C Diff Molecular

C Diff Molecular

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Impact of environmental conditions and gut microbiota on the in vitro germination and growth of Clostridioides difficile
Impact of environmental conditions and gut microbiota on the in vitro germination and growth of Clostridioides difficile
Clostridioides difficile is a spore-forming anaerobic Gram-positive bacterium responsible for a broad spectrum of intestinal symptoms and healthcare associated diarrhoea. The hypothesis of this work was that different in vitro conditions, notably pH and human faecal microbiota composition impact the …
·pubmed.ncbi.nlm.nih.gov·
Impact of environmental conditions and gut microbiota on the in vitro germination and growth of Clostridioides difficile
Impact of environmental conditions and gut microbiota on the in vitro germination and growth of Clostridioides difficile
Impact of environmental conditions and gut microbiota on the in vitro germination and growth of Clostridioides difficile
Clostridioides difficile is a spore-forming anaerobic Gram-positive bacterium responsible for a broad spectrum of intestinal symptoms and healthcare associated diarrhoea. The hypothesis of this work was that different in vitro conditions, notably pH and human faecal microbiota composition impact the …
·pubmed.ncbi.nlm.nih.gov·
Impact of environmental conditions and gut microbiota on the in vitro germination and growth of Clostridioides difficile
Recognition of extracellular DNA by type IV pili promotes biofilm formation by Clostridioides difficile - PubMed
Recognition of extracellular DNA by type IV pili promotes biofilm formation by Clostridioides difficile - PubMed
Clostridioides difficile is a Gram-positive bacillus, which is a frequent cause of gastrointestinal infections triggered by the depletion of the gut microbiome. Because of the frequent recurrence of these infections after antibiotic treatment, mechanisms of C. difficile persistence and recurrence, i …
·pubmed.ncbi.nlm.nih.gov·
Recognition of extracellular DNA by type IV pili promotes biofilm formation by Clostridioides difficile - PubMed
Plakoglobin and High-Mobility Group Box 1 Mediate Intestinal Epithelial Cell Apoptosis Induced by Clostridioides difficile TcdB - PubMed
Plakoglobin and High-Mobility Group Box 1 Mediate Intestinal Epithelial Cell Apoptosis Induced by Clostridioides difficile TcdB - PubMed
Clostridioides difficile infection (CDI) is the leading cause of antibiotic-associated intestinal disease, resulting in severe diarrhea and fatal pseudomembranous colitis. TcdB, one of the essential virulence factors secreted by this bacterium, induces host cell apoptosis through a poorly understood …
·pubmed.ncbi.nlm.nih.gov·
Plakoglobin and High-Mobility Group Box 1 Mediate Intestinal Epithelial Cell Apoptosis Induced by Clostridioides difficile TcdB - PubMed
Clostridioides difficile toxin is infrequently detected in inflammatory bowel disease and does not associate with clinical outcomes - PubMed
Clostridioides difficile toxin is infrequently detected in inflammatory bowel disease and does not associate with clinical outcomes - PubMed
When compared to those without IBD, patients with IBD have a reduced proportion of cases of C. difficile with toxin positivity. Differences in clinical outcomes among patients with IBD were not detected and limited by the infrequent detection of expressed toxin.
