C Diff Molecular

C Diff Molecular

1791 bookmarks
Custom sorting
Amount of toxin in stool correlates with C. difficile severity, study shows - Healio
Amount of toxin in stool correlates with C. difficile severity, study shows - Healio
Using a new highly sensitive assay, researchers demonstrated that the amount of toxin in stool correlates with the severity of Clostridioides difficile infection, with higher concentrations associated with severe disease at diagnosis. The highly sensitive toxin test is based on a technology called Simoa and allowed the researchers to quantify the amount of toxin in the stool of patients with
·healio.com·
Amount of toxin in stool correlates with C. difficile severity, study shows - Healio
Inactivation of the riboswitch-controlled GMP synthase GuaA in Clostridioides difficile is associated with severe growth defects and poor infectivity in a mouse model of infection
Inactivation of the riboswitch-controlled GMP synthase GuaA in Clostridioides difficile is associated with severe growth defects and poor infectivity in a mouse model of infection
Clostridioides difficile is the main cause of nosocomial antibiotic-associated diarrhoea. There is a need for new antimicrobials to tackle this pathogen. Guanine riboswitches have been proposed as promising new antimicrobial targets, but experimental evidence of their importance in C. diff …
·pubmed.ncbi.nlm.nih.gov·
Inactivation of the riboswitch-controlled GMP synthase GuaA in Clostridioides difficile is associated with severe growth defects and poor infectivity in a mouse model of infection
Term infant formula supplemented with milk-derived oligosaccharides shifts the gut microbiota closer to that of human milk-fed infants and improves intestinal immune defense: A randomized controlled trial
Term infant formula supplemented with milk-derived oligosaccharides shifts the gut microbiota closer to that of human milk-fed infants and improves intestinal immune defense: A randomized controlled trial
Infant formula with MOS shifts the gut microbiota and metabolic signature closer to that of HFI, has a strong bifidogenic effect, reduces fecal pathogens, and improves intestinal immune response.
·pubmed.ncbi.nlm.nih.gov·
Term infant formula supplemented with milk-derived oligosaccharides shifts the gut microbiota closer to that of human milk-fed infants and improves intestinal immune defense: A randomized controlled trial
Clostridioides difficile toxin A-mediated Caco-2 cell barrier damage was attenuated by insect-derived fractions and corresponded to increased gene transcription of cell junctional and proliferation proteins
Clostridioides difficile toxin A-mediated Caco-2 cell barrier damage was attenuated by insect-derived fractions and corresponded to increased gene transcription of cell junctional and proliferation proteins
Pathogenesis of C. difficile in the intestine is associated with the secretion of toxins which can damage the intestinal epithelial layer and result in diseases such as diarrhoea. Treatment for C. difficile infections consists of antibiotics which, however, have non-specific microbioci …
·pubmed.ncbi.nlm.nih.gov·
Clostridioides difficile toxin A-mediated Caco-2 cell barrier damage was attenuated by insect-derived fractions and corresponded to increased gene transcription of cell junctional and proliferation proteins
Phase-variable expression of pdcB, a phosphodiesterase, influences sporulation in Clostridioides difficile
Phase-variable expression of pdcB, a phosphodiesterase, influences sporulation in Clostridioides difficile
Clostridioides difficile is the causative agent of antibiotic-associated diarrhea and is the leading cause of nosocomial infection in developed countries. An increasing number of C. difficile infections are attributed to epidemic strains that produce more toxins and spores. C. difficile spores are t …
·pubmed.ncbi.nlm.nih.gov·
Phase-variable expression of pdcB, a phosphodiesterase, influences sporulation in Clostridioides difficile
A new phenothiazine derivate is active against Clostridioides difficile and shows low cytotoxicity
A new phenothiazine derivate is active against Clostridioides difficile and shows low cytotoxicity
The rapid evolution of antibiotic resistance in Clostridioides difficile and the consequent effects on prevention and treatment of C. difficile infections (CDIs) are matters of concern for public health. Thioridazine, a compound belonging to the phenothiazine group, has previous shown antimicrobial …
