C Diff Molecular

C Diff Molecular

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The Human Microbiome: A New Frontier in Health
The Human Microbiome: A New Frontier in Health
Microbiome expands the genetic and functional capacity of its human host. Susan Lynch explains that human microbiome develops early in life and that gut microbes shape immune function and relate to disease outcomes in childhood. She also explores next-generation microbiome therapeutics and research. Recorded on 11/07/2019. [12/2019] [Show ID: 35240] More from: Next: UCSF Scientists Outline What’s To Come (https://www.uctv.tv/mini-med-next) UCTV is the broadcast and online media platform of the University of California, featuring programming from its ten campuses, three national labs and affiliated research institutions. UCTV explores a broad spectrum of subjects for a general audience, including science, health and medicine, public affairs, humanities, arts and music, business, education, and agriculture. Launched in January 2000, UCTV embraces the core missions of the University of California -- teaching, research, and public service – by providing quality, in-depth television far beyond the campus borders to inquisitive viewers around the world. (https://www.uctv.tv)
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The Human Microbiome: A New Frontier in Health
Helping C. difficile to thrive - Nature.com
Helping C. difficile to thrive - Nature.com
Nature Reviews Microbiology - This study reports that Enterococcus species can remodel the metabolic environment in the gut and reprogramme the metabolism of Clostridioides difficile, enhancing its...
·news.google.com·
Helping C. difficile to thrive - Nature.com
The correlation of the fecal microbiome with the biochemical profile during menopause: a Brazilian cohort study - BMC Women's Health - BioMed Central
The correlation of the fecal microbiome with the biochemical profile during menopause: a Brazilian cohort study - BMC Women's Health - BioMed Central
Background Hormonal, biochemical, and metabolic changes after menopause may alter the quality of life of women, leading to vasomotor, psychological, and genitourinary symptoms, and changes in their gut microbiota, which regulates estrogen levels through the estroboloma. Fecal samples were used to investigate the changes in the gut microbiota during aging and hormonal changes in women. A balanced gut microbiota has been associated with health or disease conditions and remains poorly understood after menopause. This study identified the fecal microbiota, and their association with biochemical and hormonal parameters of a cohort of women in the climacteric in the city of Ouro Preto—MG, Brazil. Methods A total of 102 women aged 40 to 65 years old were recruited and distributed into three groups according to the STRAW criteria for reproductive stage: reproductive (n = 18), premenopausal (n = 26), and postmenopausal (n = 58). Blood samples were collected to measure their serum biochemical and hormone levels, and the participants answered a questionnaire. The gut microbiota was analyzed from fecal samples by qPCR using the genera Bifidobacterium, Bacteroides, Lactobacillus, and Clostridium. Results The following parameters showed differences among the groups: total cholesterol, triglycerides, VLDL, ApoB, urea, calcium, uric acid, and alkaline phosphatase (p
·news.google.com·
The correlation of the fecal microbiome with the biochemical profile during menopause: a Brazilian cohort study - BMC Women's Health - BioMed Central
Peroxisome proliferator-activated receptor-γ as the gatekeeper of tight junction in Clostridioides difficile infection
Peroxisome proliferator-activated receptor-γ as the gatekeeper of tight junction in Clostridioides difficile infection
Clostridioides difficile is a major causative pathogen of nosocomial antibiotic-associated diarrhea and severe colitis. Despite the use of vancomycin and fidaxomicin as standard drugs for the treatment of C. difficile infection (CDI), clinical relapse rates remain high. Therefore, new …
·pubmed.ncbi.nlm.nih.gov·
Peroxisome proliferator-activated receptor-γ as the gatekeeper of tight junction in Clostridioides difficile infection
Risk Factors Associated with Severe Clostridioides difficile Infection in Patients with Cancer
Risk Factors Associated with Severe Clostridioides difficile Infection in Patients with Cancer
Use of metronidazole for non-CDI indications within 90 days prior to diagnosis and presence of toxin A/B in stools were associated with severe CDI. Findings provide valuable insights into risk factors for severe CDI in an underserved population with cancer that warrants further exploration.
