C Diff Molecular

C Diff Molecular

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High-resolution analyses of associations between medications, microbiome, and mortality in cancer patients - PubMed
High-resolution analyses of associations between medications, microbiome, and mortality in cancer patients - PubMed
Discerning the effect of pharmacological exposures on intestinal bacterial communities in cancer patients is challenging. Here, we deconvoluted the relationship between drug exposures and changes in microbial composition by developing and applying a new computational method, PARADIGM (parameters ass …
·pubmed.ncbi.nlm.nih.gov·
High-resolution analyses of associations between medications, microbiome, and mortality in cancer patients - PubMed
Ecological principles of fecal microbiota transplantation - PubMed
Ecological principles of fecal microbiota transplantation - PubMed
Fecal microbiota transplantation (FMT) is a procedure used to treat diseases related to microbiome imbalances. We discuss how ecological principles can inform the design of FMT clinical trials and contribute to data interpretation. This effort will promote a better understanding of microbiome engraf …
·pubmed.ncbi.nlm.nih.gov·
Ecological principles of fecal microbiota transplantation - PubMed
Improving therapeutic protein secretion in the probiotic yeast Saccharomyces boulardii using a multifactorial engineering approach - PubMed
Improving therapeutic protein secretion in the probiotic yeast Saccharomyces boulardii using a multifactorial engineering approach - PubMed
The probiotic yeast Saccharomyces boulardii (Sb) is a promising chassis to deliver therapeutic proteins to the gut due to Sb's innate therapeutic properties, resistance to phage and antibiotics, and high protein secretion capacity. To maintain therapeutic efficacy in the context of challenges such a …
·pubmed.ncbi.nlm.nih.gov·
Improving therapeutic protein secretion in the probiotic yeast Saccharomyces boulardii using a multifactorial engineering approach - PubMed
Risk factors for complicated course and recurrence of Clostridioides Difficile infections during COVID-19 pandemic - PubMed
Risk factors for complicated course and recurrence of Clostridioides Difficile infections during COVID-19 pandemic - PubMed
Clinical nutrition and the number of antibiotics used during an episode of diarrhea are independent risk factors for the death of a patient with CDI. Infection with a hypervirulent strain increases the risk for relapse.
·pubmed.ncbi.nlm.nih.gov·
Risk factors for complicated course and recurrence of Clostridioides Difficile infections during COVID-19 pandemic - PubMed
Microbiome Science on Twitter
Microbiome Science on Twitter
Of patients who have had a #Cdiff recurrence, up to 65% will experience subsequent recurrence. #guthealth #GITwitter #IDTwitter pic.twitter.com/wpl2yHevo3— Microbiome Science (@MbiomeScience) June 5, 2023
·twitter.com·
Microbiome Science on Twitter
Microbiome Science on Twitter
Microbiome Science on Twitter
After an initial episode of #Cdiff infection, up to 25% of patients experience a recurrence. #GITwitter #IDTwitter #guthealth pic.twitter.com/JJIg2ccGpJ— Microbiome Science (@MbiomeScience) June 4, 2023
·twitter.com·
Microbiome Science on Twitter
Microbiome Science on Twitter
Microbiome Science on Twitter
Clinical manifestations of the infection caused by #Cdiff can vary. #GITwitter #IDTwitter #guthealth pic.twitter.com/fLYURwSRCD— Microbiome Science (@MbiomeScience) May 31, 2023
·twitter.com·
Microbiome Science on Twitter
Investigating the Correlation Between Clostridioides difficile Infection and Vitamin D Deficiency
Investigating the Correlation Between Clostridioides difficile Infection and Vitamin D Deficiency
Introduction: Clostridioides difficile infection (CDI) is the most common healthcare-associated infection in the US. Symptoms include watery diarrhea, nausea, and anorexia and it can present with leukocytosis on laboratory evaluation. Treatment is based on disease severity and recurrence. Despite antibiotic usage being the highest risk factor for infection, they are also the first-line treatment for initial CDI. Prevention of CDI mostly involves good hand hygiene, antibiotic stewardship, and appropriate precautions when interacting with infected individuals. Vitamin D deficiency (VDD) has been linked to CDI, however, there is limited insight into the correlation between both states. Our aim was to further investigate the potential link between VDD and CDI. Methods: Data