C Diff Molecular

C Diff Molecular

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Clostridioides (Clostridium) difficile in children with diarrhoea in Vietnam
Clostridioides (Clostridium) difficile in children with diarrhoea in Vietnam
The prevalence of C. difficile in children with diarrhoea was high (37.8%) although the proportion of toxigenic strains was comparatively low. The clinical significance of any isolate needs to be determined.
·pubmed.ncbi.nlm.nih.gov·
Clostridioides (Clostridium) difficile in children with diarrhoea in Vietnam
Activation of the Extracytoplasmic Function sigma Factor sigma(V) in Clostridioides difficile Requires Regulated Intramembrane Proteolysis of the Anti-sigma Factor RsiV
Activation of the Extracytoplasmic Function sigma Factor sigma(V) in Clostridioides difficile Requires Regulated Intramembrane Proteolysis of the Anti-sigma Factor RsiV
Clostridioides (Clostridium) difficile is one of the leading causes of nosocomial diarrhea. Lysozyme is a common host defense against many pathogenic bacteria. C. difficile exhibits high levels of lysozyme resistance, which is due in part to the extracytoplasmic functioning (ECF) σ factor, σV …
·pubmed.ncbi.nlm.nih.gov·
Activation of the Extracytoplasmic Function sigma Factor sigma(V) in Clostridioides difficile Requires Regulated Intramembrane Proteolysis of the Anti-sigma Factor RsiV
RT @pssalgado: Are you a UK resident #BlackStudent with an interest in #superbugs #microbiology #biochemistry or #structuralbiology and wan…
RT @pssalgado: Are you a UK resident #BlackStudent with an interest in #superbugs #microbiology #biochemistry or #structuralbiology and wan…
Are you a UK resident #BlackStudent with an interest in #superbugs #microbiology #biochemistry or #structuralbiology and wanting to do a #PhD? Contact me if you'd like to join us studying #Cdiff and apply for a @UniofNewcastle #PhDstudentship https://t.co/BwxIrT4JKl Pls RT/share— Paula Salgado (@pssalgado) March 21, 2022
·twitter.com·
RT @pssalgado: Are you a UK resident #BlackStudent with an interest in #superbugs #microbiology #biochemistry or #structuralbiology and wan…
Genomic and Phenotypic Characterization of the Nontoxigenic Clostridioides difficile Strain CCUG37785 and Demonstration of Its Therapeutic Potential for the Prevention of C. difficile Infection
Genomic and Phenotypic Characterization of the Nontoxigenic Clostridioides difficile Strain CCUG37785 and Demonstration of Its Therapeutic Potential for the Prevention of C. difficile Infection
Symptoms of Clostridioides difficile infection (CDI) are attributed largely to two toxins, TcdA and TcdB. About 17-23% of C. difficile isolates produce binary toxin, which enhances C. difficile pathogenesis. Previously, we engineered the nontoxigenic C. difficile strain CCUG37785 (designated as CCUG …
·pubmed.ncbi.nlm.nih.gov·
Genomic and Phenotypic Characterization of the Nontoxigenic Clostridioides difficile Strain CCUG37785 and Demonstration of Its Therapeutic Potential for the Prevention of C. difficile Infection
Structure and conformational dynamics of Clostridioides difficile toxin A
Structure and conformational dynamics of Clostridioides difficile toxin A
Clostridioides difficile toxin A and B (TcdA and TcdB) are two major virulence factors responsible for diseases associated with C. difficile infection (CDI). Here, we report the 3.18-Å resolution crystal structure of a TcdA fragment (residues L843-T2481), which advances our understandi …
·pubmed.ncbi.nlm.nih.gov·
Structure and conformational dynamics of Clostridioides difficile toxin A
Metronidazole-Resistant Clostridioides difficile: Genomic and Transcriptomic Traits Acquired under In vitro Metronidazole Induction
