C Diff Molecular

C Diff Molecular

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[The fliL gene significantly affects the motility and sporulation abilities of Clostridioides difficile] - PubMed
[The fliL gene significantly affects the motility and sporulation abilities of Clostridioides difficile] - PubMed
Flagella are the main motility structure of Clostridioides difficile that affects the adhesion, colonization, and virulence of C. difficile in the human gastrointestinal tract. The FliL protein is a single transmembrane protein bound to the flagellar matrix. This study aimed to investi …
·pubmed.ncbi.nlm.nih.gov·
[The fliL gene significantly affects the motility and sporulation abilities of Clostridioides difficile] - PubMed
Infectious colitis: Types, symptoms, and more
Infectious colitis: Types, symptoms, and more
Infectious colitis is inflammation of the intestines resulting from an underlying bacterial, viral, or parasitic infection. Learn more here.
·medicalnewstoday.com·
Infectious colitis: Types, symptoms, and more
Kate Lee on Twitter
Kate Lee on Twitter
Excellent talk at #DDW2023 by Dr. ⁦@CTropini⁩ on creating a healthy gut microbiome environment. You wouldn’t “plant trees during a forest fire”. We need to create the gut environment (e.g pH, osmolality) to increase survival of #FMT treatment. ⁦@getgutsycanada⁩ pic.twitter.com/CNfspRloX4— Kate Lee (@KateLeeIBD) May 9, 2023
·twitter.com·
Kate Lee on Twitter
Re-evaluation of FDA-approved antibiotics with increased diagnostic accuracy for assessment of antimicrobial resistance
Re-evaluation of FDA-approved antibiotics with increased diagnostic accuracy for assessment of antimicrobial resistance
Heithoff et al. observe that antibiotic testing in cell culture medium improves the accuracy by which laboratory testing predicts clinical outcomes in mice. Test methods with increased diagnostic accuracy will address the antimicrobial resistance crisis by improving the way antibiotics are developed, tested, and prescribed.
·cell.com·
Re-evaluation of FDA-approved antibiotics with increased diagnostic accuracy for assessment of antimicrobial resistance
UCLA Gastroenterology and Hepatology on Twitter
UCLA Gastroenterology and Hepatology on Twitter
“Recent Trends and Risk Factors Associated with #cdiff Infections in Hospitalized Patients with Inflammatory Bowel Disease #IBD 🌠Ellen Spartz, MD 👥@drdedeck Kush Fansiwala @ShayaNoorian Andrew Roney @Hakimian_MD Jenny Sauk @berkeleydoc ⏰#DDW2023 Poster, Monday, May 8, 12:30pm”
·twitter.com·
UCLA Gastroenterology and Hepatology on Twitter
[The fliL gene significantly affects the motility and sporulation abilities of Clostridioides difficile] - PubMed
[The fliL gene significantly affects the motility and sporulation abilities of Clostridioides difficile] - PubMed
Flagella are the main motility structure of Clostridioides difficile that affects the adhesion, colonization, and virulence of C. difficile in the human gastrointestinal tract. The FliL protein is a single transmembrane protein bound to the flagellar matrix. This study aimed to investi …
·pubmed.ncbi.nlm.nih.gov·
[The fliL gene significantly affects the motility and sporulation abilities of Clostridioides difficile] - PubMed
Dormant Crohn's Disease Reactivated by Clostridioides difficile Infection - PubMed
Dormant Crohn's Disease Reactivated by Clostridioides difficile Infection - PubMed
Crohn's disease (CD) is a type of inflammatory bowel disease (IBD) characterized by chronic transmural inflammation of any portion of the gastrointestinal tract. The etiology of CD remains unknown although genetic, immunological, and acquired factors have been recognized as contributing to its devel …
·pubmed.ncbi.nlm.nih.gov·
Dormant Crohn's Disease Reactivated by Clostridioides difficile Infection - PubMed
[Study on the features of Clostridioides difficile infection among diarrhea patients in Kunming from 2018 to 2020] - PubMed
[Study on the features of Clostridioides difficile infection among diarrhea patients in Kunming from 2018 to 2020] - PubMed
Objective: We analyze the characteristics of Clostridioides difficile (C. difficile) infection among diarrhea patients in Kunming from 2018 to 2020 and provide evidence for follow-up surveillance and prevention. Methods: A total of 388 fecal samples of diarrhea patients f …
·pubmed.ncbi.nlm.nih.gov·
[Study on the features of Clostridioides difficile infection among diarrhea patients in Kunming from 2018 to 2020] - PubMed
GUT Microbiome
GUT Microbiome
The Gut Microbiome Conference has become a successful event for keeping healthcare professionals and scientists informed about the latest advances in human microbiome science. Now in its 4th year, this one-of-a-kind platform provides attendees the opportunity to interact with the leading authorities on gut microbiome r
·gutmicrobes.org·
GUT Microbiome
Checkpoint Inhibitor Colitis With Superimposed Clostridioides difficile Infection - PubMed
Checkpoint Inhibitor Colitis With Superimposed Clostridioides difficile Infection - PubMed
Immune checkpoint inhibitors (ICI) are commonly used for various malignancies. A particular checkpoint inhibitor is the anti-PD-1 antibody pembrolizumab. Immune-mediated diarrhea and colitis (IMDC) is the most frequently observed immune-related adverse event (irAE) involving the gastrointestinal sys …
