C Diff Molecular

C Diff Molecular

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CDT of Clostridioides difficile Induces MLC-Dependent Intestinal Barrier Dysfunction in HT-29/B6 Epithelial Cell Monolayers - PubMed
CDT of Clostridioides difficile Induces MLC-Dependent Intestinal Barrier Dysfunction in HT-29/B6 Epithelial Cell Monolayers - PubMed
CDT compromised epithelial barrier function in a human intestinal colonic cell model, even in sublethal concentrations, pointing to barrier dysfunction in the intestine and leak flux induction as a diarrheal mechanism. However, this cannot be attributed to the appearance of apoptosis and necrosis, b …
·pubmed.ncbi.nlm.nih.gov·
CDT of Clostridioides difficile Induces MLC-Dependent Intestinal Barrier Dysfunction in HT-29/B6 Epithelial Cell Monolayers - PubMed
Different CprABC amino acid sequences affect nisin A susceptibility in Clostridioides difficile isolates - PubMed
Different CprABC amino acid sequences affect nisin A susceptibility in Clostridioides difficile isolates - PubMed
Clinical isolates of Clostridioides difficile sometimes exhibit multidrug resistance and cause diarrhea after antibiotic administration. Metronidazole and vancomycin are often used as therapeutic agents, but resistance to these antibiotics has been found clinically. Therefore, the development of alt …
·pubmed.ncbi.nlm.nih.gov·
Different CprABC amino acid sequences affect nisin A susceptibility in Clostridioides difficile isolates - PubMed
Michael J Rosen, MD, MSCI on Twitter
Michael J Rosen, MD, MSCI on Twitter
@Maribeth_MD challenging #cdiff dogma: #cdiff toxin positivity does not distinguish patients with c diff disease vs colonization amongst pediatric patients with positive NAAT test, including in #IBD. #CCCongress23 pic.twitter.com/ph71GDBCZQ— Michael J Rosen, MD, MSCI (@DrRosenIBD) January 19, 2023
·twitter.com·
Michael J Rosen, MD, MSCI on Twitter
Clostridioides Difficile Infection
Clostridioides Difficile Infection
The main goals of this Research Topic are the following:• Assess CD underdiagnosis and the reasons for underdiagnosis, which can lead to a delay in prescribing adequate therapy and consequently may cause a higher complication rate. In addition, underdiagnosis may contribute to an increase in the CDI transmission within hospitals due to the missed or delayed application of infection prevention and control measures, including patient isolation.• Assess the best treatment for primary and recurrent CD infections, including severe, complicated and fulminant manifestations• Assess the role of antimicrobial stewardship and infection control to reduce the risk of CD acquisition in the hospital settings• Assess the role of microbiota/microbiome in CD infection• Antibiotics and CD infectionThe scope of this Research Topic is to collect manuscripts on the epidemiology of CD infection, risk factors for CD infect...
·frontiersin.org·
Clostridioides Difficile Infection
Microbiome Science on Twitter
Microbiome Science on Twitter
#DYK C. difficile bacteria may reside in a healthy gut? #WednesdayWisdom #guthealth #Cdiff pic.twitter.com/Tt5NhQXjPj— Microbiome Science (@MbiomeScience) January 18, 2023
·twitter.com·
Microbiome Science on Twitter
Baseline stool toxin concentration is associated with risk of recurrence in children with Clostridioides difficile infection | Infection Control & Hospital Epidemiology | Cambridge Core
Baseline stool toxin concentration is associated with risk of recurrence in children with Clostridioides difficile infection | Infection Control & Hospital Epidemiology | Cambridge Core
Baseline stool toxin concentration is associated with risk of recurrence in children with Clostridioides difficile infection
·cambridge.org·
Baseline stool toxin concentration is associated with risk of recurrence in children with Clostridioides difficile infection | Infection Control & Hospital Epidemiology | Cambridge Core
A Single-Center, Retrospective Cohort Study Evaluating the Use of Probiotics for the Prevention of Hospital-Onset Clostridioides difficile Infection in Hospitalized Patients Receiving Intravenous Antibiotics - PubMed
A Single-Center, Retrospective Cohort Study Evaluating the Use of Probiotics for the Prevention of Hospital-Onset Clostridioides difficile Infection in Hospitalized Patients Receiving Intravenous Antibiotics - PubMed
The addition of probiotics did not reduce the incidence of HO-CDI among inpatients receiving IV antibiotics.