·pubmed.ncbi.nlm.nih.gov·
A new phenothiazine derivate is active against Clostridioides difficile and shows low cytotoxicity
The Binary Toxin of Clostridioides difficile Alters the Proteome and Phosphoproteome of HEp-2 Cells
The Binary Toxin of Clostridioides difficile Alters the Proteome and Phosphoproteome of HEp-2 Cells
Clostridioides difficile is a major cause of nosocomial infection worldwide causing antibiotic-associated diarrhea and some cases are leading to pseudomembranous colitis. The main virulence factors are toxin A and toxin B. Hypervirulent strains of C. difficile are linked to higher mort …
·pubmed.ncbi.nlm.nih.gov·
The Binary Toxin of Clostridioides difficile Alters the Proteome and Phosphoproteome of HEp-2 Cells
A lipoprotein allosterically activates the CwlD amidase during Clostridioides difficile spore formation
A lipoprotein allosterically activates the CwlD amidase during Clostridioides difficile spore formation
Spore-forming pathogens like Clostridioides difficile depend on germination to initiate infection. During gemination, spores must degrade their cortex layer, which is a thick, protective layer of modified peptidoglycan. Cortex degradation depends on the presence of the spore-specific peptidoglycan m …
·pubmed.ncbi.nlm.nih.gov·
A lipoprotein allosterically activates the CwlD amidase during Clostridioides difficile spore formation
High Serum Levels of Toxin A Correlate with Disease Severity in Patients with Clostridioides difficile Infection
High Serum Levels of Toxin A Correlate with Disease Severity in Patients with Clostridioides difficile Infection
Cloistridioides difficile (CD) represents a major public healthcare-associated infection causing significant morbidity and mortality. The pathogenic effects of CD are mainly caused by the release of two exotoxins into the intestine: toxin A (TcdA) and toxin B (TcdB). CD infection (CDI) can al …
·pubmed.ncbi.nlm.nih.gov·
High Serum Levels of Toxin A Correlate with Disease Severity in Patients with Clostridioides difficile Infection
An Osmotic Laxative Renders Mice Susceptible to Prolonged Clostridioides difficile Colonization and Hinders Clearance
An Osmotic Laxative Renders Mice Susceptible to Prolonged Clostridioides difficile Colonization and Hinders Clearance
Antibiotics are a major risk factor for Clostridioides difficile infections (CDIs) because of their impact on the microbiota. However, nonantibiotic medications such as the ubiquitous osmotic laxative polyethylene glycol 3350 (PEG 3350) also alter the microbiota. Clinicians also hypothesize that PEG …
·pubmed.ncbi.nlm.nih.gov·
An Osmotic Laxative Renders Mice Susceptible to Prolonged Clostridioides difficile Colonization and Hinders Clearance
C Difficile Risk Factors Identified
C Difficile Risk Factors Identified
Age, antibiotic use, and proton pump inhibitor use was associated with an increase in C difficile infections.
·hcplive.com·
C Difficile Risk Factors Identified
C DIFF FOUNDATION on Twitter: "RT @tomsandora: Exciting new #cdiff research: @NiraPollock showed toxin concentration in stool is associated with severe disease, outcomes,…" / Twitter
C DIFF FOUNDATION on Twitter: "RT @tomsandora: Exciting new #cdiff research: @NiraPollock showed toxin concentration in stool is associated with severe disease, outcomes,…" / Twitter
“Exciting new #cdiff research: @NiraPollock showed toxin concentration in stool is associated with severe disease, outcomes, & recurrence in adult patients. We have been collecting data on pediatric CDI to see if the same is true for kids--stay tuned for results! https://t.co/SM1HBZVq8r”
·mobile.twitter.com·
C DIFF FOUNDATION on Twitter: "RT @tomsandora: Exciting new #cdiff research: @NiraPollock showed toxin concentration in stool is associated with severe disease, outcomes,…" / Twitter
Pneumonia, urinary tract infection, bacteremia, and Clostridioides difficile infection following major head and neck free and pedicled flap surgeries
Pneumonia, urinary tract infection, bacteremia, and Clostridioides difficile infection following major head and neck free and pedicled flap surgeries
One-seventh of major head and neck flap surgeries were complicated by MPIs, three-quarters of infections developed within 1 week postoperatively. Gram-negative bacilli and S. aureus were the predominant pathogens.
