C Diff Molecular

C Diff Molecular

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Case report of SARS-CoV-2 with secondary Clostridioides difficile infection - PubMed
Case report of SARS-CoV-2 with secondary Clostridioides difficile infection - PubMed
There has been an overuse of antibiotics in most patients suffering from COVID-19 which predisposes patients to hospital acquired C. difficile Infection (CDI). Also, COVID infection of the gastrointestinal tract also predisposes the patient to CDI. We here present a fatal case of SARS-CoV-2 coinfect …
·pubmed.ncbi.nlm.nih.gov·
Case report of SARS-CoV-2 with secondary Clostridioides difficile infection - PubMed
Characterization of the Gut Microbiome in Healthy Dogs and Dogs with Diabetes Mellitus - PubMed
Characterization of the Gut Microbiome in Healthy Dogs and Dogs with Diabetes Mellitus - PubMed
With a close pathogenetic resemblance to human diabetes, canine Diabetes Mellitus, a chronic metabolic disease featuring abnormally high blood sugar levels, is increasing in prevalence worldwide. Unlike humans, canine glycemic control requires life-long insulin injections and dietary control in most …
·pubmed.ncbi.nlm.nih.gov·
Characterization of the Gut Microbiome in Healthy Dogs and Dogs with Diabetes Mellitus - PubMed
Clostridioides difficile Infection in Inflammatory Bowel Disease Patients: A Systematic Review of Risk Factors and Approach in Management
Clostridioides difficile Infection in Inflammatory Bowel Disease Patients: A Systematic Review of Risk Factors and Approach in Management
Clostridioides difficile infection (CDI) is one of the most common diseases associated with medical care, having a more significant impact on patients with inflammatory bowel disease (IBD). The latest studies have proposed a change in management for CDI in IBD patients. This study aims to perform a systematic review that explores the risk factors associated with the infection and the most optimal approach in management. Multiple databases were used for this research, including PubMed, Google Scholar, Science Direct, and Cochrane Library. Studies published in the last five years in the English language were selected based on pre-established criteria. The quality assessment used was the Assessment of Multiple Systematic Review, the Newcastle-Ottawa Scale, and the Scale for the Assessment of Narrative Review Articles. Twelve studies met the inclusion criteria in this systematic review, including literature reviews, a case and control study, and systematic reviews and meta-analyses. Based on the findings in this research, we conclude that the treatment for an initial episode of CDI in IBD patients is the use of antibiotics, vancomycin, or fidaxomicin. For episodes of recurrent CDI (rCDI), fetal microbiota transplantation should be considered. The most common risk factors associated are gut microbiota disturbances, the use of antibiotics, and hospitalization. Due to a wide range of risk factors mentioned in some studies but disregarded in others, further research is needed to determine the most prevalent risk factors.
·cureus.com·
Clostridioides difficile Infection in Inflammatory Bowel Disease Patients: A Systematic Review of Risk Factors and Approach in Management
Ulcerative colitis induced by paraneoplastic syndrome | JIR
Ulcerative colitis induced by paraneoplastic syndrome | JIR
Paraneoplastic syndromes often cause endocrine, neurological, cutaneous, and hematologic pathologies, and cases with digestive symptoms as prominent are rare.
