C Diff Molecular

Age, antibiotic use, and proton pump inhibitor use was associated with an increase in C difficile infections.

“Exciting new #cdiff research: @NiraPollock showed toxin concentration in stool is associated with severe disease, outcomes, & recurrence in adult patients. We have been collecting data on pediatric CDI to see if the same is true for kids--stay tuned for results! https://t.co/SM1HBZVq8r”

One-seventh of major head and neck flap surgeries were complicated by MPIs, three-quarters of infections developed within 1 week postoperatively. Gram-negative bacilli and S. aureus were the predominant pathogens.

RT001 and RT176 were the most prevalent C difficile ribotypes found from C difficile isolates using PCR testing.

Clostridioides difficile infection (CDI) is a health issue of utmost significance in Europe and North America, due to its high prevalence, morbidity, and mortality rate. The clinical spectrum of CDI is broad, ranging from asymptomatic to deadly fulminant colitis. When associated with chronic …

Patients with pediatric solid tumors and hematological malignancies were more prone to C difficile infections.

In this large database study, we uncovered that cirrhotic patients have a significantly higher CDI prevalence than those without cirrhosis. Liver cirrhosis may be an independent risk factor for CDI. Further prospective studies are needed to clarify this possible risk association that may lead to the …

While Clostridioides difficile is recognized as an important human pathogen, it is also a significant cause of gastroenteritis and associated diarrhea in neonatal pigs. Since clinical disease is rarely diagnosed in piglets older than 1 week of age, it is hypothesized that natural resistance is assoc …

Nature Chemical Biology - This Review article explores how uncovering phenotypes linked to the human microbiome often progresses from correlative studies to studies in germ-free animals and fecal...

A significant difference in CDID development was not detected. The use of non-steroidal anti-inflammatory drugs for 7 days and longer was a risk factor for CDID development. Additionally, an excessive inappropriate use of GASs was observed. Clinicians should be cautious of all these factors, which m …

In CDI patients, ultrasensitive stool toxin detection and concentration correlated with severe baseline disease, severe CDI-attributable outcomes, and recurrence, confirming the contribution of toxin quantity to disease presentation and clinical course.

In this study, we identified the specific genomic characteristics of Korean C. difficile strains, which could serve as basic information for CDI prevention and treatment in Korea.

European Journal of Clinical Microbiology & Infectious Diseases - Antimicrobial resistance (AMR) in Clostridioides difficile remains a significant threat to global healthcare systems, not just...

Colitis causes inflammation and discomfort in the colon and abdomen. Learn about the various types of this disease affecting different areas of the GI tract.

The microbiota inhabiting the intestinal tract provide several critical functions to its host. Microorganisms found at the mucosal layer form organized three-dimensional structures which are considered to be biofilms. Their development and functions are influenced by host factors, host-microbe interactions, and microbe-microbe interactions. These structures can dictate the health of their host by strengthening the natural defenses of the gut epithelium or cause disease by exacerbating underlying conditions. Biofilm communities can also block the establishment of pathogens and prevent infectious diseases. Although these biofilms are important for colonization resistance, new data provide evidence that gut biofilms can act as a reservoir for pathogens such as Clostridioides difficile. In this review, we will look at the biofilms of the intestinal tract, their contribution to health and disease, and the factors influencing their formation. We will then focus on the factors contributing to biofilm formation in C. difficile, how these biofilms are formed, and their properties. In the last section, we will look at how the gut microbiota and the gut biofilm influence C. difficile biofilm formation, persistence, and transmission.

#FMT for Recurrent #cdiff Infection Enhances Adaptive Immunity to C difficile Toxin B (#TcdB) https://t.co/AdxUdihH09— Wiep Klaas Smits (@SmitsLab) September 16, 2021

The microbiota inhabiting the intestinal tract provide several critical functions to its host. Microorganisms found at the mucosal layer form organized three-dimensional structures which are considered to be biofilms. Their development and functions are influenced by host factors, host-microbe interactions, and microbe-microbe interactions. These structures can dictate the health of their host by strengthening the natural defenses of the gut epithelium or cause disease by exacerbating underlying conditions. Biofilm communities can also block the establishment of pathogens and prevent infectious diseases. Although these biofilms are important for colonization resistance, new data provide evidence that gut biofilms can act as a reservoir for pathogens such as Clostridioides difficile. In this review, we will look at the biofilms of the intestinal tract, their contribution to health and disease, and the factors influencing their formation. We will then focus on the factors contributing to biofilm formation in C. difficile, how these biofilms are formed, and their properties. In the last section, we will look at how the gut microbiota and the gut biofilm influence C. difficile biofilm formation, persistence, and transmission.

The specific NLRP3 N-terminal domain is essential for NLRP3 activation and inflammasome formation in response to K+ efflux.

🎬Just finished taping #IDWeek2021 talk -- tune in 10/2 to learn about #machinelearning to predict #cdiff & #COVID19 outcomes. 💯awesome team of collaborators👏👏👏 @MIT_CSAIL @UMich @MassGeneralNews @MassGenBrigham UCSF & UT Southwest Medical Center @IDSAInfo @SHEA_Epi https://t.co/q44gOtIKh0

One of the many talks I've stayed awake since 3.30 am for!! Exciting talk from @DanRJKnight on the 'New evolutionary and ecological insights into the #Cdiff species' 😎 https://t.co/U7wufSC0Ur

Changing the gut microbiome may be a useful treatment strategy to improve eczema.

The human microbiome can protect against colonization with pathogenic antibiotic-resistant bacteria (ARB), but its impacts on the spread of antibiotic resistance are poorly understood. We propose a mathematical modelling framework for ARB epidemiology formalizing within-host ARB-microbiome competiti …

Clostridioides difficile is the leading cause of nosocomial intestinal infections in the United States. Ingested C. difficile spores encounter host bile acids and other cues that are necessary for germinating into toxin-producing vegetative cells. While gut microbiota disruption (often by antibiotic …

Clostridiodes difficile (C. difficile) was ranked an "urgent threat" by the Centers for Disease Control and Prevention (CDC) in 2019. C. difficile infection (CDI) is the most common healthcare-associated infection (HAI) in the United States of America as well as the leading cause of antibiotic-assoc …

The latest Tweets from Australasian Human Microbiome Research Network (@microbiome_net). The Network serves to advance impactful microbiome research for the benefit of human health and disease prevention. https://t.co/9FvEbaiSP5. Australasia

Severe isolated ICI-enteritis is rare and can lead to clinically significant gastrointestinal hemorrhage. Patients with severe ICI-enteritis on endoscopy should be carefully monitored for steroid refractory disease for consideration of step-up therapy such as infliximab.

Clostridioides difficile is a nosocomial pathogen which causes severe diarrhea and colonic inflammation. C. difficile causes disease in susceptible patients when endospores germinate into the toxin-producing vegetative form. The action of these toxins results in diarrhea and the spread of spores int …

In this study, it was found that a sACR≤3.4 could predict the 30-day all-cause mortality in patients with CDAD.