C Diff Molecular

C Diff Molecular

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Nutrients | Free Full-Text | Does the Gut Microbial Metabolome Really Matter? The Connection between GUT Metabolome and Neurological Disorders
Nutrients | Free Full-Text | Does the Gut Microbial Metabolome Really Matter? The Connection between GUT Metabolome and Neurological Disorders
Herein we gathered updated knowledge regarding the alterations of gut microbiota (dysbiosis) and its correlation with human neurodegenerative and brain-related diseases, e.g., Alzheimer’s and Parkinson’s. This review underlines the importance of gut-derived metabolites and gut metabolic status as the main players in gut-brain crosstalk and their implications on the severity of neural conditions. Scientific evidence indicates that the administration of probiotic bacteria exerts beneficial and protective effects as reduced systemic inflammation, neuroinflammation, and inhibited neurodegeneration. The experimental results performed on animals, but also human clinical trials, show the importance of designing a novel microbiota-based probiotic dietary supplementation with the aim to prevent or ease the symptoms of Alzheimer’s and Parkinson’s diseases or other forms of dementia or neurodegeneration.
·mdpi.com·
Nutrients | Free Full-Text | Does the Gut Microbial Metabolome Really Matter? The Connection between GUT Metabolome and Neurological Disorders
RT @BacPath: Session 6 // featured five brilliant ECR and MCR talks on antibiotic resistance and novel approaches to combat MDR infections…
RT @BacPath: Session 6 // featured five brilliant ECR and MCR talks on antibiotic resistance and novel approaches to combat MDR infections…
Session 6 // featured five brilliant ECR and MCR talks on antibiotic resistance and novel approaches to combat MDR infections #AMR #acinetobacterbaumannii #Cdiff #staphylococcus #chryseobacterium by @DrDe_Oliveira; Yogi Srikhanta @LyrasLab; Winton Wu; @JhihHang & @ann_hahahah pic.twitter.com/inX2YT08ZH— BacPath 16 (@BacPath) September 29, 2022
·twitter.com·
RT @BacPath: Session 6 // featured five brilliant ECR and MCR talks on antibiotic resistance and novel approaches to combat MDR infections…
Crystal structure of the sliding DNA clamp from the Gram-positive anaerobic bacterium Clostridioides difficile - PubMed
Crystal structure of the sliding DNA clamp from the Gram-positive anaerobic bacterium Clostridioides difficile - PubMed
The sliding DNA clamp is a ring-shaped protein that encircles DNA within its central channel. It binds to multiple proteins, such as DNA polymerases and DNA repair enzymes, and stimulates their enzymatic activities, thereby playing a crucial role in cell survival and proliferation. Accordingly, the …
·pubmed.ncbi.nlm.nih.gov·
Crystal structure of the sliding DNA clamp from the Gram-positive anaerobic bacterium Clostridioides difficile - PubMed
Gut Microbiome Health and Dysbiosis: A Clinical Primer - PubMed
Gut Microbiome Health and Dysbiosis: A Clinical Primer - PubMed
The gut microbiome has been referred to as the "forgotten organ." Although much about the gut microbiome remains incompletely understood, data on its clinical importance is emerging at rapid speed. Many practicing clinicians may be unaware of the essential role that the microbiome plays in both heal …
·pubmed.ncbi.nlm.nih.gov·
Gut Microbiome Health and Dysbiosis: A Clinical Primer - PubMed
Crystal structure of the sliding DNA clamp from the Gram-positive anaerobic bacterium Clostridioides difficile
Crystal structure of the sliding DNA clamp from the Gram-positive anaerobic bacterium Clostridioides difficile
The sliding DNA clamp is a ring-shaped protein that encircles DNA within its central channel. It binds to multiple proteins, such as DNA polymerases and DNA repair enzymes, and stimulates their enzymatic activities, thereby playing a crucial role in cell survival and proliferation. Accordingly, the …