Metronidazole-Resistant Clostridioides difficile: Genomic and Transcriptomic Traits Acquired under In vitro Metronidazole Induction
Decreased effectiveness of metronidazole in Clostridioides difficile infection treatment has been documented. One reason is levels of metronidazole in the colon are generally low therefore a modest increase in the minimal inhibitory concentration of metronidazole for C. difficile may result in insuf …
·pubmed.ncbi.nlm.nih.gov·
Metronidazole-Resistant Clostridioides difficile: Genomic and Transcriptomic Traits Acquired under In vitro Metronidazole Induction
TFPI is a colonic crypt receptor for TcdB from hypervirulent clade 2 C. difficile
TFPI is a colonic crypt receptor for TcdB from hypervirulent clade 2 C. difficile
The emergence of hypervirulent clade 2 Clostridioides difficile is associated with severe symptoms and accounts for 20% of global infections. TcdB is a dominant virulence factor of C. difficile, and clade 2 strains exclusively express two TcdB variants (TcdB2 and TcdB4) that use unknown receptor …
·pubmed.ncbi.nlm.nih.gov·
TFPI is a colonic crypt receptor for TcdB from hypervirulent clade 2 C. difficile
Environmental factors and ulcerative colitis: Causes, risks, and more
Environmental factors and ulcerative colitis: Causes, risks, and more
Certain factors in the environment may cause ulcerative colitis flares. Learn more about the connections between these different factors and how to reduce their effect on symptoms.
·medicalnewstoday.com·
Environmental factors and ulcerative colitis: Causes, risks, and more
Molecular characterization of Clostridioides difficile by multi-locus sequence typing (MLST): A study from tertiary care center in India
Molecular characterization of Clostridioides difficile by multi-locus sequence typing (MLST): A study from tertiary care center in India
ST 17 is most prominent sequence type. This is the first report of MLST based study of C. difficile from India. Further studies from diverse geographical regions can help better understand the epidemiology of CDI in India.
·pubmed.ncbi.nlm.nih.gov·
Molecular characterization of Clostridioides difficile by multi-locus sequence typing (MLST): A study from tertiary care center in India
The Critical Role of Environmental Synergies in the Creation of Bionanohybrid Microbes
The Critical Role of Environmental Synergies in the Creation of Bionanohybrid Microbes
A wide range of bacteria can synthesize surface-associated nanoparticles (SANs) through exogenous metal ions reacting with sulfide produced via cysteine metabolism, resulting in the emergence of a biological-nanoparticle hybrid (bionanohybrid). The attached nanoparticles may couple to extracellular …
·pubmed.ncbi.nlm.nih.gov·
The Critical Role of Environmental Synergies in the Creation of Bionanohybrid Microbes
Characterization of a Clostridioides difficile outbreak caused by PCR ribotype 046, associated with increased mortality
Characterization of a Clostridioides difficile outbreak caused by PCR ribotype 046, associated with increased mortality
This study describe a large nosocomial outbreak of Clostridioides difficile infections (CDI) dominated by ribotype (RT) 046 in a Swedish hospital. The aim of the present study was to examine the pathogenicity of this RT, explore epidemiological links by whole genome sequencing (WGS) and evalu …
·pubmed.ncbi.nlm.nih.gov·
Characterization of a Clostridioides difficile outbreak caused by PCR ribotype 046, associated with increased mortality
A Case Report and Review of the Literature: Reactive Arthritis Caused by Clostridioides difficile ribotype 027
A Case Report and Review of the Literature: Reactive Arthritis Caused by Clostridioides difficile ribotype 027
