C Diff Molecular

C Diff Molecular

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Biology undergraduate awarded research opportunity at McMaster and Guelph
Biology undergraduate awarded research opportunity at McMaster and Guelph
Biology student Paige Hopkinson has been awarded the new One Health Summer Research Studentship, a partnership between the Global Nexus School for Pandemic Prevention and Response at McMaster and the University of Guelph's One Health Institute.
·brighterworld.mcmaster.ca·
Biology undergraduate awarded research opportunity at McMaster and Guelph
Molecular “Superpower” of Antibiotic-Resistant Bacteria Revealed in New Research
Molecular “Superpower” of Antibiotic-Resistant Bacteria Revealed in New Research
A species of ordinary gut bacteria that we all carry flourishes when the intestinal flora is knocked out by a course of antibiotics. Since the bacteria is naturally resistant to many antibiotics, it causes problems, particularly in healthcare settings. A study led by Lund University in Sweden now sh
·scitechdaily.com·
Molecular “Superpower” of Antibiotic-Resistant Bacteria Revealed in New Research
Roles of the gut microbiome in weight management
Roles of the gut microbiome in weight management
Nature Reviews Microbiology - In this Review, Carmody and Bisanz examine the role of the gut microbiome in energy metabolism, the two-way relationship between the gut microbiome and weight...
·nature.com·
Roles of the gut microbiome in weight management
Emerging Pathogens in Planetary Health and Lessons from Comparative Genome Analyses of Three Clostridia Species - PubMed
Emerging Pathogens in Planetary Health and Lessons from Comparative Genome Analyses of Three Clostridia Species - PubMed
Clostridioides difficile (CD) is a major planetary health burden. A Gram-positive opportunistic pathogen, CD, colonizes the large intestine and is implicated in sepsis, pseudomembranous colitis, and colorectal cancer. C. difficile infection typically following antibiotic exposure resul …
·pubmed.ncbi.nlm.nih.gov·
Emerging Pathogens in Planetary Health and Lessons from Comparative Genome Analyses of Three Clostridia Species - PubMed
Gut microbiota interspecies interactions shape the response of Clostridioides difficile to clinically relevant antibiotics | PLOS Biology
Gut microbiota interspecies interactions shape the response of Clostridioides difficile to clinically relevant antibiotics | PLOS Biology
This study examines how interactions between constituent members of the human gut microbiome influence the pathogen C. difficile’s response to clinically relevant antibiotics, providing key insights into ecological principles and molecular mechanisms that influence antibiotic susceptibility in this health-relevant system.
·journals.plos.org·
Gut microbiota interspecies interactions shape the response of Clostridioides difficile to clinically relevant antibiotics | PLOS Biology
Clostridioides difficile Toxin B Induced Senescence: A New Pathologic Player for Colorectal Cancer? - PubMed
Clostridioides difficile Toxin B Induced Senescence: A New Pathologic Player for Colorectal Cancer? - PubMed
Clostridioides difficile (C. difficile) is responsible for a high percentage of gastrointestinal infections and its pathological activity is due to toxins A and B. C. difficile infection (CDI) is increasing worldwide due to the unstoppable spread of C. difficile in the an …
·pubmed.ncbi.nlm.nih.gov·
Clostridioides difficile Toxin B Induced Senescence: A New Pathologic Player for Colorectal Cancer? - PubMed
C. Diff Antibiotic Efficacy Depends on Gut Microbiome
C. Diff Antibiotic Efficacy Depends on Gut Microbiome
Researchers suggest that entire gut microbiome should be considered when designing antibiotic treatments, after finding that the susceptibility of the pathogen Clostridioides difficile depends on the presence of other bacteria.