·pubmed.ncbi.nlm.nih.gov·
Crystal structure of the sliding DNA clamp from the Gram-positive anaerobic bacterium Clostridioides difficile
P2X7 receptor blockade decreases inflammation, apoptosis, and enteric neuron loss during Clostridioides difficile toxin A-induced ileitis in mice - PubMed
P2X7 receptor blockade decreases inflammation, apoptosis, and enteric neuron loss during Clostridioides difficile toxin A-induced ileitis in mice - PubMed
Our findings demonstrated that TcdA induced the upregulation of the P2X7 receptor, which promoted enteric neuron loss, S100B synthesis, tissue damage, inflammation, and cell death in the mouse ileum. These findings contribute to the future directions in understanding the mechanism involved in intest …
·pubmed.ncbi.nlm.nih.gov·
P2X7 receptor blockade decreases inflammation, apoptosis, and enteric neuron loss during Clostridioides difficile toxin A-induced ileitis in mice - PubMed
Microbial Interdomain Interactions Delineate the Disruptive Intestinal Homeostasis in Clostridioides difficile Infection
Microbial Interdomain Interactions Delineate the Disruptive Intestinal Homeostasis in Clostridioides difficile Infection
Clostridioides difficile infection (CDI) creates an imbalance in the intestinal microbiota due to the interaction of the components making up this ecosystem, but little is known about the impact of this disease on other microbial members. This work has thus been aimed at evaluating the taxonomic com …
·pubmed.ncbi.nlm.nih.gov·
Microbial Interdomain Interactions Delineate the Disruptive Intestinal Homeostasis in Clostridioides difficile Infection
RT @ilads_lyme: 2/Hazan: #Dysbiosis is an imbalance in the microbiome. #CDiff is a basic model of dysbiosis. #ILADS2022 https://t.co/RCu33S…
RT @ilads_lyme: 2/Hazan: #Dysbiosis is an imbalance in the microbiome. #CDiff is a basic model of dysbiosis. #ILADS2022 https://t.co/RCu33S…
2/Hazan: #Dysbiosis is an imbalance in the microbiome. #CDiff is a basic model of dysbiosis. #ILADS2022 pic.twitter.com/RCu33S0jL5— ILADS/International Lyme & Assoc. Diseases Society (@ilads_lyme) September 24, 2022
·twitter.com·
RT @ilads_lyme: 2/Hazan: #Dysbiosis is an imbalance in the microbiome. #CDiff is a basic model of dysbiosis. #ILADS2022 https://t.co/RCu33S…
Infectious complications after second allogeneic hematopoietic cell transplant in adult patients with hematological malignancies
Infectious complications after second allogeneic hematopoietic cell transplant in adult patients with hematological malignancies
We conducted a retrospective review of the infectious complications and outcomes over a 2-year follow-up period of adult patients who received a second allogeneic hematopoietic cell transplant (2nd allo-HCT) during a five-year period at two cancer centers in Michigan. Sixty patients, of whom 44 (73% …
·pubmed.ncbi.nlm.nih.gov·
Infectious complications after second allogeneic hematopoietic cell transplant in adult patients with hematological malignancies
Gut community alterations associated with Clostridioides difficile colonization in hospitalized gastroenterological patients with or without inflammatory bowel disease
Gut community alterations associated with Clostridioides difficile colonization in hospitalized gastroenterological patients with or without inflammatory bowel disease
Clostridioides difficile colonization and development of infection commonly occur in inflammatory bowel disease (IBD) patients and can trigger flare-ups. Both conditions are inherently linked to disrupted gut microbiota. This study included 149 hospitalized gastrointestinal patients, which we …
·pubmed.ncbi.nlm.nih.gov·
Gut community alterations associated with Clostridioides difficile colonization in hospitalized gastroenterological patients with or without inflammatory bowel disease
Gut community alterations associated with Clostridioides difficile colonization in hospitalized gastroenterological patients with or without inflammatory bowel disease - PubMed
