Clostridioides difficile S-Layer Protein A (SlpA) Serves as a General Phage Receptor - PubMed
Therapeutic bacteriophages (phages) are being considered as alternatives in the fight against Clostridioides difficile infections. To be efficient, phages should have a wide host range, buthe lack of knowledge about the cell receptor used by C. difficile phages hampers the rational design of phage c …
Characterizing metabolic drivers of Clostridioides difficile infection with activity-based hydrazine probes - PubMed
Many enzymes require post-translational modifications or cofactor machinery for primary function. As these catalytically essential moieties are highly regulated, they act as dual sensors and chemical handles for context-dependent metabolic activity. Clostridioides difficile is a major nosocom …
Characterizing metabolic drivers of Clostridioides difficile infection with activity-based hydrazine probes - PubMed
Many enzymes require post-translational modifications or cofactor machinery for primary function. As these catalytically essential moieties are highly regulated, they act as dual sensors and chemical handles for context-dependent metabolic activity. Clostridioides difficile is a major nosocom …
C. Difficile Infection Associated With Drop in Prostate Cancer Risk
The results show 2.56% of the CDI group developed prostate cancer, compared to 7.79% in the control group in patients matched by age range and Charlson Comorbidity Index.
A leaky human colon model reveals uncoupled apical/basal cytotoxicity in early Clostridioides difficile toxin exposure - PubMed
Clostridioides difficile (C. difficile) toxins A (TcdA) and B (TcdB) cause antibiotic-associated colitis in part by disrupting epithelial barrier function. Accurate in vitro models are necessary to detect early toxicity kinetics, investigate disease etiology, and develop preclinical models for new t …
C. difficile colonization associated with CDI development among patients in the ICU
Patients in the ICU with Clostridioides difficile colonization, histories of inflammatory bowel disease and longer ICU stays had an increased risk for developing C. difficile infection, according to a study in Infection Control & Hospital Epidemiology.
Cytotoxic synergism of Clostridioides difficile toxin B with proinflammatory cytokines in subjects with inflammatory bowel diseases - PubMed
Clostridioides difficile (C. difficile) is progressively colonizing humans and animals living with humans. During this process, hypervirulent strains and mutated toxin A and B of C. difficile (TcdA and TcdB) are originating and developing. While in healthy subjects colonization …
PATHOGEN-SPECIFIC ALTERATIONS IN THE GUT MICROBIOTA PREDICT OUTCOMES IN FLARE OF INFLAMMATORY BOWEL DISEASE COMPLICATED BY GASTROINTESTINAL INFECTION - PubMed
Distinctive pathogen-specific gut microbiomes were associated with subsequent IBD outcomes. These findings may have direct implications for the management of IBD flares complicated by enteric pathogens.
Nature Reviews Microbiology - This study reports that Enterococcus species can remodel the metabolic environment in the gut and reprogramme the metabolism of Clostridioides difficile, enhancing its...
The impact of the gut microbiome on extra-intestinal autoimmune diseases
Nature Reviews Immunology - Patients with autoimmune diseases, such as multiple sclerosis, rheumatoid arthritis, type 1 diabetes and systemic lupus erythematosus, have distinct gut microbiota...
Adenosine receptors differentially mediate enteric glial cell death induced by Clostridioides difficile Toxins A and B - PubMed
Increased risk of intestinal dysfunction has been reported in patients after Clostridioides difficile infection (CDI). Enteric glial cells (EGCs), a component of the enteric nervous system (ENS), contribute to gut homeostasis. Previous studies showed that adenosine receptors, A2A and A2B, mod …
A Rare Case of Pseudomembrane-Associated Ulcerative Colitis - PubMed
Ulcerative colitis (UC) is a chronic, life-long inflammatory bowel disease that normally presents with bloody diarrhea, fever, abdominal pain, and leukocytosis. Diagnosis is usually based on clinical presentation, endoscopy with biopsy, and exclusion of alternative diagnoses. In very rare cases, pse …
Association of Single Nucleotide Polymorphisms in Nucleotide-Binding Domain Leucine-Rich Repeat Protein 1 with Clostridioides difficile Colonization or Infection - PubMed
For hospitalized adults, the association of CC genotype in NLRP1 rs3744717 and CdC as well as the CC+GC genotype in NLRP1 rs878329 and CDI was respectively evidenced. We believed the prompt identification of patients having specific genotype in NLRP1 would prevent and improve the quality of care in …
Clostridium difficile Infection Is Associated With Decreased Prostate Cancer Risk: A Retrospective Cohort Study
Background Clostridium difficile (C. difficile) is one of the most common hospital-acquired infections and causes the release of various cytokines. Prostate cancer (PC) is the second most com...
Bacterial droplet-based single-cell RNA-seq reveals antibiotic-associated heterogeneous cellular states
BacDrop is a droplet-based technology for single-cell RNA-seq in bacteria that can
be scaled to millions of bacterial cells or hundreds of samples and was used to elucidate
transcriptionally distinct bacterial subpopulations associated with varying phenotypic
outcomes linked to antibiotic resistance and persistence.
Clostridioides difficile recovered in pleural fluid: Contamination or infection? A case report of a proven empyema and a literature review - PubMed
As in the previously reported cases, aspiration was the most plausible hypothesis of mechanism of infection in our patient. Empyema by Clostridioidesdifficile is a diagnostic challenge, since it is necessary to rule out that the isolation of this microorganism in pleural fluid is not a contamination …
A design of experiments screen reveals that Clostridium novyi-NT spore germinant sensing is stereoflexible for valine and its analogs
Communications Biology - A screen for germination of Clostridium novyi-NT spores reveals that germinant sensing of this tumor-destructive anaerobic bacterium is stereoflexible for valine and its...
