C Diff Molecular

C Diff Molecular

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Adding data to gut feelings: Cell
Adding data to gut feelings: Cell
Pain-sensing neurons detect environmental insults and tissue injury, driving avoidance behavior and the local release of neuropeptides. Two related papers in this issue of Cell report that gut-innervating pain neurons sense bacterial presence to both shape the constituents of the gut microbiome and protect against excessive inflammation.
·cell.com·
Adding data to gut feelings: Cell
Microbiome Science on Twitter
Microbiome Science on Twitter
Studies have demonstrated that the amount of Clostridioides difficile toxin found in stool correlates with disease severity #Cdiff #guthealth #FridayMicrobiomeFeels pic.twitter.com/WMWgCp0CKN— Microbiome Science (@MbiomeScience) December 16, 2022
·twitter.com·
Microbiome Science on Twitter
Adoption and Trends in Uptake of Updated ICD-10 Codes for Clostridioides difficile-A Retrospective Observational Study
Adoption and Trends in Uptake of Updated ICD-10 Codes for Clostridioides difficile-A Retrospective Observational Study
Our study findings suggest no delay in transition to the updated CDI-related codes. Treatment patterns for rCDI vs nrCDI encounters were consistent with Infectious Diseases Society of America guidelines, regardless of concordance status.
·pubmed.ncbi.nlm.nih.gov·
Adoption and Trends in Uptake of Updated ICD-10 Codes for Clostridioides difficile-A Retrospective Observational Study
Clostridioides difficile Induced Rhabdomyolysis Associated With Decompensated Cirrhosis
Clostridioides difficile Induced Rhabdomyolysis Associated With Decompensated Cirrhosis
Rhabdomyolysis (RBD) occurs secondary to tissue injury, resulting in (muscle) cell lysis and release of intracellular electrolytes and proteins into circulation. An elevation in the muscle enzyme, creatine kinase (CK), is a diagnostic marker and indicates muscle breakdown. Symptoms include dark urin …
·pubmed.ncbi.nlm.nih.gov·
Clostridioides difficile Induced Rhabdomyolysis Associated With Decompensated Cirrhosis
Wiep Klaas Smits on Twitter
Wiep Klaas Smits on Twitter
We also found published #CDI due to C-II isolates that were not classified as such, or misclassified; a toxinotype XXXII #cdiff strain with similar #paloc (https://t.co/HME0bqzPlV) and RA09-70, previously suggested to be clade 5 (https://t.co/bzQtfYRQFf) #settingtherecordstraight— Wiep Klaas Smits (@SmitsLab) December 12, 2022
·twitter.com·
Wiep Klaas Smits on Twitter
Wiep Klaas Smits on Twitter
Wiep Klaas Smits on Twitter
An ANI analysis (thanks to @DanRJKnight for suggesting this) confirms our phylogenetic placement and supports the notion that C-II #cdiff isolates are indeed a separate genomospecies - https://t.co/wfv7DKfLXo pic.twitter.com/C3rr22pfCD— Wiep Klaas Smits (@SmitsLab) December 12, 2022
·twitter.com·
Wiep Klaas Smits on Twitter
Gut microbiota, pathogenic proteins and neurodegenerative diseases
Gut microbiota, pathogenic proteins and neurodegenerative diseases
As the world’s population ages, neurodegenerative diseases (NDs) have brought a great burden to the world. However, effective treatment measures have not been found to alleviate the occurrence and development of NDs. Abnormal accumulation of pathogenic proteins is an important cause of NDs. Therefore, effective inhibition of the accumulation of pathogenic proteins has become a priority. As the second brain of human, the gut plays an important role in regulate emotion and cognition functions. Recent studies have reported that the disturbance of gut microbiota (GM) is closely related to accumulation of pathogenic proteins in NDs. On the one hand, pathogenic proteins directly produced by GM are transmitted from the gut to the central center via vagus nerve. On the other hand, The harmful substances produced by GM enter the peripheral circulation through intestinal barrier and cause inflammation, or cross the blood–brain barrier into the central center to cause inflammation, and cytokines produced by the central center cause the production of pathogenic proteins. These pathogenic proteins can produced by the above two aspects can cause the activation of central microglia and further lead to NDs development. In addition, certain GM and metabolites have been shown to have neuroprotective effects. Therefore, modulating GM may be a potential clinical therapeutic approach for NDs. In this review, we summarized the possible mechanism of NDs caused by abnormal accumulation of pathoge...
