C Diff Molecular

C Diff Molecular

1791 bookmarks
Custom sorting
Gut associated metabolites and their roles in Clostridioides difficile pathogenesis - PubMed
Gut associated metabolites and their roles in Clostridioides difficile pathogenesis - PubMed
The nosocomial pathogen Clostridioides difficile is a burden to the healthcare system. Gut microbiome disruption, most commonly by broad-spectrum antibiotic treatment, is well established to generate a state that is susceptible to CDI. A variety of metabolites produced by the host and/or gut …
·pubmed.ncbi.nlm.nih.gov·
Gut associated metabolites and their roles in Clostridioides difficile pathogenesis - PubMed
Host and Clostridioides difficile-Response Modulated by Micronutrients and Glutamine: An Overview - PubMed
Host and Clostridioides difficile-Response Modulated by Micronutrients and Glutamine: An Overview - PubMed
Changes in intestinal microbiota are integral to development of Clostridioides difficile (C. difficile)-associated nosocomial diarrhea. Certain diets, especially Western diets, increase susceptibility to C. difficile infection (CDI). Here, we discuss recent findings regarding ho …
·pubmed.ncbi.nlm.nih.gov·
Host and Clostridioides difficile-Response Modulated by Micronutrients and Glutamine: An Overview - PubMed
Thiol Metabolism and Volatile Metabolome of Clostridioides difficile
Thiol Metabolism and Volatile Metabolome of Clostridioides difficile
Clostridioides difficile (previously Clostridium difficile) causes life-threatening gut infections. The central metabolism of the bacterium is strongly influencing toxin production and consequently the infection progress. In this context, the composition and potential origin of the vol …
·pubmed.ncbi.nlm.nih.gov·
Thiol Metabolism and Volatile Metabolome of Clostridioides difficile
An Unusual Presentation of Clostridioides Difficile Colitis in a Patient on Opioids
An Unusual Presentation of Clostridioides Difficile Colitis in a Patient on Opioids
Clostridioides difficile colitis is an inflammation of the colon due to toxins produced by a gram-positive bacterium called Clostridioides difficile (also known as Clostridium difficile). Clostridioides difficile colitis is associated with an increased risk of morbidity a …
·pubmed.ncbi.nlm.nih.gov·
An Unusual Presentation of Clostridioides Difficile Colitis in a Patient on Opioids
Clostridioides difficile infection in cancer patients receiving immune checkpoint inhibitors
Clostridioides difficile infection in cancer patients receiving immune checkpoint inhibitors
CDI is common in ICI-treated cancer patients, especially those with IMDC requiring immunosuppressants. Antibiotics did not alter the need for immunosuppressants in those with concurrent IMDC. Use of PPI and antibiotics while receiving immunosuppressants for IMDC was associated with a greater risk of …
·pubmed.ncbi.nlm.nih.gov·
Clostridioides difficile infection in cancer patients receiving immune checkpoint inhibitors
Absence of toxin gene transfer from Clostridioides difficile strain 630Δerm to nontoxigenic C. difficile strain NTCD-M3r in filter mating experiments - PubMed
Absence of toxin gene transfer from Clostridioides difficile strain 630Δerm to nontoxigenic C. difficile strain NTCD-M3r in filter mating experiments - PubMed
Nontoxigenic Clostridioides difficile strain M3 (NTCD-M3) protects hamsters and humans against C. difficile infection. Transfer in vitro of the pathogenicity locus (PaLoc) to nontoxigenic strain CD37 has been reported. We repeated these conjugations using toxigenic strain 630Δerm as donor and NTCD-M …
·pubmed.ncbi.nlm.nih.gov·
Absence of toxin gene transfer from Clostridioides difficile strain 630Δerm to nontoxigenic C. difficile strain NTCD-M3r in filter mating experiments - PubMed
Strain Variation in Clostridioides difficile Cytotoxicity Associated with Genomic Variation at Both Pathogenic and Nonpathogenic Loci - PubMed
Strain Variation in Clostridioides difficile Cytotoxicity Associated with Genomic Variation at Both Pathogenic and Nonpathogenic Loci - PubMed
Clinical disease from Clostridioides difficile infection can be mediated by two toxins and their neighboring regulatory genes located within the five-gene pathogenicity locus (PaLoc). We provide several lines of evidence that the cytotoxicity of C. difficile may be modulated by genomic variants outs …