·pubmed.ncbi.nlm.nih.gov·
Checkpoint Inhibitor Colitis With Superimposed Clostridioides difficile Infection - PubMed
A network of small RNAs regulates sporulation initiation in Clostridioides difficile - PubMed
A network of small RNAs regulates sporulation initiation in Clostridioides difficile - PubMed
The obligate anaerobic, enteric pathogen Clostridioides difficile persists in the intestinal tract by forming antibiotic-resistant endospores that contribute to relapsing and recurrent infections. Despite the importance of sporulation for C. difficile pathogenesis, environmental cues and molecular m …
·pubmed.ncbi.nlm.nih.gov·
A network of small RNAs regulates sporulation initiation in Clostridioides difficile - PubMed
Intestinal bile acids provide a surmountable barrier against C. difficile TcdB-induced disease pathogenesis - PubMed
Intestinal bile acids provide a surmountable barrier against C. difficile TcdB-induced disease pathogenesis - PubMed
Intestinal bile acids play an essential role in the Clostridioides difficile lifecycle having been shown in vitro to modulate various aspects of pathogenesis, including spore germination, vegetative growth, and more recently the action of the primary virulence determinant, TcdB. Here, we inve …
·pubmed.ncbi.nlm.nih.gov·
Intestinal bile acids provide a surmountable barrier against C. difficile TcdB-induced disease pathogenesis - PubMed
Fulminant Clostridioides difficile Colitis With SARS-CoV-2 Infection
Fulminant Clostridioides difficile Colitis With SARS-CoV-2 Infection
Clostridioides difficile (C. difficile) and coronavirus disease 2019 (COVID-19) infections can have overlapping symptoms. Recently, the association and outcomes of coinfection have been studied....
·news.google.com·
Fulminant Clostridioides difficile Colitis With SARS-CoV-2 Infection
The vanRCd Mutation 343AG, Resulting in a Thr115Ala Substitution, Is Associated with an Elevated Minimum Inhibitory Concentration (MIC) of Vancomycin in Clostridioides difficile Clinical Isolates from Florida - PubMed
The vanRCd Mutation 343AG, Resulting in a Thr115Ala Substitution, Is Associated with an Elevated Minimum Inhibitory Concentration (MIC) of Vancomycin in Clostridioides difficile Clinical Isolates from Florida - PubMed
Clostridioides difficile, the primary cause of nosocomial antibiotic-associated diarrhea, has a complex relationship with antibiotics. While the use of broad-spectrum antibiotics disrupts the gut microbiota and increases the risk of C. difficile infection (CDI), antibiotics are also the primary trea …
·pubmed.ncbi.nlm.nih.gov·
The vanRCd Mutation 343AG, Resulting in a Thr115Ala Substitution, Is Associated with an Elevated Minimum Inhibitory Concentration (MIC) of Vancomycin in Clostridioides difficile Clinical Isolates from Florida - PubMed
Characterization of the gut microbiome of patients with Clostridioides difficile infection, patients with non- C. difficile diarrhea, and C. difficile-colonized patients - PubMed
Characterization of the gut microbiome of patients with Clostridioides difficile infection, patients with non- C. difficile diarrhea, and C. difficile-colonized patients - PubMed
We observed differences in microbiome patterns between healthy individuals, colonized patients, CDI, R-CDI, and NOCDI diarrhea. We identified possible microbiome biomarkers that could prove useful in the diagnosis of true CDI infections. Further studies are warranted.
·pubmed.ncbi.nlm.nih.gov·
Characterization of the gut microbiome of patients with Clostridioides difficile infection, patients with non- C. difficile diarrhea, and C. difficile-colonized patients - PubMed
Characterization of the gut microbiome of patients with Clostridioides difficile infection, patients with non- C. difficile diarrhea, and C. difficile-colonized patients - PubMed
Characterization of the gut microbiome of patients with Clostridioides difficile infection, patients with non- C. difficile diarrhea, and C. difficile-colonized patients - PubMed
We observed differences in microbiome patterns between healthy individuals, colonized patients, CDI, R-CDI, and NOCDI diarrhea. We identified possible microbiome biomarkers that could prove useful in the diagnosis of true CDI infections. Further studies are warranted.
·pubmed.ncbi.nlm.nih.gov·
Characterization of the gut microbiome of patients with Clostridioides difficile infection, patients with non- C. difficile diarrhea, and C. difficile-colonized patients - PubMed
How dormant bacteria come back to life: Research provides answers to long-standing mystery of bacterial spores, illuminating new paths for disease prevention
How dormant bacteria come back to life: Research provides answers to long-standing mystery of bacterial spores, illuminating new paths for disease prevention
Bacterial spores can survive for years, even centuries, without nutrients, resisting heat, UV radiation, and antibiotics. How inert, sleeping bacteria -- or spores -- spring back to life has been a century-long mystery. New research identifies how sensor proteins revive dormant bacteria. Discovery opens new routes to combat spore resistance to antibiotics and sterilization. Findings can inform novel strategies to prevent infections, food spoilage.
