Characterization of C difficile Infections Among Adults - Medscape
How do the characteristics of adult patients with healthcare-associated C. difficile compare to those with community-associated infections?
C Diff Molecular
Molecular epidemiology and antimicrobial resistance patterns of Clostridioides difficile isolates in Algerian hospitals
Overall prevalence of C. difficile in our healthcare settings was 6%. Antibiotic resistance rates ranged from 72.2% (clindamycin) to 16.6% (tetracycline). This study highlighted a relatively high genetic diversity in term of ribotypes, sequence types, toxin and antibiotic resistance patterns, in the …
Coordinated modulation of multiple processes through phase variation of a c-di-GMP phosphodiesterase in Clostridioides difficile - PubMed
The opportunistic nosocomial pathogen Clostridioides difficile exhibits phenotypic heterogeneity through phase variation, a stochastic, reversible process that modulates expression. In C. difficile, multiple sequences in the genome undergo inversion through site-specific recombination. Two such loci …
Gut associated metabolites and their roles in Clostridioides difficile pathogenesis - PubMed
The nosocomial pathogen Clostridioides difficile is a burden to the healthcare system. Gut microbiome disruption, most commonly by broad-spectrum antibiotic treatment, is well established to generate a state that is susceptible to CDI. A variety of metabolites produced by the host and/or gut …
Host and Clostridioides difficile-Response Modulated by Micronutrients and Glutamine: An Overview - PubMed
Changes in intestinal microbiota are integral to development of Clostridioides difficile (C. difficile)-associated nosocomial diarrhea. Certain diets, especially Western diets, increase susceptibility to C. difficile infection (CDI). Here, we discuss recent findings regarding ho …
Thiol Metabolism and Volatile Metabolome of Clostridioides difficile
Clostridioides difficile (previously Clostridium difficile) causes life-threatening gut infections. The central metabolism of the bacterium is strongly influencing toxin production and consequently the infection progress. In this context, the composition and potential origin of the vol …
An Unusual Presentation of Clostridioides Difficile Colitis in a Patient on Opioids
Clostridioides difficile colitis is an inflammation of the colon due to toxins produced by a gram-positive bacterium called Clostridioides difficile (also known as Clostridium difficile). Clostridioides difficile colitis is associated with an increased risk of morbidity a …
Clostridioides difficile infection in cancer patients receiving immune checkpoint inhibitors
CDI is common in ICI-treated cancer patients, especially those with IMDC requiring immunosuppressants. Antibiotics did not alter the need for immunosuppressants in those with concurrent IMDC. Use of PPI and antibiotics while receiving immunosuppressants for IMDC was associated with a greater risk of …
The Role of the Microbiome in C. difficile Infection and Its Impact on Overall Health - Pharmacy Times
The first step to reducing recurrent C. difficile infections is prevention.
Comparing gastroenteritis and colitis: What are the differences?
Gastroenteritis and colitis are two gastrointestinal disorders that share a few similarities. However, they are distinct conditions. Learn more here.
BIDMC Grand Rounds: J. Thomas Lamont, M.D. on Major Advances in Gastroenterology & Hepatology - C. Diff In 30 Minutes: The Book
In January 2020, J. Thomas Lamont, M.D. gave a grand rounds presentation. He was looking back at Major Advances in Gastroenterology & Hepatology from 1965 to the present.