were obtained from the National Inpatient Sample (NIS) from 2016 to 2019. Patients with CDI were identified and stratified based on a diagnosis of VDD. Primary outcomes were mortality, CDI recurrence, ileus, toxic megacolon, perforation, and colectomy. Chi-squared and independent t-tests were performed to assess categorical and continuous data, respectively. Multiple logistic regression was used to control for confounders. Results: Patients with VDD had higher rates of CDI recurrence (17.4% versus 14.7%, p<0.05), but lower rates of mortality (3.1% versus 6.1%, p<0.05). Differences in rates of ileus, toxic megacolon, perforation, and colectomy were statistically insignificant. Length of stay was higher in the VDD group (10.38 days versus 9.83 days). Total charges were lower in the VDD group ($93,935.85 versus $102,527.9). Discussion: CDI patients with comorbid VDD are at higher risk for the recurrence of CDI. This is likely due to the role of vitamin D in the expression of intestinal epithelial antimicrobial peptides, macrophage activation, and maintenance of tight junctions between gut epithelial cells. Furthermore, vitamin D plays a role in maintaining a healthy gut microbiome. Alternatively, deficiency results in poor gut health and detrimental changes to the gut microbiome. In effect, VDD promotes the proliferation of C. difficile within the large colon, resulting in an increased predisposition for CDI.
·cureus.com·
Investigating the Correlation Between Clostridioides difficile Infection and Vitamin D Deficiency
Fulminant Clostridioides difficile Colitis With SARS-CoV-2 Infection - PubMed
Fulminant Clostridioides difficile Colitis With SARS-CoV-2 Infection - PubMed
Clostridioides difficile (C. difficile)and coronavirus disease 2019 (COVID-19) infections can have overlapping symptoms. Recently, the association and outcomes of coinfection have been studied. We present the case of an 83-year-old lady with Parkinson's disease (PD) who was admitted wi …
·pubmed.ncbi.nlm.nih.gov·
Fulminant Clostridioides difficile Colitis With SARS-CoV-2 Infection - PubMed
Fulminant Clostridioides difficile Colitis With SARS-CoV-2 Infection - PubMed
Fulminant Clostridioides difficile Colitis With SARS-CoV-2 Infection - PubMed
Clostridioides difficile (C. difficile)and coronavirus disease 2019 (COVID-19) infections can have overlapping symptoms. Recently, the association and outcomes of coinfection have been studied. We present the case of an 83-year-old lady with Parkinson's disease (PD) who was admitted wi …
·pubmed.ncbi.nlm.nih.gov·
Fulminant Clostridioides difficile Colitis With SARS-CoV-2 Infection - PubMed
Anjan Dhar on Twitter
Anjan Dhar on Twitter
Make sure to join the IBD update including the link between #cdiff and #IBD on 7th June 2023 @ Crowne Plaza Sheffield with @ThoufeeqMo Dr Phil Smith and @anjan_dhar6 Looking forward to it! pic.twitter.com/drNz6bBW5Y— Sheffield Gastro (@shefgastro) May 31, 2023
·twitter.com·
Anjan Dhar on Twitter
Microbiota Predict Infections and Acute Graft-Versus-Host Disease after Pediatric Allogeneic Hematopoietic Stem Cell Transplantation - PubMed
Microbiota Predict Infections and Acute Graft-Versus-Host Disease after Pediatric Allogeneic Hematopoietic Stem Cell Transplantation - PubMed
Interactions between medical interventions, pediatric hosts and microbial communities may be responsible for these consistent microbiota signatures that predict infections. A future multi-center investigation will be needed to demonstrate whether these ratios can be generalized to other pediatric co …
·pubmed.ncbi.nlm.nih.gov·
Microbiota Predict Infections and Acute Graft-Versus-Host Disease after Pediatric Allogeneic Hematopoietic Stem Cell Transplantation - PubMed
Gut microbiome determines therapeutic effects of OCA on NAFLD by modulating bile acid metabolism - PubMed
Gut microbiome determines therapeutic effects of OCA on NAFLD by modulating bile acid metabolism - PubMed
Non-alcoholic fatty liver disease (NAFLD), the most common chronic liver disease, had no approved pharmacological agents yet. Obeticholic acid (OCA), a novel bile acid derivative, was demonstrated to ameliorate NAFLD-related manifestations. Regarding the role of gut-liver axis in liver disease devel …
·pubmed.ncbi.nlm.nih.gov·
Gut microbiome determines therapeutic effects of OCA on NAFLD by modulating bile acid metabolism - PubMed
Overview of Gut Microbiome
Overview of Gut Microbiome
Experts provide an overview of the gut microbiome and its importance to nutrition and overall health.
