C Diff Molecular

C Diff Molecular

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Inhibition of selenoprotein synthesis is not the mechanism by which auranofin inhibits growth of Clostridioides difficile - PubMed
Inhibition of selenoprotein synthesis is not the mechanism by which auranofin inhibits growth of Clostridioides difficile - PubMed
Clostridioides difficile infections (CDIs) are responsible for a significant number of antibiotic-associated diarrheal cases. The standard-of-care antibiotics for C. difficile are limited to fidaxomicin and vancomycin, with the recently obsolete metronidazole recommended if both are unavailable. No …
·pubmed.ncbi.nlm.nih.gov·
Inhibition of selenoprotein synthesis is not the mechanism by which auranofin inhibits growth of Clostridioides difficile - PubMed
Olfactomedin-4 + neutrophils exacerbate intestinal epithelial damage and worsen host survival after Clostridioides difficile infection - PubMed
Olfactomedin-4 + neutrophils exacerbate intestinal epithelial damage and worsen host survival after Clostridioides difficile infection - PubMed
Utilizing single-cell transcriptomics, IEC-epithelial co-cultures, and pre-clinical models of CDI, we have identified a subset of neutrophils that are marked by OLFM4 expression as pathogenic determinants of IEC barrier damage after CDI.
·pubmed.ncbi.nlm.nih.gov·
Olfactomedin-4 + neutrophils exacerbate intestinal epithelial damage and worsen host survival after Clostridioides difficile infection - PubMed
Olfactomedin-4 + neutrophils exacerbate intestinal epithelial damage and worsen host survival after Clostridioides difficile infection - PubMed
Olfactomedin-4 + neutrophils exacerbate intestinal epithelial damage and worsen host survival after Clostridioides difficile infection - PubMed
Utilizing single-cell transcriptomics, IEC-epithelial co-cultures, and pre-clinical models of CDI, we have identified a subset of neutrophils that are marked by OLFM4 expression as pathogenic determinants of IEC barrier damage after CDI.
·pubmed.ncbi.nlm.nih.gov·
Olfactomedin-4 + neutrophils exacerbate intestinal epithelial damage and worsen host survival after Clostridioides difficile infection - PubMed
Butyrate enhances Clostridioides difficile sporulation in vitro - PubMed
Butyrate enhances Clostridioides difficile sporulation in vitro - PubMed
Short-chain fatty acids (SCFAs) are products of bacterial fermentation that help maintain important gut functions such as maintenance of the intestinal barrier, cell signaling, and immune homeostasis. The main SCFAs acetate, propionate, and butyrate have demonstrated beneficial effects for the host, …
·pubmed.ncbi.nlm.nih.gov·
Butyrate enhances Clostridioides difficile sporulation in vitro - PubMed
Clostridioides difficile Infection in Pediatric Inflammatory Bowel Disease - PubMed
Clostridioides difficile Infection in Pediatric Inflammatory Bowel Disease - PubMed
Children with IBD have an elevated incidence of CDI, but their CDI risk does not associate with established risk factors in adults with IBD. Existing testing methodologies are inadequate at differentiating CDI from C. difficile colonization in children with IBD. Fecal microbiota transplantation offe …
·pubmed.ncbi.nlm.nih.gov·
Clostridioides difficile Infection in Pediatric Inflammatory Bowel Disease - PubMed
Clostridioides difficile resistance to antibiotics, including post-COVID-19 data - PubMed
Clostridioides difficile resistance to antibiotics, including post-COVID-19 data - PubMed
C. difficile antimicrobial susceptibility varied by country/region, study period, and circulating ribotypes. For CDI treatment, fidaxomicin (preferably) or vancomycin is recommended, while metronidazole is suitable for mild infections. New approaches, including biotherapeutics (Rebyota), stra …
·pubmed.ncbi.nlm.nih.gov·
Clostridioides difficile resistance to antibiotics, including post-COVID-19 data - PubMed
