C Diff Molecular

Our results suggest an association between reduced antibiotic susceptibility and biofilm production capacity. This finding reinforces the importance of antibiotic susceptibility testing, mainly in recurrence infections that may be induced by a strain that is both antibiotic tolerant and biofilm prod …

Clostridioides difficile spores, like the spores from most endospore-forming organisms, are a metabolically dormant stage of development with a complex structure that conveys considerable resistance to environmental conditions, e.g., wet heat. This resistance is due to the large amount …

The type 4 secretion system (T4SS) represents a bacterial nanomachine capable of trans-cell wall transportation of proteins and DNA and has attracted intense interest due to its roles in the pathogenesis of infectious diseases. In the current investigation, we uncovered three distinct gene clusters …

All clinical Clostridioides difficile strains identified to date express a surface capsule-like polysaccharide structure known as polysaccharide II (PSII). The PSII antigen is immunogenic and when conjugated to a protein carrier induces a protective antibody response in animal models. Given t …

Its been so great seeing all the #biofilmweek images! It inspired me throw this one into the mix- here is a SEM of C. difficile and F. nucleatum biofilms! #biofilmsinthelab #biofilm #Cdiff #Fusobacterium pic.twitter.com/1rPPpJse7q— Mindy Engevik (@MicroMindy) August 21, 2021

Clostridioides difficile infection (CDI) is on the rise worldwide and is associated with an increase in deaths and socio-health burden. C. difficile has become ubiquitous in anthropized environments because of the extreme resistance of its spores. Based on the epidemiological data and …

Cellobiose metabolism is linked to the virulence properties in numerous bacterial pathogens. Here, we characterized a putative cellobiose PTS operon of Clostridiodes difficile to investigate the role of cellobiose metabolism in C. difficile pathogenesis. Our gene knockout experiments d …

The co-existence of Blastocystis and C. difficile in IBD patients was observed in the current study. Moreover, it can be proposed that these microorganisms may have synergistic effects on their colonization in the gastrointestinal tract.

A recent study in Nature finds significant shifts in the gut microbiome of post-menopausal women on severe calorie restriction concomitant with weight loss. Microbiota transplantation to germ-free mice display a similar weight loss, along with a bloom in C. difficile, unlocking clues to microbial metabolic alteration in weight loss.

It takes less than a minute to download C diff and You app.Available from the Apple Store and Google Play Store 📱We place the C. diff. community in the palm of your hands 🤲 #cdiff #CDI #Cdifficile #healthcare #clinicaltrials #nutrition #support #microbiome #Cdiffeducation pic.twitter.com/EaXHWJaYA7— C DIFF FOUNDATION (@cdiffFoundation) August 9, 2021

The Colneyvirus could potentially be lifesaving by fighting the C.diff infection, researchers say.

Clostridioides difficile infection (CDI) is the leading cause of life-threatening health care-related gastrointestinal illness worldwide. Phylogenetically appropriate closed reference genomes are essential for studies of C. difficile transmission and evolution. Here, we provide high-quality complete …

Clostridioides difficile R20291 is the most studied PCR-Ribotype 027 isolate. The two predominant lineages of this hypervirulent strain, however, exhibit substantive phenotypic differences and possess genomes that differ by a small number of nucleotide changes. It is important that the source of R20 …

When babies are given antibiotics, their but microbiome is changed. This puts the little ones at a higher risk of developing Type 1 diabetes.

The TLR2 rs3804099 polymorphism is marginally associated with the development of CDI, and the pathogenic role of TLR2 is further supported by a mouse model.

Centenarians display decreased susceptibility to ageing-associated illness, chronic inflammation, and infectious disease1-3. Here we show that centenarians have a distinct gut microbiome enriched in microbes capable of generating unique secondary bile acids (BAs), including iso-, 3-oxo-, …

Colitis refers to inflammation in the colon (large intestine). There are many causes of colitis, some of which are serious and even life-threatening.

Professor Dena Lyras, the first female ARC Laureate fellow in Monash University’s Faculty of Medicine, is on a continuing mission to understand the formidable enemy of antibiotic-resistant bacteria, particularly those in the human gut. Read more at Monash Lens