C Diff Molecular

C Diff Molecular

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Oxygen tolerance in anaerobes as a virulence factor and a health-beneficial property - PubMed
Oxygen tolerance in anaerobes as a virulence factor and a health-beneficial property - PubMed
Oxygen tolerance of anaerobes is a virulence factor, but can also be a beneficial property. Many species have evolved to tolerate or take advantage of the presence of low, especially nanaerobic (≤0.14%) oxygen concentrations. Oxygen tolerance is genus-, species- and strain-dependent according to the …
·pubmed.ncbi.nlm.nih.gov·
Oxygen tolerance in anaerobes as a virulence factor and a health-beneficial property - PubMed
Identification of a family of peptidoglycan transpeptidases reveals that Clostridioides difficile requires noncanonical cross-links for viability - PubMed
Identification of a family of peptidoglycan transpeptidases reveals that Clostridioides difficile requires noncanonical cross-links for viability - PubMed
Most bacteria are surrounded by a cell wall that contains peptidoglycan (PG), a large polymer composed of glycan strands held together by short peptide cross-links. There are two major types of cross-links, termed 4-3 and 3-3 based on the amino acids involved. 4-3 cross-links are created by penicill …
·pubmed.ncbi.nlm.nih.gov·
Identification of a family of peptidoglycan transpeptidases reveals that Clostridioides difficile requires noncanonical cross-links for viability - PubMed
Identification of a family of peptidoglycan transpeptidases reveals that Clostridioides difficile requires noncanonical cross-links for viability - PubMed
Identification of a family of peptidoglycan transpeptidases reveals that Clostridioides difficile requires noncanonical cross-links for viability - PubMed
Most bacteria are surrounded by a cell wall that contains peptidoglycan (PG), a large polymer composed of glycan strands held together by short peptide cross-links. There are two major types of cross-links, termed 4-3 and 3-3 based on the amino acids involved. 4-3 cross-links are created by penicill …
·pubmed.ncbi.nlm.nih.gov·
Identification of a family of peptidoglycan transpeptidases reveals that Clostridioides difficile requires noncanonical cross-links for viability - PubMed
Symbiotic biofilms formed by Clostridioides difficile and bacteroides thetaiotaomicron in the presence of vancomycin - PubMed
Symbiotic biofilms formed by Clostridioides difficile and bacteroides thetaiotaomicron in the presence of vancomycin - PubMed
Vancomycin (VAN) treatment in Clostridioides difficile infection (CDI) suffers from a relatively high rate of recurrence, with a variety of reasons behind this, including biofilm-induced recurrent infections. C. difficile can form monophyletic or symbiotic biofilms with other microbes …
·pubmed.ncbi.nlm.nih.gov·
Symbiotic biofilms formed by Clostridioides difficile and bacteroides thetaiotaomicron in the presence of vancomycin - PubMed
Healing from Within: How Gut Microbiota Predicts IBD Treatment Success-A Systematic Review - PubMed
Healing from Within: How Gut Microbiota Predicts IBD Treatment Success-A Systematic Review - PubMed
Recent research indicates that the microbiome has a significant impact on the progression of inflammatory bowel disease (IBD) and that creating therapies that change its composition could positively impact the outcomes of IBD treatment. This review summarizes the results of extensive studies that ex …
·pubmed.ncbi.nlm.nih.gov·
Healing from Within: How Gut Microbiota Predicts IBD Treatment Success-A Systematic Review - PubMed
MicroRNA miR-27a-5p reduces intestinal inflammation induced by Clostridioides difficile flagella by regulating the NF-κB signaling pathway - PubMed
MicroRNA miR-27a-5p reduces intestinal inflammation induced by Clostridioides difficile flagella by regulating the NF-κB signaling pathway - PubMed