·contagionlive.com·
Overview of Gut Microbiome
Detection of Enterotoxigenic Escherichia coli and Clostridia in the Aetiology of Neonatal Piglet Diarrhoea: Important Factors for Their Prevention - PubMed
Detection of Enterotoxigenic Escherichia coli and Clostridia in the Aetiology of Neonatal Piglet Diarrhoea: Important Factors for Their Prevention - PubMed
This study aimed to research the involvement of enterotoxigenic E. coli (ETEC) and C. difficile or C. perfringens type C in the aetiology of neonatal piglet diarrhoea in Greece and to identify preventive factors for them. A total of 78 pooled faecal samples were collected random …
·pubmed.ncbi.nlm.nih.gov·
Detection of Enterotoxigenic Escherichia coli and Clostridia in the Aetiology of Neonatal Piglet Diarrhoea: Important Factors for Their Prevention - PubMed
Two bacteria that co-occur with C. difficile as emerging potential threats in planetary health
Two bacteria that co-occur with C. difficile as emerging potential threats in planetary health
A new study published in the peer-reviewed OMICS: A Journal of Integrative Biology identified genes for virulence and antimicrobial resistance in two bacteria that co-occur with C. difficile, suggesting these pathogens as emerging potential threats in planetary health.
·news.google.com·
Two bacteria that co-occur with C. difficile as emerging potential threats in planetary health
Molecular Basis of TcdR-Dependent Promoter Activity for Toxin Production by Clostridioides difficile Studied by a Heterologous Reporter System - PubMed
Molecular Basis of TcdR-Dependent Promoter Activity for Toxin Production by Clostridioides difficile Studied by a Heterologous Reporter System - PubMed
The alternative σ factor TcdR controls the synthesis of two major enterotoxins: TcdA and TcdB in Clostridioides difficile. Four potential TcdR-dependent promoters in the pathogenicity locus of C. difficile showed different activities. In this study, we constructed a heterologous system …
·pubmed.ncbi.nlm.nih.gov·
Molecular Basis of TcdR-Dependent Promoter Activity for Toxin Production by Clostridioides difficile Studied by a Heterologous Reporter System - PubMed
Fresh findings on bacterial drug resistance.
Fresh findings on bacterial drug resistance.
Researchers uncover characteristics of ARE-ABCF proteins in three bacterial species, shedding light on their function and potent combined resistance.
·newswise.com·
Fresh findings on bacterial drug resistance.
C. difficile, emerging pathogens, genomics, and antimicrobial resistance
C. difficile, emerging pathogens, genomics, and antimicrobial resistance
A new study published in OMICS: A Journal of Integrative Biology has identified genes for virulence and antimicrobial resistance in two bacteria that co-occur with C. difficile, suggesting these pathogens ...