Gut community alterations associated with Clostridioides difficile colonization in hospitalized gastroenterological patients with or without inflammatory bowel disease - PubMed
Clostridioides difficile colonization and development of infection commonly occur in inflammatory bowel disease (IBD) patients and can trigger flare-ups. Both conditions are inherently linked to disrupted gut microbiota. This study included 149 hospitalized gastrointestinal patients, which we …
·pubmed.ncbi.nlm.nih.gov·
Gut community alterations associated with Clostridioides difficile colonization in hospitalized gastroenterological patients with or without inflammatory bowel disease - PubMed
Prevalence and trends of Clostridioides difficile infection among persons requiring maintenance hemodialysis: A systematic review and meta-analysis | Infection Control & Hospital Epidemiology | Cambridge Core
Prevalence and trends of Clostridioides difficile infection among persons requiring maintenance hemodialysis: A systematic review and meta-analysis | Infection Control & Hospital Epidemiology | Cambridge Core
Prevalence and trends of Clostridioides difficile infection among persons requiring maintenance hemodialysis: A systematic review and meta-analysis
·cambridge.org·
Prevalence and trends of Clostridioides difficile infection among persons requiring maintenance hemodialysis: A systematic review and meta-analysis | Infection Control & Hospital Epidemiology | Cambridge Core
Intestinal Dysbiosis and Risk of Posttransplant Clostridioides difficile Infection in a Longitudinal Cohort of Liver Transplant Recipients
Intestinal Dysbiosis and Risk of Posttransplant Clostridioides difficile Infection in a Longitudinal Cohort of Liver Transplant Recipients
Clostridioides difficile infection (CDI) has a higher incidence in solid organ transplant recipients than other hospitalized patients and can lead to poor outcomes. Perturbations to the intestinal microbiome are common in patients undergoing liver transplant (LT); however, the impacts of microbial d …
·pubmed.ncbi.nlm.nih.gov·
Intestinal Dysbiosis and Risk of Posttransplant Clostridioides difficile Infection in a Longitudinal Cohort of Liver Transplant Recipients
Toxins | Free Full-Text | Gut Non-Bacterial Microbiota: Emerging Link to Irritable Bowel Syndrome | HTML
Toxins | Free Full-Text | Gut Non-Bacterial Microbiota: Emerging Link to Irritable Bowel Syndrome | HTML
As a common functional gastrointestinal disorder, irritable bowel syndrome (IBS) significantly affects personal health and imposes a substantial economic burden on society, but the current understanding of its occurrence and treatment is still inadequate. Emerging evidence suggests that IBS is associated with gut microbial dysbiosis, but most studies focus on the bacteria and neglect other communities of the microbiota, including fungi, viruses, archaea, and other parasitic microorganisms. This review summarizes the latest findings that link the nonbacterial microbiota with IBS. IBS patients show less fungal and viral diversity but some alterations in mycobiome, virome, and archaeome, such as an increased abundance of Candida albicans. Moreover, fungi and methanogens can aid in diagnosis. Fungi are related to distinct IBS symptoms and induce immune responses, intestinal barrier disruption, and visceral hypersensitivity via specific receptors, cells, and metabolites. Novel therapeutic methods for IBS include fungicides, inhibitors targeting fungal pathogenic pathways, probiotic fungi, prebiotics, and fecal microbiota transplantation. Additionally, viruses, methanogens, and parasitic microorganisms are also involved in the pathophysiology and treatment. Therefore, the gut nonbacterial microbiota is involved in the pathogenesis of IBS, which provides a novel perspective on the noninvasive diagnosis and precise treatment of this disease.