·news.google.com·
C. Diff Antibiotic Efficacy Depends on Gut Microbiome
Host Immunity and Immunization Strategies for Clostridioides difficile Infection - PubMed
Host Immunity and Immunization Strategies for Clostridioides difficile Infection - PubMed
Clostridioides difficile infection (CDI) represents a significant challenge to public health. C. difficile-associated mortality and morbidity have led the U.S. CDC to designate it as an urgent threat. Moreover, recurrence or relapses can occur in up to a third of CDI patients, due in part to antibio …
·pubmed.ncbi.nlm.nih.gov·
Host Immunity and Immunization Strategies for Clostridioides difficile Infection - PubMed
Personalized Clostridioides difficile engraftment risk prediction and probiotic therapy assessment in the human gut - PubMed
Personalized Clostridioides difficile engraftment risk prediction and probiotic therapy assessment in the human gut - PubMed
Clostridioides difficile colonizes up to 30-40% of community-dwelling adults without causing disease 1, 2 . C. difficile infections (CDIs) are the leading cause of antibiotic-associated diarrhea in the U.S. 3, 4 and typically develop in individuals following disru …
·pubmed.ncbi.nlm.nih.gov·
Personalized Clostridioides difficile engraftment risk prediction and probiotic therapy assessment in the human gut - PubMed
The cell wall lipoprotein CD1687 acts as a DNA binding protein during deoxycholate-induced biofilm formation in Clostridioides difficile - PubMed
The cell wall lipoprotein CD1687 acts as a DNA binding protein during deoxycholate-induced biofilm formation in Clostridioides difficile - PubMed
The ability of bacterial pathogens to establish recurrent and persistent infections is frequently associated with their ability to form biofilms. Clostridioides difficile infections have a high rate of recurrence and relapses and it is hypothesized that biofilms are involved in its pathogenicity and …
·pubmed.ncbi.nlm.nih.gov·
The cell wall lipoprotein CD1687 acts as a DNA binding protein during deoxycholate-induced biofilm formation in Clostridioides difficile - PubMed
Gut microbiota interspecies interactions shape the response of Clostridioides difficile to clinically relevant antibiotics - PubMed
Gut microbiota interspecies interactions shape the response of Clostridioides difficile to clinically relevant antibiotics - PubMed
In the human gut, the growth of the pathogen Clostridioides difficile is impacted by a complex web of interspecies interactions with members of human gut microbiota. We investigate the contribution of interspecies interactions on the antibiotic response of C. difficile to clinically relevant antibio …
·pubmed.ncbi.nlm.nih.gov·
Gut microbiota interspecies interactions shape the response of Clostridioides difficile to clinically relevant antibiotics - PubMed
Answers to Long-Standing Mystery: How Dormant Bacteria Come Back to Life
Answers to Long-Standing Mystery: How Dormant Bacteria Come Back to Life
Research provides answers to the long-standing mystery of bacterial spores, illuminating new paths for disease prevention. Inert, sleeping bacteria — or spores — can survive for years, even centuries, without nutrients, resisting heat, UV radiation, antibiotics, and other harsh chemicals. Ho
·news.google.com·
Answers to Long-Standing Mystery: How Dormant Bacteria Come Back to Life
Personalized Clostridioides difficile engraftment risk prediction and probiotic therapy assessment in the human gut - PubMed
Personalized Clostridioides difficile engraftment risk prediction and probiotic therapy assessment in the human gut - PubMed
Clostridioides difficile colonizes up to 30-40% of community-dwelling adults without causing disease 1, 2 . C. difficile infections (CDIs) are the leading cause of antibiotic-associated diarrhea in the U.S. 3, 4 and typically develop in individuals following disru …
·pubmed.ncbi.nlm.nih.gov·
Personalized Clostridioides difficile engraftment risk prediction and probiotic therapy assessment in the human gut - PubMed
Butyrate enhances Clostridioides difficile sporulation in vitro - PubMed
Butyrate enhances Clostridioides difficile sporulation in vitro - PubMed
Several studies suggest that butyrate may be important in alleviating gut infections, such as reducing inflammation caused by the healthcare-associated Clostridioides difficile . While studies in both animal models and human studies correlate high levels of butyrate with reduced C. diffici …
·pubmed.ncbi.nlm.nih.gov·
Butyrate enhances Clostridioides difficile sporulation in vitro - PubMed
C. diff's powers of antibiotic resistance revealed
C. diff's powers of antibiotic resistance revealed
A species of ordinary gut bacteria that we all carry flourishes when the intestinal flora is knocked out by a course of antibiotics.
·news.google.com·
C. diff's powers of antibiotic resistance revealed
[The fliL gene significantly affects the motility and sporulation abilities of Clostridioides difficile] - PubMed
[The fliL gene significantly affects the motility and sporulation abilities of Clostridioides difficile] - PubMed
Flagella are the main motility structure of Clostridioides difficile that affects the adhesion, colonization, and virulence of C. difficile in the human gastrointestinal tract. The FliL protein is a single transmembrane protein bound to the flagellar matrix. This study aimed to investi …
·pubmed.ncbi.nlm.nih.gov·
[The fliL gene significantly affects the motility and sporulation abilities of Clostridioides difficile] - PubMed
Infectious colitis: Types, symptoms, and more
Infectious colitis: Types, symptoms, and more
Infectious colitis is inflammation of the intestines resulting from an underlying bacterial, viral, or parasitic infection. Learn more here.