·pubmed.ncbi.nlm.nih.gov·
A Single-Center, Retrospective Cohort Study Evaluating the Use of Probiotics for the Prevention of Hospital-Onset Clostridioides difficile Infection in Hospitalized Patients Receiving Intravenous Antibiotics - PubMed
Gut Bacteria Worsen C. diff Infections in Some People
Gut Bacteria Worsen C. diff Infections in Some People
Researchers have shown that a group of antibiotic-resistant pathogens found in the gut—called enterococci—can make C. difficile more potent and dangerous.
·news.google.com·
Gut Bacteria Worsen C. diff Infections in Some People
Diversity of binary toxin positive Clostridioides difficile in Korea - PubMed
Diversity of binary toxin positive Clostridioides difficile in Korea - PubMed
The objective of this study is to determine the trend and diversity of binary toxin-positive Clostridioides difficile over 10 years in Korea. Binary toxin-positive strains were selected from a tertiary hospital in Korea in 2009-2018. The multi-locus sequence typing and antibiotic susceptibility test …
·pubmed.ncbi.nlm.nih.gov·
Diversity of binary toxin positive Clostridioides difficile in Korea - PubMed
Nonmammalian models to study Clostridioides difficile infection; a systematic review - PubMed
Nonmammalian models to study Clostridioides difficile infection; a systematic review - PubMed
Clostridioide difficile is the leading cause of diarrhea disease worldwide and is a CDC-designated urgent threat level pathogen. Mammalian models are commonly utilized as gold standard to study the pathogenesis of C. difficile infection (CDI); however, alternatives are needed due to cost, higher thr …
·pubmed.ncbi.nlm.nih.gov·
Nonmammalian models to study Clostridioides difficile infection; a systematic review - PubMed
Baseline stool toxin concentration is associated with risk of recurrence in children with Clostridioides difficile infection - PubMed
Baseline stool toxin concentration is associated with risk of recurrence in children with Clostridioides difficile infection - PubMed
Higher baseline stool toxin concentrations are present in children with CDI recurrence. Toxin quantification should be included in CDI treatment trials to evaluate its use in severity assessment and outcome prediction.
·pubmed.ncbi.nlm.nih.gov·
Baseline stool toxin concentration is associated with risk of recurrence in children with Clostridioides difficile infection - PubMed
Clostridioides difficile-mesocolonic oedema in neonatal suckling piglets develops regardless of the fibre composition in sow's diets - PubMed
Clostridioides difficile-mesocolonic oedema in neonatal suckling piglets develops regardless of the fibre composition in sow's diets - PubMed
Maternal dietary factors have been reported to influence Clostridioides difficile colonisation in the offspring. Twenty suckling piglets from sows fed diets supplemented with high-fermentable sugar beet pulp (SBP) or low-fermentable lignocellulose (LNC) fibres during gestation and lactation were dis …
·pubmed.ncbi.nlm.nih.gov·
Clostridioides difficile-mesocolonic oedema in neonatal suckling piglets develops regardless of the fibre composition in sow's diets - PubMed
Comparative biofilm-forming ability between Clostridioides difficile strains isolated in Latin America and the epidemic NAP1/027 strain - PubMed
Comparative biofilm-forming ability between Clostridioides difficile strains isolated in Latin America and the epidemic NAP1/027 strain - PubMed
The three MLST Clade 2 isolated from different rybotipes, two of which were isolated from Latin America, are competent biofilm-forming bacteria, indicating their ability to induce C. difficile infection recurrence, making treatment difficult.
