C Diff Molecular

C Diff Molecular

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Toward an improved definition of a healthy microbiome for healthy aging
Toward an improved definition of a healthy microbiome for healthy aging
Nature Aging - The authors analyze microbiome profiles from several public repositories to identify the higher-level indices that best reflect the abundance and ranking of disease-associated and...
·nature.com·
Toward an improved definition of a healthy microbiome for healthy aging
The role of the gut microbiome in colonization resistance and recurrent Clostridioides difficile infection - PubMed
The role of the gut microbiome in colonization resistance and recurrent Clostridioides difficile infection - PubMed
The Role of the Gut Microbiome in Clostridioides difficile Infection Introduction: A rich and diverse gut microbiome is key to immune system regulation and colonization resistance against pathogens.A disruption in the gut microbiome composition can make the gut more vulnerable t …
·pubmed.ncbi.nlm.nih.gov·
The role of the gut microbiome in colonization resistance and recurrent Clostridioides difficile infection - PubMed
Pathogenicity and virulence of Clostridioides difficile - PubMed
Pathogenicity and virulence of Clostridioides difficile - PubMed
Clostridioides difficile is the most common cause of nosocomial antibiotic-associated diarrhoea, and is responsible for a spectrum of diseases characterised by high levels of recurrence, morbidity and mortality. Treatment is complex, since antibiotics constitute both the main treatment and th …
·pubmed.ncbi.nlm.nih.gov·
Pathogenicity and virulence of Clostridioides difficile - PubMed
Clostridioides Difficile Infection before and during Coronavirus Disease 2019 Pandemic-Similarities and Differences - PubMed
Clostridioides Difficile Infection before and during Coronavirus Disease 2019 Pandemic-Similarities and Differences - PubMed
The aim of this study was to investigate the differences of Clostridioides difficile infection (CDI) during the COVID-19 pandemic compared to the pre-COVID-19 era. CDI patients treated at the Clinic for Infectious Diseases, Clinical Center of Vojvodina, Serbia during 2017-2019 (n = 304 …
·pubmed.ncbi.nlm.nih.gov·
Clostridioides Difficile Infection before and during Coronavirus Disease 2019 Pandemic-Similarities and Differences - PubMed
Computational modeling of complex bioenergetic mechanisms that modulate CD4+ T cell effector and regulatory functions
Computational modeling of complex bioenergetic mechanisms that modulate CD4+ T cell effector and regulatory functions
We built a computational model of complex mechanisms at the intersection of immunity and metabolism that regulate CD4+ T cell effector and regulatory functions by using coupled ordinary differential equations. The model provides an improved understanding of how CD4+ T cells are shaping the immune re …
·pubmed.ncbi.nlm.nih.gov·
Computational modeling of complex bioenergetic mechanisms that modulate CD4+ T cell effector and regulatory functions
GutMicrobiota Health on Twitter
GutMicrobiota Health on Twitter
Hypervirulent strains of C. difficile are relevant nowadays and several issues arise from newer therapies available that need to be tackled according to @bhmullish @esnm_eu #GMFHCoverage pic.twitter.com/gueeBUsYAb— GutMicrobiota Health (@GMFHx) November 22, 2022
·twitter.com·
GutMicrobiota Health on Twitter
Researchers found C. difficile has a secret ally - Becker's Hospital Review
Researchers found C. difficile has a secret ally - Becker's Hospital Review
Children's Hospital of Philadelphia researchers found that Enterococcus, an antibiotic-resistant pathogen, works with Clostridioides difficile, or C. diff, to change the metabolic environment in the gut so C. diff can thrive, Science Daily reported Nov. 16.