miR-27a-5p plays a crucial role in regulating C. difficile-induced inflammation, suggesting its potential as a therapeutic target for controlling severe infection. These findings offer valuable insights into potential therapeutic strategies for managing C. difficile infection and associated inflamma …
·pubmed.ncbi.nlm.nih.gov·
MicroRNA miR-27a-5p reduces intestinal inflammation induced by Clostridioides difficile flagella by regulating the NF-κB signaling pathway - PubMed
Clostridium septicum manifests a bile salt germinant response mediated by Clostridioides difficile csp gene orthologs - PubMed
Clostridium septicum manifests a bile salt germinant response mediated by Clostridioides difficile csp gene orthologs - PubMed
Clostridium septicum infections are highly predictive of certain malignancies in human patients. To initiate infections, C. septicum spores must first germinate and regain vegetative growth. Yet, what triggers the germination of C. septicum spores is still unknown. Here, we observe that C. septicum …
·pubmed.ncbi.nlm.nih.gov·
Clostridium septicum manifests a bile salt germinant response mediated by Clostridioides difficile csp gene orthologs - PubMed
Proteolytic activity of surface-exposed HtrA determines its expression level and is needed to survive acidic conditions in Clostridioides difficile - PubMed
Proteolytic activity of surface-exposed HtrA determines its expression level and is needed to survive acidic conditions in Clostridioides difficile - PubMed
To survive in the host, pathogenic bacteria need to be able to react to the unfavorable conditions that they encounter, like low pH, elevated temperatures, antimicrobial peptides and many more. These conditions may lead to unfolding of envelope proteins and this may be lethal. One of the mechanisms …
·pubmed.ncbi.nlm.nih.gov·
Proteolytic activity of surface-exposed HtrA determines its expression level and is needed to survive acidic conditions in Clostridioides difficile - PubMed
Human gut microbiota interactions shape the long-term growth dynamics and evolutionary adaptations of Clostridioides difficile - PubMed
Human gut microbiota interactions shape the long-term growth dynamics and evolutionary adaptations of Clostridioides difficile - PubMed
Clostridioides difficile can transiently or persistently colonize the human gut, posing a risk factor for infections. This colonization is influenced by complex molecular and ecological interactions with human gut microbiota. By investigating C. difficile dynamics in human gut communit …
·pubmed.ncbi.nlm.nih.gov·
Human gut microbiota interactions shape the long-term growth dynamics and evolutionary adaptations of Clostridioides difficile - PubMed
Clostridioides difficile colonization is not mediated by bile salts and requires Stickland fermentation of proline in an in vitro model of infection - PubMed
Clostridioides difficile colonization is not mediated by bile salts and requires Stickland fermentation of proline in an in vitro model of infection - PubMed
C. difficile is one of the leading causes of hospital-acquired infections and antibiotic-associated diarrhea. Several potential mechanisms through which the microbiota can limit C. difficile infection have been identified and are potential targets for new therapeutics. However, it is u …
·pubmed.ncbi.nlm.nih.gov·
Clostridioides difficile colonization is not mediated by bile salts and requires Stickland fermentation of proline in an in vitro model of infection - PubMed
A case of community-acquired Clostridioides difficile infection causing intussusception, severe pneumonia, and severe hypokalemia - PubMed
A case of community-acquired Clostridioides difficile infection causing intussusception, severe pneumonia, and severe hypokalemia - PubMed
This case report highlights a binary toxin-producing C. difficile that caused intussusception. The consideration of community-acquired C. difficile in the differential diagnosis of severe enteritis is necessary, even in Japan.