·news.google.com·
How dormant bacteria come back to life: Research provides answers to long-standing mystery of bacterial spores, illuminating new paths for disease prevention
Metabolism from the magic angle - Nature Chemical Biology
Metabolism from the magic angle - Nature Chemical Biology
Anaerobes have developed unique metabolic pathways and strategies, some of which are still not well understood. Now, a study that integrates spectroscopy with dynamic metabolic modeling reveals the metabolism of the anaerobic pathogen Clostridioides difficile.
·nature.com·
Metabolism from the magic angle - Nature Chemical Biology
Clostridioides difficile, a New "Superbug" - PubMed
Clostridioides difficile, a New "Superbug" - PubMed
Clostridioides difficile is a Gram-positive, spore-forming, anaerobic bacterium. The clinical features of C. difficile infections (CDIs) can vary, ranging from the asymptomatic carriage and mild self-limiting diarrhoea to severe and sometimes fatal pseudomembranous colitis. C. diffi …
·pubmed.ncbi.nlm.nih.gov·
Clostridioides difficile, a New "Superbug" - PubMed
Membrane Vesicles of Toxigenic Clostridioides difficile Affect the Metabolism of Liver HepG2 Cells - PubMed
Membrane Vesicles of Toxigenic Clostridioides difficile Affect the Metabolism of Liver HepG2 Cells - PubMed
Clostridioides difficile infection (CDI) appears to be associated with different liver diseases. C. difficile secretes membrane vesicles (MVs), which may be involved in the development of nonalcoholic fatty liver disease (NALFD) and drug-induced liver injury (DILI). In this study, we i …
·pubmed.ncbi.nlm.nih.gov·
Membrane Vesicles of Toxigenic Clostridioides difficile Affect the Metabolism of Liver HepG2 Cells - PubMed
Regulatory Role of Anti-Sigma Factor RsbW in Clostridioides difficile Stress Response, Persistence, and Infection - PubMed
Regulatory Role of Anti-Sigma Factor RsbW in Clostridioides difficile Stress Response, Persistence, and Infection - PubMed
The anaerobic pathogen Clostridioides difficile, which is a primary cause of antibiotic-associated diarrhea, faces a variety of stresses in the environment and in the mammalian gut. To cope with these stresses, alternative sigma factor B (σsupB/sup) is employed to modulate gene transcription, an …
·pubmed.ncbi.nlm.nih.gov·
Regulatory Role of Anti-Sigma Factor RsbW in Clostridioides difficile Stress Response, Persistence, and Infection - PubMed
Network analysis of toxin production in Clostridioides difficile identifies key metabolic dependencies - PubMed
Network analysis of toxin production in Clostridioides difficile identifies key metabolic dependencies - PubMed
Clostridioides difficile pathogenesis is mediated through its two toxin proteins, TcdA and TcdB, which induce intestinal epithelial cell death and inflammation. It is possible to alter C. difficile toxin production by changing various metabolite concentrations within the extracellular environment. H …
·pubmed.ncbi.nlm.nih.gov·
Network analysis of toxin production in Clostridioides difficile identifies key metabolic dependencies - PubMed
Complete Genome Sequences of Evolutionary Clade C-III Strains of Clostridioides ( Clostridium) difficile Isolated from the Environment in Western Australia - PubMed
Complete Genome Sequences of Evolutionary Clade C-III Strains of Clostridioides ( Clostridium) difficile Isolated from the Environment in Western Australia - PubMed
Clostridioides (Clostridium) difficile in the environment is thought to contribute to C. difficile infection in community settings. Here, we provide complete genome assemblies for two esculin hydrolysis-negative strains of C. difficile that were isolated from soils in Western Australia; the strains …
·pubmed.ncbi.nlm.nih.gov·
Complete Genome Sequences of Evolutionary Clade C-III Strains of Clostridioides ( Clostridium) difficile Isolated from the Environment in Western Australia - PubMed
Regulatory Role of Anti-Sigma Factor RsbW in Clostridioides difficile Stress Response, Persistence, and Infection - PubMed
Regulatory Role of Anti-Sigma Factor RsbW in Clostridioides difficile Stress Response, Persistence, and Infection - PubMed
The anaerobic pathogen Clostridioides difficile, which is a primary cause of antibiotic-associated diarrhea, faces a variety of stresses in the environment and in the mammalian gut. To cope with these stresses, alternative sigma factor B (σB) is employed to modulate gene transcription, an …
·pubmed.ncbi.nlm.nih.gov·
Regulatory Role of Anti-Sigma Factor RsbW in Clostridioides difficile Stress Response, Persistence, and Infection - PubMed