C Diff Molecular

C Diff Molecular

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Impact of Helicobacter pylori Eradication on Inflammatory Bowel Disease Onset and Disease Activity: To Eradicate or Not to Eradicate? - PubMed
Impact of Helicobacter pylori Eradication on Inflammatory Bowel Disease Onset and Disease Activity: To Eradicate or Not to Eradicate? - PubMed
Helicobacter pylori infection has significant epidemiological relevance due to the carcinogenic nature of this bacterium, which is potentially associated with cancer. When detected, it should ideally be eradicated using a treatment that currently involves a combination of gastric acid suppres …
·pubmed.ncbi.nlm.nih.gov·
Impact of Helicobacter pylori Eradication on Inflammatory Bowel Disease Onset and Disease Activity: To Eradicate or Not to Eradicate? - PubMed
Emerging Clostridioides difficile ribotypes have divergent metabolic phenotypes - PubMed
Emerging Clostridioides difficile ribotypes have divergent metabolic phenotypes - PubMed
The gut pathogen Clostridioides difficile utilizes a wide range of carbon sources. Microbial communities can be rationally designed to combat C. difficile by depleting its preferred nutrients in the gut. However, C. difficile is genetically diverse with hundreds of identified ri …
·pubmed.ncbi.nlm.nih.gov·
Emerging Clostridioides difficile ribotypes have divergent metabolic phenotypes - PubMed
A Clostridioides difficile endolysin modulates toxin secretion without cell lysis - PubMed
A Clostridioides difficile endolysin modulates toxin secretion without cell lysis - PubMed
The Clostridia produce and secrete Large Clostridial Glucosylating Toxins (LCGTs) responsible for disease symptoms, but the secretion mechanism is largely unknown. Recently, a holin-like protein was shown to be essential for toxin secretion. Holins, typically bacteriophage-specific proteins, are par …
·pubmed.ncbi.nlm.nih.gov·
A Clostridioides difficile endolysin modulates toxin secretion without cell lysis - PubMed
Physiological role and complex regulation of O2-reducing enzymes in the obligate anaerobe Clostridioides difficile - PubMed
Physiological role and complex regulation of O2-reducing enzymes in the obligate anaerobe Clostridioides difficile - PubMed
The gastrointestinal tract is a hypoxic environment, with the existence of two gradients of O2 along the gut, one longitudinal anteroposterior decreasing gradient and one proximodistal increasing from the lumen to the epithelial cells. O2 is a major source of stress for an obli …
·pubmed.ncbi.nlm.nih.gov·
Physiological role and complex regulation of O2-reducing enzymes in the obligate anaerobe Clostridioides difficile - PubMed
Role of glycogen metabolism in Clostridioides difficile virulence - PubMed
Role of glycogen metabolism in Clostridioides difficile virulence - PubMed
Glycogen plays a vital role as an energy reserve in various bacterial and fungal species. Clostridioides difficile possesses a glycogen metabolism operon that contains genes for both glycogen synthesis and utilization. In our investigation, we focused on understanding the significance of glyc …
·pubmed.ncbi.nlm.nih.gov·
Role of glycogen metabolism in Clostridioides difficile virulence - PubMed
Elucidating human gut microbiota interactions that robustly inhibit diverse Clostridioides difficile strains across different nutrient landscapes
Elucidating human gut microbiota interactions that robustly inhibit diverse Clostridioides difficile strains across different nutrient landscapes
Nature Communications - In this paper, the authors use a systems biology approach to explore human gut microbiota interactions impacting multiple Clostridioides difficile strains in various...
