Metronidazole-Resistant Clostridioides difficile: Genomic and Transcriptomic Traits Acquired under In vitro Metronidazole Induction
Decreased effectiveness of metronidazole in Clostridioides difficile infection treatment has been documented. One reason is levels of metronidazole in the colon are generally low therefore a modest increase in the minimal inhibitory concentration of metronidazole for C. difficile may result in insuf …