·pubmed.ncbi.nlm.nih.gov·
Strain Variation in Clostridioides difficile Cytotoxicity Associated with Genomic Variation at Both Pathogenic and Nonpathogenic Loci - PubMed
Molecular characterization and antibiotic resistance of Clostridioides difficile in patients with inflammatory bowel disease from two hospitals in China
Molecular characterization and antibiotic resistance of Clostridioides difficile in patients with inflammatory bowel disease from two hospitals in China
The incidence and molecular epidemiology of C. difficile infection in adult IBD patients resembled CDI in the general inpatient population. A higher antibiotic resistance rate was identified among the C. difficile isolates obtained from pediatric IBD patients than adult patients, and few STs account …
·pubmed.ncbi.nlm.nih.gov·
Molecular characterization and antibiotic resistance of Clostridioides difficile in patients with inflammatory bowel disease from two hospitals in China
Molecular characterization and antibiotic resistance of Clostridioides difficile in patients with inflammatory bowel disease from two hospitals in China
Molecular characterization and antibiotic resistance of Clostridioides difficile in patients with inflammatory bowel disease from two hospitals in China
The incidence and molecular epidemiology of C. difficile infection in adult IBD patients resembled CDI in the general inpatient population. A higher antibiotic resistance rate was identified among the C. difficile isolates obtained from pediatric IBD patients than adult patients, and few STs account …
·pubmed.ncbi.nlm.nih.gov·
Molecular characterization and antibiotic resistance of Clostridioides difficile in patients with inflammatory bowel disease from two hospitals in China
Imaging Clostridioides difficile Spore Germination and Germination Proteins
Imaging Clostridioides difficile Spore Germination and Germination Proteins
Clostridioides difficile spores are the infective form for this endospore-forming organism. The vegetative cells are intolerant to oxygen and poor competitors with a healthy gut microbiota. Therefore, in order for C. difficile to establish infection, the spores have to germinate in an environment th …
·pubmed.ncbi.nlm.nih.gov·
Imaging Clostridioides difficile Spore Germination and Germination Proteins
Clinical Determinants Predicting Clostridioides difficile Infection among Patients with Chronic Kidney Disease - PubMed
Clinical Determinants Predicting Clostridioides difficile Infection among Patients with Chronic Kidney Disease - PubMed
The majority of recently published studies indicate a greater incidence rate and mortality due to Clostridioides difficile infection (CDI) in patients with chronic kidney disease (CKD). The aim of this study was to assess the clinical determinants predicting CDI among hospitalized patients with CKD …
·pubmed.ncbi.nlm.nih.gov·
Clinical Determinants Predicting Clostridioides difficile Infection among Patients with Chronic Kidney Disease - PubMed
Histologic Features of Clostridioides difficile Colitis in Patients with Inflammatory Bowel Disease - PubMed
Histologic Features of Clostridioides difficile Colitis in Patients with Inflammatory Bowel Disease - PubMed
Although colonic biopsies from IBD patients with C. difficile infection usually lack features that aid distinction from colitic flares, some cases show an acute colitis pattern not seen in IBD alone. When identified in biopsies from symptomatic IBD patients, these changes should alert pathologists t …
·pubmed.ncbi.nlm.nih.gov·
Histologic Features of Clostridioides difficile Colitis in Patients with Inflammatory Bowel Disease - PubMed
Gut Microbiota and Metabolite Changes in Patients With Ulcerative Colitis and Clostridioides difficile Infection - PubMed
Gut Microbiota and Metabolite Changes in Patients With Ulcerative Colitis and Clostridioides difficile Infection - PubMed
Our study identified 11 differential genera and 16 perturbed metabolites in patients with UC and CDI compared to those with UC alone. These findings may guide the design of research on potential mechanisms and specific treatments for CDI in patients with UC.