·pubmed.ncbi.nlm.nih.gov·
Risk Factors Associated with Severe Clostridioides difficile Infection in Patients with Cancer
Redistribution of the Novel Clostridioides difficile Spore Adherence Receptor E-Cadherin by TcdA and TcdB Increases Spore Binding to Adherens Junctions
Redistribution of the Novel Clostridioides difficile Spore Adherence Receptor E-Cadherin by TcdA and TcdB Increases Spore Binding to Adherens Junctions
Clostridioides difficile causes antibiotic-associated diseases in humans, ranging from mild diarrhea to severe pseudomembranous colitis and death. A major clinical challenge is the prevention of disease recurrence, which affects nearly ~20 to 30% of the patients with a primary C. difficile infection …
·pubmed.ncbi.nlm.nih.gov·
Redistribution of the Novel Clostridioides difficile Spore Adherence Receptor E-Cadherin by TcdA and TcdB Increases Spore Binding to Adherens Junctions
Clostridioides difficile bile salt hydrolase activity has substrate specificity and affects biofilm formation
Clostridioides difficile bile salt hydrolase activity has substrate specificity and affects biofilm formation
The Clostridioides difficile pathogen is responsible for nosocomial infections. Germination is an essential step for the establishment of C. difficile infection (CDI) because toxins that are secreted by vegetative cells are responsible for the symptoms of CDI. Germination can be stimulated by the co …
·pubmed.ncbi.nlm.nih.gov·
Clostridioides difficile bile salt hydrolase activity has substrate specificity and affects biofilm formation
Inhibition of Arp2/3 Complex after ADP-Ribosylation of Arp2 by Binary Clostridioides Toxins
Inhibition of Arp2/3 Complex after ADP-Ribosylation of Arp2 by Binary Clostridioides Toxins
Clostridioides bacteria are responsible for life threatening infections. Here, we show that in addition to actin, the binary toxins CDT, C2I, and Iota from Clostridioides difficile, botulinum, and perfrigens, respectively, ADP-ribosylate the actin-related protein Arp2 of Arp2/3 …
·pubmed.ncbi.nlm.nih.gov·
Inhibition of Arp2/3 Complex after ADP-Ribosylation of Arp2 by Binary Clostridioides Toxins
Toward an improved definition of a healthy microbiome for healthy aging
Toward an improved definition of a healthy microbiome for healthy aging
Nature Aging - The authors analyze microbiome profiles from several public repositories to identify the higher-level indices that best reflect the abundance and ranking of disease-associated and...
·nature.com·
Toward an improved definition of a healthy microbiome for healthy aging
The role of the gut microbiome in colonization resistance and recurrent Clostridioides difficile infection - PubMed
The role of the gut microbiome in colonization resistance and recurrent Clostridioides difficile infection - PubMed
The Role of the Gut Microbiome in Clostridioides difficile Infection Introduction: A rich and diverse gut microbiome is key to immune system regulation and colonization resistance against pathogens.A disruption in the gut microbiome composition can make the gut more vulnerable t …
·pubmed.ncbi.nlm.nih.gov·
The role of the gut microbiome in colonization resistance and recurrent Clostridioides difficile infection - PubMed
Pathogenicity and virulence of Clostridioides difficile - PubMed
Pathogenicity and virulence of Clostridioides difficile - PubMed
Clostridioides difficile is the most common cause of nosocomial antibiotic-associated diarrhoea, and is responsible for a spectrum of diseases characterised by high levels of recurrence, morbidity and mortality. Treatment is complex, since antibiotics constitute both the main treatment and th …
·pubmed.ncbi.nlm.nih.gov·
Pathogenicity and virulence of Clostridioides difficile - PubMed
Clostridioides Difficile Infection before and during Coronavirus Disease 2019 Pandemic-Similarities and Differences - PubMed