·pubmed.ncbi.nlm.nih.gov·
Comparative biofilm-forming ability between Clostridioides difficile strains isolated in Latin America and the epidemic NAP1/027 strain - PubMed
Food for thought-The link between Clostridioides difficile metabolism and pathogenesis - PubMed
Food for thought-The link between Clostridioides difficile metabolism and pathogenesis - PubMed
Clostridioides difficile (C. difficile) is an opportunistic pathogen that leads to antibiotic-associated diarrhoea and is a leading cause of morbidity and mortality worldwide. Antibiotic usage is the main risk factor leading to C. difficile infection (CDI), as a dysbiotic gut environment allows colo …
·pubmed.ncbi.nlm.nih.gov·
Food for thought-The link between Clostridioides difficile metabolism and pathogenesis - PubMed
Microbiota-mediated colonization resistance: mechanisms and regulation
Microbiota-mediated colonization resistance: mechanisms and regulation
Nature Reviews Microbiology - In this Review, Caballero-Flores, Pickard and Núñez explore how the microbiota limits colonization by pathogens and the strategies used by pathogens to...
·nature.com·
Microbiota-mediated colonization resistance: mechanisms and regulation
Food for thought-The link between Clostridioides difficile metabolism and pathogenesis - PubMed
Food for thought-The link between Clostridioides difficile metabolism and pathogenesis - PubMed
Clostridioides difficile (C. difficile) is an opportunistic pathogen that leads to antibiotic-associated diarrhoea and is a leading cause of morbidity and mortality worldwide. Antibiotic usage is the main risk factor leading to C. difficile infection (CDI), as a dysbiotic gut environment allows colo …
·pubmed.ncbi.nlm.nih.gov·
Food for thought-The link between Clostridioides difficile metabolism and pathogenesis - PubMed
Characterization of a Clostridioides difficile ST-293 isolate from a recurrent infection in Argentina - PubMed
Characterization of a Clostridioides difficile ST-293 isolate from a recurrent infection in Argentina - PubMed
Clostridioides difficile is an opportunistic spore-forming pathogen responsible for antibiotic-associated diarrhea in humans. C. difficile produces two main toxins: TcdA and TcdB as well as a third toxin named binary toxin (CDT) that is also involved in virulence. The present study aimed at characte …
·pubmed.ncbi.nlm.nih.gov·
Characterization of a Clostridioides difficile ST-293 isolate from a recurrent infection in Argentina - PubMed
Heidi Hau - 2023sv - PMWC Precision Medicine World Conference
Heidi Hau - 2023sv - PMWC Precision Medicine World Conference
Clinical Microbiomics. Heidi Hau, PhD, leads business and scientific activities in the US including development strategies, external partnerships and CRO organi...
