C Diff Molecular

Clostridioides difficile (C. difficile) is responsible for a high percentage of gastrointestinal infections and its pathological activity is due to toxins A and B. C. difficile infection (CDI) is increasing worldwide due to the unstoppable spread of C. difficile in the an …

Researchers suggest that entire gut microbiome should be considered when designing antibiotic treatments, after finding that the susceptibility of the pathogen Clostridioides difficile depends on the presence of other bacteria.

Despite antecedent risk factors for CDI, the overall prevalence of CDI in ASUC was low and the outcomes were determined by underlying disease severity.

Clostridioides difficile infection (CDI) represents a significant challenge to public health. C. difficile-associated mortality and morbidity have led the U.S. CDC to designate it as an urgent threat. Moreover, recurrence or relapses can occur in up to a third of CDI patients, due in part to antibio …

Clostridioides difficile colonizes up to 30-40% of community-dwelling adults without causing disease 1, 2 . C. difficile infections (CDIs) are the leading cause of antibiotic-associated diarrhea in the U.S. 3, 4 and typically develop in individuals following disru …

The ability of bacterial pathogens to establish recurrent and persistent infections is frequently associated with their ability to form biofilms. Clostridioides difficile infections have a high rate of recurrence and relapses and it is hypothesized that biofilms are involved in its pathogenicity and …

In the human gut, the growth of the pathogen Clostridioides difficile is impacted by a complex web of interspecies interactions with members of human gut microbiota. We investigate the contribution of interspecies interactions on the antibiotic response of C. difficile to clinically relevant antibio …

Research provides answers to the long-standing mystery of bacterial spores, illuminating new paths for disease prevention. Inert, sleeping bacteria — or spores — can survive for years, even centuries, without nutrients, resisting heat, UV radiation, antibiotics, and other harsh chemicals. Ho

Higher BMI and exposure to antibiotics are risk factors for C. difficile asymptomatic bacterial colonization in kids with cystic fibrosis.

A new study showed an introduction of beneficial microbiota.

Clostridioides difficile colonizes up to 30-40% of community-dwelling adults without causing disease 1, 2 . C. difficile infections (CDIs) are the leading cause of antibiotic-associated diarrhea in the U.S. 3, 4 and typically develop in individuals following disru …

Several studies suggest that butyrate may be important in alleviating gut infections, such as reducing inflammation caused by the healthcare-associated Clostridioides difficile . While studies in both animal models and human studies correlate high levels of butyrate with reduced C. diffici …

A species of ordinary gut bacteria that we all carry flourishes when the intestinal flora is knocked out by a course of antibiotics.

Flagella are the main motility structure of Clostridioides difficile that affects the adhesion, colonization, and virulence of C. difficile in the human gastrointestinal tract. The FliL protein is a single transmembrane protein bound to the flagellar matrix. This study aimed to investi …

Infectious colitis is inflammation of the intestines resulting from an underlying bacterial, viral, or parasitic infection. Learn more here.

Excellent talk at #DDW2023 by Dr. ⁦@CTropini⁩ on creating a healthy gut microbiome environment. You wouldn’t “plant trees during a forest fire”. We need to create the gut environment (e.g pH, osmolality) to increase survival of #FMT treatment. ⁦@getgutsycanada⁩ pic.twitter.com/CNfspRloX4— Kate Lee (@KateLeeIBD) May 9, 2023

Heithoff et al. observe that antibiotic testing in cell culture medium improves the accuracy by which laboratory testing predicts clinical outcomes in mice. Test methods with increased diagnostic accuracy will address the antimicrobial resistance crisis by improving the way antibiotics are developed, tested, and prescribed.

“Recent Trends and Risk Factors Associated with #cdiff Infections in Hospitalized Patients with Inflammatory Bowel Disease #IBD 🌠Ellen Spartz, MD 👥@drdedeck Kush Fansiwala @ShayaNoorian Andrew Roney @Hakimian_MD Jenny Sauk @berkeleydoc ⏰#DDW2023 Poster, Monday, May 8, 12:30pm”

Flagella are the main motility structure of Clostridioides difficile that affects the adhesion, colonization, and virulence of C. difficile in the human gastrointestinal tract. The FliL protein is a single transmembrane protein bound to the flagellar matrix. This study aimed to investi …

Crohn's disease (CD) is a type of inflammatory bowel disease (IBD) characterized by chronic transmural inflammation of any portion of the gastrointestinal tract. The etiology of CD remains unknown although genetic, immunological, and acquired factors have been recognized as contributing to its devel …

The intestinal microbiota is the set of bacteria and viruses that live inside your gut. Microbiota perform a variety of functions, including digesting food and protecting against specific pathogens.

Objective: We analyze the characteristics of Clostridioides difficile (C. difficile) infection among diarrhea patients in Kunming from 2018 to 2020 and provide evidence for follow-up surveillance and prevention. Methods: A total of 388 fecal samples of diarrhea patients f …

The Gut Microbiome Conference has become a successful event for keeping healthcare professionals and scientists informed about the latest advances in human microbiome science. Now in its 4th year, this one-of-a-kind platform provides attendees the opportunity to interact with the leading authorities on gut microbiome r

Immune checkpoint inhibitors (ICI) are commonly used for various malignancies. A particular checkpoint inhibitor is the anti-PD-1 antibody pembrolizumab. Immune-mediated diarrhea and colitis (IMDC) is the most frequently observed immune-related adverse event (irAE) involving the gastrointestinal sys …

The obligate anaerobic, enteric pathogen Clostridioides difficile persists in the intestinal tract by forming antibiotic-resistant endospores that contribute to relapsing and recurrent infections. Despite the importance of sporulation for C. difficile pathogenesis, environmental cues and molecular m …

A new study shows that the gut microbiota has little or no effect on our weight, metabolism and risk of developing chronic diseases.

Intestinal bile acids play an essential role in the Clostridioides difficile lifecycle having been shown in vitro to modulate various aspects of pathogenesis, including spore germination, vegetative growth, and more recently the action of the primary virulence determinant, TcdB. Here, we inve …

Clostridioides difficile (C. difficile) and coronavirus disease 2019 (COVID-19) infections can have overlapping symptoms. Recently, the association and outcomes of coinfection have been studied....

Clostridioides difficile, the primary cause of nosocomial antibiotic-associated diarrhea, has a complex relationship with antibiotics. While the use of broad-spectrum antibiotics disrupts the gut microbiota and increases the risk of C. difficile infection (CDI), antibiotics are also the primary trea …

Co-existing CMV colitis should be considered in patients with aggravated C. difficile infection on appropriate treatment, even in immunocompetent hosts.