·news.google.com·
Ulcerative colitis induced by paraneoplastic syndrome | JIR
Mucosal-associated invariant T (MAIT) cells from Clostridioides difficile-infected patients exhibit a distinct proinflammatory phenotype and enhanced cytotoxic activity - PubMed
Mucosal-associated invariant T (MAIT) cells from Clostridioides difficile-infected patients exhibit a distinct proinflammatory phenotype and enhanced cytotoxic activity - PubMed
Mucosal-associated invariant T (MAIT) cells are innate-like T cells mainly found in the mucosa and peripheral blood. We have recently demonstrated that Clostridioides difficile activates MAIT cell in vitro. However, their role in the pathogenesis of C. difficile infection (CDI) in human patients rem …
·pubmed.ncbi.nlm.nih.gov·
Mucosal-associated invariant T (MAIT) cells from Clostridioides difficile-infected patients exhibit a distinct proinflammatory phenotype and enhanced cytotoxic activity - PubMed
The microbial metabolite Urolithin A reduces C. difficile toxin expression and repairs toxin-induced epithelial damage - PubMed
The microbial metabolite Urolithin A reduces C. difficile toxin expression and repairs toxin-induced epithelial damage - PubMed
Therapy for C. difficile infections includes the use of antibiotics, immunosuppressors, and fecal microbiota transplantation (FMT). However, these treatments have several drawbacks, including the loss of colonization resistance, promotion of autoimmune disorders, and the potential for unknown …
·pubmed.ncbi.nlm.nih.gov·
The microbial metabolite Urolithin A reduces C. difficile toxin expression and repairs toxin-induced epithelial damage - PubMed
Mucosal-associated invariant T (MAIT) cells from Clostridioides difficile-infected patients exhibit a distinct proinflammatory phenotype and enhanced cytotoxic activity - PubMed
Mucosal-associated invariant T (MAIT) cells from Clostridioides difficile-infected patients exhibit a distinct proinflammatory phenotype and enhanced cytotoxic activity - PubMed
Mucosal-associated invariant T (MAIT) cells are innate-like T cells mainly found in the mucosa and peripheral blood. We have recently demonstrated that Clostridioides difficile activates MAIT cell in vitro. However, their role in the pathogenesis of C. difficile infection (CDI) in human patients rem …
·pubmed.ncbi.nlm.nih.gov·
Mucosal-associated invariant T (MAIT) cells from Clostridioides difficile-infected patients exhibit a distinct proinflammatory phenotype and enhanced cytotoxic activity - PubMed
The predicted acetoin dehydrogenase pathway represses sporulation of Clostridioides difficile - PubMed
The predicted acetoin dehydrogenase pathway represses sporulation of Clostridioides difficile - PubMed
Clostridioides difficile, or C. diff , is an anaerobic bacterium that lives within the gut of many mammals and causes infectious diarrhea. C. difficile is able to survive outside of the gut and transmit to new hosts by forming dormant spores. It is known that the pH of the intes …
·pubmed.ncbi.nlm.nih.gov·
The predicted acetoin dehydrogenase pathway represses sporulation of Clostridioides difficile - PubMed
Rise of the guardians: Gut microbial maneuvers in bacterial infections - PubMed
Rise of the guardians: Gut microbial maneuvers in bacterial infections - PubMed
The current review discussed the gut microbial population and function-specific aspects contributing to bacterial infection susceptibility and prophylaxis. Collectively, this review provides a comprehensive understanding of the mechanisms related to the dual role of gut microbiota in bacterial infec …
·pubmed.ncbi.nlm.nih.gov·
Rise of the guardians: Gut microbial maneuvers in bacterial infections - PubMed
Transcriptomic analysis of biofilm formation in strains of Clostridioides difficile associated with recurrent and non-recurrent infection reveals potential candidate markers for recurrence - PubMed
Transcriptomic analysis of biofilm formation in strains of Clostridioides difficile associated with recurrent and non-recurrent infection reveals potential candidate markers for recurrence - PubMed