·frontiersin.org·
Gut microbiota, pathogenic proteins and neurodegenerative diseases
Redistribution of the Novel Clostridioides difficile Spore Adherence Receptor E-Cadherin by TcdA and TcdB Increases Spore Binding to Adherens Junctions | Infection and Immunity
Redistribution of the Novel Clostridioides difficile Spore Adherence Receptor E-Cadherin by TcdA and TcdB Increases Spore Binding to Adherens Junctions | Infection and Immunity
Clostridioides difficile causes antibiotic-associated diseases in humans, ranging from mild diarrhea to severe pseudomembranous colitis and death. A major clinical challenge is the prevention of disease recurrence, which affects nearly ~20 to 30% of the ...
·journals.asm.org·
Redistribution of the Novel Clostridioides difficile Spore Adherence Receptor E-Cadherin by TcdA and TcdB Increases Spore Binding to Adherens Junctions | Infection and Immunity
Investigation of Microbial Cooperation via Imaging Mass Spectrometry Analysis of Bacterial Colonies Grown on Agar and in Tissue During Infection - PubMed
Investigation of Microbial Cooperation via Imaging Mass Spectrometry Analysis of Bacterial Colonies Grown on Agar and in Tissue During Infection - PubMed
Understanding the metabolic consequences of microbial interactions that occur during infection presents a unique challenge to the field of biomedical imaging. Matrix-assisted laser desorption/ionization (MALDI) imaging mass spectrometry represents a label-free, in situ imaging modality capable of ge …
·pubmed.ncbi.nlm.nih.gov·
Investigation of Microbial Cooperation via Imaging Mass Spectrometry Analysis of Bacterial Colonies Grown on Agar and in Tissue During Infection - PubMed
Neutralizing epitopes on Clostridioides difficile toxin A revealed by the structures of two camelid VHH antibodies - PubMed
Neutralizing epitopes on Clostridioides difficile toxin A revealed by the structures of two camelid VHH antibodies - PubMed
Toxin A (TcdA) and toxin B (TcdB) are two key virulence factors secreted by Clostridioides difficile, which is listed as an urgent threat by the CDC. These two large homologous exotoxins are mainly responsible for diseases associated with C. difficile infection (CDI) with symptoms rang …
·pubmed.ncbi.nlm.nih.gov·
Neutralizing epitopes on Clostridioides difficile toxin A revealed by the structures of two camelid VHH antibodies - PubMed
The Human Microbiome: A New Frontier in Health
The Human Microbiome: A New Frontier in Health
Microbiome expands the genetic and functional capacity of its human host. Susan Lynch explains that human microbiome develops early in life and that gut microbes shape immune function and relate to disease outcomes in childhood. She also explores next-generation microbiome therapeutics and research. Recorded on 11/07/2019. [12/2019] [Show ID: 35240] More from: Next: UCSF Scientists Outline What’s To Come (https://www.uctv.tv/mini-med-next) UCTV is the broadcast and online media platform of the University of California, featuring programming from its ten campuses, three national labs and affiliated research institutions. UCTV explores a broad spectrum of subjects for a general audience, including science, health and medicine, public affairs, humanities, arts and music, business, education, and agriculture. Launched in January 2000, UCTV embraces the core missions of the University of California -- teaching, research, and public service – by providing quality, in-depth television far beyond the campus borders to inquisitive viewers around the world. (https://www.uctv.tv)
·youtube.com·
The Human Microbiome: A New Frontier in Health
Helping C. difficile to thrive - Nature.com
Helping C. difficile to thrive - Nature.com
Nature Reviews Microbiology - This study reports that Enterococcus species can remodel the metabolic environment in the gut and reprogramme the metabolism of Clostridioides difficile, enhancing its...