·medicalnewstoday.com·
Infectious colitis: Types, symptoms, and more
Kate Lee on Twitter
Kate Lee on Twitter
Excellent talk at #DDW2023 by Dr. ⁦@CTropini⁩ on creating a healthy gut microbiome environment. You wouldn’t “plant trees during a forest fire”. We need to create the gut environment (e.g pH, osmolality) to increase survival of #FMT treatment. ⁦@getgutsycanada⁩ pic.twitter.com/CNfspRloX4— Kate Lee (@KateLeeIBD) May 9, 2023
·twitter.com·
Kate Lee on Twitter
Re-evaluation of FDA-approved antibiotics with increased diagnostic accuracy for assessment of antimicrobial resistance
Re-evaluation of FDA-approved antibiotics with increased diagnostic accuracy for assessment of antimicrobial resistance
Heithoff et al. observe that antibiotic testing in cell culture medium improves the accuracy by which laboratory testing predicts clinical outcomes in mice. Test methods with increased diagnostic accuracy will address the antimicrobial resistance crisis by improving the way antibiotics are developed, tested, and prescribed.
·cell.com·
Re-evaluation of FDA-approved antibiotics with increased diagnostic accuracy for assessment of antimicrobial resistance
UCLA Gastroenterology and Hepatology on Twitter
UCLA Gastroenterology and Hepatology on Twitter
“Recent Trends and Risk Factors Associated with #cdiff Infections in Hospitalized Patients with Inflammatory Bowel Disease #IBD 🌠Ellen Spartz, MD 👥@drdedeck Kush Fansiwala @ShayaNoorian Andrew Roney @Hakimian_MD Jenny Sauk @berkeleydoc ⏰#DDW2023 Poster, Monday, May 8, 12:30pm”
·twitter.com·
UCLA Gastroenterology and Hepatology on Twitter
[The fliL gene significantly affects the motility and sporulation abilities of Clostridioides difficile] - PubMed
[The fliL gene significantly affects the motility and sporulation abilities of Clostridioides difficile] - PubMed
Flagella are the main motility structure of Clostridioides difficile that affects the adhesion, colonization, and virulence of C. difficile in the human gastrointestinal tract. The FliL protein is a single transmembrane protein bound to the flagellar matrix. This study aimed to investi …
·pubmed.ncbi.nlm.nih.gov·
[The fliL gene significantly affects the motility and sporulation abilities of Clostridioides difficile] - PubMed
Dormant Crohn's Disease Reactivated by Clostridioides difficile Infection - PubMed
Dormant Crohn's Disease Reactivated by Clostridioides difficile Infection - PubMed
Crohn's disease (CD) is a type of inflammatory bowel disease (IBD) characterized by chronic transmural inflammation of any portion of the gastrointestinal tract. The etiology of CD remains unknown although genetic, immunological, and acquired factors have been recognized as contributing to its devel …
·pubmed.ncbi.nlm.nih.gov·
Dormant Crohn's Disease Reactivated by Clostridioides difficile Infection - PubMed
[Study on the features of Clostridioides difficile infection among diarrhea patients in Kunming from 2018 to 2020] - PubMed
[Study on the features of Clostridioides difficile infection among diarrhea patients in Kunming from 2018 to 2020] - PubMed
Objective: We analyze the characteristics of Clostridioides difficile (C. difficile) infection among diarrhea patients in Kunming from 2018 to 2020 and provide evidence for follow-up surveillance and prevention. Methods: A total of 388 fecal samples of diarrhea patients f …
·pubmed.ncbi.nlm.nih.gov·
[Study on the features of Clostridioides difficile infection among diarrhea patients in Kunming from 2018 to 2020] - PubMed
GUT Microbiome
GUT Microbiome
The Gut Microbiome Conference has become a successful event for keeping healthcare professionals and scientists informed about the latest advances in human microbiome science. Now in its 4th year, this one-of-a-kind platform provides attendees the opportunity to interact with the leading authorities on gut microbiome r
·gutmicrobes.org·
GUT Microbiome
Checkpoint Inhibitor Colitis With Superimposed Clostridioides difficile Infection - PubMed
Checkpoint Inhibitor Colitis With Superimposed Clostridioides difficile Infection - PubMed
Immune checkpoint inhibitors (ICI) are commonly used for various malignancies. A particular checkpoint inhibitor is the anti-PD-1 antibody pembrolizumab. Immune-mediated diarrhea and colitis (IMDC) is the most frequently observed immune-related adverse event (irAE) involving the gastrointestinal sys …
·pubmed.ncbi.nlm.nih.gov·
Checkpoint Inhibitor Colitis With Superimposed Clostridioides difficile Infection - PubMed