C Diff Molecular

Only recent hospitalization and proton pump inhibitor use was deemed an independent risk factor for C difficile infections.

Redefining genomic view of Clostridioides difficile through pangenome analysis and identification of drug targets from its core genome

Hypervirulent strains of C. difficile are relevant nowadays and several issues arise from newer therapies available that need to be tackled according to @bhmullish @esnm_eu #GMFHCoverage pic.twitter.com/gueeBUsYAb— GutMicrobiota Health (@GMFHx) November 22, 2022

‎Show Inside Scope, Ep BONUS: Microbiota changes associated with C. difficile infection - Nov 15, 2022

Study showed how Enterococcus fine tunes the environment around C. diff, restricting some nutrients and supplying others, to increase its fitness and virulence.

Study showed how Enterococcus fine tunes the environment around C. diff, restricting some nutrients and supplying others, to increase its fitness and virulence.

Children's Hospital of Philadelphia researchers found that Enterococcus, an antibiotic-resistant pathogen, works with Clostridioides difficile, or C. diff, to change the metabolic environment in the gut so C. diff can thrive, Science Daily reported Nov. 16.

The bacterium Clostridioides difficile tends to “cooperate” with microorganisms in the gastrointestinal tract, such as the pathogen Enterococcus, which can help the bacterium thrive, according to a study published in Nature.

Probiotic supplementation can help to mitigate the pathogenesis of irritable bowel syndrome (IBS) by reinforcing the intestinal barrier, and reducing both inflammation and proteolytic activity. Here, a combination of in vitro tests was performed on 33 Bifidobacterium strains as probiotic candidates …

Clostridioides difficile infection (CDI) is a gastro-intestinal (GI) infection that illustrates how perturbations in symbiotic host-microbiome interactions render the GI tract vulnerable to the opportunistic pathogens. CDI also serves as an example of how such perturbations could be reversed via gut …

Enteric pathogens are exposed to a dynamic polymicrobial environment in the gastrointestinal tract1. This microbial community has been shown to be important during infection, but there are few examples illustrating how microbial interactions can influence the virulence of invading pathoge …

Nature Metabolism - Diener and Dai et al. analyse blood metabolites from 1,569 individuals and identify metabolites associated with the microbiome, host genetics or under hybrid...

/PRNewswire/ -- Clostridioides difficile, often referred to as C. difficile or C. diff, is a bacterium that causes severe intestinal illness and, as its name...

Nature - Enterococci enhance the fitness and pathogenesis of Clostridioides difficile in the gut by altering the amino acid composition and providing signals that increase its virulence towards the...

Clostridioides difficile, often referred to as C. difficile or C. diff, is a bacterium that causes severe intestinal illness and, as its name suggests, can be difficult to study and treat.

Researchers have found that Enterococcus -- an antibiotic-resistant, opportunistic pathogen -- works together with C. difficile, reshaping and enhancing the metabolic environment in the gut so that C. difficile can thrive.

In recent years, both postpartum women and healthy adults have seen increased risk for CDI. #cdiff #cdiffawarenessmonth #seecdiff #seecdiffclearly— Peggy Lillis Fund (@PeggyFund) November 9, 2022

Nature Communications - Toxin B (TcdB) is a major exotoxin responsible for diseases associated with C. difficile infection. Here, Tian et al. show that several TcdB subtypes do not recognize the...

Clostridioides (Clostridium) difficile is a well-known cause of enteritis and antibiotic-associated diarrhea. Extraintestinal C. difficile infection is uncommon, with most extraintestinal infections involving the intra-abdominal cavity and anatomic structures adjacent to the colon. Emp …

Clostridioides difficile infection (CDI) is responsible for an increasing number of cases of post-antibiotic diarrhea worldwide, which has high severity and mortality among hospitalized elderly patients. The disruption of gut microbiota due to antibacterial medication facilitates the intestin …

Toxin B (TcdB) is a major exotoxin responsible for diseases associated with Clostridioides difficile infection. Its sequence variations among clinical isolates may contribute to the difficulty in developing effective therapeutics. Here, we investigate receptor-binding specificity of major TcdB subty …

Just one month before friends and families gather around the Christmas table, November is here to bring awareness around Clostridioides difficile infection, and the importance of microbiota-derived treatments

Emerging technologies are in the pipeline for better exploring the microbiome. @nsegata et al. have developed a computational pipeline that was used to interrogate a massively expanded dataset of metagenome and virome assemblies https://t.co/KlczhHSdSD— GutMicrobiota Health (@GMFHx) November 11, 2022

A two-plasmid mutagenesis system for Clostridioides difficile is described that improves ease of use and efficiency in creating site-directed mutations. pJB06 contains a xylose-inducible cas9 gene, while the second plasmid (pJB07) encodes the corresponding guide RNA (gRNA) and regions of homo …

ISME Communications - Predicting the re‐distribution of antibiotic molecules caused by inter‐species interactions in microbial communities

Among patients with CDI, CRE coinfections were associated with prolonged hospitalization for CDI. Age was an independent risk factor for CRE coinfection among patients with CDI.

Clostridioides (Clostridium) difficile is a well-known cause of enteritis and antibiotic-associated diarrhea. Extraintestinal C. difficile infection is uncommon, with most extraintestinal infections involving the intra-abdominal cavity and anatomic structures adjacent to the colon. Emp …

Nature Microbiology - Metagenomics and metabolomics analysis of a longitudinal cohort of 123 very preterm infants reveals multiple drivers of gut microbiome development and indicates that there are...

Nature Communications - Here, the authors show that SARS-CoV-2 infection causes gut microbiome dysbiosis and gut epithelial cell alterations in a mouse model, and correlate dysbiosis observed in...