With an annual incidence of 250-300 per 100,000 inhabitants, reactive arthritis is not uncommon. However, the fact that Clostridioides difficile infection (CDI) can also lead to this complication is largely unknown. We report on a 69-years-old man who developed reactive arthritis of his right …
·pubmed.ncbi.nlm.nih.gov·
A Case Report and Review of the Literature: Reactive Arthritis Caused by Clostridioides difficile ribotype 027
Unique Features of Alarmone Metabolism in Clostridioides difficile
Unique Features of Alarmone Metabolism in Clostridioides difficile
The "magic spot" alarmones (pp)pGpp, previously implicated in Clostridioides difficile antibiotic survival, are synthesized by the RelA-SpoT homolog (RSH) of C. difficile (RSHCd) and RelQCd. These enzymes are transcriptionally activated by diverse environmental stresses. RSH …
·pubmed.ncbi.nlm.nih.gov·
Unique Features of Alarmone Metabolism in Clostridioides difficile
Satyendra Dhar MD FHM🕊(𑆱𑆠𑇀𑆪𑆼𑆁𑆢𑇀𑆫 𑆣𑆫) on Twitter
Satyendra Dhar MD FHM🕊(𑆱𑆠𑇀𑆪𑆼𑆁𑆢𑇀𑆫 𑆣𑆫) on Twitter
The incidence of rec CDI is ⬆️. After an initial episode, ⤴️35% have recurrence. ⤴️60% who have a recurrence have another one. Exposure to antibiotics is a critical modifiable risk factor. Most cases occur within 2 wks of antibiotic Rx. #CDiff #antibiotics #antibioticstewardship pic.twitter.com/NTgwYohGZ0— Satyendra Dhar MD FHM🕊(𑆱𑆠𑇀𑆪𑆼𑆁𑆢𑇀𑆫 𑆣𑆫) (@DharSaty) March 2, 2022
·twitter.com·
Satyendra Dhar MD FHM🕊(𑆱𑆠𑇀𑆪𑆼𑆁𑆢𑇀𑆫 𑆣𑆫) on Twitter
Delayed Diagnosis of Clostridium difficile Colitis in a 48-Year-Old Woman with a Homozygous Mutation of the UGT1A1 Gene While on Chemotherapy for Colorectal Carcinoma
Delayed Diagnosis of Clostridium difficile Colitis in a 48-Year-Old Woman with a Homozygous Mutation of the UGT1A1 Gene While on Chemotherapy for Colorectal Carcinoma
BACKGROUND There are many causes of chronic colitis and diarrhea, including the effects of chemotherapy. Mutations in the UGT1A1 gene can be associated with increased toxicity from irinotecan-based chemotherapy. This report is of a case of delayed diagnosis of Clostridium difficile (C. difficile) co …
·pubmed.ncbi.nlm.nih.gov·
Delayed Diagnosis of Clostridium difficile Colitis in a 48-Year-Old Woman with a Homozygous Mutation of the UGT1A1 Gene While on Chemotherapy for Colorectal Carcinoma
Clostridioides difficile from brazilian hospitals: characterization of virulence genes by whole genome sequencing
Clostridioides difficile from brazilian hospitals: characterization of virulence genes by whole genome sequencing
Clostridioides difficile (CD) is the most frequent cause of healthcare related diarrhea and its severity has increased in the last decade by the spread of hypervirulent strains. Most important CD virulence factor is toxin production; however, not only toxins are responsible for Clostridioides virule …
·pubmed.ncbi.nlm.nih.gov·
Clostridioides difficile from brazilian hospitals: characterization of virulence genes by whole genome sequencing
Genetic and phenotypic characteristics of Clostridium (Clostridioides) difficile from canine, bovine, and pediatric populations
Genetic and phenotypic characteristics of Clostridium (Clostridioides) difficile from canine, bovine, and pediatric populations
Growth rates and relative cytotoxicity of isolates were significantly higher and lower, respectively, in bovine-derived isolates compared to pediatric- and canine-derived isolates. Analysis of core genes showed clustering by host species, though in a few cases, human strains co-clustered with canine …
·pubmed.ncbi.nlm.nih.gov·
Genetic and phenotypic characteristics of Clostridium (Clostridioides) difficile from canine, bovine, and pediatric populations