C Diff Molecular

Infection with Clostridioides difficile (CDI), a common healthcare-associated infection, includes symptoms ranging from mild diarrhea to severe cases of pseudomembranous colitis. Toxin A (TcdA) and toxin B (TcdB) cause cytotoxicity and cellular detachment from intestinal epithelium and are re …

Ultrasensitive, quantitative Clostridioides difficile stool toxin measurement demonstrated significantly higher concentrations of toxins A and B in patients infected with the NAP-1/027 strain compared to patients infected with other strains. These data provide in vivo confirmation of the in vitro as …

Scientific Reports - Effects of broad-spectrum antibiotics on the colonisation of probiotic yeast Saccharomyces boulardii in the murine gastrointestinal tract

Patients with PPP have significantly higher risk for ankylosing spondylitis, Graves disease than those with psoriasis vulgaris

Clostridioides difficile is an anaerobic, Gram-positive pathogen that is responsible for C. difficile infection (CDI). To survive in the environment and spread to new hosts, C. difficile must form metabolically dormant spores. The formation of spores requires activation of the transcription factor S …

Our study reiterates that despite prophylaxis, infectious complications in GVHD following LT are common and lead to exceptionally high mortality. Individualized antimicrobial treatment, prophylaxis and monitoring strategies remain a critical component of GVHD management. Further study to optimize th …

Clostridium difficile is often the primary cause of nosocomial diarrhea, leading to thousands of deaths annually worldwide. The availability of an efficient genome editing tool for C. difficile is essential to understanding its pathogenic mechanism and physiological behavior. Here, we describe a str …

Clostridioides difficile: New global perspectives

Nature - A fez gene cluster drives formation of ferrosomes, a distinct lipid-bounded organelle for iron storage, in diverse bacterial species.

Researchers have used a systems biology approach to parse the genetic diversity of Clostridioides difficile, a particularly problematic pathogen, particularly in health care settings.

Notes from the Field: Escherichia coli O157:H7 Outbreak in Children with Clostridioides difficile Colonization Associated with an Improperly Treated Swimming Pool - Pennsylvania, June 2021

At the 10th GMFH World Summit, a panel of experts came together to share the latest in gut microbiota research.

Can Clostridium innocuum masquerade as Clostridioides difficile?

The WalR-WalK two-component regulatory system (TCS) is found in all Firmicutes, in which it regulates the expression of multiple genes required for remodeling the cell envelope during growth and division. Unlike most TCSs, WalRK is essential for viability, so it has attracted interest as a po …

The glycyl radical enzyme (GRE) family utilizes a glycyl radical cofactor, installed by AdoMet radical activating enzymes, to catalyze difficult chemical reactions in a variety of microbial metabolic pathways. Although GREs are widely encoded and expressed by bacteria found in the gut microbiome, th …

These results suggest that K. pneumoniae can cross-feed and shift the metabolism of C. difficile, as well as enhance the pro-inflammatory capacity of C. difficile. We speculate that interspecies interactions could be among the earliest events that occur as C. difficile colonizes the host. As a resul …

Clostridioides difficile is the leading cause of nosocomial infectious diarrhea, with clinical symptoms ranging from mild diarrhea to pseudomembranous colitis and toxic megacolon. Despite the use of vancomycin and fidaxomicin as standard drugs for the treatment of C. difficileinfection (CDI), clinic …

Most of the discussion around fecal microbiota transplantation has focused on bacterial communities, but new advances have shed more light on the role of the virome.

The use of 5-aminosalicylic acid significantly increases the risk for emClostridioides difficile/em infection in children with inflammatory bowel disease.

The Papin Lab makes it possible to apply the understanding of the nature of the bacteria to new treatment options for C. difficile bacterial infection. 

Clostridioides difficile is a Gram-positive, obligate anaerobic, spore-producing intestinal opportunistic pathogen. CDI outbreaks in Europe and the Americas in recent years are a major health concern. Intestinal short-chain fatty acids (SCFAs) are an important energy source for colonic epithelial ce …

A Clostridioides difficile infection (CDI) is the most common nosocomial infection worldwide. The main virulence factors of pathogenic C. difficile are TcdA and TcdB, which inhibit small Rho-GTPases. The inhibition of small Rho-GTPases leads to the so-called cytopathic effect, a reorga …

Venous sinus thrombosis secondary to disseminated intravascular coagulation after Clostridioides difficile infection

The fecal concentration of vancomycin was dependent on the intragastric dose administered. Only the 500 mg dose of VCM reached therapeutic concentration for C. difficile (MIC and MBC90), in the mice. We suggest starting a dose of 500 mg QID for achieving therapeutic concentration against …

Adjuvant chemotherapy and colorectal anastomosis leakage increase risk of Clostridium difficile infection. Patients with Clostridium difficile infection also ha

SignificanceClostridioides difficile infections are the most common source of hospital-acquired infections and are responsible for an extensive burden on the health care system. Strains of the C. difficile species comprise diverse lineages and demonstrate genome variability, with advan …

Nature Microbiology - Multi-omics analyses of faecal, urine and blood samples from women with and without recurrent urinary tract infections reveal that gut dysbiosis and differential immune...

Vancomycin is a front-line antibiotic for the treatment of Clostridioides difficile infections. However, C. difficile isolates exhibiting reduced susceptibility