·pubmed.ncbi.nlm.nih.gov·
Clostridioides difficile toxin is infrequently detected in inflammatory bowel disease and does not associate with clinical outcomes - PubMed
Clostridioides difficile TcdB Toxin Glucosylates Rho GTPase by an S Ni Mechanism and Ion Pair Transition State - PubMed
Clostridioides difficile TcdB Toxin Glucosylates Rho GTPase by an S Ni Mechanism and Ion Pair Transition State - PubMed
Toxins TcdA and TcdB from Clostridioides difficile glucosylate human colon Rho GTPases. TcdA and TcdB glucosylation of RhoGTPases results in cytoskeletal changes, causing cell rounding and loss of intestinal integrity. Clostridial toxins TcdA and TcdB are proposed to catalyze glucosylation of …
·pubmed.ncbi.nlm.nih.gov·
Clostridioides difficile TcdB Toxin Glucosylates Rho GTPase by an S Ni Mechanism and Ion Pair Transition State - PubMed
In Silico Characterization of Uncharacterized Proteins From Multiple Strains of Clostridium Difficile
In Silico Characterization of Uncharacterized Proteins From Multiple Strains of Clostridium Difficile
Clostridium difficile (C. difficile) is a multi-strain, spore-forming, Gram-positive, opportunistic enteropathogen bacteria, majorly associated with nosocomial infections, resulting in severe diarrhoea and colon inflammation. Several antibiotics including penicillin, tetracycline, and …
·pubmed.ncbi.nlm.nih.gov·
In Silico Characterization of Uncharacterized Proteins From Multiple Strains of Clostridium Difficile
Clostridioides difficile spore: coat assembly and formation
Clostridioides difficile spore: coat assembly and formation
Clostridioides difficile (C. difficile) is a Gram-positive, spore-forming, toxin-producing, obligate anaerobic bacterium. C. difficile infection (CDI) is the leading cause of health-care-associated infective diarrhea. The infection is mediated by the spore, a metabolically inact …
·pubmed.ncbi.nlm.nih.gov·
Clostridioides difficile spore: coat assembly and formation
Human Colon Cancer–Derived Clostridioides difficile Strains Drive Colonic Tumorigenesis in Mice | Cancer Discovery | American Association for Cancer Research
Human Colon Cancer–Derived Clostridioides difficile Strains Drive Colonic Tumorigenesis in Mice | Cancer Discovery | American Association for Cancer Research
The patient-derived Clostridioides difficile bacterial strain was found to drive colon tumorigenesis through its toxin TcdB, which induced Wnt signaling and a protumorigenic mucosal immune response.
·aacrjournals.org·
Human Colon Cancer–Derived Clostridioides difficile Strains Drive Colonic Tumorigenesis in Mice | Cancer Discovery | American Association for Cancer Research
Antibiotic Resistance Profile of RT 027/176 Versus Other Clostridioides difficile Isolates in Silesia, Southern Poland
Antibiotic Resistance Profile of RT 027/176 Versus Other Clostridioides difficile Isolates in Silesia, Southern Poland
Clostridioides difficile is an important health care-associated pathogen. The aim of this study was to analyze the antibiotic susceptibility of C. difficile isolates from feces of patients from 13 hospitals in Silesia, Poland. The incidence of CDI per 100.000 people in Silesia in 2018- …
·pubmed.ncbi.nlm.nih.gov·
Antibiotic Resistance Profile of RT 027/176 Versus Other Clostridioides difficile Isolates in Silesia, Southern Poland
Characterization of the virulence of three novel clade 2 Clostridioides (Clostridium) difficile strains and a two-year screening in animals and humans in Brazil
Characterization of the virulence of three novel clade 2 Clostridioides (Clostridium) difficile strains and a two-year screening in animals and humans in Brazil
Clostridioides (Clostridium) difficile infection (CDI) is an evolving global healthcare problem, and owing to the diverse and dynamic molecular epidemiology of C. difficile, new strains continue to emerge. In Brazil, only two cases of CDI due to the so called hypervirulent PCR ribotype (RT) 027 belo …
·pubmed.ncbi.nlm.nih.gov·
Characterization of the virulence of three novel clade 2 Clostridioides (Clostridium) difficile strains and a two-year screening in animals and humans in Brazil