·pubmed.ncbi.nlm.nih.gov·
A case of community-acquired Clostridioides difficile infection causing intussusception, severe pneumonia, and severe hypokalemia - PubMed
Gut microbiota regulates gut homeostasis, mucosal immunity and influences immune-related diseases - PubMed
Gut microbiota regulates gut homeostasis, mucosal immunity and influences immune-related diseases - PubMed
The intestinal microbiome constitutes a sophisticated and massive ecosystem pivotal for maintaining gastrointestinal equilibrium and mucosal immunity via diverse pathways. The gut microbiota is continuously reshaped by multiple environmental factors, thereby influencing overall wellbeing or predispo …
·pubmed.ncbi.nlm.nih.gov·
Gut microbiota regulates gut homeostasis, mucosal immunity and influences immune-related diseases - PubMed
Characterization of Clostridioides difficile Persister Cells and Their Role in Antibiotic Tolerance - PubMed
Characterization of Clostridioides difficile Persister Cells and Their Role in Antibiotic Tolerance - PubMed
Clostridioides difficile is a Gram-positive pathogen known for its toxin production and spore formation. It is primarily responsible for most cases of antibiotic-associated diarrhea. Bacterial persisters are a small subset of the population that exhibits transient tolerance to bactericidal su …
·pubmed.ncbi.nlm.nih.gov·
Characterization of Clostridioides difficile Persister Cells and Their Role in Antibiotic Tolerance - PubMed
Genomic study of European Clostridioides difficile ribotype 002/sequence type 8 - PubMed
Genomic study of European Clostridioides difficile ribotype 002/sequence type 8 - PubMed
Clostridioides difficile has significant clinical importance as a leading cause of healthcare-associated infections, with symptoms ranging from mild diarrhoea to severe colitis, and possible life-threatening complications. C. difficile ribotype (RT) 002, mainly associated with MLST seq …
·pubmed.ncbi.nlm.nih.gov·
Genomic study of European Clostridioides difficile ribotype 002/sequence type 8 - PubMed
Antimicrobial susceptibilities, resistance mechanisms and molecular characteristics of toxigenic Clostridioides difficile isolates in a large teaching hospital in Chongqing, China - PubMed
Antimicrobial susceptibilities, resistance mechanisms and molecular characteristics of toxigenic Clostridioides difficile isolates in a large teaching hospital in Chongqing, China - PubMed
In contrast to prior studies, we found higher proportions of ST3 isolates with decreased tigecycline sensitivity, sharing similar resistance patterns and resistance genes. In the resistance process of tigecycline and tetracycline, the tetA(P) and tetB(P) genes may play a weak role.
·pubmed.ncbi.nlm.nih.gov·
Antimicrobial susceptibilities, resistance mechanisms and molecular characteristics of toxigenic Clostridioides difficile isolates in a large teaching hospital in Chongqing, China - PubMed
Spores of Clostridioides difficile are toxin delivery vehicles
Spores of Clostridioides difficile are toxin delivery vehicles
Communications Biology - This study shows that the genes coding for the two main toxins produced by Clostridioides difficile are expressed during sporulation and that the toxins associate with the...
·nature.com·
Spores of Clostridioides difficile are toxin delivery vehicles
Antimicrobial susceptibilities, resistance mechanisms and molecular characteristics of toxigenic Clostridioides difficile isolates in a large teaching hospital in Chongqing, China - PubMed
Antimicrobial susceptibilities, resistance mechanisms and molecular characteristics of toxigenic Clostridioides difficile isolates in a large teaching hospital in Chongqing, China - PubMed
In contrast to prior studies, we found higher proportions of ST3 isolates with decreased tigecycline sensitivity, sharing similar resistance patterns and resistance genes. In the resistance process of tigecycline and tetracycline, the tetA(P) and tetB(P) genes may play a weak role.
·pubmed.ncbi.nlm.nih.gov·
Antimicrobial susceptibilities, resistance mechanisms and molecular characteristics of toxigenic Clostridioides difficile isolates in a large teaching hospital in Chongqing, China - PubMed
Genomic study of European Clostridioides difficile ribotype 002/sequence type 8 - PubMed
Genomic study of European Clostridioides difficile ribotype 002/sequence type 8 - PubMed
Clostridioides difficile has significant clinical importance as a leading cause of healthcare-associated infections, with symptoms ranging from mild diarrhoea to severe colitis, and possible life-threatening complications. C. difficile ribotype (RT) 002, mainly associated with MLST seq …
·pubmed.ncbi.nlm.nih.gov·
Genomic study of European Clostridioides difficile ribotype 002/sequence type 8 - PubMed
Antimicrobial susceptibility in Clostridioides difficile varies according to European region and isolate source - PubMed
Antimicrobial susceptibility in Clostridioides difficile varies according to European region and isolate source - PubMed
Increased antimicrobial resistance was detected in eastern Europe and mostly associated with RT027 and related emerging RT181, while clinical isolates from northern and western Europe had the lowest general levels of resistance.