The transcriptomic profile in a biofilm model of ribotypes (RT) 001 and 027 associated with recurrent Clostridioides difficile infection (R-CDI) and not associated with recurrent (NR)-CDI was analyzed to identify genes that may favor the recurrence. Twenty strains were selected, 10 RT001 and 10 RT02 …
·pubmed.ncbi.nlm.nih.gov·
Transcriptomic analysis of biofilm formation in strains of Clostridioides difficile associated with recurrent and non-recurrent infection reveals potential candidate markers for recurrence - PubMed
Virulence and genomic diversity among clinical isolates of ST1 (BI/NAP1/027) Clostridioides difficile - PubMed
Virulence and genomic diversity among clinical isolates of ST1 (BI/NAP1/027) Clostridioides difficile - PubMed
Clostridioides difficile produces toxins that damage the colonic epithelium, causing colitis. Variation in disease severity is poorly understood and has been attributed to host factors and virulence differences between C. difficile strains. We test 23 epidemic ST1 C. difficile clinical isolates for …
·pubmed.ncbi.nlm.nih.gov·
Virulence and genomic diversity among clinical isolates of ST1 (BI/NAP1/027) Clostridioides difficile - PubMed
Virulence and genomic diversity among clinical isolates of ST1 (BI/NAP1/027) Clostridioides difficile - PubMed
Virulence and genomic diversity among clinical isolates of ST1 (BI/NAP1/027) Clostridioides difficile - PubMed
Clostridioides difficile produces toxins that damage the colonic epithelium, causing colitis. Variation in disease severity is poorly understood and has been attributed to host factors and virulence differences between C. difficile strains. We test 23 epidemic ST1 C. difficile clinical isolates for …
·pubmed.ncbi.nlm.nih.gov·
Virulence and genomic diversity among clinical isolates of ST1 (BI/NAP1/027) Clostridioides difficile - PubMed
Gut microbiota analyses of inflammatory bowel diseases from a representative Saudi population - BMC Gastroenterology
Gut microbiota analyses of inflammatory bowel diseases from a representative Saudi population - BMC Gastroenterology
Background Crohn’s diseases and ulcerative colitis, both of which are chronic immune-mediated disorders of the gastrointestinal tract are major contributors to the overarching Inflammatory bowel diseases. It has become increasingly evident that the pathological processes of IBDs results from interactions between genetic and environmental factors, which can skew immune responses against normal intestinal flora. Methods The aim of this study is to assess and analyze the taxa diversity and relative abundances in CD and UC in the Saudi population. We utilized a sequencing strategy that targets all variable regions in the 16 S rRNA gene using the Swift Amplicon 16 S rRNA Panel on Illumina NovaSeq 6000. Results The composition of stool 16 S rRNA was analyzed from 219 patients with inflammatory bowel disease and from 124 healthy controls. We quantified the abundance of microbial communities to examine any significant differences between subpopulations of samples. At the genus level, two genera in particular, Veillonella and Lachnoclostridium showed significant association with CD versus controls. There were significant differences between subjects with CD versus UC, with the top differential genera spanning Akkermansia, Harryflintia, Maegamonas and Phascolarctobacterium. Furthermore, statistically significant taxa diversity in microbiome composition was observed within the UC and CD groups. Conclusions In conclusion we have shown that there are significant differences in gut microbiota between UC, CD and controls in a Saudi Arabian inflammatory bowel disease cohort. This reinforces the need for further studies in large populations that are ethnically and geographically diverse. In addition, our results show the potential to develop classifiers that may have add additional richness of context to clinical diagnosis of UC and CD with larger inflammatory bowel disease cohorts.
