C Diff Molecular

This article focuses on the role of the gut mycobiota in immune system homeostasis and its relevance for host health.

Clostridioides difficile (C. difficile) toxins A (TcdA) and B (TcdB) cause antibiotic-associated colitis in part by disrupting epithelial barrier function. Accurate in vitro models are necessary to detect early toxicity kinetics, investigate disease etiology, and develop preclinical models for new t …

Patients in the ICU with Clostridioides difficile colonization, histories of inflammatory bowel disease and longer ICU stays had an increased risk for developing C. difficile infection, according to a study in Infection Control & Hospital Epidemiology.

Clostridioides difficile (C. difficile) is progressively colonizing humans and animals living with humans. During this process, hypervirulent strains and mutated toxin A and B of C. difficile (TcdA and TcdB) are originating and developing. While in healthy subjects colonization …

Scientific Reports - Diversity of binary toxin positive Clostridioides difficile in Korea

Distinctive pathogen-specific gut microbiomes were associated with subsequent IBD outcomes. These findings may have direct implications for the management of IBD flares complicated by enteric pathogens.

Nature Reviews Microbiology - This study reports that Enterococcus species can remodel the metabolic environment in the gut and reprogramme the metabolism of Clostridioides difficile, enhancing its...

Nature Reviews Immunology - Patients with autoimmune diseases, such as multiple sclerosis, rheumatoid arthritis, type 1 diabetes and systemic lupus erythematosus, have distinct gut microbiota...

Increased risk of intestinal dysfunction has been reported in patients after Clostridioides difficile infection (CDI). Enteric glial cells (EGCs), a component of the enteric nervous system (ENS), contribute to gut homeostasis. Previous studies showed that adenosine receptors, A2A and A2B, mod …

Ulcerative colitis (UC) is a chronic, life-long inflammatory bowel disease that normally presents with bloody diarrhea, fever, abdominal pain, and leukocytosis. Diagnosis is usually based on clinical presentation, endoscopy with biopsy, and exclusion of alternative diagnoses. In very rare cases, pse …

For hospitalized adults, the association of CC genotype in NLRP1 rs3744717 and CdC as well as the CC+GC genotype in NLRP1 rs878329 and CDI was respectively evidenced. We believed the prompt identification of patients having specific genotype in NLRP1 would prevent and improve the quality of care in …

Background Clostridium difficile (C. difficile) is one of the most common hospital-acquired infections and causes the release of various cytokines. Prostate cancer (PC) is the second most com...

BacDrop is a droplet-based technology for single-cell RNA-seq in bacteria that can be scaled to millions of bacterial cells or hundreds of samples and was used to elucidate transcriptionally distinct bacterial subpopulations associated with varying phenotypic outcomes linked to antibiotic resistance and persistence.

As in the previously reported cases, aspiration was the most plausible hypothesis of mechanism of infection in our patient. Empyema by Clostridioidesdifficile is a diagnostic challenge, since it is necessary to rule out that the isolation of this microorganism in pleural fluid is not a contamination …

Communications Biology - A screen for germination of Clostridium novyi-NT spores reveals that germinant sensing of this tumor-destructive anaerobic bacterium is stereoflexible for valine and its...

Researchers determined independent predictors for hospital-acquired Clostridioides difficile infection in pediatric patients with antibiotic-associated diarrhea.

Pseudomembranes on colostomy in a patient with recurrent Clostridioides difficile infection

Patients with COVID-19 and CDI had a higher incidence of sepsis, shock, ICU admission, and acute kidney injuries.

