C Diff Molecular

C Diff Molecular

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Clostridioides difficile Modifies its Aromatic Compound Metabolism in Response to Amidochelocardin-Induced Membrane Stress
Clostridioides difficile Modifies its Aromatic Compound Metabolism in Response to Amidochelocardin-Induced Membrane Stress
Amidochelocardin is a broad-spectrum antibiotic with activity against many Gram-positive and Gram-negative bacteria. According to recent data, the antibiotic effect of this atypical tetracycline is directed against the cytoplasmic membrane, which is associated with the dissipation of the membrane po …
·pubmed.ncbi.nlm.nih.gov·
Clostridioides difficile Modifies its Aromatic Compound Metabolism in Response to Amidochelocardin-Induced Membrane Stress
Deciphering Resistome in Patients With Chronic Obstructive Pulmonary Diseases and Clostridioides difficile Infections
Deciphering Resistome in Patients With Chronic Obstructive Pulmonary Diseases and Clostridioides difficile Infections
Antibiotics alter the gut microbiome and cause dysbiosis leading to antibiotic-resistant organisms. Different patterns of antibiotic administration cause a difference in bacterial composition and resistome in the human gut. We comprehensively investigated the association between the distribution of …
·pubmed.ncbi.nlm.nih.gov·
Deciphering Resistome in Patients With Chronic Obstructive Pulmonary Diseases and Clostridioides difficile Infections
GutMicrobiota Health on Twitter
GutMicrobiota Health on Twitter
Perceived stress has been associated with symptomatic flares in inflammatory bowel disease. @emeranamayer et al. identify physiological factors associated with perceived stress in people with ulcerative colitis and their link with flare via @AGA_CGH https://t.co/E3vWRse2Ne pic.twitter.com/N5ZiQZyJpZ— GutMicrobiota Health (@GMFHx) August 19, 2022
·twitter.com·
GutMicrobiota Health on Twitter
Artificial Sweeteners Alter Gut Bacteria in Humans
Artificial Sweeteners Alter Gut Bacteria in Humans
When consumed for as little as two weeks, common alternatives to sugar affect intestinal bacterial communities, with some reducing the body's ability to regulate blood glucose levels, a study finds.
·the-scientist.com·
Artificial Sweeteners Alter Gut Bacteria in Humans
Adipose tissue derived bacteria are associated with inflammation in obesity and type 2 diabetes | Gut
Adipose tissue derived bacteria are associated with inflammation in obesity and type 2 diabetes | Gut
Objective Bacterial translocation to various organs including human adipose tissue (AT) due to increased intestinal permeability remains poorly understood. We hypothesised that: (1) bacterial presence is highly tissue specific and (2) related in composition and quantity to immune inflammatory and metabolic burden. Design We quantified and sequenced the bacterial 16S rRNA gene in blood and AT samples (omental, mesenteric and subcutaneous) of 75 subjects with obesity with or without type 2 diabetes (T2D) and used catalysed reporter deposition (CARD) – fluorescence in situ hybridisation (FISH) to detect bacteria in AT. Results Under stringent experimental and bioinformatic control for contaminants, bacterial DNA was detected in blood and omental, subcutaneous and mesenteric AT samples in the range of 0.1 to 5 pg/µg DNA isolate. Moreover, CARD-FISH allowed the detection of living, AT-borne bacteria. Proteobacteria and Firmicutes were the predominant phyla, and bacterial quantity was associated with immune cell infiltration, inflammatory and metabolic parameters in a tissue-specific manner. Bacterial composition differed between subjects with and without T2D and was associated with related clinical measures, including systemic and tissues-specific inflammatory markers. Finally, treatment of adipocytes with bacterial DNA in vitro stimulated the expression of TNFA and IL6 . Conclusions Our study provides contaminant aware evidence for the presence of bacteria and bacterial DNA in several ATs in obesity and T2D and suggests an important role of bacteria in initiating and sustaining local AT subclinical inflammation and therefore impacting metabolic sequelae of obesity.
