The gut microbiota and depressive symptoms across ethnic groups | Nature Communications
Nature Communications - Here, by studying a multi-ethnic cross-sectional urban cohort (N = 3211, 6 ethnic groups), the authors show that depressive symptom levels are related to the gut...
What are the factors that predict complications associated with Clostridioides difficile infection and what can be done in clinical practice?
This article focuses on the factors that predict long-term complications of C. difficile infection and what can be done in clinical practice to minimize them.
Microbiota-immune-brain interactions: A lifespan perspective - ScienceDirect
There is growing appreciation of key roles of the gut microbiota in maintaining homeostasis and influencing brain and behaviour at critical windows ac…
Clostridioides difficile infection with isolates of cryptic clade C-II: a genomic analysis of PCR ribotype 151
This study shows that RT151 encompasses both typical and cryptic clades and provides conclusive evidence for CDI due to clade C-II isolates that was hitherto lacking. Vigilance towards CDI as a result of cryptic clade isolates is warranted.
In vitro models to study Clostridioides difficile infection: current systems and future advances
As in vitro models continue to evolve, they become more physiologically relevant, offering improved simulations of CDI, and extending their applicability.
We also found published #CDI due to C-II isolates that were not classified as such, or misclassified; a toxinotype XXXII #cdiff strain with similar #paloc (https://t.co/HME0bqzPlV) and RA09-70, previously suggested to be clade 5 (https://t.co/bzQtfYRQFf) #settingtherecordstraight— Wiep Klaas Smits (@SmitsLab) December 12, 2022
An ANI analysis (thanks to @DanRJKnight for suggesting this) confirms our phylogenetic placement and supports the notion that C-II #cdiff isolates are indeed a separate genomospecies - https://t.co/wfv7DKfLXo pic.twitter.com/C3rr22pfCD— Wiep Klaas Smits (@SmitsLab) December 12, 2022
Gut microbiota, pathogenic proteins and neurodegenerative diseases
As the world’s population ages, neurodegenerative diseases (NDs) have brought a great burden to the world. However, effective treatment measures have not been found to alleviate the occurrence and development of NDs. Abnormal accumulation of pathogenic proteins is an important cause of NDs. Therefore, effective inhibition of the accumulation of pathogenic proteins has become a priority. As the second brain of human, the gut plays an important role in regulate emotion and cognition functions. Recent studies have reported that the disturbance of gut microbiota (GM) is closely related to accumulation of pathogenic proteins in NDs. On the one hand, pathogenic proteins directly produced by GM are transmitted from the gut to the central center via vagus nerve. On the other hand, The harmful substances produced by GM enter the peripheral circulation through intestinal barrier and cause inflammation, or cross the blood–brain barrier into the central center to cause inflammation, and cytokines produced by the central center cause the production of pathogenic proteins. These pathogenic proteins can produced by the above two aspects can cause the activation of central microglia and further lead to NDs development. In addition, certain GM and metabolites have been shown to have neuroprotective effects. Therefore, modulating GM may be a potential clinical therapeutic approach for NDs. In this review, we summarized the possible mechanism of NDs caused by abnormal accumulation of pathoge...
Redistribution of the Novel Clostridioides difficile Spore Adherence Receptor E-Cadherin by TcdA and TcdB Increases Spore Binding to Adherens Junctions | Infection and Immunity
Clostridioides difficile causes antibiotic-associated diseases in humans, ranging from mild diarrhea to severe
pseudomembranous colitis and death. A major clinical challenge is the prevention of
disease recurrence, which affects nearly ~20 to 30% of the ...
Investigation of Microbial Cooperation via Imaging Mass Spectrometry Analysis of Bacterial Colonies Grown on Agar and in Tissue During Infection - PubMed
Understanding the metabolic consequences of microbial interactions that occur during infection presents a unique challenge to the field of biomedical imaging. Matrix-assisted laser desorption/ionization (MALDI) imaging mass spectrometry represents a label-free, in situ imaging modality capable of ge …
Neutralizing epitopes on Clostridioides difficile toxin A revealed by the structures of two camelid VHH antibodies - PubMed
Toxin A (TcdA) and toxin B (TcdB) are two key virulence factors secreted by Clostridioides difficile, which is listed as an urgent threat by the CDC. These two large homologous exotoxins are mainly responsible for diseases associated with C. difficile infection (CDI) with symptoms rang …
Microbiome expands the genetic and functional capacity of its human host. Susan Lynch explains that human microbiome develops early in life and that gut microbes shape immune function and relate to disease outcomes in childhood. She also explores next-generation microbiome therapeutics and research. Recorded on 11/07/2019. [12/2019] [Show ID: 35240]
More from: Next: UCSF Scientists Outline What’s To Come
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UCTV is the broadcast and online media platform of the University of California, featuring programming from its ten campuses, three national labs and affiliated research institutions. UCTV explores a broad spectrum of subjects for a general audience, including science, health and medicine, public affairs, humanities, arts and music, business, education, and agriculture. Launched in January 2000, UCTV embraces the core missions of the University of California -- teaching, research, and public service – by providing quality, in-depth television far beyond the campus borders to inquisitive viewers around the world.