·news.google.com·
C. difficile, emerging pathogens, genomics, and antimicrobial resistance
Grad-seq identifies KhpB as a global RNA-binding protein in Clostridioides difficile that regulates toxin production - PubMed
Grad-seq identifies KhpB as a global RNA-binding protein in Clostridioides difficile that regulates toxin production - PubMed
Much of our current knowledge about cellular RNA-protein complexes in bacteria is derived from analyses in gram-negative model organisms, with the discovery of RNA-binding proteins (RBPs) generally lagging behind in Gram-positive species. Here, we have applied Grad-seq analysis of native RNA-protein …
·pubmed.ncbi.nlm.nih.gov·
Grad-seq identifies KhpB as a global RNA-binding protein in Clostridioides difficile that regulates toxin production - PubMed
Extracellular succinate induces spatially organized biofilm formation in Clostridioides difficile - PubMed
Extracellular succinate induces spatially organized biofilm formation in Clostridioides difficile - PubMed
Clostridioides difficile infection associated to gut microbiome dysbiosis is the leading cause for nosocomial diarrhea. The ability of C. difficile to form biofilms has been progressively linked to its pathogenesis as well as its persistence in the gut. Although C. difficile has …
·pubmed.ncbi.nlm.nih.gov·
Extracellular succinate induces spatially organized biofilm formation in Clostridioides difficile - PubMed
Emerging Pathogens in Planetary Health and Lessons from Comparative Genome Analyses of Three Clostridia Species - PubMed
Emerging Pathogens in Planetary Health and Lessons from Comparative Genome Analyses of Three Clostridia Species - PubMed
Clostridioides difficile (CD) is a major planetary health burden. A Gram-positive opportunistic pathogen, CD, colonizes the large intestine and is implicated in sepsis, pseudomembranous colitis, and colorectal cancer. C. difficile infection typically following antibiotic exposure resul …
·pubmed.ncbi.nlm.nih.gov·
Emerging Pathogens in Planetary Health and Lessons from Comparative Genome Analyses of Three Clostridia Species - PubMed
COVID-19 and the Genetics of Inflammation : Critical Care Medicine
COVID-19 and the Genetics of Inflammation : Critical Care Medicine
logic mutations leading to clonal hematopoiesis (CH) may further increase vulnerability to adverse sequelae. This review summarizes the available literature examining genetic predispositions to severe COVID-19 and describes how these findings could eventually be used to improve its clinical management. DATA SOURCES: A PubMed literature search was performed. STUDY SELECTION: Studies examining the significance of inherited genetic variation or acquired CH mutations in severe COVID-19 were selected for inclusion. DATA EXTRACTION: Relevant genetic association data and aspects of study design were qualitatively assessed and narratively synthesized. DATA SYNTHESIS: Genetic variants affecting inflammatory responses may increase susceptibility to severe COVID-19. Genome-wide association studies and candidate gene approaches have identified a list of inherited mutations, which likely alter cytokine and interferon secretion, and lung-specific mechanisms of immunity in COVID-19. The potential role of CH in COVID-19 is more uncertain at present; however, the available evidence suggests that the various types of acquired mutations and their differential influence on immune cell function must be carefully considered. CONCLUSIONS: The current literature supports the hypothesis that host genetic factors affect vulnerability to severe COVID-19. Further research is required to confirm the full scope of relevant variants and the causal mechanisms underlying these associations. Clinical approaches, which consider the genetic basis of interindividual variability in COVID-19 and potentially other causes of critical illness, could optimize hospital resource allocation, predict responsiveness to treatment, identify more efficacious drug targets, and ultimately improve outcomes....
·news.google.com·
COVID-19 and the Genetics of Inflammation : Critical Care Medicine
Influence of high- and low-fermentable dietary fibres in sows' diet on the colostrum potential against Clostridioides difficile toxin-induced effects in IPEC-J2 cells - PubMed
Influence of high- and low-fermentable dietary fibres in sows' diet on the colostrum potential against Clostridioides difficile toxin-induced effects in IPEC-J2 cells - PubMed
Sow colostrum has been reported to protect the IPEC-J2 cells and piglet colon tissues from detrimental effect of Clostridioides difficile toxins. Since dietary fibre can influence the colostrum composition in sows, we hypothesised that it can also differentially affect the colostrum potential agains …
·pubmed.ncbi.nlm.nih.gov·
Influence of high- and low-fermentable dietary fibres in sows' diet on the colostrum potential against Clostridioides difficile toxin-induced effects in IPEC-J2 cells - PubMed
Microbiome Science on Twitter
Microbiome Science on Twitter
#Cdiff is known to colonize in the large intestine of humans. #guthealth #GITwitter #IDTwitter pic.twitter.com/cmi7ySohdi— Microbiome Science (@MbiomeScience) May 17, 2023
·twitter.com·
Microbiome Science on Twitter