·pubmed.ncbi.nlm.nih.gov·
Gut Microbiota and Metabolite Changes in Patients With Ulcerative Colitis and Clostridioides difficile Infection - PubMed
Age-associated gut microbiota impairs hippocampus-dependent memory in a vagus-dependent manner - PubMed
Age-associated gut microbiota impairs hippocampus-dependent memory in a vagus-dependent manner - PubMed
Aging is known to be associated with hippocampus-dependent memory decline, but the underlying causes of this age-related memory impairment remain yet highly debated. Here we showed that fecal microbiota transplantation (FMT) from aged, but not young, animal donors in young mice is sufficient to trig …
·t.co·
Age-associated gut microbiota impairs hippocampus-dependent memory in a vagus-dependent manner - PubMed
Histologic Features of Clostridioides difficile Colitis in Patients with Inflammatory Bowel Disease - PubMed
Histologic Features of Clostridioides difficile Colitis in Patients with Inflammatory Bowel Disease - PubMed
Although colonic biopsies from IBD patients with C. difficile infection usually lack features that aid distinction from colitic flares, some cases show an acute colitis pattern not seen in IBD alone. When identified in biopsies from symptomatic IBD patients, these changes should alert pathologists t …
·pubmed.ncbi.nlm.nih.gov·
Histologic Features of Clostridioides difficile Colitis in Patients with Inflammatory Bowel Disease - PubMed
[Clostridioides difficile toxin B gen amplification cycle threshold as a predictor of severity] - PubMed
[Clostridioides difficile toxin B gen amplification cycle threshold as a predictor of severity] - PubMed
Basándonos en los resultados de nuestro estudio, no ha sido posible la implementación sistemática del valor Ct como predictor de gravedad al informe clínico, no siendo posible extrapolar esta variable predictora de enfermedad por C difficile-G y estandarizar el valor Ct como factor predictor de grav …
·pubmed.ncbi.nlm.nih.gov·
[Clostridioides difficile toxin B gen amplification cycle threshold as a predictor of severity] - PubMed
Antimicrobial safety considerations in critically ill patients: part II: focused on anti-microbial toxicities
Antimicrobial safety considerations in critically ill patients: part II: focused on anti-microbial toxicities
Critically ill patients who receive antimicrobial agents should be monitored for neurological, hematologic toxicities especially seizure, thrombocytopenia, and clostridioides infections. Other toxicities including QTc prolongation, electrolyte disturbances, liver enzyme elevation, and infusion-relat …
·pubmed.ncbi.nlm.nih.gov·
Antimicrobial safety considerations in critically ill patients: part II: focused on anti-microbial toxicities
Clostridioides difficile toxin B gen amplification cycle threshold as a predictor of severity
Clostridioides difficile toxin B gen amplification cycle threshold as a predictor of severity
Basándonos en los resultados de nuestro estudio, no ha sido posible la implementación sistemática del valor Ct como predictor de gravedad al informe clínico, no siendo posible extrapolar esta variable predictora de enfermedad por C difficile-G y estandarizar el valor Ct como factor predictor de grav …
·pubmed.ncbi.nlm.nih.gov·
Clostridioides difficile toxin B gen amplification cycle threshold as a predictor of severity
Association between Clostridium innocuum and antibiotic-associated diarrhea in adults and children: A cross-sectional study and comparative genomics analysis
Association between Clostridium innocuum and antibiotic-associated diarrhea in adults and children: A cross-sectional study and comparative genomics analysis
C. innocuum was frequently isolated and at a greater frequency in asymptomatic controls than those with AAD. We did not identify strain lineages or accessory genomic elements associated with AAD. These data highlight that differentiating C. innocuum-associated diarrhea from asymptomatic colonization …
·pubmed.ncbi.nlm.nih.gov·
Association between Clostridium innocuum and antibiotic-associated diarrhea in adults and children: A cross-sectional study and comparative genomics analysis
Do bacteria hold the key to their own defeat? - Medical News Today
Do bacteria hold the key to their own defeat? - Medical News Today
Using a special algorithm, researchers found an unresistible antibiotic produced by some bacteria. This approach could advance the fight against antibiotic resistance.
·medicalnewstoday.com·
Do bacteria hold the key to their own defeat? - Medical News Today
Prior Antibiotic Exposure Is Associated With Reoperation After Elective Non-colorectal Surgery
Prior Antibiotic Exposure Is Associated With Reoperation After Elective Non-colorectal Surgery
Among Veterans, recent antibiotic exposure within 90 days of elective surgery was associated with a 39% increase in the odds of return to the operating room. Further work is needed to evaluate the effects of antibiotic exposure and dysbiosis on surgical outcomes.
·pubmed.ncbi.nlm.nih.gov·
Prior Antibiotic Exposure Is Associated With Reoperation After Elective Non-colorectal Surgery
Reconsidering the in vivo functions of Clostridial Stickland amino acid fermentations
Reconsidering the in vivo functions of Clostridial Stickland amino acid fermentations
Stickland amino acid fermentations occur primarily among species of Clostridia. An ancient form of metabolism, Stickland fermentations use amino acids as electron acceptors in the absence of stronger oxidizing agents and provide metabolic capabilities to support growth when other fermentable substra …
·pubmed.ncbi.nlm.nih.gov·
Reconsidering the in vivo functions of Clostridial Stickland amino acid fermentations
Incidence of Early and Late-Onset Clostridioides difficile Infection following Appendectomy Compared to Other Common Abdominal Surgical Procedures
Incidence of Early and Late-Onset Clostridioides difficile Infection following Appendectomy Compared to Other Common Abdominal Surgical Procedures
The incidence of CDAD after various abdominal surgeries ranged between 2% and 7% in this study. Whereas, hemicolectomy patients had predominantly early onset CDAD, and appendectomy and cholecystectomy may increase the risk for late-onset CDAD. Appendectomy per se does not seem to increase the risk f …
·pubmed.ncbi.nlm.nih.gov·
Incidence of Early and Late-Onset Clostridioides difficile Infection following Appendectomy Compared to Other Common Abdominal Surgical Procedures