·gut.bmj.com·
Adipose tissue derived bacteria are associated with inflammation in obesity and type 2 diabetes | Gut
Clostridioides difficile Infection in Patients after Organ Transplantation-A Narrative Overview
Clostridioides difficile Infection in Patients after Organ Transplantation-A Narrative Overview
Clostridioides difficile infection (CDI) is one of the most common causes of antibiotic-associated diarrhea. The pathogenesis of this infection participates in the unstable colonization of the intestines with the physiological microbiota. Solid-organ-transplant (SOT) patients and patients aft …
·pubmed.ncbi.nlm.nih.gov·
Clostridioides difficile Infection in Patients after Organ Transplantation-A Narrative Overview
Meta-analysis of the microbial biomarkers in the gut-lung crosstalk in COVID-19, community-acquired pneumonia and Clostridium difficile infections
Meta-analysis of the microbial biomarkers in the gut-lung crosstalk in COVID-19, community-acquired pneumonia and Clostridium difficile infections
Respiratory infections are the leading causes of mortality and the current pandemic COVID-19 is one such trauma that imposed catastrophic devastation to the health and economy of the world. Unravelling the correlations and interplay of the human microbiota in the gut-lung axis would offer incredible …
·pubmed.ncbi.nlm.nih.gov·
Meta-analysis of the microbial biomarkers in the gut-lung crosstalk in COVID-19, community-acquired pneumonia and Clostridium difficile infections
Clostridioides (Clostridium) difficile-associated disease, epiploic foramen entrapment, and gastric rupture in a Thoroughbred racehorse: case report and literature review
Clostridioides (Clostridium) difficile-associated disease, epiploic foramen entrapment, and gastric rupture in a Thoroughbred racehorse: case report and literature review
Epiploic foramen entrapment (EFE) is a common cause of small intestinal colic in horses and may lead to intestinal strangulation. Strangulating intestinal obstruction impairs the gastrointestinal outflow and can lead to secondary gastric rupture and endotoxemia. Clostridioides difficile can c …
·pubmed.ncbi.nlm.nih.gov·
Clostridioides (Clostridium) difficile-associated disease, epiploic foramen entrapment, and gastric rupture in a Thoroughbred racehorse: case report and literature review
C Diff; Toxin Negative Or Toxin Positive | Knowledge is Power - Gastroenterology Nursing - allnurses
C Diff; Toxin Negative Or Toxin Positive | Knowledge is Power - Gastroenterology Nursing - allnurses
C diff, now called Clostridioides or Clostridioides difficile, is often found in nursing homes or in post-surgical patients after multiple doses of antibiotics1. Antibiotics disrupt the normal gut flora, and in a weakened immune system, it is allowed to flourish. Immunocompromised patients fall p...
·allnurses.com·
C Diff; Toxin Negative Or Toxin Positive | Knowledge is Power - Gastroenterology Nursing - allnurses
Risk of Gastrointestinal Infections After Initiating... : Journal of Clinical Gastroenterology
Risk of Gastrointestinal Infections After Initiating... : Journal of Clinical Gastroenterology
nal infections including CDI and CMVC among patients with UC; however, the risk according to the biological class is poorly understood. Study: A retrospective cohort study of adults with UC involving the initiation of vedolizumab or anti-TNFα agents during June 1, 2014 to December 31, 2020 was conducted at a large academic health system. The primary outcomes for both CDI and CMVC analyses were first CDI or CMVC after biological initiation. The secondary outcome for the CDI analysis was severe CDI (10,000 white blood cells or serum creatinine 1.5 mg/dL). Independent variables included demographics and UC history/severity factors. Inverse probability of treatment weighted Cox regression was performed to assess the hazard of CDI by biological group. Due to few outcomes, CMVC was reported descriptively. Results: A total of 805 UC patients initiated vedolizumab (n=195) or anti-TNFα agents (n=610). There were 43 CDIs and 11 severe CDIs over 1436 patient-years. The inverse probability of treatment weighted Cox regression demonstrated no association between CDI and vedolizumab versus anti-TNFα (hazard ratio 0.33, 95% confidence interval 0.05-2.03), but identified a significantly lower hazard of severe CDI for vedolizumab versus anti-TNFα (hazard ratio 0.10, 95% confidence interval 0.01-0.76). There were 5 cases of CMVC, all in the anti-TNFα group. Conclusions: There was a lower adjusted risk of severe CDI but not total CDI associated with vedolizumab. CMVC was not observed after initiating vedolizumab. These findings may provide reassurance regarding the use of vedolizumab when also considering the risk of gastrointestinal infections....
