During the study period, the sentinel #surveillance sch…
During the study period, the sentinel #surveillance scheme included ca 14–15% of all Danish cases of #Cdiff infections Binary toxin-negative strains accounted for 75% and 16 of the 20 most prevalent types⬇️https://t.co/AKfrYzexu7#antibiotic #AMR #AntimicrobialResistance pic.twitter.com/6B5zfAs4wY— 𝘌𝘶𝘳𝘰𝘴𝘶𝘳𝘷𝘦𝘪𝘭𝘭𝘢𝘯𝘤𝘦 (@Eurosurveillanc) December 14, 2022
Microbiota-mediated colonization resistance: mechanisms and ... - Nature.com
Nature Reviews Microbiology - In this Review, Caballero-Flores, Pickard and Núñez explore how the microbiota limits colonization by pathogens and the strategies used by pathogens to...
Comparison between Symptomatic and Asymptomatic Mice after Clostridioides difficile Infection Reveals Novel Inflammatory Pathways and Contributing Microbiota
Clostridioides difficile causes the highest number of nosocomial infections. Currently, treatment options for C. difficile infection (CDI) are very limited, resulting in poor treatment outcomes and high recurrence rates. Although the disease caused by CDI is inflammatory in nature, the …
#Gutbacteria put people at risk for severe #Cdifficile, a #bacterium that can cause potentially deadly infections, particularly among #elderly and people on long-term #antibiotics. #Antibioticresistant #pathogens in #gut make #Cdiff more dangerous. https://t.co/7mXNcPfNLP— Greg Slabodkin (@Slabodkin) December 21, 2022
Diversity and Prevalence of Clostridium innocuum in the Human Gut Microbiota - PubMed
Clostridia are a polyphyletic group of Gram-positive, spore-forming anaerobes in the Firmicutes phylum that significantly impact metabolism and functioning of the human gastrointestinal tract. Recently, Clostridia were divided into two separate classes, Clostridia and …
Pain-sensing neurons detect environmental insults and tissue injury, driving avoidance behavior and the local release of neuropeptides. Two related papers in this issue of Cell report that gut-innervating pain neurons sense bacterial presence to both shape the constituents of the gut microbiome and protect against excessive inflammation.
Studies have demonstrated that the amount of Clostridioides difficile toxin found in stool correlates with disease severity #Cdiff #guthealth #FridayMicrobiomeFeels pic.twitter.com/WMWgCp0CKN— Microbiome Science (@MbiomeScience) December 16, 2022
Adoption and Trends in Uptake of Updated ICD-10 Codes for Clostridioides difficile-A Retrospective Observational Study
Our study findings suggest no delay in transition to the updated CDI-related codes. Treatment patterns for rCDI vs nrCDI encounters were consistent with Infectious Diseases Society of America guidelines, regardless of concordance status.
Gut microbiome-wide association study of depressive symptoms | Nature Communications
Nature Communications - Here, the authors analyze the relation of fecal microbiota diversity and composition with depressive symptoms in 1,054 participants from the Rotterdam Study cohort and in...
Clostridioides difficile Induced Rhabdomyolysis Associated With Decompensated Cirrhosis
Rhabdomyolysis (RBD) occurs secondary to tissue injury, resulting in (muscle) cell lysis and release of intracellular electrolytes and proteins into circulation. An elevation in the muscle enzyme, creatine kinase (CK), is a diagnostic marker and indicates muscle breakdown. Symptoms include dark urin …
The gut microbiota and depressive symptoms across ethnic groups | Nature Communications
Nature Communications - Here, by studying a multi-ethnic cross-sectional urban cohort (N = 3211, 6 ethnic groups), the authors show that depressive symptom levels are related to the gut...
What are the factors that predict complications associated with Clostridioides difficile infection and what can be done in clinical practice?
This article focuses on the factors that predict long-term complications of C. difficile infection and what can be done in clinical practice to minimize them.
Microbiota-immune-brain interactions: A lifespan perspective - ScienceDirect
There is growing appreciation of key roles of the gut microbiota in maintaining homeostasis and influencing brain and behaviour at critical windows ac…
Clostridioides difficile infection with isolates of cryptic clade C-II: a genomic analysis of PCR ribotype 151
This study shows that RT151 encompasses both typical and cryptic clades and provides conclusive evidence for CDI due to clade C-II isolates that was hitherto lacking. Vigilance towards CDI as a result of cryptic clade isolates is warranted.
In vitro models to study Clostridioides difficile infection: current systems and future advances
As in vitro models continue to evolve, they become more physiologically relevant, offering improved simulations of CDI, and extending their applicability.
