C Diff Molecular

Notes from the Field: Escherichia coli O157:H7 Outbreak in Children with Clostridioides difficile Colonization Associated with an Improperly Treated Swimming Pool - Pennsylvania, June 2021

At the 10th GMFH World Summit, a panel of experts came together to share the latest in gut microbiota research.

Can Clostridium innocuum masquerade as Clostridioides difficile?

The WalR-WalK two-component regulatory system (TCS) is found in all Firmicutes, in which it regulates the expression of multiple genes required for remodeling the cell envelope during growth and division. Unlike most TCSs, WalRK is essential for viability, so it has attracted interest as a po …

The glycyl radical enzyme (GRE) family utilizes a glycyl radical cofactor, installed by AdoMet radical activating enzymes, to catalyze difficult chemical reactions in a variety of microbial metabolic pathways. Although GREs are widely encoded and expressed by bacteria found in the gut microbiome, th …

These results suggest that K. pneumoniae can cross-feed and shift the metabolism of C. difficile, as well as enhance the pro-inflammatory capacity of C. difficile. We speculate that interspecies interactions could be among the earliest events that occur as C. difficile colonizes the host. As a resul …

Clostridioides difficile is the leading cause of nosocomial infectious diarrhea, with clinical symptoms ranging from mild diarrhea to pseudomembranous colitis and toxic megacolon. Despite the use of vancomycin and fidaxomicin as standard drugs for the treatment of C. difficileinfection (CDI), clinic …

Most of the discussion around fecal microbiota transplantation has focused on bacterial communities, but new advances have shed more light on the role of the virome.

The use of 5-aminosalicylic acid significantly increases the risk for emClostridioides difficile/em infection in children with inflammatory bowel disease.

The Papin Lab makes it possible to apply the understanding of the nature of the bacteria to new treatment options for C. difficile bacterial infection. 

Clostridioides difficile is a Gram-positive, obligate anaerobic, spore-producing intestinal opportunistic pathogen. CDI outbreaks in Europe and the Americas in recent years are a major health concern. Intestinal short-chain fatty acids (SCFAs) are an important energy source for colonic epithelial ce …

A Clostridioides difficile infection (CDI) is the most common nosocomial infection worldwide. The main virulence factors of pathogenic C. difficile are TcdA and TcdB, which inhibit small Rho-GTPases. The inhibition of small Rho-GTPases leads to the so-called cytopathic effect, a reorga …

Venous sinus thrombosis secondary to disseminated intravascular coagulation after Clostridioides difficile infection

The fecal concentration of vancomycin was dependent on the intragastric dose administered. Only the 500 mg dose of VCM reached therapeutic concentration for C. difficile (MIC and MBC90), in the mice. We suggest starting a dose of 500 mg QID for achieving therapeutic concentration against …

Adjuvant chemotherapy and colorectal anastomosis leakage increase risk of Clostridium difficile infection. Patients with Clostridium difficile infection also ha

SignificanceClostridioides difficile infections are the most common source of hospital-acquired infections and are responsible for an extensive burden on the health care system. Strains of the C. difficile species comprise diverse lineages and demonstrate genome variability, with advan …

Nature Microbiology - Multi-omics analyses of faecal, urine and blood samples from women with and without recurrent urinary tract infections reveal that gut dysbiosis and differential immune...

Vancomycin is a front-line antibiotic for the treatment of Clostridioides difficile infections. However, C. difficile isolates exhibiting reduced susceptibility

HA-CDI incidence has not increased during the COVID19 pandemic in two tertiary centers in Spain, in spite of a slightly higher antibiotic consumption during the COVID19 period in both hospitals. These findings suggest that, in the presence of strict infection control measures, hospital antibiotic co …

We evaluated whether hospitalized patients without diagnosed Clostridioides difficile infection (CDI) increased the risk for CDI among their family members after discharge. We used 2001-2017 US insurance claims data to compare monthly CDI incidence between persons in households with and without a fa …

We present the case of a 71-year-old male who suffered an episode of acute renal failure caused by the uncommon association of two different diseases (Clostridioides difficile infection and McKittrick-Wheelock syndrome). He presented with hypovolemic shock, severe hypokalemia, hyponatremia, m …

Reducing perioperative antibiotic use can mitigate this risk.

Correction for Paulick et al., "Characterization of Clostridioides difficile Isolates Available through the CDC & FDA Antibiotic Resistance Isolate Bank"

New research suggests that COVID-19 may have worsened antibiotic resistance in hospitals.

Antibiotic resistance happens when bacteria develop genetic mutations that allow them to survive an antibiotic. Here is a look at how this happens and how it can be prevented.

Abstract. We are host to an assembly of microorganisms that vary in structure and function along the length of the gut and from the lumen to the mucosa. This ec

Author Correction: Entry of spores into intestinal epithelial cells contributes to recurrence of Clostridioides difficile infection

Nature Reviews Gastroenterology & Hepatology - Clostridioides difficile infection has a notable health and economic burden worldwide. In this Review, the authors provide insights into the...

NCT04031469 (PCR-) and 04359836 (PCR+).