·mdpi.com·
Toxins | Free Full-Text | Gut Non-Bacterial Microbiota: Emerging Link to Irritable Bowel Syndrome | HTML
Investigation of metabolic crosstalk between host and pathogenic Clostridioides difficile via multiomics approaches - PubMed
Investigation of metabolic crosstalk between host and pathogenic Clostridioides difficile via multiomics approaches - PubMed
Clostridioides difficile is a gram-positive anaerobic bacterium that causes antibiotic-associated infections in the gut. C. difficile infection develops in the intestine of a host with an imbalance of the intestinal microbiota and, in severe cases, can lead to toxic megacolon, intestin …
·pubmed.ncbi.nlm.nih.gov·
Investigation of metabolic crosstalk between host and pathogenic Clostridioides difficile via multiomics approaches - PubMed
GutMicrobiota Health on Twitter
GutMicrobiota Health on Twitter
We're happy to organize together with @esnm_eu this new webinar on the management of recurrence of Clostridioides difficile infection.🗣 Daniel Pohl, Steven Johnson & Tariq Iqbal.👉 Join us on 12th October: https://t.co/r1Bf5MuTOk pic.twitter.com/Wzx1RrZX4T— GutMicrobiota Health (@GMFHx) September 15, 2022
·twitter.com·
GutMicrobiota Health on Twitter
Antibiotic resistance and genomic features of Clostridioides difficile in southwest China - PubMed
Antibiotic resistance and genomic features of Clostridioides difficile in southwest China - PubMed
Most of the C. difficile isolates in this study were resistant to macrolide and aminoglycoside antibiotics. Moreover, the MDR strains were commonly found. All the isolates belonged to clade 1 and clade 4 according to phylogenetic analysis of bacterial genome, and highly genomic diversity of c …
·pubmed.ncbi.nlm.nih.gov·
Antibiotic resistance and genomic features of Clostridioides difficile in southwest China - PubMed
Clostridiumnovyi's Alpha-Toxin Changes Proteome and Phosphoproteome of HEp-2 Cells
Clostridiumnovyi's Alpha-Toxin Changes Proteome and Phosphoproteome of HEp-2 Cells
C. novyi type A produces the alpha-toxin (TcnA) that belongs to the large clostridial glucosylating toxins (LCGTs) and is able to modify small GTPases by N-acetylglucosamination on conserved threonine residues. In contrast, other LCGTs including Clostridioides difficile toxin A and tox …
·pubmed.ncbi.nlm.nih.gov·
Clostridiumnovyi's Alpha-Toxin Changes Proteome and Phosphoproteome of HEp-2 Cells
Comparison of the Risk of Recurrent Clostridioides Difficile Infections Among Patients in 2018 Versus 2013 - PubMed
Comparison of the Risk of Recurrent Clostridioides Difficile Infections Among Patients in 2018 Versus 2013 - PubMed
Among persons with an initial Clostridioides difficile infection (CDI) across 10 US sites in 2018 compared with 2013, 18.3% versus 21.1% had ≥1 recurrent CDI (rCDI) within 180 days. We observed a 16% lower adjusted risk of rCDI in 2018 versus 2013 (P .0001).
·pubmed.ncbi.nlm.nih.gov·
Comparison of the Risk of Recurrent Clostridioides Difficile Infections Among Patients in 2018 Versus 2013 - PubMed
Role of Pannexin-1-P2X7R signaling on cell death and pro-inflammatory mediator expression induced by Clostridioides difficile toxins in enteric glia - PubMed
Role of Pannexin-1-P2X7R signaling on cell death and pro-inflammatory mediator expression induced by Clostridioides difficile toxins in enteric glia - PubMed
Clostridioides difficile (C. difficile) produces toxins A (TcdA) and B (TcdB), both associated with intestinal damage and diarrhea. Pannexin-1 (Panx1) channels allows the passage of messenger molecules, such as adenosine triphosphate (ATP), which in turn activate the P2X7 receptors (P2 …
·pubmed.ncbi.nlm.nih.gov·
Role of Pannexin-1-P2X7R signaling on cell death and pro-inflammatory mediator expression induced by Clostridioides difficile toxins in enteric glia - PubMed
Impact of Clostridioides difficile infection in patients admitted with ulcerative colitis - PubMed
Impact of Clostridioides difficile infection in patients admitted with ulcerative colitis - PubMed
CDI is a prevalent situation in hospitalised UC patients related to higher mortality within the first 3 months after the infection, need for therapy intensification within the first year and readmission. Our results underline the importance of CDI detection in patients with a flare of UC.
·pubmed.ncbi.nlm.nih.gov·
Impact of Clostridioides difficile infection in patients admitted with ulcerative colitis - PubMed