Absence of toxin gene transfer from Clostridioides difficile strain 630Δerm to nontoxigenic C. difficile strain NTCD-M3r in filter mating experiments - PubMed
Nontoxigenic Clostridioides difficile strain M3 (NTCD-M3) protects hamsters and humans against C. difficile infection. Transfer in vitro of the pathogenicity locus (PaLoc) to nontoxigenic strain CD37 has been reported. We repeated these conjugations using toxigenic strain 630Δerm as donor and NTCD-M …
Strain Variation in Clostridioides difficile Cytotoxicity Associated with Genomic Variation at Both Pathogenic and Nonpathogenic Loci - PubMed
Clinical disease from Clostridioides difficile infection can be mediated by two toxins and their neighboring regulatory genes located within the five-gene pathogenicity locus (PaLoc). We provide several lines of evidence that the cytotoxicity of C. difficile may be modulated by genomic variants outs …
Expanding Links Between Gut Microbiota and Bowel Inflammation - Gastroenterology
An Artificial Microbiome Consortium Prevents Recurrence of Clostridioides difficile Infection: Paving the Way for Fecal Microbiota Transplantation 2.0 - Gastroenterology
Molecular characterization and antibiotic resistance of Clostridioides difficile in patients with inflammatory bowel disease from two hospitals in China
The incidence and molecular epidemiology of C. difficile infection in adult IBD patients resembled CDI in the general inpatient population. A higher antibiotic resistance rate was identified among the C. difficile isolates obtained from pediatric IBD patients than adult patients, and few STs account …
Molecular characterization and antibiotic resistance of Clostridioides difficile in patients with inflammatory bowel disease from two hospitals in China
The incidence and molecular epidemiology of C. difficile infection in adult IBD patients resembled CDI in the general inpatient population. A higher antibiotic resistance rate was identified among the C. difficile isolates obtained from pediatric IBD patients than adult patients, and few STs account …
Imaging Clostridioides difficile Spore Germination and Germination Proteins
Clostridioides difficile spores are the infective form for this endospore-forming organism. The vegetative cells are intolerant to oxygen and poor competitors with a healthy gut microbiota. Therefore, in order for C. difficile to establish infection, the spores have to germinate in an environment th …
Clinical Determinants Predicting Clostridioides difficile Infection among Patients with Chronic Kidney Disease - PubMed
The majority of recently published studies indicate a greater incidence rate and mortality due to Clostridioides difficile infection (CDI) in patients with chronic kidney disease (CKD). The aim of this study was to assess the clinical determinants predicting CDI among hospitalized patients with CKD …
Histologic Features of Clostridioides difficile Colitis in Patients with Inflammatory Bowel Disease - PubMed
Although colonic biopsies from IBD patients with C. difficile infection usually lack features that aid distinction from colitic flares, some cases show an acute colitis pattern not seen in IBD alone. When identified in biopsies from symptomatic IBD patients, these changes should alert pathologists t …
Gut Microbiota and Metabolite Changes in Patients With Ulcerative Colitis and Clostridioides difficile Infection - PubMed
Our study identified 11 differential genera and 16 perturbed metabolites in patients with UC and CDI compared to those with UC alone. These findings may guide the design of research on potential mechanisms and specific treatments for CDI in patients with UC.
Age-associated gut microbiota impairs hippocampus-dependent memory in a vagus-dependent manner - PubMed
Aging is known to be associated with hippocampus-dependent memory decline, but the underlying causes of this age-related memory impairment remain yet highly debated. Here we showed that fecal microbiota transplantation (FMT) from aged, but not young, animal donors in young mice is sufficient to trig …
Histologic Features of Clostridioides difficile Colitis in Patients with Inflammatory Bowel Disease - PubMed
Although colonic biopsies from IBD patients with C. difficile infection usually lack features that aid distinction from colitic flares, some cases show an acute colitis pattern not seen in IBD alone. When identified in biopsies from symptomatic IBD patients, these changes should alert pathologists t …
[Clostridioides difficile toxin B gen amplification cycle threshold as a predictor of severity] - PubMed
Basándonos en los resultados de nuestro estudio, no ha sido posible la implementación sistemática del valor Ct como predictor de gravedad al informe clínico, no siendo posible extrapolar esta variable predictora de enfermedad por C difficile-G y estandarizar el valor Ct como factor predictor de grav …
Antimicrobial safety considerations in critically ill patients: part II: focused on anti-microbial toxicities
Critically ill patients who receive antimicrobial agents should be monitored for neurological, hematologic toxicities especially seizure, thrombocytopenia, and clostridioides infections. Other toxicities including QTc prolongation, electrolyte disturbances, liver enzyme elevation, and infusion-relat …
Clostridioides difficile toxin B gen amplification cycle threshold as a predictor of severity
Basándonos en los resultados de nuestro estudio, no ha sido posible la implementación sistemática del valor Ct como predictor de gravedad al informe clínico, no siendo posible extrapolar esta variable predictora de enfermedad por C difficile-G y estandarizar el valor Ct como factor predictor de grav …
Binding of the extracellular matrix laminin-1 to Clostridioides difficile strains - PubMed
These findings show that in the presence of glucose, each C. difficile ribotype interacts differently with LMN-1, and the adhesin responsible for recognition could be SlpA protein.
Association between Clostridium innocuum and antibiotic-associated diarrhea in adults and children: A cross-sectional study and comparative genomics analysis
C. innocuum was frequently isolated and at a greater frequency in asymptomatic controls than those with AAD. We did not identify strain lineages or accessory genomic elements associated with AAD. These data highlight that differentiating C. innocuum-associated diarrhea from asymptomatic colonization …
Do bacteria hold the key to their own defeat? - Medical News Today
Using a special algorithm, researchers found an unresistible antibiotic produced by some bacteria. This approach could advance the fight against antibiotic resistance.
Ischemic Colitis Is a Risk Factor for Clostridium difficile Infection - Cureus
Introduction: Clostridium difficile infection (CDI) is an anaerobic infection that can carry detrimental outcomes for patients and is a growing burden to the US healthcare system. Various theori...