·pmwcintl.com·
Heidi Hau - 2023sv - PMWC Precision Medicine World Conference
Children gut microbiota exhibits a different composition and metabolic profile after in vitro exposure to Clostridioides difficile and increases its sporulation - PubMed
Children gut microbiota exhibits a different composition and metabolic profile after in vitro exposure to Clostridioides difficile and increases its sporulation - PubMed
Clostridioides difficile (Clostridium difficile) infection (CDI) is one of the main public health concerns in adults, while children under 2 years of age are often colonized asymptomatically. In both adults and children, CDI is strongly associated with disturbances in gut microbiota. In this …
·pubmed.ncbi.nlm.nih.gov·
Children gut microbiota exhibits a different composition and metabolic profile after in vitro exposure to Clostridioides difficile and increases its sporulation - PubMed
C. difficile-targeted antibiotics disrupt the #microbiome, which can produce a favorable environment for the unaffected dormant #Cdiff spores to germinate and grow. #MicrobiomeMonday
C. difficile-targeted antibiotics disrupt the #microbiome, which can produce a favorable environment for the unaffected dormant #Cdiff spores to germinate and grow. #MicrobiomeMonday
C. difficile-targeted antibiotics disrupt the #microbiome, which can produce a favorable environment for the unaffected dormant #Cdiff spores to germinate and grow. #MicrobiomeMonday pic.twitter.com/L08ltfiVjt— Microbiome Science (@MbiomeScience) January 2, 2023
·twitter.com·
C. difficile-targeted antibiotics disrupt the #microbiome, which can produce a favorable environment for the unaffected dormant #Cdiff spores to germinate and grow. #MicrobiomeMonday
The gut mycobiome in health, disease, and clinical applications in association with the gut bacterial microbiome assembly
The gut mycobiome in health, disease, and clinical applications in association with the gut bacterial microbiome assembly
The gut mycobiome (fungi) is a small but crucial component of the gut microbiome in humans. Intestinal fungi regulate host homoeostasis, pathophysiological and physiological processes, and the assembly of the co-residing gut bacterial microbiome. Over the past decade, accumulating studies have characterised the gut mycobiome in health and several pathological conditions. We review the compositional and functional diversity of the gut mycobiome in healthy populations from birth to adulthood. We describe factors influencing the gut mycobiome and the roles of intestinal fungi—especially Candida and Saccharomyces spp—in diseases and therapies with a particular focus on their synergism with the gut bacterial microbiome and host immunity.
·thelancet.com·
The gut mycobiome in health, disease, and clinical applications in association with the gut bacterial microbiome assembly
In summary: we confirmed plasmid co-carriage in a single isolate, confirmed two new replicons, and added a new complete genome #cdiff to GBK. Thanks to @EicJrood for handling our submission and the anonymous reviewers for comments that improved the work!
In summary: we confirmed plasmid co-carriage in a single isolate, confirmed two new replicons, and added a new complete genome #cdiff to GBK. Thanks to @EicJrood for handling our submission and the anonymous reviewers for comments that improved the work!
In summary: we confirmed plasmid co-carriage in a single isolate, confirmed two new replicons, and added a new complete genome #cdiff to GBK. Thanks to @EicJrood for handling our submission and the anonymous reviewers for comments that improved the work! (11/11)— Wiep Klaas Smits (@SmitsLab) December 27, 2022
·twitter.com·
In summary: we confirmed plasmid co-carriage in a single isolate, confirmed two new replicons, and added a new complete genome #cdiff to GBK. Thanks to @EicJrood for handling our submission and the anonymous reviewers for comments that improved the work!
Human clinical #cdiff isolate JMR5 (ST9, RT081) carries 3 plasmids; using @LucigenCorp PlasmidSafe DNase we confirmed their extrachromosomal nature. Though we predicted co-carriage previously (https://t.co/R4qipcX49j) this had not been shown experimentall
Human clinical #cdiff isolate JMR5 (ST9, RT081) carries 3 plasmids; using @LucigenCorp PlasmidSafe DNase we confirmed their extrachromosomal nature. Though we predicted co-carriage previously (https://t.co/R4qipcX49j) this had not been shown experimentall
·twitter.com·
Human clinical #cdiff isolate JMR5 (ST9, RT081) carries 3 plasmids; using @LucigenCorp PlasmidSafe DNase we confirmed their extrachromosomal nature. Though we predicted co-carriage previously (https://t.co/R4qipcX49j) this had not been shown experimentall
Wiep Klaas Smits on Twitter
Wiep Klaas Smits on Twitter
This work goes back to the initial in silico identification of extrachromosomal elements of #cdiff, by Bastian Hornung in our lab (https://t.co/ZjbAuaSoD0). We used the same method here, on a new set of strains. (2/11)— Wiep Klaas Smits (@SmitsLab) December 27, 2022
·twitter.com·
Wiep Klaas Smits on Twitter