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Nature Reviews Microbiology - This study reports that Enterococcus species can remodel the metabolic environment in the gut and reprogramme the metabolism of Clostridioides difficile, enhancing its...
The correlation of the fecal microbiome with the biochemical profile during menopause: a Brazilian cohort study - BMC Women's Health - BioMed Central
Background Hormonal, biochemical, and metabolic changes after menopause may alter the quality of life of women, leading to vasomotor, psychological, and genitourinary symptoms, and changes in their gut microbiota, which regulates estrogen levels through the estroboloma. Fecal samples were used to investigate the changes in the gut microbiota during aging and hormonal changes in women. A balanced gut microbiota has been associated with health or disease conditions and remains poorly understood after menopause. This study identified the fecal microbiota, and their association with biochemical and hormonal parameters of a cohort of women in the climacteric in the city of Ouro Preto—MG, Brazil. Methods A total of 102 women aged 40 to 65 years old were recruited and distributed into three groups according to the STRAW criteria for reproductive stage: reproductive (n = 18), premenopausal (n = 26), and postmenopausal (n = 58). Blood samples were collected to measure their serum biochemical and hormone levels, and the participants answered a questionnaire. The gut microbiota was analyzed from fecal samples by qPCR using the genera Bifidobacterium, Bacteroides, Lactobacillus, and Clostridium. Results The following parameters showed differences among the groups: total cholesterol, triglycerides, VLDL, ApoB, urea, calcium, uric acid, and alkaline phosphatase (p
Peroxisome proliferator-activated receptor-γ as the gatekeeper of tight junction in Clostridioides difficile infection
Clostridioides difficile is a major causative pathogen of nosocomial antibiotic-associated diarrhea and severe colitis. Despite the use of vancomycin and fidaxomicin as standard drugs for the treatment of C. difficile infection (CDI), clinical relapse rates remain high. Therefore, new …
Risk Factors Associated with Severe Clostridioides difficile Infection in Patients with Cancer
Use of metronidazole for non-CDI indications within 90 days prior to diagnosis and presence of toxin A/B in stools were associated with severe CDI. Findings provide valuable insights into risk factors for severe CDI in an underserved population with cancer that warrants further exploration.
Redistribution of the Novel Clostridioides difficile Spore Adherence Receptor E-Cadherin by TcdA and TcdB Increases Spore Binding to Adherens Junctions
Clostridioides difficile causes antibiotic-associated diseases in humans, ranging from mild diarrhea to severe pseudomembranous colitis and death. A major clinical challenge is the prevention of disease recurrence, which affects nearly ~20 to 30% of the patients with a primary C. difficile infection …
Clostridioides difficile bile salt hydrolase activity has substrate specificity and affects biofilm formation
The Clostridioides difficile pathogen is responsible for nosocomial infections. Germination is an essential step for the establishment of C. difficile infection (CDI) because toxins that are secreted by vegetative cells are responsible for the symptoms of CDI. Germination can be stimulated by the co …
Inhibition of Arp2/3 Complex after ADP-Ribosylation of Arp2 by Binary Clostridioides Toxins
Clostridioides bacteria are responsible for life threatening infections. Here, we show that in addition to actin, the binary toxins CDT, C2I, and Iota from Clostridioides difficile, botulinum, and perfrigens, respectively, ADP-ribosylate the actin-related protein Arp2 of Arp2/3 …
Toward an improved definition of a healthy microbiome for healthy aging
Nature Aging - The authors analyze microbiome profiles from several public repositories to identify the higher-level indices that best reflect the abundance and ranking of disease-associated and...
The role of the gut microbiome in colonization resistance and recurrent Clostridioides difficile infection - PubMed
The Role of the Gut Microbiome in Clostridioides difficile Infection Introduction: A rich and diverse gut microbiome is key to immune system regulation and colonization resistance against pathogens.A disruption in the gut microbiome composition can make the gut more vulnerable t …
Gut Microbiota for Health World Summit 2023 - Gut Microbiota for Health
Join the ESNM and the AGA for the 11th annual Gut Microbiota for Health World Summit 2023. This meeting will take place in March 2023 in Prague, Czech Republic.
Pathogenicity and virulence of Clostridioides difficile - PubMed
Clostridioides difficile is the most common cause of nosocomial antibiotic-associated diarrhoea, and is responsible for a spectrum of diseases characterised by high levels of recurrence, morbidity and mortality. Treatment is complex, since antibiotics constitute both the main treatment and th …
Clostridioides Difficile Infection before and during Coronavirus Disease 2019 Pandemic-Similarities and Differences - PubMed
The aim of this study was to investigate the differences of Clostridioides difficile infection (CDI) during the COVID-19 pandemic compared to the pre-COVID-19 era. CDI patients treated at the Clinic for Infectious Diseases, Clinical Center of Vojvodina, Serbia during 2017-2019 (n = 304 …
Computational modeling of complex bioenergetic mechanisms that modulate CD4+ T cell effector and regulatory functions
We built a computational model of complex mechanisms at the intersection of immunity and metabolism that regulate CD4+ T cell effector and regulatory functions by using coupled ordinary differential equations. The model provides an improved understanding of how CD4+ T cells are shaping the immune re …