Biochemical Characterizations of the Putative Endolysin Ecd09610 Catalytic Domain from Clostridioides difficile https://t.co/oZPXRD6mGo #cdi #cdiff
Biochemical Characterizations of the Putative Endolysin Ecd09610 Catalytic Domain from Clostridioides difficile https://t.co/oZPXRD6mGo #cdi #cdiff
Biochemical Characterizations of the Putative Endolysin Ecd09610 Catalytic Domain from Clostridioides difficile https://t.co/oZPXRD6mGo #cdi #cdiff— Dave Roberts (@CDifficile1) August 28, 2022
·twitter.com·
Biochemical Characterizations of the Putative Endolysin Ecd09610 Catalytic Domain from Clostridioides difficile https://t.co/oZPXRD6mGo #cdi #cdiff
Biochemical Characterizations of the Putative Endolysin Ecd09610 Catalytic Domain from Clostridioides difficile
Biochemical Characterizations of the Putative Endolysin Ecd09610 Catalytic Domain from Clostridioides difficile
Clostridioides difficile is the major pathogen of pseudomembranous colitis, and novel antimicrobial agents are sought after for its treatment. Phage-derived endolysins with species-specific lytic activity have potential as novel antimicrobial agents. We surveyed the genome of C. difficile …
·pubmed.ncbi.nlm.nih.gov·
Biochemical Characterizations of the Putative Endolysin Ecd09610 Catalytic Domain from Clostridioides difficile
James Wilson, DO, FAWM on Twitter
James Wilson, DO, FAWM on Twitter
Not sure who needs to hear this, but:#metronidazole can be q12h and not q8h for everything except CNS infections & fulminant #cdiff#idtwitter #MedTwitter #idcrit @IdVilchez @IDstewardship— James Wilson, DO, FAWM (@JamesWilsonDO1) August 25, 2022
·twitter.com·
James Wilson, DO, FAWM on Twitter
Characterization of the virulence of three novel clade 2 Clostridioides (Clostridium) difficile strains and a two-year screening in animals and humans in Brazil
Characterization of the virulence of three novel clade 2 Clostridioides (Clostridium) difficile strains and a two-year screening in animals and humans in Brazil
Clostridioides (Clostridium) difficile infection (CDI) is an evolving global healthcare problem, and owing to the diverse and dynamic molecular epidemiology of C. difficile, new strains continue to emerge. In Brazil, only two cases of CDI due to the so called hypervirulent PCR ribotype (RT) 027 belo …
·pubmed.ncbi.nlm.nih.gov·
Characterization of the virulence of three novel clade 2 Clostridioides (Clostridium) difficile strains and a two-year screening in animals and humans in Brazil
Antibiotic Resistance Profile of RT 027/176 Versus Other Clostridioides difficile Isolates in Silesia, Southern Poland
Antibiotic Resistance Profile of RT 027/176 Versus Other Clostridioides difficile Isolates in Silesia, Southern Poland
Clostridioides difficile is an important health care-associated pathogen. The aim of this study was to analyze the antibiotic susceptibility of C. difficile isolates from feces of patients from 13 hospitals in Silesia, Poland. The incidence of CDI per 100.000 people in Silesia in 2018- …
·pubmed.ncbi.nlm.nih.gov·
Antibiotic Resistance Profile of RT 027/176 Versus Other Clostridioides difficile Isolates in Silesia, Southern Poland
Clostridium difficile Induced Inflammasome Activation and Coagulation Derangements
Clostridium difficile Induced Inflammasome Activation and Coagulation Derangements
C. difficile enterocolitis (CDAC) is the most common hospital infection, burdened by an increased incidence of coagulation-related complications such as deep vein thrombosis (DVT) and disseminated intravascular coagulation (DIC) as well as a significant sepsis-related mortality. In this revie …
·pubmed.ncbi.nlm.nih.gov·
Clostridium difficile Induced Inflammasome Activation and Coagulation Derangements
Characterization of the Effects of Candida Gastrointestinal Colonization on Clostridioides difficile Infection in a Murine Model
Characterization of the Effects of Candida Gastrointestinal Colonization on Clostridioides difficile Infection in a Murine Model
The role of fungal colonizers of the gastrointestinal tract during disease states is not well understood. Antibiotic treatment renders patients highly susceptible to infection by the bacterial pathogen C. difficile while also leading to blooms in fungal commensals, setting the stage for trans-kingdo …
