C Diff Molecular

Nature Reviews Microbiology - The gut microbiota metabolizes bile acids, thereby influencing human health and diseases including obesity, colitis and cancer. In this Review, Patterson and...

Gut BA metabolism dynamics differ in primary CDI patients between those developing recurrence and those who do not. Individual BAs show promise as potential novel biomarkers to predict CDI recurrence.

Clostridioides difficile is the leading cause of post-antibiotic diarrhrea in adults. During infection, the bacterium must rapidly adapt to the host environment by using survival strategies. Protein phosphorylation is a reversible post-translational modification employed ubiquitously for signal tran …

Nature Communications - Binary toxin translocation system consists of an enzymatic subunit and translocation pore. Here, the authors report the high-resolution cryo-EM structure of Clostridioides...

Monique BrouilletteA flurry of microbiome research over the past two decades has led to many insights about the link between the microbes and health, but now the race to the clinic is on.

This article summarizes major highlights on diet and gut microbiome interactions of relevance for irritable bowel syndrome.

Accumulating evidence indicates that gut transit time is a key factor in shaping the gut microbiota composition and activity, which are linked to human health. Both population-wide and small-scale studies have identified transit time as a top covariate contributing to the large interindividual variation in the faecal microbiota composition. Despite this, transit time is still rarely being considered in the field of the human gut microbiome. Here, we review the latest research describing how and why whole gut and segmental transit times vary substantially between and within individuals, and how variations in gut transit time impact the gut microbiota composition, diversity and metabolism. Furthermore, we discuss the mechanisms by which the gut microbiota may causally affect gut motility. We argue that by taking into account the interindividual and intraindividual differences in gut transit time, we can advance our understanding of diet–microbiota interactions and disease-related microbiome signatures, since these may often be confounded by transient or persistent alterations in transit time. Altogether, a better understanding of the complex, bidirectional interactions between the gut microbiota and transit time is required to better understand gut microbiome variations in health and disease.

Iqbal: Severe C. difficile infection is defined by high white blood cell count, increased serum creatinine, pyrexia and radiological evidence of severe colitis and leaky gut @esnm_eu #GMFHCoverage pic.twitter.com/5cVc1Duih9— GutMicrobiota Health (@GMFHx) October 12, 2022

C. difficile Patient Journey C. difficile infection (CDI) occurs when Clostridioides difficile bacteria grow out of control in the digestive tract. The bacteria and their spores are resistant to many common cleaning methods so they can transfer easily between surfaces if people do not wash their hands adequately

Registration for the FENS Friday webinar on “The microbiome, immunity, and neurodevelopment trialogue: from womb to adulthood” is now open. The microbiome topic has emerged as a field of great…

Fecal microbiota transplantation (FMT) has shown promising results in animal models of obesity, while results in human studies are inconsistent. We ai…

Despite brain physiological functions or pathological dysfunctions relying on the activity of neuronal/non-neuronal populations, over the last decades a plethora of evidence unraveled the essential contribution of the microbial populations living and residing within the gut, called gut microbiota. T …

Selected findings about Clostridioides difficile (formerly Clostridium difficile) toxins are presented in a narrative review. Starting with a personal view on research about G proteins, adenylyl cyclase, and ADP-ribosylating toxins in the laboratory of Günter Schultz in Heidelberg, milestones of C. …

Elevated MICs to antibiotics used for treatment of C. difficile infection were rare and there was no increase in MICs over time. The lack of vanA/B genes or mutations consistently associated with elevated vancomycin MICs suggests there are multifactorial mechanisms of resistance. Ongoing surveillanc …

Despite brain physiological functions or pathological dysfunctions relying on the activity of neuronal/non-neuronal populations, over the last decades a plethora of evidence unraveled the essential contribution of the microbial populations living and residing within the gut, called gut microbiota. T …

Selected findings about Clostridioides difficile (formerly Clostridium difficile) toxins are presented in a narrative review. Starting with a personal view on research about G proteins, adenylyl cyclase, and ADP-ribosylating toxins in the laboratory of Günter Schultz in Heidelberg, milestones of C. …

Nature Reviews Genetics - Microbiome epidemiology associates microbial community features with health outcomes, traits or exposures in human host populations. In this Review, the authors discuss...

On episode 002 of the Inside Matters Podcast, I speak with Dr Ben Mullish about DIY #FMT and how the field has evolved. We also discuss some super interesting new research that links the #gut #microbiome to #cancer. Tune in tomorrow to hear more: https://t.co/MOognlRkYS pic.twitter.com/2OaKgSf8jb— drjamesmcilroy (@drjamesmcilroy) October 5, 2022

The human body plays host to hundreds of diverse species of microbial life that have an enormous impact on human health and longevity. These microscopic organisms make up the human microbiome, and each person’s community of microbes is unique. Healthy bodies have a beneficial balance of “good” and “bad” bacteria, called symbiosis. But ...

The glmS ribozyme regulates the expression of the essential GlmS enzyme being involved in cell wall biosynthesis. While 450 variants of the glmS ribozyme were identified by in silico approaches and homology searches, only a few have yet been experimentally investigated. Herein, we validate and …

Toxic Megacolon Due to Fulminant Clostridioides difficile Infection

Proteins seem to have an important role in the biofilm's initial adherence and maturation. slpA and cwp84 are differentially expressed by C. difficile ribotype and biofilm production level.

A gastroenterologist reviews long-term impact of dysbiosis and C. difficile infection (CDI).

When bacteria retain the crystal violet dye during the Gram stain test, they are called Gram-positive bacteria. Learn more here.

Researchers assessed the role of gut bacterial microbiome assembly and the gut mycobiome in relation to health, pathology, and clinical applications.

Scientific Reports - Clostridium difficile flagella induce a pro-inflammatory response in intestinal epithelium of mice in cooperation with toxins

In January 2020, J. Thomas Lamont, M.D. gave a grand rounds presentation. He was looking back at Major Advances in Gastroenterology & Hepatology from 1965 to the present.

Nature Reviews Microbiology - In this Review, Rogers, Mileto and Lyras explore the impact of enteric bacterial infections at and beyond the epithelial barrier. They highlight how different...

Profile of Secondary Bacterial and Fungal Infections in Hospitalized COVID-19 Patients in a Tertiary Care Centre

Herein we gathered updated knowledge regarding the alterations of gut microbiota (dysbiosis) and its correlation with human neurodegenerative and brain-related diseases, e.g., Alzheimer’s and Parkinson’s. This review underlines the importance of gut-derived metabolites and gut metabolic status as the main players in gut-brain crosstalk and their implications on the severity of neural conditions. Scientific evidence indicates that the administration of probiotic bacteria exerts beneficial and protective effects as reduced systemic inflammation, neuroinflammation, and inhibited neurodegeneration. The experimental results performed on animals, but also human clinical trials, show the importance of designing a novel microbiota-based probiotic dietary supplementation with the aim to prevent or ease the symptoms of Alzheimer’s and Parkinson’s diseases or other forms of dementia or neurodegeneration.