C Diff Molecular

C Diff Molecular

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Carriage of three plasmids in a single human clinical isolate of Clostridioides difficile
Carriage of three plasmids in a single human clinical isolate of Clostridioides difficile
A subset of clinical isolates of Clostridioides difficile contains one or more plasmids and these plasmids can harbor virulence and antimicrobial resistance determinants. Despite their potential importance, C. difficile plasmids remain poorly characterized. Here, we provide the complete genome seque …
·pubmed.ncbi.nlm.nih.gov·
Carriage of three plasmids in a single human clinical isolate of Clostridioides difficile
Carriage of three plasmids in a single human clinical isolate of Clostridioides difficile
Carriage of three plasmids in a single human clinical isolate of Clostridioides difficile
A subset of clinical isolates of Clostridioides difficile contains one or more plasmids and these plasmids can harbor virulence and antimicrobial resistance determinants. Despite their potential importance, C. difficile plasmids remain poorly characterized. Here, we provide the complete genome seque …
·pubmed.ncbi.nlm.nih.gov·
Carriage of three plasmids in a single human clinical isolate of Clostridioides difficile
Children gut microbiota exhibits a different composition and metabolic profile after in vitro exposure to Clostridioides difficile and increases its sporulation
Children gut microbiota exhibits a different composition and metabolic profile after in vitro exposure to Clostridioides difficile and increases its sporulation
Clostridioides difficile (Clostridium difficile) infection (CDI) is one of the main public health concerns in adults, while children under 2 years of age are often colonized asymptomatically. In both adults and children, CDI is strongly associated with disturbances in gut microbiota. In this …
·pubmed.ncbi.nlm.nih.gov·
Children gut microbiota exhibits a different composition and metabolic profile after in vitro exposure to Clostridioides difficile and increases its sporulation
During the study period, the sentinel #surveillance sch…
During the study period, the sentinel #surveillance sch…
During the study period, the sentinel #surveillance scheme included ca 14–15% of all Danish cases of #Cdiff infections Binary toxin-negative strains accounted for 75% and 16 of the 20 most prevalent types⬇️https://t.co/AKfrYzexu7#antibiotic #AMR #AntimicrobialResistance pic.twitter.com/6B5zfAs4wY— 𝘌𝘶𝘳𝘰𝘴𝘶𝘳𝘷𝘦𝘪𝘭𝘭𝘢𝘯𝘤𝘦 (@Eurosurveillanc) December 14, 2022
·twitter.com·
During the study period, the sentinel #surveillance sch…
Comparison between Symptomatic and Asymptomatic Mice after Clostridioides difficile Infection Reveals Novel Inflammatory Pathways and Contributing Microbiota
Comparison between Symptomatic and Asymptomatic Mice after Clostridioides difficile Infection Reveals Novel Inflammatory Pathways and Contributing Microbiota
Clostridioides difficile causes the highest number of nosocomial infections. Currently, treatment options for C. difficile infection (CDI) are very limited, resulting in poor treatment outcomes and high recurrence rates. Although the disease caused by CDI is inflammatory in nature, the …
·pubmed.ncbi.nlm.nih.gov·
Comparison between Symptomatic and Asymptomatic Mice after Clostridioides difficile Infection Reveals Novel Inflammatory Pathways and Contributing Microbiota
Greg Slabodkin on Twitter
Greg Slabodkin on Twitter
#Gutbacteria put people at risk for severe #Cdifficile, a #bacterium that can cause potentially deadly infections, particularly among #elderly and people on long-term #antibiotics. #Antibioticresistant #pathogens in #gut make #Cdiff more dangerous. https://t.co/7mXNcPfNLP— Greg Slabodkin (@Slabodkin) December 21, 2022
·twitter.com·
Greg Slabodkin on Twitter
Diversity and Prevalence of Clostridium innocuum in the Human Gut Microbiota - PubMed
Diversity and Prevalence of Clostridium innocuum in the Human Gut Microbiota - PubMed
Clostridia are a polyphyletic group of Gram-positive, spore-forming anaerobes in the Firmicutes phylum that significantly impact metabolism and functioning of the human gastrointestinal tract. Recently, Clostridia were divided into two separate classes, Clostridia and …
·pubmed.ncbi.nlm.nih.gov·
Diversity and Prevalence of Clostridium innocuum in the Human Gut Microbiota - PubMed
Adding data to gut feelings: Cell
Adding data to gut feelings: Cell
Pain-sensing neurons detect environmental insults and tissue injury, driving avoidance behavior and the local release of neuropeptides. Two related papers in this issue of Cell report that gut-innervating pain neurons sense bacterial presence to both shape the constituents of the gut microbiome and protect against excessive inflammation.
·cell.com·
Adding data to gut feelings: Cell
Microbiome Science on Twitter
Microbiome Science on Twitter
Studies have demonstrated that the amount of Clostridioides difficile toxin found in stool correlates with disease severity #Cdiff #guthealth #FridayMicrobiomeFeels pic.twitter.com/WMWgCp0CKN— Microbiome Science (@MbiomeScience) December 16, 2022
·twitter.com·
Microbiome Science on Twitter
Adoption and Trends in Uptake of Updated ICD-10 Codes for Clostridioides difficile-A Retrospective Observational Study
Adoption and Trends in Uptake of Updated ICD-10 Codes for Clostridioides difficile-A Retrospective Observational Study
Our study findings suggest no delay in transition to the updated CDI-related codes. Treatment patterns for rCDI vs nrCDI encounters were consistent with Infectious Diseases Society of America guidelines, regardless of concordance status.