·pubmed.ncbi.nlm.nih.gov·
Characterization of the Effects of Candida Gastrointestinal Colonization on Clostridioides difficile Infection in a Murine Model
[Clostridioides Infection in Patients with Inflammatory Bowel Disease] - PubMed
[Clostridioides Infection in Patients with Inflammatory Bowel Disease] - PubMed
Inflammatory bowel disease (IBD), comprising Crohn's disease and ulcerative colitis, is a chronic inflammatory condition of the gastrointestinal tract, which is often accompanied by altered gut microbial composition. Gut dysbiosis in IBD is considered to be the reason for the high risk of Clostri …
·pubmed.ncbi.nlm.nih.gov·
[Clostridioides Infection in Patients with Inflammatory Bowel Disease] - PubMed
Characterization of the Effects of Candida Gastrointestinal Colonization on Clostridioides difficile Infection in a Murine Model - PubMed
Characterization of the Effects of Candida Gastrointestinal Colonization on Clostridioides difficile Infection in a Murine Model - PubMed
The role of fungal colonizers of the gastrointestinal tract during disease states is not well understood. Antibiotic treatment renders patients highly susceptible to infection by the bacterial pathogen C. difficile while also leading to blooms in fungal commensals, setting the stage for trans-kingdo …
·pubmed.ncbi.nlm.nih.gov·
Characterization of the Effects of Candida Gastrointestinal Colonization on Clostridioides difficile Infection in a Murine Model - PubMed
Clostridium difficile colitis portends poor outcomes in lower extremity orthopaedic trauma surgery
Clostridium difficile colitis portends poor outcomes in lower extremity orthopaedic trauma surgery
The incidence of CDC in lower extremity orthopedic trauma patients was 0.71%. An occurrence of CDC was associated with approximately a 2.5 times increase in 30-day mortality, five times the readmission rate, and a longer hospital stay compared to patients without CDC. Mitigating the spread of c. dif …
·pubmed.ncbi.nlm.nih.gov·
Clostridium difficile colitis portends poor outcomes in lower extremity orthopaedic trauma surgery
Lethal acute diarrhea associated with Clostridioides difficile toxin A and B in a buffy-tufted-ear marmoset (Callithrix aurita)
Lethal acute diarrhea associated with Clostridioides difficile toxin A and B in a buffy-tufted-ear marmoset (Callithrix aurita)
This is a case of lethal acute diarrhea associated with a mild neutrophilic enteritis in a buffy-tufted-ear marmoset (Callithrix aurita) with detection of A/B toxins and isolation of a toxigenic clade 3 Clostridioides difficile strain (A+ B+ CDT+ , ST5), which should …
·pubmed.ncbi.nlm.nih.gov·
Lethal acute diarrhea associated with Clostridioides difficile toxin A and B in a buffy-tufted-ear marmoset (Callithrix aurita)
The value of fecal calprotectin in Clostridioides difficile infection: A systematic review
The value of fecal calprotectin in Clostridioides difficile infection: A systematic review
As a marker of inflammation, calprotectin has potential application value in a variety of inflammatory diseases, such as arthritis and bacterial infections. Clostridioides difficile infection (CDI) is an infectious disease that causes intestinal damage and inflammation. This systematic review …
·pubmed.ncbi.nlm.nih.gov·
The value of fecal calprotectin in Clostridioides difficile infection: A systematic review
Requirement of Peptidyl-Prolyl Cis/Trans isomerases and chaperones for cellular uptake of bacterial AB-type toxins
Requirement of Peptidyl-Prolyl Cis/Trans isomerases and chaperones for cellular uptake of bacterial AB-type toxins
Bacterial AB-type toxins are proteins released by the producing bacteria and are the causative agents for several severe diseases including cholera, whooping cough, diphtheria or enteric diseases. Their unique AB-type structure enables their uptake into mammalian cells via sophisticated mecha …
·pubmed.ncbi.nlm.nih.gov·
Requirement of Peptidyl-Prolyl Cis/Trans isomerases and chaperones for cellular uptake of bacterial AB-type toxins