Predictors of Hospital-Acquired C difficile Infection in Children With Diarrhea Identified
Researchers determined independent predictors for hospital-acquired Clostridioides difficile infection in pediatric patients with antibiotic-associated diarrhea.
Job TitlePostdoctoral Research Associate-Sorg Lab Agency Texas A&M University Department Biology Proposed Minimum SalaryCommensurate Job LocationCollege Station, Texas Job TypeStaff Job Description Our Commitment Texas A&M University is committed to enriching the learning and working environment for all visitors, students, faculty, and staff by promoting a culture that embraces inclusion, diversity, equity, and accountability. Diverse perspectives, talents, and identities are vital to accomplishing our mission and living our core values. Who We Are The Department of Biology at Texas A&M University is responsible for research and teaching within the vast disciplines of the biological sciences, from molecular cell biology to ecology and evolutionary biology. Our faculty perform cutting-edge research in a wide array of biological sciences in the laboratory and in the field. Our graduate research programs prepare scientists for careers in academia, industry and government and enhance our understanding of the central role of biological systems in the global environment. Our undergraduate students gain a firm foundation in modern biological sciences to prepare them for a multitude of careers that depend on a solid understanding of biology. To learn more, please visit us at https://www.bio.tamu.edu/. What We Want The Postdoctoral Research Associate will be responsible for exploring the how UV irradiation of C. difficile spores impacts mutation across the genome and how mutation in key metabolic pathways impact C. difficile pathogenesis. The selected candidate will also be responsible for the documentation/publication of their research findings, as well as training undergraduate and junior graduate students in the lab. The selected candidate will subscribe to and support our commitment to Inclusion, Diversity, Equity and Accountability as stated above. If the description sounds interesting to you, we invite you to apply to be considered for this opportunity. What You Need To Know Salary: Salary will be commensurate based on the selected candidate's education and experience. Required Education and Experience: Appropriate doctoral degree Required Knowledge, Skills, and Abilities: Excellent written and oral communication skills Ability to work in an organized and independent manner Strong interpersonal skills with willingness to work as part of a team Ability to multi-task and work cooperatively with others Preferred Education and Experience: PhD. In Microbiology, Molecular Biology, or related field Three to five years of experience performing molecular biology, genetics, and/or biochemical techniques Expertise in next-generation sequence analysis using R or Python Experience with animal models of infectious disease Preferred Knowledge, Skills, and Abilities: Expertise in bacterial genetics, molecular biology, and/or biochemistry to join our team Responsibilities: Research: Conduct research involving bacterial genetics and biochemistry, including collecting, recording, maintaining, analyzing, and reporting experimental data Documentation/Publishing: Analyze scientific literature to find new directions and techniques for research projects and prepare scientific manuscripts for publication Training: Train and assist with mentoring of undergraduate and junior graduate students in the lab Lab Duties: Maintain the work area and lab environment and perform other duties as assigned Instructions to Applicants: Applications received by Texas A&M University must either have all job application data entered or a resume attached. Failure to provide all job application data or a complete resume could result in an invalid submission and a rejected application. We encourage all applicants to upload a resume or use a LinkedIn profile to pre-populate the online application. All positions are security-sensitive. Applicants are subject to a criminal history investigation, and employment is contingent upon the institution’s verification of credentials and/or other information required by the institution’s procedures, including the completion of the criminal history check. Equal Opportunity/Affirmative Action/Veterans/Disability Employer committed to diversity. Howdy and thank you for your interest in a career with Texas A&M University. As the flagship campus of The Texas A&M University System, we are located in College Station, Texas with a student population of more than 64,000 and nearly 9,000 faculty and staff. The Spirit of Aggieland is unmistakable. We are a unique American institution, fostering a culture of friendliness, diversity, compassion and respect for one another. Our unique history and rich traditions make Texas A&M special. From our benefits package and professional development opportunities to our retirement programs, Texas A&M is a great place to work. Your path to a great career starts here! Equal Opportunity/Affirmative Action/Veterans/Disability Employer committed to diversity. If you need assistance in applying for this job, please contact (979) 845-5154. Useful Links: Benefit Programs Retirement Employee Discount Program Flexible Spending Accounts University Holidays Legal Statements New Employee Orientation Prospective Employees Safety and Security Notices Training and Development USERRA Nondiscrimination Notice
With #ECCMID2023 on the horizon, if you’re a #Cdiff enthusiast please consider joining #ESGCD - the first @ESCMID Study Group with a patient representative on the exec! Always a great opportunity to meet and collaborate with other researchers & clinicians @FfitzP— Jane Freeman (@drjanefreeman) January 24, 2023
Butyrate Differentiates Permissiveness to Clostridioides difficile Infection and Influences Growth of Diverse C. difficile Isolates - PubMed
A disrupted "dysbiotic" gut microbiome engenders susceptibility to the diarrheal pathogen Clostridioides difficile by impacting the metabolic milieu of the gut. Diet, in particular the microbiota-accessible carbohydrates (MACs) found in dietary fiber, is one of the most powerful ways to affect the c …
Human Fecal Bile Acid Analysis after Investigational Microbiota-Based Live Biotherapeutic Delivery for Recurrent Clostridioides difficile Infection - PubMed
Microbiome-based therapeutics are increasingly evaluated as a strategy to reduce recurrent Clostridioides difficile infection (rCDI), with proposed mechanisms including restoration of the microbiota and microbiota-mediated functions, such as bile acid (BA) metabolism. This study reports a qua …
The Burden of Clostridioides Difficile on COVID-19 Hospitalizations in the United States - PubMed
Our study revealed the prevalence of CDI in COVID-19 patients was 0.65%. Although the prevalence was low, its presence is associated with worse outcomes and higher resource utilization.