Role of the Alteration in Calcium Homeostasis in Cell Death Induced by Clostridioides difficile Toxin A and Toxin B - PubMed
Role of the Alteration in Calcium Homeostasis in Cell Death Induced by Clostridioides difficile Toxin A and Toxin B - PubMed
Clostridioides difficile (C. difficile), responsible for 15-25% of gastrointestinal infections, causes health problems mainly due to the toxic activity of toxins A and B (Tcds). These are responsible for its clinical manifestations, including diarrhea, pseudomembranous colitis, toxic m …
·pubmed.ncbi.nlm.nih.gov·
Role of the Alteration in Calcium Homeostasis in Cell Death Induced by Clostridioides difficile Toxin A and Toxin B - PubMed
MICROBIOME: the kingdom of the gut
MICROBIOME: the kingdom of the gut
Meet your gut microbiome: a community of around 4,500 different types of bacteria living in your bowels
·cam.ac.uk·
MICROBIOME: the kingdom of the gut
Absence of Toll-like Receptor 7 Ameliorates Survival and Reduces Intestinal Injury in Mice after Clostridium difficile Infection - PubMed
Absence of Toll-like Receptor 7 Ameliorates Survival and Reduces Intestinal Injury in Mice after Clostridium difficile Infection - PubMed
Clostridioides difficile (CD) is a major cause of antibiotic-associated diarrhea and pseudomembranous enteritis. C. difficile infection (CDI) is increasingly present in the community and represents a significant burden on the healthcare system. Identification of novel immune-based therapeutic target …
·pubmed.ncbi.nlm.nih.gov·
Absence of Toll-like Receptor 7 Ameliorates Survival and Reduces Intestinal Injury in Mice after Clostridium difficile Infection - PubMed
Your height may influence the diversity of your gut microbiome
Your height may influence the diversity of your gut microbiome
Taller people may have longer gastrointestinal tracts that can house a broader array of microorganisms and could protect them against infections from bacteria such as Clostridium difficile
·news.google.com·
Your height may influence the diversity of your gut microbiome
Is Dysbiotic Gut the Cause of Low Back Pain? - PubMed
Is Dysbiotic Gut the Cause of Low Back Pain? - PubMed
Low back pain (LBP) is the foremost cause of disability that affects the day-to-day activities of millions of people worldwide. The putative trigger of LBP is linked to the gut microbiome (GM) and its dysbiotic environment. With the concept of GM, various disease pathogenesis has been revisited with …
·pubmed.ncbi.nlm.nih.gov·
Is Dysbiotic Gut the Cause of Low Back Pain? - PubMed
Dual RNA-seq identifies genes and pathways modulated during Clostridioides difficile colonization - PubMed
Dual RNA-seq identifies genes and pathways modulated during Clostridioides difficile colonization - PubMed
The gastrointestinal pathogen Clostridioides difficile is the most common cause of hospital-acquired diarrhea. Bacterial interactions with the gut mucosa are crucial for the establishment of C. difficile infection; however, key infection events like bacterial attachment and gut penetra …
·pubmed.ncbi.nlm.nih.gov·
Dual RNA-seq identifies genes and pathways modulated during Clostridioides difficile colonization - PubMed
Dual RNA-seq identifies genes and pathways modulated during Clostridioides difficile colonization - PubMed
Dual RNA-seq identifies genes and pathways modulated during Clostridioides difficile colonization - PubMed
The gastrointestinal pathogen Clostridioides difficile is the most common cause of hospital-acquired diarrhea. Bacterial interactions with the gut mucosa are crucial for the establishment of C. difficile infection; however, key infection events like bacterial attachment and gut penetra …
·pubmed.ncbi.nlm.nih.gov·
Dual RNA-seq identifies genes and pathways modulated during Clostridioides difficile colonization - PubMed
Role of the Alteration in Calcium Homeostasis in Cell Death Induced by Clostridioides difficile Toxin A and Toxin B - PubMed
Role of the Alteration in Calcium Homeostasis in Cell Death Induced by Clostridioides difficile Toxin A and Toxin B - PubMed