Job TitlePostdoctoral Research Associate-Sorg Lab Agency Texas A&M University Department Biology Proposed Minimum SalaryCommensurate Job LocationCollege Station, Texas Job TypeStaff Job Description Our Commitment Texas A&M University is committed to enriching the learning and working environment for all visitors, students, faculty, and staff by promoting a culture that embraces inclusion, diversity, equity, and accountability. Diverse perspectives, talents, and identities are vital to accomplishing our mission and living our core values. Who We Are The Department of Biology at Texas A&M University is responsible for research and teaching within the vast disciplines of the biological sciences, from molecular cell biology to ecology and evolutionary biology. Our faculty perform cutting-edge research in a wide array of biological sciences in the laboratory and in the field. Our graduate research programs prepare scientists for careers in academia, industry and government and enhance our understanding of the central role of biological systems in the global environment. Our undergraduate students gain a firm foundation in modern biological sciences to prepare them for a multitude of careers that depend on a solid understanding of biology. To learn more, please visit us at https://www.bio.tamu.edu/. What We Want The Postdoctoral Research Associate will be responsible for exploring the how UV irradiation of C. difficile spores impacts mutation across the genome and how mutation in key metabolic pathways impact C. difficile pathogenesis. The selected candidate will also be responsible for the documentation/publication of their research findings, as well as training undergraduate and junior graduate students in the lab. The selected candidate will subscribe to and support our commitment to Inclusion, Diversity, Equity and Accountability as stated above. If the description sounds interesting to you, we invite you to apply to be considered for this opportunity. What You Need To Know Salary: Salary will be commensurate based on the selected candidate's education and experience. Required Education and Experience: Appropriate doctoral degree Required Knowledge, Skills, and Abilities: Excellent written and oral communication skills Ability to work in an organized and independent manner Strong interpersonal skills with willingness to work as part of a team Ability to multi-task and work cooperatively with others Preferred Education and Experience: PhD. In Microbiology, Molecular Biology, or related field Three to five years of experience performing molecular biology, genetics, and/or biochemical techniques Expertise in next-generation sequence analysis using R or Python Experience with animal models of infectious disease Preferred Knowledge, Skills, and Abilities: Expertise in bacterial genetics, molecular biology, and/or biochemistry to join our team Responsibilities: Research: Conduct research involving bacterial genetics and biochemistry, including collecting, recording, maintaining, analyzing, and reporting experimental data Documentation/Publishing: Analyze scientific literature to find new directions and techniques for research projects and prepare scientific manuscripts for publication Training: Train and assist with mentoring of undergraduate and junior graduate students in the lab Lab Duties: Maintain the work area and lab environment and perform other duties as assigned Instructions to Applicants: Applications received by Texas A&M University must either have all job application data entered or a resume attached. Failure to provide all job application data or a complete resume could result in an invalid submission and a rejected application. We encourage all applicants to upload a resume or use a LinkedIn profile to pre-populate the online application. All positions are security-sensitive. Applicants are subject to a criminal history investigation, and employment is contingent upon the institution’s verification of credentials and/or other information required by the institution’s procedures, including the completion of the criminal history check. Equal Opportunity/Affirmative Action/Veterans/Disability Employer committed to diversity. Howdy and thank you for your interest in a career with Texas A&M University. As the flagship campus of The Texas A&M University System, we are located in College Station, Texas with a student population of more than 64,000 and nearly 9,000 faculty and staff. The Spirit of Aggieland is unmistakable. We are a unique American institution, fostering a culture of friendliness, diversity, compassion and respect for one another. Our unique history and rich traditions make Texas A&M special. From our benefits package and professional development opportunities to our retirement programs, Texas A&M is a great place to work. Your path to a great career starts here! Equal Opportunity/Affirmative Action/Veterans/Disability Employer committed to diversity. If you need assistance in applying for this job, please contact (979) 845-5154. Useful Links: Benefit Programs Retirement Employee Discount Program Flexible Spending Accounts University Holidays Legal Statements New Employee Orientation Prospective Employees Safety and Security Notices Training and Development USERRA Nondiscrimination Notice

With #ECCMID2023 on the horizon, if you’re a #Cdiff enthusiast please consider joining #ESGCD - the first @ESCMID Study Group with a patient representative on the exec! Always a great opportunity to meet and collaborate with other researchers & clinicians @FfitzP— Jane Freeman (@drjanefreeman) January 24, 2023

A disrupted "dysbiotic" gut microbiome engenders susceptibility to the diarrheal pathogen Clostridioides difficile by impacting the metabolic milieu of the gut. Diet, in particular the microbiota-accessible carbohydrates (MACs) found in dietary fiber, is one of the most powerful ways to affect the c …

Editorial: Microbial interactions of Clostridioides difficile

Higher BMI and exposure to antibiotics are risk factors for C. difficile asymptomatic bacterial colonization in kids with cystic fibrosis.

Microbiome-based therapeutics are increasingly evaluated as a strategy to reduce recurrent Clostridioides difficile infection (rCDI), with proposed mechanisms including restoration of the microbiota and microbiota-mediated functions, such as bile acid (BA) metabolism. This study reports a qua …

Our study revealed the prevalence of CDI in COVID-19 patients was 0.65%. Although the prevalence was low, its presence is associated with worse outcomes and higher resource utilization.

CDT compromised epithelial barrier function in a human intestinal colonic cell model, even in sublethal concentrations, pointing to barrier dysfunction in the intestine and leak flux induction as a diarrheal mechanism. However, this cannot be attributed to the appearance of apoptosis and necrosis, b …

Clinical isolates of Clostridioides difficile sometimes exhibit multidrug resistance and cause diarrhea after antibiotic administration. Metronidazole and vancomycin are often used as therapeutic agents, but resistance to these antibiotics has been found clinically. Therefore, the development of alt …

@Maribeth_MD challenging #cdiff dogma: #cdiff toxin positivity does not distinguish patients with c diff disease vs colonization amongst pediatric patients with positive NAAT test, including in #IBD. #CCCongress23 pic.twitter.com/ph71GDBCZQ— Michael J Rosen, MD, MSCI (@DrRosenIBD) January 19, 2023

The main goals of this Research Topic are the following:• Assess CD underdiagnosis and the reasons for underdiagnosis, which can lead to a delay in prescribing adequate therapy and consequently may cause a higher complication rate. In addition, underdiagnosis may contribute to an increase in the CDI transmission within hospitals due to the missed or delayed application of infection prevention and control measures, including patient isolation.• Assess the best treatment for primary and recurrent CD infections, including severe, complicated and fulminant manifestations• Assess the role of antimicrobial stewardship and infection control to reduce the risk of CD acquisition in the hospital settings• Assess the role of microbiota/microbiome in CD infection• Antibiotics and CD infectionThe scope of this Research Topic is to collect manuscripts on the epidemiology of CD infection, risk factors for CD infect...

#DYK C. difficile bacteria may reside in a healthy gut? #WednesdayWisdom #guthealth #Cdiff pic.twitter.com/Tt5NhQXjPj— Microbiome Science (@MbiomeScience) January 18, 2023