·journals.lww.com·
Risk of Gastrointestinal Infections After Initiating... : Journal of Clinical Gastroenterology
Haley Mertens on Twitter
Haley Mertens on Twitter
Come learn about #Cdiff 🦠🦠 in #IBD with us on @MondayNightIBD ‼️‼️#GITwitter #IBDTwitter https://t.co/BeYdRVD13A— Haley Mertens (@halesj126) August 1, 2022
·twitter.com·
Haley Mertens on Twitter
Hiding in Plain Sight: A Novel Microbial Driver for Colorectal Cancer?
Hiding in Plain Sight: A Novel Microbial Driver for Colorectal Cancer?
In this issue of Cancer Discovery, Drewes and colleagues demonstrate a surprising role for the common gut pathogen Clostridioides difficile in driving colorectal cancer in preclinical models through the bacterial toxin-dependent reprogramming of the epithelial and immune compartments. See related ar …
·pubmed.ncbi.nlm.nih.gov·
Hiding in Plain Sight: A Novel Microbial Driver for Colorectal Cancer?
JCM | Free Full-Text | Pathophysiology and Clinical Management of Bile Acid Diarrhea | HTML
JCM | Free Full-Text | Pathophysiology and Clinical Management of Bile Acid Diarrhea | HTML
Bile acid malabsorption (BAM) represents a common cause of chronic diarrhea whose prevalence is under-investigated. We reviewed the evidence available regarding the pathophysiology and clinical management of bile acid diarrhea (BAD). BAD results from dysregulation of the enterohepatic recirculation of bile acids. It has been estimated that 25–33% of patients with functional diarrhea and irritable bowel syndrome with diarrhea have BAM. Currently, the selenium homotaurocholic acid test is the gold standard for BAD diagnosis and severity assessment. However, it is an expensive method and not widely available. The validation of the utility in the clinical practice of several other serum markers, such as 7α-hydroxy-4-cholesten-3-one (C4) and the fibroblast growth factor 19 (FGF19) is ongoing. The first-line treatment of patients with BAD is bile acid sequestrants. Patients that are refractory to first-line therapy should undergo further diagnostics to confirm the diagnosis and to treat the underlying cause of BAD. An early and correct diagnosis of BAD would improve patient’s quality of life, avoiding additional diagnostic tests that burden health care systems. Considering the limited availability and tolerability of specific medications for BAD treatment, future research is awaited to identify other therapeutic approaches, such as gut microbiota modulating therapies.
·mdpi.com·
JCM | Free Full-Text | Pathophysiology and Clinical Management of Bile Acid Diarrhea | HTML
Beyond the gut - PubMed
Beyond the gut - PubMed
Mycobiota modulate immunity and behavior.
·pubmed.ncbi.nlm.nih.gov·
Beyond the gut - PubMed
Prevalence of Clostridioides difficile Infection After Ileal Pouch-anal Anastomosis in Patients With Chronic Antibiotic-dependent Pouchitis and Crohn's-like Disease of the Pouch
Prevalence of Clostridioides difficile Infection After Ileal Pouch-anal Anastomosis in Patients With Chronic Antibiotic-dependent Pouchitis and Crohn's-like Disease of the Pouch
Although chronic inflammatory conditions of the pouch arise postoperatively, the prevalence of CDI in this population appears to be similar compared with the general population of patients with inflammatory bowel disease prior to and post IPAA. Preoperative CDI appears to be the greatest risk for po …
·pubmed.ncbi.nlm.nih.gov·
Prevalence of Clostridioides difficile Infection After Ileal Pouch-anal Anastomosis in Patients With Chronic Antibiotic-dependent Pouchitis and Crohn's-like Disease of the Pouch
A unique class of Zn2+-binding serine-based PBPs underlies cephalosporin resistance and sporogenesis in Clostridioides difficile
A unique class of Zn2+-binding serine-based PBPs underlies cephalosporin resistance and sporogenesis in Clostridioides difficile
Treatment with β-lactam antibiotics, particularly cephalosporins, is a major risk factor for Clostridioides difficile infection. These broad-spectrum antibiotics irreversibly inhibit penicillin-binding proteins (PBPs), which are serine-based enzymes that assemble the bacterial cell wall. However, C. …
·pubmed.ncbi.nlm.nih.gov·