Clostridioides difficile (C. difficile), responsible for 15-25% of gastrointestinal infections, causes health problems mainly due to the toxic activity of toxins A and B (Tcds). These are responsible for its clinical manifestations, including diarrhea, pseudomembranous colitis, toxic m …
·pubmed.ncbi.nlm.nih.gov·
Role of the Alteration in Calcium Homeostasis in Cell Death Induced by Clostridioides difficile Toxin A and Toxin B - PubMed
Microbiota in Irritable Bowel Syndrome and Endometriosis: Birds of a Feather Flock Together-A Review - PubMed
Microbiota in Irritable Bowel Syndrome and Endometriosis: Birds of a Feather Flock Together-A Review - PubMed
Endometriosis and irritable bowel syndrome (IBS) are chronic conditions affecting up to 10% of the global population, imposing significant burdens on healthcare systems and patient quality of life. Interestingly, around 20% of endometriosis patients also present with symptoms indicative of IBS. The …
·pubmed.ncbi.nlm.nih.gov·
Microbiota in Irritable Bowel Syndrome and Endometriosis: Birds of a Feather Flock Together-A Review - PubMed
Analyses of cell wall synthesis in Clostridioides difficile reveal a diversification in cell division mechanisms in endospore-forming bacteria - PubMed
Analyses of cell wall synthesis in Clostridioides difficile reveal a diversification in cell division mechanisms in endospore-forming bacteria - PubMed
Current models of bacterial cell division assume that the core synthases of the multiprotein divisome complex, FtsW-FtsI, are the primary drivers of septal peptidoglycan (PG) synthesis. These enzymes are typically encoded in the highly conserved division and cell wall ( dcw ) cluster and are …
·pubmed.ncbi.nlm.nih.gov·
Analyses of cell wall synthesis in Clostridioides difficile reveal a diversification in cell division mechanisms in endospore-forming bacteria - PubMed
Diarrheal-associated gut dysbiosis in cancer and inflammatory bowel disease patients is exacerbated by Clostridioides difficile infection - PubMed
Diarrheal-associated gut dysbiosis in cancer and inflammatory bowel disease patients is exacerbated by Clostridioides difficile infection - PubMed
Our data indicate that different external and internal factors drive comparable profiles of low diversity dysbiosis. While diarrheal-related low diversity dysbiosis may be a consequence of systemic cancer therapy, a similar phenotype is observed in cases of moderate to severe IBD, and in both cases, …
·pubmed.ncbi.nlm.nih.gov·
Diarrheal-associated gut dysbiosis in cancer and inflammatory bowel disease patients is exacerbated by Clostridioides difficile infection - PubMed
Case report of SARS-CoV-2 with secondary Clostridioides difficile infection - PubMed
Case report of SARS-CoV-2 with secondary Clostridioides difficile infection - PubMed
There has been an overuse of antibiotics in most patients suffering from COVID-19 which predisposes patients to hospital acquired C. difficile Infection (CDI). Also, COVID infection of the gastrointestinal tract also predisposes the patient to CDI. We here present a fatal case of SARS-CoV-2 coinfect …
·pubmed.ncbi.nlm.nih.gov·
Case report of SARS-CoV-2 with secondary Clostridioides difficile infection - PubMed
Clostridioides difficile and Enterococci's Interplay in the Human Gut: Bacterial Alliance or Competition? A Systematic Literature Review - PubMed
Clostridioides difficile and Enterococci's Interplay in the Human Gut: Bacterial Alliance or Competition? A Systematic Literature Review - PubMed
Clostridioides difficile and Enterococcus spp. are two common bacterial pathogens populating the human microbiota. We possess scant data on how Clostridioides difficile interacts with Enterococcus spp. in the gut microbiota in subjects colonized with Clostridioides dif …
·pubmed.ncbi.nlm.nih.gov·
Clostridioides difficile and Enterococci's Interplay in the Human Gut: Bacterial Alliance or Competition? A Systematic Literature Review - PubMed