·pubmed.ncbi.nlm.nih.gov·
Adoption and Trends in Uptake of Updated ICD-10 Codes for Clostridioides difficile-A Retrospective Observational Study
Clostridioides difficile Induced Rhabdomyolysis Associated With Decompensated Cirrhosis
Clostridioides difficile Induced Rhabdomyolysis Associated With Decompensated Cirrhosis
Rhabdomyolysis (RBD) occurs secondary to tissue injury, resulting in (muscle) cell lysis and release of intracellular electrolytes and proteins into circulation. An elevation in the muscle enzyme, creatine kinase (CK), is a diagnostic marker and indicates muscle breakdown. Symptoms include dark urin …
·pubmed.ncbi.nlm.nih.gov·
Clostridioides difficile Induced Rhabdomyolysis Associated With Decompensated Cirrhosis
Wiep Klaas Smits on Twitter
Wiep Klaas Smits on Twitter
We also found published #CDI due to C-II isolates that were not classified as such, or misclassified; a toxinotype XXXII #cdiff strain with similar #paloc (https://t.co/HME0bqzPlV) and RA09-70, previously suggested to be clade 5 (https://t.co/bzQtfYRQFf) #settingtherecordstraight— Wiep Klaas Smits (@SmitsLab) December 12, 2022
·twitter.com·
Wiep Klaas Smits on Twitter
Wiep Klaas Smits on Twitter
Wiep Klaas Smits on Twitter
An ANI analysis (thanks to @DanRJKnight for suggesting this) confirms our phylogenetic placement and supports the notion that C-II #cdiff isolates are indeed a separate genomospecies - https://t.co/wfv7DKfLXo pic.twitter.com/C3rr22pfCD— Wiep Klaas Smits (@SmitsLab) December 12, 2022
·twitter.com·
Wiep Klaas Smits on Twitter
Gut microbiota, pathogenic proteins and neurodegenerative diseases
Gut microbiota, pathogenic proteins and neurodegenerative diseases
As the world’s population ages, neurodegenerative diseases (NDs) have brought a great burden to the world. However, effective treatment measures have not been found to alleviate the occurrence and development of NDs. Abnormal accumulation of pathogenic proteins is an important cause of NDs. Therefore, effective inhibition of the accumulation of pathogenic proteins has become a priority. As the second brain of human, the gut plays an important role in regulate emotion and cognition functions. Recent studies have reported that the disturbance of gut microbiota (GM) is closely related to accumulation of pathogenic proteins in NDs. On the one hand, pathogenic proteins directly produced by GM are transmitted from the gut to the central center via vagus nerve. On the other hand, The harmful substances produced by GM enter the peripheral circulation through intestinal barrier and cause inflammation, or cross the blood–brain barrier into the central center to cause inflammation, and cytokines produced by the central center cause the production of pathogenic proteins. These pathogenic proteins can produced by the above two aspects can cause the activation of central microglia and further lead to NDs development. In addition, certain GM and metabolites have been shown to have neuroprotective effects. Therefore, modulating GM may be a potential clinical therapeutic approach for NDs. In this review, we summarized the possible mechanism of NDs caused by abnormal accumulation of pathoge...
·frontiersin.org·
Gut microbiota, pathogenic proteins and neurodegenerative diseases
Redistribution of the Novel Clostridioides difficile Spore Adherence Receptor E-Cadherin by TcdA and TcdB Increases Spore Binding to Adherens Junctions | Infection and Immunity
Redistribution of the Novel Clostridioides difficile Spore Adherence Receptor E-Cadherin by TcdA and TcdB Increases Spore Binding to Adherens Junctions | Infection and Immunity
Clostridioides difficile causes antibiotic-associated diseases in humans, ranging from mild diarrhea to severe pseudomembranous colitis and death. A major clinical challenge is the prevention of disease recurrence, which affects nearly ~20 to 30% of the ...
·journals.asm.org·
Redistribution of the Novel Clostridioides difficile Spore Adherence Receptor E-Cadherin by TcdA and TcdB Increases Spore Binding to Adherens Junctions | Infection and Immunity
Investigation of Microbial Cooperation via Imaging Mass Spectrometry Analysis of Bacterial Colonies Grown on Agar and in Tissue During Infection - PubMed
Investigation of Microbial Cooperation via Imaging Mass Spectrometry Analysis of Bacterial Colonies Grown on Agar and in Tissue During Infection - PubMed
Understanding the metabolic consequences of microbial interactions that occur during infection presents a unique challenge to the field of biomedical imaging. Matrix-assisted laser desorption/ionization (MALDI) imaging mass spectrometry represents a label-free, in situ imaging modality capable of ge …
·pubmed.ncbi.nlm.nih.gov·
Investigation of Microbial Cooperation via Imaging Mass Spectrometry Analysis of Bacterial Colonies Grown on Agar and in Tissue During Infection - PubMed
Neutralizing epitopes on Clostridioides difficile toxin A revealed by the structures of two camelid VHH antibodies - PubMed
Neutralizing epitopes on Clostridioides difficile toxin A revealed by the structures of two camelid VHH antibodies - PubMed
Toxin A (TcdA) and toxin B (TcdB) are two key virulence factors secreted by Clostridioides difficile, which is listed as an urgent threat by the CDC. These two large homologous exotoxins are mainly responsible for diseases associated with C. difficile infection (CDI) with symptoms rang …
·pubmed.ncbi.nlm.nih.gov·
Neutralizing epitopes on Clostridioides difficile toxin A revealed by the structures of two camelid VHH antibodies - PubMed