A unique class of Zn2+-binding serine-based PBPs underlies cephalosporin resistance and sporogenesis in Clostridioides difficile
Clostridium difficile Infection in Patients with Ulcerative Colitis Treated with Tofacitinib in the Ulcerative Colitis Program | Inflammatory Bowel Diseases | Oxford Academic
Clostridium difficile Infection in Patients with Ulcerative Colitis Treated with Tofacitinib in the Ulcerative Colitis Program | Inflammatory Bowel Diseases | Oxford Academic
AbstractBackground. Tofacitinib is an oral, small molecule Janus kinase inhibitor for the treatment of ulcerative colitis (UC). Patients with inflammatory bowel
·academic.oup.com·
Clostridium difficile Infection in Patients with Ulcerative Colitis Treated with Tofacitinib in the Ulcerative Colitis Program | Inflammatory Bowel Diseases | Oxford Academic
Intestinal Inflammation Reversibly Alters the Microbiota to Drive Susceptibility to Clostridioides difficile Colonization in a Mouse Model of Colitis
Intestinal Inflammation Reversibly Alters the Microbiota to Drive Susceptibility to Clostridioides difficile Colonization in a Mouse Model of Colitis
Susceptibility to Clostridioides difficile infection (CDI) typically follows the administration of antibiotics. Patients with inflammatory bowel disease (IBD) have increased incidence of CDI, even in the absence of antibiotic treatment. However, the mechanisms underlying this susceptibility are not …
·pubmed.ncbi.nlm.nih.gov·
Intestinal Inflammation Reversibly Alters the Microbiota to Drive Susceptibility to Clostridioides difficile Colonization in a Mouse Model of Colitis
Concurrent and Subsequent Co-Infections of Clostridioides difficile Colitis in the Era of Gut Microbiota and Expanding Treatment Options - PubMed
Concurrent and Subsequent Co-Infections of Clostridioides difficile Colitis in the Era of Gut Microbiota and Expanding Treatment Options - PubMed
We narratively reviewed the physiopathology, epidemiology, and management of co-infections in Clostridioides difficile colitis (CDI) by searching the following keywords in Embase, MedLine, and PubMed: "Clostridium/Clostridioides difficile", "co-infection", "blood-stream infection" (BSI …
·pubmed.ncbi.nlm.nih.gov·
Concurrent and Subsequent Co-Infections of Clostridioides difficile Colitis in the Era of Gut Microbiota and Expanding Treatment Options - PubMed
Early Life Antimicrobial Exposure: Impact on Clostridioides difficile Colonization in Infants - PubMed
Early Life Antimicrobial Exposure: Impact on Clostridioides difficile Colonization in Infants - PubMed
The relationship between antibiotic use and Clostridioides difficile (C. difficile) has been well established in adults and older children but remains unclear and is yet to be fully examined in infant populations. This study aimed to determine the separate and cumulative impact from an …
·pubmed.ncbi.nlm.nih.gov·
Early Life Antimicrobial Exposure: Impact on Clostridioides difficile Colonization in Infants - PubMed
The Current Knowledge on Clostridioides difficile Infection in Patients with Inflammatory Bowel Diseases - PubMed
The Current Knowledge on Clostridioides difficile Infection in Patients with Inflammatory Bowel Diseases - PubMed
Clostridioides difficile (C. difficile) represents a major health burden with substantial economic and clinical impact. Patients with inflammatory bowel diseases (IBD) were identified as a risk category for Clostridioides difficile infection (CDI). In addition to traditional ris …
·pubmed.ncbi.nlm.nih.gov·
The Current Knowledge on Clostridioides difficile Infection in Patients with Inflammatory Bowel Diseases - PubMed
Gut Microbiota Composition Associated with Clostridioides difficile Colonization and Infection - PubMed
Gut Microbiota Composition Associated with Clostridioides difficile Colonization and Infection - PubMed
Clostridioides difficile is an anaerobic Gram-positive and spore-forming bacterium. The majority of C. difficile strains produce two toxins, A and B, associated with the development of acute diarrhea and/or colitis. In this review, two situations are distinguished: C. difficile …
·pubmed.ncbi.nlm.nih.gov·
Gut Microbiota Composition Associated with Clostridioides difficile Colonization and Infection - PubMed