C Diff Molecular

Elevated MICs to antibiotics used for treatment of C. difficile infection were rare and there was no increase in MICs over time. The lack of vanA/B genes or mutations consistently associated with elevated vancomycin MICs suggests there are multifactorial mechanisms of resistance. Ongoing surveillanc …

Despite brain physiological functions or pathological dysfunctions relying on the activity of neuronal/non-neuronal populations, over the last decades a plethora of evidence unraveled the essential contribution of the microbial populations living and residing within the gut, called gut microbiota. T …

Selected findings about Clostridioides difficile (formerly Clostridium difficile) toxins are presented in a narrative review. Starting with a personal view on research about G proteins, adenylyl cyclase, and ADP-ribosylating toxins in the laboratory of Günter Schultz in Heidelberg, milestones of C. …

Nature Reviews Genetics - Microbiome epidemiology associates microbial community features with health outcomes, traits or exposures in human host populations. In this Review, the authors discuss...

On episode 002 of the Inside Matters Podcast, I speak with Dr Ben Mullish about DIY #FMT and how the field has evolved. We also discuss some super interesting new research that links the #gut #microbiome to #cancer. Tune in tomorrow to hear more: https://t.co/MOognlRkYS pic.twitter.com/2OaKgSf8jb— drjamesmcilroy (@drjamesmcilroy) October 5, 2022

The human body plays host to hundreds of diverse species of microbial life that have an enormous impact on human health and longevity. These microscopic organisms make up the human microbiome, and each person’s community of microbes is unique. Healthy bodies have a beneficial balance of “good” and “bad” bacteria, called symbiosis. But ...

The glmS ribozyme regulates the expression of the essential GlmS enzyme being involved in cell wall biosynthesis. While 450 variants of the glmS ribozyme were identified by in silico approaches and homology searches, only a few have yet been experimentally investigated. Herein, we validate and …

Toxic Megacolon Due to Fulminant Clostridioides difficile Infection

Proteins seem to have an important role in the biofilm's initial adherence and maturation. slpA and cwp84 are differentially expressed by C. difficile ribotype and biofilm production level.

A gastroenterologist reviews long-term impact of dysbiosis and C. difficile infection (CDI).

When bacteria retain the crystal violet dye during the Gram stain test, they are called Gram-positive bacteria. Learn more here.

Researchers assessed the role of gut bacterial microbiome assembly and the gut mycobiome in relation to health, pathology, and clinical applications.

Scientific Reports - Clostridium difficile flagella induce a pro-inflammatory response in intestinal epithelium of mice in cooperation with toxins

In January 2020, J. Thomas Lamont, M.D. gave a grand rounds presentation. He was looking back at Major Advances in Gastroenterology & Hepatology from 1965 to the present.

Nature Reviews Microbiology - In this Review, Rogers, Mileto and Lyras explore the impact of enteric bacterial infections at and beyond the epithelial barrier. They highlight how different...

Profile of Secondary Bacterial and Fungal Infections in Hospitalized COVID-19 Patients in a Tertiary Care Centre

Herein we gathered updated knowledge regarding the alterations of gut microbiota (dysbiosis) and its correlation with human neurodegenerative and brain-related diseases, e.g., Alzheimer’s and Parkinson’s. This review underlines the importance of gut-derived metabolites and gut metabolic status as the main players in gut-brain crosstalk and their implications on the severity of neural conditions. Scientific evidence indicates that the administration of probiotic bacteria exerts beneficial and protective effects as reduced systemic inflammation, neuroinflammation, and inhibited neurodegeneration. The experimental results performed on animals, but also human clinical trials, show the importance of designing a novel microbiota-based probiotic dietary supplementation with the aim to prevent or ease the symptoms of Alzheimer’s and Parkinson’s diseases or other forms of dementia or neurodegeneration.

Session 6 // featured five brilliant ECR and MCR talks on antibiotic resistance and novel approaches to combat MDR infections #AMR #acinetobacterbaumannii #Cdiff #staphylococcus #chryseobacterium by @DrDe_Oliveira; Yogi Srikhanta @LyrasLab; Winton Wu; @JhihHang & @ann_hahahah pic.twitter.com/inX2YT08ZH— BacPath 16 (@BacPath) September 29, 2022

The sliding DNA clamp is a ring-shaped protein that encircles DNA within its central channel. It binds to multiple proteins, such as DNA polymerases and DNA repair enzymes, and stimulates their enzymatic activities, thereby playing a crucial role in cell survival and proliferation. Accordingly, the …

The gut microbiome has been referred to as the "forgotten organ." Although much about the gut microbiome remains incompletely understood, data on its clinical importance is emerging at rapid speed. Many practicing clinicians may be unaware of the essential role that the microbiome plays in both heal …

The sliding DNA clamp is a ring-shaped protein that encircles DNA within its central channel. It binds to multiple proteins, such as DNA polymerases and DNA repair enzymes, and stimulates their enzymatic activities, thereby playing a crucial role in cell survival and proliferation. Accordingly, the …

Our findings demonstrated that TcdA induced the upregulation of the P2X7 receptor, which promoted enteric neuron loss, S100B synthesis, tissue damage, inflammation, and cell death in the mouse ileum. These findings contribute to the future directions in understanding the mechanism involved in intest …

Clostridioides difficile infection (CDI) creates an imbalance in the intestinal microbiota due to the interaction of the components making up this ecosystem, but little is known about the impact of this disease on other microbial members. This work has thus been aimed at evaluating the taxonomic com …

2/Hazan: #Dysbiosis is an imbalance in the microbiome. #CDiff is a basic model of dysbiosis. #ILADS2022 pic.twitter.com/RCu33S0jL5— ILADS/International Lyme & Assoc. Diseases Society (@ilads_lyme) September 24, 2022

We conducted a retrospective review of the infectious complications and outcomes over a 2-year follow-up period of adult patients who received a second allogeneic hematopoietic cell transplant (2nd allo-HCT) during a five-year period at two cancer centers in Michigan. Sixty patients, of whom 44 (73% …

Clostridioides difficile colonization and development of infection commonly occur in inflammatory bowel disease (IBD) patients and can trigger flare-ups. Both conditions are inherently linked to disrupted gut microbiota. This study included 149 hospitalized gastrointestinal patients, which we …

Clostridioides difficile colonization and development of infection commonly occur in inflammatory bowel disease (IBD) patients and can trigger flare-ups. Both conditions are inherently linked to disrupted gut microbiota. This study included 149 hospitalized gastrointestinal patients, which we …

Prevalence and trends of Clostridioides difficile infection among persons requiring maintenance hemodialysis: A systematic review and meta-analysis

Clostridioides difficile infection (CDI) has a higher incidence in solid organ transplant recipients than other hospitalized patients and can lead to poor outcomes. Perturbations to the intestinal microbiome are common in patients undergoing liver transplant (LT); however, the impacts of microbial d …