·news.google.com·
Gut microbiota analyses of inflammatory bowel diseases from a representative Saudi population - BMC Gastroenterology
Antibiotic-Induced Dysbiosis of the Gut Microbiota Impairs Gene Expression in Gut-Liver Axis of Mice - PubMed
Antibiotic-Induced Dysbiosis of the Gut Microbiota Impairs Gene Expression in Gut-Liver Axis of Mice - PubMed
Antibiotics can be a double-edged sword. The application of broad-spectrum antibiotics leads to the suppression of microorganisms in the human body without selective targeting, including numerous non-pathogenic microorganisms within the gut. As a result, dysbiosis of the gut microbiota can occur. Th …
·pubmed.ncbi.nlm.nih.gov·
Antibiotic-Induced Dysbiosis of the Gut Microbiota Impairs Gene Expression in Gut-Liver Axis of Mice - PubMed
Genomic Analysis of Clostridioides difficile Recovered from Horses in Western Australia - PubMed
Genomic Analysis of Clostridioides difficile Recovered from Horses in Western Australia - PubMed
Clostridioides difficile poses an ongoing threat as a cause of gastrointestinal disease in humans and animals. Traditionally considered a human healthcare-related disease, increases in community-associated C. difficile infection (CDI) and growing evidence of inter-species transmission …
·pubmed.ncbi.nlm.nih.gov·
Genomic Analysis of Clostridioides difficile Recovered from Horses in Western Australia - PubMed
Clostridioides difficile and colorectal cancer: a dangerous liaison - PubMed
Clostridioides difficile and colorectal cancer: a dangerous liaison - PubMed
Many colorectal diseases depend on complex interactions between several pathophysiological factors, including the intestinal microbiota. In recent years, the widespread use of antibiotics has been recognized as a main cause of intestinal dysbiosis and a favouring factor for Clostridioides difficile …
·pubmed.ncbi.nlm.nih.gov·
Clostridioides difficile and colorectal cancer: a dangerous liaison - PubMed
GutMicrobiota Health on Twitter
GutMicrobiota Health on Twitter
Not all environmental conditions work the same for our gut microbiota..@CTropini & colleagues assessed the growth of 92 representative human gut bacterial strains spanning 28 families across multiple pH values and osmolalities:https://t.co/g4fXOgemhQ— GutMicrobiota Health (@GMFHx) July 27, 2023
·twitter.com·
GutMicrobiota Health on Twitter
A Young Adult With Multisystem Inflammatory Syndrome Following Weeks of Initial COVID-19 Respiratory Infection, With No Prior COVID-19 Vaccination: A Case Report - PubMed
A Young Adult With Multisystem Inflammatory Syndrome Following Weeks of Initial COVID-19 Respiratory Infection, With No Prior COVID-19 Vaccination: A Case Report - PubMed
Multisystem inflammatory syndrome (MIS) following COVID-19, a condition primarily diagnosed in children, has also been observed less frequently in adults. It usually presents with a multitude of symptoms, mimicking a shock-like state characterized by multiple organ failure. Diagnosis often involves …
·pubmed.ncbi.nlm.nih.gov·
A Young Adult With Multisystem Inflammatory Syndrome Following Weeks of Initial COVID-19 Respiratory Infection, With No Prior COVID-19 Vaccination: A Case Report - PubMed
Ultra-deep sequencing of Hadza hunter-gatherers recovers vanishing gut microbes
Ultra-deep sequencing of Hadza hunter-gatherers recovers vanishing gut microbes
Ultra-high-depth sequencing of the gut microbiome of hunter-gatherers enables comparative analysis with industrialized microbiomes and provides a unique resource of the non-industrialized microbiome and an interrogation of the ecology and evolution of bacterial symbionts.
·cell.com·
Ultra-deep sequencing of Hadza hunter-gatherers recovers vanishing gut microbes
What Impact Do Changes to a Newborn's Microbiota Have?
What Impact Do Changes to a Newborn's Microbiota Have?
Dysbiosis of the microbiota affects short-term pathogenesis and may play a role in long-term pathology, too, said an infectious disease pediatrician.
·news.google.com·
What Impact Do Changes to a Newborn's Microbiota Have?
Host microbiome-pathogen interactions in pediatric infections - PubMed
Host microbiome-pathogen interactions in pediatric infections - PubMed
The microbiome has emerged as a key modifier of infection susceptibility and severity among children. Further research is needed to define the roles of microbes other than bacteria and to elucidate the mechanisms underlying microbiome-host and microbiome-pathogen interactions of importance to infect …
·pubmed.ncbi.nlm.nih.gov·
Host microbiome-pathogen interactions in pediatric infections - PubMed