·pubmed.ncbi.nlm.nih.gov·
Antimicrobial susceptibility in Clostridioides difficile varies according to European region and isolate source - PubMed
RelQ-mediated alarmone signalling regulates growth, stress-induced biofilm formation and spore accumulation in Clostridioides difficile - PubMed
RelQ-mediated alarmone signalling regulates growth, stress-induced biofilm formation and spore accumulation in Clostridioides difficile - PubMed
The bacterial stringent response (SR) is a conserved transcriptional reprogramming pathway mediated by the nucleotide signalling alarmones, (pp)pGpp. The SR has been implicated in antibiotic survival in Clostridioides difficile, a biofilm- and spore-forming pathogen that causes resilient, hig …
·pubmed.ncbi.nlm.nih.gov·
RelQ-mediated alarmone signalling regulates growth, stress-induced biofilm formation and spore accumulation in Clostridioides difficile - PubMed
Commensal-pathogen dynamics structure disease outcomes during Clostridioides difficile colonization - PubMed
Commensal-pathogen dynamics structure disease outcomes during Clostridioides difficile colonization - PubMed
Gastrointestinal colonization by Clostridioides difficile is common in healthcare settings and ranges in clinical presentation from asymptomatic carriage to lethal C. difficile infection (CDI). We used a systems biology approach to investigate why patients colonized with C. difficil …
·pubmed.ncbi.nlm.nih.gov·
Commensal-pathogen dynamics structure disease outcomes during Clostridioides difficile colonization - PubMed
Commensal-pathogen dynamics structure disease outcomes during Clostridioides difficile colonization - PubMed
Commensal-pathogen dynamics structure disease outcomes during Clostridioides difficile colonization - PubMed
Gastrointestinal colonization by Clostridioides difficile is common in healthcare settings and ranges in clinical presentation from asymptomatic carriage to lethal C. difficile infection (CDI). We used a systems biology approach to investigate why patients colonized with C. difficil …
·pubmed.ncbi.nlm.nih.gov·
Commensal-pathogen dynamics structure disease outcomes during Clostridioides difficile colonization - PubMed
The state of play of rodent models for the study of Clostridioides difficile infection - PubMed
The state of play of rodent models for the study of Clostridioides difficile infection - PubMed
Clostridioides difficile is the most common cause of nosocomial antibiotic-associated diarrhoea and is responsible for a spectrum of diseases characterized by high levels of recurrence and morbidity. In some cases, complications can lead to death. Currently, several types of animal models hav …
·pubmed.ncbi.nlm.nih.gov·
The state of play of rodent models for the study of Clostridioides difficile infection - PubMed
RelQ-mediated alarmone signalling regulates growth, stress-induced biofilm formation and spore accumulation in Clostridioides difficile - PubMed
RelQ-mediated alarmone signalling regulates growth, stress-induced biofilm formation and spore accumulation in Clostridioides difficile - PubMed
The bacterial stringent response (SR) is a conserved transcriptional reprogramming pathway mediated by the nucleotide signalling alarmones, (pp)pGpp. The SR has been implicated in antibiotic survival in Clostridioides difficile, a biofilm- and spore-forming pathogen that causes resilient, hig …
·pubmed.ncbi.nlm.nih.gov·
RelQ-mediated alarmone signalling regulates growth, stress-induced biofilm formation and spore accumulation in Clostridioides difficile - PubMed