·news.google.com·
Helping C. difficile to thrive - Nature.com
The correlation of the fecal microbiome with the biochemical profile during menopause: a Brazilian cohort study - BMC Women's Health - BioMed Central
The correlation of the fecal microbiome with the biochemical profile during menopause: a Brazilian cohort study - BMC Women's Health - BioMed Central
Background Hormonal, biochemical, and metabolic changes after menopause may alter the quality of life of women, leading to vasomotor, psychological, and genitourinary symptoms, and changes in their gut microbiota, which regulates estrogen levels through the estroboloma. Fecal samples were used to investigate the changes in the gut microbiota during aging and hormonal changes in women. A balanced gut microbiota has been associated with health or disease conditions and remains poorly understood after menopause. This study identified the fecal microbiota, and their association with biochemical and hormonal parameters of a cohort of women in the climacteric in the city of Ouro Preto—MG, Brazil. Methods A total of 102 women aged 40 to 65 years old were recruited and distributed into three groups according to the STRAW criteria for reproductive stage: reproductive (n = 18), premenopausal (n = 26), and postmenopausal (n = 58). Blood samples were collected to measure their serum biochemical and hormone levels, and the participants answered a questionnaire. The gut microbiota was analyzed from fecal samples by qPCR using the genera Bifidobacterium, Bacteroides, Lactobacillus, and Clostridium. Results The following parameters showed differences among the groups: total cholesterol, triglycerides, VLDL, ApoB, urea, calcium, uric acid, and alkaline phosphatase (p
·news.google.com·
The correlation of the fecal microbiome with the biochemical profile during menopause: a Brazilian cohort study - BMC Women's Health - BioMed Central
Peroxisome proliferator-activated receptor-γ as the gatekeeper of tight junction in Clostridioides difficile infection
Peroxisome proliferator-activated receptor-γ as the gatekeeper of tight junction in Clostridioides difficile infection
Clostridioides difficile is a major causative pathogen of nosocomial antibiotic-associated diarrhea and severe colitis. Despite the use of vancomycin and fidaxomicin as standard drugs for the treatment of C. difficile infection (CDI), clinical relapse rates remain high. Therefore, new …
·pubmed.ncbi.nlm.nih.gov·
Peroxisome proliferator-activated receptor-γ as the gatekeeper of tight junction in Clostridioides difficile infection
Risk Factors Associated with Severe Clostridioides difficile Infection in Patients with Cancer
Risk Factors Associated with Severe Clostridioides difficile Infection in Patients with Cancer
Use of metronidazole for non-CDI indications within 90 days prior to diagnosis and presence of toxin A/B in stools were associated with severe CDI. Findings provide valuable insights into risk factors for severe CDI in an underserved population with cancer that warrants further exploration.
·pubmed.ncbi.nlm.nih.gov·
Risk Factors Associated with Severe Clostridioides difficile Infection in Patients with Cancer
Redistribution of the Novel Clostridioides difficile Spore Adherence Receptor E-Cadherin by TcdA and TcdB Increases Spore Binding to Adherens Junctions
Redistribution of the Novel Clostridioides difficile Spore Adherence Receptor E-Cadherin by TcdA and TcdB Increases Spore Binding to Adherens Junctions
Clostridioides difficile causes antibiotic-associated diseases in humans, ranging from mild diarrhea to severe pseudomembranous colitis and death. A major clinical challenge is the prevention of disease recurrence, which affects nearly ~20 to 30% of the patients with a primary C. difficile infection …
·pubmed.ncbi.nlm.nih.gov·
Redistribution of the Novel Clostridioides difficile Spore Adherence Receptor E-Cadherin by TcdA and TcdB Increases Spore Binding to Adherens Junctions
Clostridioides difficile bile salt hydrolase activity has substrate specificity and affects biofilm formation
Clostridioides difficile bile salt hydrolase activity has substrate specificity and affects biofilm formation
The Clostridioides difficile pathogen is responsible for nosocomial infections. Germination is an essential step for the establishment of C. difficile infection (CDI) because toxins that are secreted by vegetative cells are responsible for the symptoms of CDI. Germination can be stimulated by the co …
·pubmed.ncbi.nlm.nih.gov·
Clostridioides difficile bile salt hydrolase activity has substrate specificity and affects biofilm formation
Inhibition of Arp2/3 Complex after ADP-Ribosylation of Arp2 by Binary Clostridioides Toxins
Inhibition of Arp2/3 Complex after ADP-Ribosylation of Arp2 by Binary Clostridioides Toxins
Clostridioides bacteria are responsible for life threatening infections. Here, we show that in addition to actin, the binary toxins CDT, C2I, and Iota from Clostridioides difficile, botulinum, and perfrigens, respectively, ADP-ribosylate the actin-related protein Arp2 of Arp2/3 …
·pubmed.ncbi.nlm.nih.gov·
Inhibition of Arp2/3 Complex after ADP-Ribosylation of Arp2 by Binary Clostridioides Toxins