Clostridioides Difficile Infection before and during Coronavirus Disease 2019 Pandemic-Similarities and Differences - PubMed
The aim of this study was to investigate the differences of Clostridioides difficile infection (CDI) during the COVID-19 pandemic compared to the pre-COVID-19 era. CDI patients treated at the Clinic for Infectious Diseases, Clinical Center of Vojvodina, Serbia during 2017-2019 (n = 304 …
·pubmed.ncbi.nlm.nih.gov·
Clostridioides Difficile Infection before and during Coronavirus Disease 2019 Pandemic-Similarities and Differences - PubMed
Computational modeling of complex bioenergetic mechanisms that modulate CD4+ T cell effector and regulatory functions
Computational modeling of complex bioenergetic mechanisms that modulate CD4+ T cell effector and regulatory functions
We built a computational model of complex mechanisms at the intersection of immunity and metabolism that regulate CD4+ T cell effector and regulatory functions by using coupled ordinary differential equations. The model provides an improved understanding of how CD4+ T cells are shaping the immune re …
·pubmed.ncbi.nlm.nih.gov·
Computational modeling of complex bioenergetic mechanisms that modulate CD4+ T cell effector and regulatory functions
GutMicrobiota Health on Twitter
GutMicrobiota Health on Twitter
Hypervirulent strains of C. difficile are relevant nowadays and several issues arise from newer therapies available that need to be tackled according to @bhmullish @esnm_eu #GMFHCoverage pic.twitter.com/gueeBUsYAb— GutMicrobiota Health (@GMFHx) November 22, 2022
·twitter.com·
GutMicrobiota Health on Twitter
Researchers found C. difficile has a secret ally - Becker's Hospital Review
Researchers found C. difficile has a secret ally - Becker's Hospital Review
Children's Hospital of Philadelphia researchers found that Enterococcus, an antibiotic-resistant pathogen, works with Clostridioides difficile, or C. diff, to change the metabolic environment in the gut so C. diff can thrive, Science Daily reported Nov. 16.
·news.google.com·
Researchers found C. difficile has a secret ally - Becker's Hospital Review
Serpin-positive Bifidobacterium breve CNCM I-5644 improves intestinal permeability in two models of irritable bowel syndrome
Serpin-positive Bifidobacterium breve CNCM I-5644 improves intestinal permeability in two models of irritable bowel syndrome
Probiotic supplementation can help to mitigate the pathogenesis of irritable bowel syndrome (IBS) by reinforcing the intestinal barrier, and reducing both inflammation and proteolytic activity. Here, a combination of in vitro tests was performed on 33 Bifidobacterium strains as probiotic candidates …
·pubmed.ncbi.nlm.nih.gov·
Serpin-positive Bifidobacterium breve CNCM I-5644 improves intestinal permeability in two models of irritable bowel syndrome
Functional profile of host microbiome indicates Clostridioides difficile infection
Functional profile of host microbiome indicates Clostridioides difficile infection
Clostridioides difficile infection (CDI) is a gastro-intestinal (GI) infection that illustrates how perturbations in symbiotic host-microbiome interactions render the GI tract vulnerable to the opportunistic pathogens. CDI also serves as an example of how such perturbations could be reversed via gut …
·pubmed.ncbi.nlm.nih.gov·
Functional profile of host microbiome indicates Clostridioides difficile infection
Enterococci enhance Clostridioides difficile pathogenesis
Enterococci enhance Clostridioides difficile pathogenesis
Enteric pathogens are exposed to a dynamic polymicrobial environment in the gastrointestinal tract1. This microbial community has been shown to be important during infection, but there are few examples illustrating how microbial interactions can influence the virulence of invading pathoge …
·pubmed.ncbi.nlm.nih.gov·
Enterococci enhance Clostridioides difficile pathogenesis