·news.google.com·
Researchers found C. difficile has a secret ally - Becker's Hospital Review
Serpin-positive Bifidobacterium breve CNCM I-5644 improves intestinal permeability in two models of irritable bowel syndrome
Serpin-positive Bifidobacterium breve CNCM I-5644 improves intestinal permeability in two models of irritable bowel syndrome
Probiotic supplementation can help to mitigate the pathogenesis of irritable bowel syndrome (IBS) by reinforcing the intestinal barrier, and reducing both inflammation and proteolytic activity. Here, a combination of in vitro tests was performed on 33 Bifidobacterium strains as probiotic candidates …
·pubmed.ncbi.nlm.nih.gov·
Serpin-positive Bifidobacterium breve CNCM I-5644 improves intestinal permeability in two models of irritable bowel syndrome
Functional profile of host microbiome indicates Clostridioides difficile infection
Functional profile of host microbiome indicates Clostridioides difficile infection
Clostridioides difficile infection (CDI) is a gastro-intestinal (GI) infection that illustrates how perturbations in symbiotic host-microbiome interactions render the GI tract vulnerable to the opportunistic pathogens. CDI also serves as an example of how such perturbations could be reversed via gut …
·pubmed.ncbi.nlm.nih.gov·
Functional profile of host microbiome indicates Clostridioides difficile infection
Enterococci enhance Clostridioides difficile pathogenesis
Enterococci enhance Clostridioides difficile pathogenesis
Enteric pathogens are exposed to a dynamic polymicrobial environment in the gastrointestinal tract1. This microbial community has been shown to be important during infection, but there are few examples illustrating how microbial interactions can influence the virulence of invading pathoge …
·pubmed.ncbi.nlm.nih.gov·
Enterococci enhance Clostridioides difficile pathogenesis
Enterococci enhance Clostridioides difficile pathogenesis
Enterococci enhance Clostridioides difficile pathogenesis
Nature - Enterococci enhance the fitness and pathogenesis of Clostridioides difficile in the gut by altering the amino acid composition and providing signals that increase its virulence towards the...
·news.google.com·
Enterococci enhance Clostridioides difficile pathogenesis
Antibiotic-resistant microbes in the gut make C. difficile more infectious
Antibiotic-resistant microbes in the gut make C. difficile more infectious
Researchers have found that Enterococcus -- an antibiotic-resistant, opportunistic pathogen -- works together with C. difficile, reshaping and enhancing the metabolic environment in the gut so that C. difficile can thrive.
·news.google.com·
Antibiotic-resistant microbes in the gut make C. difficile more infectious
Peggy Lillis Fund on Twitter
Peggy Lillis Fund on Twitter
In recent years, both postpartum women and healthy adults have seen increased risk for CDI. #cdiff #cdiffawarenessmonth #seecdiff #seecdiffclearly— Peggy Lillis Fund (@PeggyFund) November 9, 2022
·twitter.com·
Peggy Lillis Fund on Twitter
Polymicrobial Clostridioides difficile lung empyema - PubMed
Polymicrobial Clostridioides difficile lung empyema - PubMed
Clostridioides (Clostridium) difficile is a well-known cause of enteritis and antibiotic-associated diarrhea. Extraintestinal C. difficile infection is uncommon, with most extraintestinal infections involving the intra-abdominal cavity and anatomic structures adjacent to the colon. Emp …
·pubmed.ncbi.nlm.nih.gov·
Polymicrobial Clostridioides difficile lung empyema - PubMed
Metabolic Phenotyping Study of Mouse Brain Following Microbiome Disruption by C.difficile Colonization - PubMed
Metabolic Phenotyping Study of Mouse Brain Following Microbiome Disruption by C.difficile Colonization - PubMed
Clostridioides difficile infection (CDI) is responsible for an increasing number of cases of post-antibiotic diarrhea worldwide, which has high severity and mortality among hospitalized elderly patients. The disruption of gut microbiota due to antibacterial medication facilitates the intestin …
·pubmed.ncbi.nlm.nih.gov·
Metabolic Phenotyping Study of Mouse Brain Following Microbiome Disruption by C.difficile Colonization - PubMed
Identification of TFPI as a receptor reveals recombination-driven receptor switching in Clostridioides difficile toxin B variants - PubMed
Identification of TFPI as a receptor reveals recombination-driven receptor switching in Clostridioides difficile toxin B variants - PubMed
Toxin B (TcdB) is a major exotoxin responsible for diseases associated with Clostridioides difficile infection. Its sequence variations among clinical isolates may contribute to the difficulty in developing effective therapeutics. Here, we investigate receptor-binding specificity of major TcdB subty …
·pubmed.ncbi.nlm.nih.gov·
Identification of TFPI as a receptor reveals recombination-driven receptor switching in Clostridioides difficile toxin B variants - PubMed
November, Clostridioides difficile infection awareness month
November, Clostridioides difficile infection awareness month
Just one month before friends and families gather around the Christmas table, November is here to bring awareness around Clostridioides difficile infection, and the importance of microbiota-derived treatments
·gutmicrobiotaforhealth.com·
November, Clostridioides difficile infection awareness month
GutMicrobiota Health on Twitter
GutMicrobiota Health on Twitter
Emerging technologies are in the pipeline for better exploring the microbiome. @nsegata et al. have developed a computational pipeline that was used to interrogate a massively expanded dataset of metagenome and virome assemblies https://t.co/KlczhHSdSD— GutMicrobiota Health (@GMFHx) November 11, 2022
·twitter.com·
GutMicrobiota Health on Twitter