·nature.com·
Elucidating human gut microbiota interactions that robustly inhibit diverse Clostridioides difficile strains across different nutrient landscapes
Structural and Functional Insights into the Delivery Systems of Bacillus and Clostridial Binary Toxins - PubMed
Structural and Functional Insights into the Delivery Systems of Bacillus and Clostridial Binary Toxins - PubMed
Pathogenic Bacillus and clostridial (i.e., Clostridium and Clostridioides) bacteria express a diverse repertoire of effector proteins to promote disease. This includes production of binary toxins, which enter host epithelial cells and seriously damage the intestinal tracts of in …
·pubmed.ncbi.nlm.nih.gov·
Structural and Functional Insights into the Delivery Systems of Bacillus and Clostridial Binary Toxins - PubMed
Gut microbiome and plasma lipidome analysis reveals a specific impact of Clostridioides difficile infection on intestinal bacterial communities and sterol metabolism - PubMed
Gut microbiome and plasma lipidome analysis reveals a specific impact of Clostridioides difficile infection on intestinal bacterial communities and sterol metabolism - PubMed
There is increasing evidence about the influence the changes in microbiota and its metabolism has on numerous diseases and infections such as Clostridioides difficile infection (CDI). The knowledge of these changes at local and systemic levels can help us manage this infection to avoid recurr …
·pubmed.ncbi.nlm.nih.gov·
Gut microbiome and plasma lipidome analysis reveals a specific impact of Clostridioides difficile infection on intestinal bacterial communities and sterol metabolism - PubMed
Role of glycogen metabolism in Clostridioides difficile virulence - PubMed
Role of glycogen metabolism in Clostridioides difficile virulence - PubMed
Glycogen plays a vital role as an energy reserve in various bacterial and fungal species. Clostridioides difficile possesses a glycogen metabolism operon that contains genes for both glycogen synthesis and utilization. In our investigation, we focused on understanding the significance of glyc …
·pubmed.ncbi.nlm.nih.gov·
Role of glycogen metabolism in Clostridioides difficile virulence - PubMed
Physiological role and complex regulation of O2-reducing enzymes in the obligate anaerobe Clostridioides difficile - PubMed
Physiological role and complex regulation of O2-reducing enzymes in the obligate anaerobe Clostridioides difficile - PubMed
The gastrointestinal tract is a hypoxic environment, with the existence of two gradients of O2 along the gut, one longitudinal anteroposterior decreasing gradient and one proximodistal increasing from the lumen to the epithelial cells. O2 is a major source of stress for an obli …
·pubmed.ncbi.nlm.nih.gov·
Physiological role and complex regulation of O2-reducing enzymes in the obligate anaerobe Clostridioides difficile - PubMed
Emerging Clostridioides difficile ribotypes have divergent metabolic phenotypes - PubMed
Emerging Clostridioides difficile ribotypes have divergent metabolic phenotypes - PubMed
The gut pathogen Clostridioides difficile utilizes a wide range of carbon sources. Microbial communities can be rationally designed to combat C. difficile by depleting its preferred nutrients in the gut. However, C. difficile is genetically diverse with hundreds of identified ri …
·pubmed.ncbi.nlm.nih.gov·
Emerging Clostridioides difficile ribotypes have divergent metabolic phenotypes - PubMed
A Clostridioides difficile endolysin modulates toxin secretion without cell lysis - PubMed
A Clostridioides difficile endolysin modulates toxin secretion without cell lysis - PubMed
The Clostridia produce and secrete Large Clostridial Glucosylating Toxins (LCGTs) responsible for disease symptoms, but the secretion mechanism is largely unknown. Recently, a holin-like protein was shown to be essential for toxin secretion. Holins, typically bacteriophage-specific proteins, are par …
·pubmed.ncbi.nlm.nih.gov·
A Clostridioides difficile endolysin modulates toxin secretion without cell lysis - PubMed
From Hemorrhage to Diarrhea: The Comprehensive Clinical Journey of a Patient With Pseudomembranous Colitis - PubMed
From Hemorrhage to Diarrhea: The Comprehensive Clinical Journey of a Patient With Pseudomembranous Colitis - PubMed
Pseudomembranous colitis (PC) is an inflammation of the colon primarily caused by the bacterium Clostridium difficile (C. difficile), often following antibiotic use. This case report describes the intricate clinical course of a 48-year-old male farmer with a history of chronic alcoholism, tobacco us …
·pubmed.ncbi.nlm.nih.gov·
From Hemorrhage to Diarrhea: The Comprehensive Clinical Journey of a Patient With Pseudomembranous Colitis - PubMed
Clostridioides difficile exploits xanthine and uric acid as nutrients by utilizing a selenium-dependent catabolic pathway - PubMed
Clostridioides difficile exploits xanthine and uric acid as nutrients by utilizing a selenium-dependent catabolic pathway - PubMed
Selenium is a trace element that plays critical roles in redox biology; it is typically incorporated into "selenoproteins" as the 21st amino acid selenocysteine. Additionally, selenium exists as a labile non-selenocysteine cofactor in a small subset of selenoproteins known as selenium-dependent moly …
·pubmed.ncbi.nlm.nih.gov·
Clostridioides difficile exploits xanthine and uric acid as nutrients by utilizing a selenium-dependent catabolic pathway - PubMed
Clostridioides difficile exploits xanthine and uric acid as nutrients by utilizing a selenium-dependent catabolic pathway - PubMed
Clostridioides difficile exploits xanthine and uric acid as nutrients by utilizing a selenium-dependent catabolic pathway - PubMed
Selenium is a trace element that plays critical roles in redox biology; it is typically incorporated into "selenoproteins" as the 21st amino acid selenocysteine. Additionally, selenium exists as a labile non-selenocysteine cofactor in a small subset of selenoproteins known as selenium-dependent moly …