We also found published #CDI due to C-II isolates that were not classified as such, or misclassified; a toxinotype XXXII #cdiff strain with similar #paloc (https://t.co/HME0bqzPlV) and RA09-70, previously suggested to be clade 5 (https://t.co/bzQtfYRQFf) #settingtherecordstraight— Wiep Klaas Smits (@SmitsLab) December 12, 2022
An ANI analysis (thanks to @DanRJKnight for suggesting this) confirms our phylogenetic placement and supports the notion that C-II #cdiff isolates are indeed a separate genomospecies - https://t.co/wfv7DKfLXo pic.twitter.com/C3rr22pfCD— Wiep Klaas Smits (@SmitsLab) December 12, 2022
Gut microbiota, pathogenic proteins and neurodegenerative diseases
As the world’s population ages, neurodegenerative diseases (NDs) have brought a great burden to the world. However, effective treatment measures have not been found to alleviate the occurrence and development of NDs. Abnormal accumulation of pathogenic proteins is an important cause of NDs. Therefore, effective inhibition of the accumulation of pathogenic proteins has become a priority. As the second brain of human, the gut plays an important role in regulate emotion and cognition functions. Recent studies have reported that the disturbance of gut microbiota (GM) is closely related to accumulation of pathogenic proteins in NDs. On the one hand, pathogenic proteins directly produced by GM are transmitted from the gut to the central center via vagus nerve. On the other hand, The harmful substances produced by GM enter the peripheral circulation through intestinal barrier and cause inflammation, or cross the blood–brain barrier into the central center to cause inflammation, and cytokines produced by the central center cause the production of pathogenic proteins. These pathogenic proteins can produced by the above two aspects can cause the activation of central microglia and further lead to NDs development. In addition, certain GM and metabolites have been shown to have neuroprotective effects. Therefore, modulating GM may be a potential clinical therapeutic approach for NDs. In this review, we summarized the possible mechanism of NDs caused by abnormal accumulation of pathoge...
Redistribution of the Novel Clostridioides difficile Spore Adherence Receptor E-Cadherin by TcdA and TcdB Increases Spore Binding to Adherens Junctions | Infection and Immunity
Clostridioides difficile causes antibiotic-associated diseases in humans, ranging from mild diarrhea to severe
pseudomembranous colitis and death. A major clinical challenge is the prevention of
disease recurrence, which affects nearly ~20 to 30% of the ...
Investigation of Microbial Cooperation via Imaging Mass Spectrometry Analysis of Bacterial Colonies Grown on Agar and in Tissue During Infection - PubMed
Understanding the metabolic consequences of microbial interactions that occur during infection presents a unique challenge to the field of biomedical imaging. Matrix-assisted laser desorption/ionization (MALDI) imaging mass spectrometry represents a label-free, in situ imaging modality capable of ge …
Neutralizing epitopes on Clostridioides difficile toxin A revealed by the structures of two camelid VHH antibodies - PubMed
Toxin A (TcdA) and toxin B (TcdB) are two key virulence factors secreted by Clostridioides difficile, which is listed as an urgent threat by the CDC. These two large homologous exotoxins are mainly responsible for diseases associated with C. difficile infection (CDI) with symptoms rang …
Microbiome expands the genetic and functional capacity of its human host. Susan Lynch explains that human microbiome develops early in life and that gut microbes shape immune function and relate to disease outcomes in childhood. She also explores next-generation microbiome therapeutics and research. Recorded on 11/07/2019. [12/2019] [Show ID: 35240]
More from: Next: UCSF Scientists Outline What’s To Come
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Nature Reviews Microbiology - This study reports that Enterococcus species can remodel the metabolic environment in the gut and reprogramme the metabolism of Clostridioides difficile, enhancing its...
The correlation of the fecal microbiome with the biochemical profile during menopause: a Brazilian cohort study - BMC Women's Health - BioMed Central
Background Hormonal, biochemical, and metabolic changes after menopause may alter the quality of life of women, leading to vasomotor, psychological, and genitourinary symptoms, and changes in their gut microbiota, which regulates estrogen levels through the estroboloma. Fecal samples were used to investigate the changes in the gut microbiota during aging and hormonal changes in women. A balanced gut microbiota has been associated with health or disease conditions and remains poorly understood after menopause. This study identified the fecal microbiota, and their association with biochemical and hormonal parameters of a cohort of women in the climacteric in the city of Ouro Preto—MG, Brazil. Methods A total of 102 women aged 40 to 65 years old were recruited and distributed into three groups according to the STRAW criteria for reproductive stage: reproductive (n = 18), premenopausal (n = 26), and postmenopausal (n = 58). Blood samples were collected to measure their serum biochemical and hormone levels, and the participants answered a questionnaire. The gut microbiota was analyzed from fecal samples by qPCR using the genera Bifidobacterium, Bacteroides, Lactobacillus, and Clostridium. Results The following parameters showed differences among the groups: total cholesterol, triglycerides, VLDL, ApoB, urea, calcium, uric acid, and alkaline phosphatase (p
