following Herbal Supplement Ingestion
Ischemic Colitis in a Young Female Following Herbal Supplement Ingestion
Ischemic colitis is typically considered a disease of the elderly, given their atherosclerotic risk factors and other comorbidities. Ischemic colitis in the younger population is considered very...
·news.google.com·
Ischemic Colitis in a Young Female Following Herbal Supplement Ingestion
Ischemic Colitis in a Young Female Following Herbal Supplement Ingestion
Ischemic Colitis in a Young Female Following Herbal Supplement Ingestion
Ischemic colitis is typically considered a disease of the elderly, given their atherosclerotic risk factors and other comorbidities. Ischemic colitis in the younger population is considered very...
·news.google.com·
Ischemic Colitis in a Young Female Following Herbal Supplement Ingestion
C. difficile intoxicates neurons and pericytes to drive neurogenic inflammation - PubMed
C. difficile intoxicates neurons and pericytes to drive neurogenic inflammation - PubMed
Clostridioides difficile infection (CDI) is a major cause of healthcare-associated gastrointestinal infections1,2. The exaggerated colonic inflammation caused by C. difficile toxins such as toxin B (TcdB) damages tissues and promotes C. difficile colonization3-6, but how TcdB c …
·pubmed.ncbi.nlm.nih.gov·
C. difficile intoxicates neurons and pericytes to drive neurogenic inflammation - PubMed