·pubmed.ncbi.nlm.nih.gov·
Clostridioides difficile exploits xanthine and uric acid as nutrients by utilizing a selenium-dependent catabolic pathway - PubMed
Antimicrobial resistance of Clostridioides difficile in veterinary medicine around the world: A scoping review of minimum inhibitory concentrations - PubMed
Antimicrobial resistance of Clostridioides difficile in veterinary medicine around the world: A scoping review of minimum inhibitory concentrations - PubMed
Antimicrobial susceptibility testing techniques and results were found to be diverse and heterogeneous. There is no evidence of an exclusive antimicrobial resistance pattern in any animal species. Despite the phenotypic and genomic data collected over the years, further interdisciplinary studies are …
·pubmed.ncbi.nlm.nih.gov·
Antimicrobial resistance of Clostridioides difficile in veterinary medicine around the world: A scoping review of minimum inhibitory concentrations - PubMed
Oxygen tolerance in anaerobes as a virulence factor and a health-beneficial property - PubMed
Oxygen tolerance in anaerobes as a virulence factor and a health-beneficial property - PubMed
Oxygen tolerance of anaerobes is a virulence factor, but can also be a beneficial property. Many species have evolved to tolerate or take advantage of the presence of low, especially nanaerobic (≤0.14%) oxygen concentrations. Oxygen tolerance is genus-, species- and strain-dependent according to the …
·pubmed.ncbi.nlm.nih.gov·
Oxygen tolerance in anaerobes as a virulence factor and a health-beneficial property - PubMed
Identification of a family of peptidoglycan transpeptidases reveals that Clostridioides difficile requires noncanonical cross-links for viability - PubMed
Identification of a family of peptidoglycan transpeptidases reveals that Clostridioides difficile requires noncanonical cross-links for viability - PubMed
Most bacteria are surrounded by a cell wall that contains peptidoglycan (PG), a large polymer composed of glycan strands held together by short peptide cross-links. There are two major types of cross-links, termed 4-3 and 3-3 based on the amino acids involved. 4-3 cross-links are created by penicill …
·pubmed.ncbi.nlm.nih.gov·
Identification of a family of peptidoglycan transpeptidases reveals that Clostridioides difficile requires noncanonical cross-links for viability - PubMed
Identification of a family of peptidoglycan transpeptidases reveals that Clostridioides difficile requires noncanonical cross-links for viability - PubMed
Identification of a family of peptidoglycan transpeptidases reveals that Clostridioides difficile requires noncanonical cross-links for viability - PubMed
Most bacteria are surrounded by a cell wall that contains peptidoglycan (PG), a large polymer composed of glycan strands held together by short peptide cross-links. There are two major types of cross-links, termed 4-3 and 3-3 based on the amino acids involved. 4-3 cross-links are created by penicill …
·pubmed.ncbi.nlm.nih.gov·
Identification of a family of peptidoglycan transpeptidases reveals that Clostridioides difficile requires noncanonical cross-links for viability - PubMed
Symbiotic biofilms formed by Clostridioides difficile and bacteroides thetaiotaomicron in the presence of vancomycin - PubMed
Symbiotic biofilms formed by Clostridioides difficile and bacteroides thetaiotaomicron in the presence of vancomycin - PubMed
Vancomycin (VAN) treatment in Clostridioides difficile infection (CDI) suffers from a relatively high rate of recurrence, with a variety of reasons behind this, including biofilm-induced recurrent infections. C. difficile can form monophyletic or symbiotic biofilms with other microbes …
·pubmed.ncbi.nlm.nih.gov·
Symbiotic biofilms formed by Clostridioides difficile and bacteroides thetaiotaomicron in the presence of vancomycin - PubMed
Healing from Within: How Gut Microbiota Predicts IBD Treatment Success-A Systematic Review - PubMed
Healing from Within: How Gut Microbiota Predicts IBD Treatment Success-A Systematic Review - PubMed
Recent research indicates that the microbiome has a significant impact on the progression of inflammatory bowel disease (IBD) and that creating therapies that change its composition could positively impact the outcomes of IBD treatment. This review summarizes the results of extensive studies that ex …
·pubmed.ncbi.nlm.nih.gov·
Healing from Within: How Gut Microbiota Predicts IBD Treatment Success-A Systematic Review - PubMed
MicroRNA miR-27a-5p reduces intestinal inflammation induced by Clostridioides difficile flagella by regulating the NF-κB signaling pathway - PubMed
MicroRNA miR-27a-5p reduces intestinal inflammation induced by Clostridioides difficile flagella by regulating the NF-κB signaling pathway - PubMed
miR-27a-5p plays a crucial role in regulating C. difficile-induced inflammation, suggesting its potential as a therapeutic target for controlling severe infection. These findings offer valuable insights into potential therapeutic strategies for managing C. difficile infection and associated inflamma …
·pubmed.ncbi.nlm.nih.gov·
MicroRNA miR-27a-5p reduces intestinal inflammation induced by Clostridioides difficile flagella by regulating the NF-κB signaling pathway - PubMed
Clostridium septicum manifests a bile salt germinant response mediated by Clostridioides difficile csp gene orthologs - PubMed
Clostridium septicum manifests a bile salt germinant response mediated by Clostridioides difficile csp gene orthologs - PubMed
Clostridium septicum infections are highly predictive of certain malignancies in human patients. To initiate infections, C. septicum spores must first germinate and regain vegetative growth. Yet, what triggers the germination of C. septicum spores is still unknown. Here, we observe that C. septicum …
·pubmed.ncbi.nlm.nih.gov·
Clostridium septicum manifests a bile salt germinant response mediated by Clostridioides difficile csp gene orthologs - PubMed