·pubmed.ncbi.nlm.nih.gov·
Pneumonia, urinary tract infection, bacteremia, and Clostridioides difficile infection following major head and neck free and pedicled flap surgeries
Clostridioides difficile Infection in Patients with Chronic Kidney Disease: A Systematic Review
Clostridioides difficile Infection in Patients with Chronic Kidney Disease: A Systematic Review
Clostridioides difficile infection (CDI) is a health issue of utmost significance in Europe and North America, due to its high prevalence, morbidity, and mortality rate. The clinical spectrum of CDI is broad, ranging from asymptomatic to deadly fulminant colitis. When associated with chronic …
·pubmed.ncbi.nlm.nih.gov·
Clostridioides difficile Infection in Patients with Chronic Kidney Disease: A Systematic Review
Clostridioides difficile infection in liver cirrhosis patients: A population-based study in United States
Clostridioides difficile infection in liver cirrhosis patients: A population-based study in United States
In this large database study, we uncovered that cirrhotic patients have a significantly higher CDI prevalence than those without cirrhosis. Liver cirrhosis may be an independent risk factor for CDI. Further prospective studies are needed to clarify this possible risk association that may lead to the …
·pubmed.ncbi.nlm.nih.gov·
Clostridioides difficile infection in liver cirrhosis patients: A population-based study in United States
Neonatal Piglets Are Protected from Clostridioides difficile Infection by Age-Dependent Increase in Intestinal Microbial Diversity
Neonatal Piglets Are Protected from Clostridioides difficile Infection by Age-Dependent Increase in Intestinal Microbial Diversity
While Clostridioides difficile is recognized as an important human pathogen, it is also a significant cause of gastroenteritis and associated diarrhea in neonatal pigs. Since clinical disease is rarely diagnosed in piglets older than 1 week of age, it is hypothesized that natural resistance is assoc …
·pubmed.ncbi.nlm.nih.gov·
Neonatal Piglets Are Protected from Clostridioides difficile Infection by Age-Dependent Increase in Intestinal Microbial Diversity
Effect of gastric acid suppression on Clostridioides difficile-induced diarrhea and appropriateness of gastric acid suppressors in hospitalized patients: A matched case-control study
Effect of gastric acid suppression on Clostridioides difficile-induced diarrhea and appropriateness of gastric acid suppressors in hospitalized patients: A matched case-control study
A significant difference in CDID development was not detected. The use of non-steroidal anti-inflammatory drugs for 7 days and longer was a risk factor for CDID development. Additionally, an excessive inappropriate use of GASs was observed. Clinicians should be cautious of all these factors, which m …
·pubmed.ncbi.nlm.nih.gov·
Effect of gastric acid suppression on Clostridioides difficile-induced diarrhea and appropriateness of gastric acid suppressors in hospitalized patients: A matched case-control study
Ultrasensitive and quantitative toxin measurement correlates with baseline severity, severe outcomes, and recurrence among hospitalized patients with Clostridioides difficile infection
Ultrasensitive and quantitative toxin measurement correlates with baseline severity, severe outcomes, and recurrence among hospitalized patients with Clostridioides difficile infection
In CDI patients, ultrasensitive stool toxin detection and concentration correlated with severe baseline disease, severe CDI-attributable outcomes, and recurrence, confirming the contribution of toxin quantity to disease presentation and clinical course.
·pubmed.ncbi.nlm.nih.gov·
Ultrasensitive and quantitative toxin measurement correlates with baseline severity, severe outcomes, and recurrence among hospitalized patients with Clostridioides difficile infection
Antimicrobial resistance in Clostridioides difficile | SpringerLink
Antimicrobial resistance in Clostridioides difficile | SpringerLink
European Journal of Clinical Microbiology & Infectious Diseases - Antimicrobial resistance (AMR) in Clostridioides difficile remains a significant threat to global healthcare systems, not just...
·link.springer.com·
Antimicrobial resistance in Clostridioides difficile | SpringerLink
Microorganisms | Free Full-Text | Wolf in Sheep’s Clothing: Clostridioides difficile Biofilm as a Reservoir for Recurrent Infections
Microorganisms | Free Full-Text | Wolf in Sheep’s Clothing: Clostridioides difficile Biofilm as a Reservoir for Recurrent Infections
The microbiota inhabiting the intestinal tract provide several critical functions to its host. Microorganisms found at the mucosal layer form organized three-dimensional structures which are considered to be biofilms. Their development and functions are influenced by host factors, host-microbe interactions, and microbe-microbe interactions. These structures can dictate the health of their host by strengthening the natural defenses of the gut epithelium or cause disease by exacerbating underlying conditions. Biofilm communities can also block the establishment of pathogens and prevent infectious diseases. Although these biofilms are important for colonization resistance, new data provide evidence that gut biofilms can act as a reservoir for pathogens such as Clostridioides difficile. In this review, we will look at the biofilms of the intestinal tract, their contribution to health and disease, and the factors influencing their formation. We will then focus on the factors contributing to biofilm formation in C. difficile, how these biofilms are formed, and their properties. In the last section, we will look at how the gut microbiota and the gut biofilm influence C. difficile biofilm formation, persistence, and transmission.
·mdpi.com·
Microorganisms | Free Full-Text | Wolf in Sheep’s Clothing: Clostridioides difficile Biofilm as a Reservoir for Recurrent Infections
Microorganisms | Free Full-Text | Wolf in Sheep’s Clothing: Clostridioides difficile Biofilm as a Reservoir for Recurrent Infections
Microorganisms | Free Full-Text | Wolf in Sheep’s Clothing: Clostridioides difficile Biofilm as a Reservoir for Recurrent Infections
The microbiota inhabiting the intestinal tract provide several critical functions to its host. Microorganisms found at the mucosal layer form organized three-dimensional structures which are considered to be biofilms. Their development and functions are influenced by host factors, host-microbe interactions, and microbe-microbe interactions. These structures can dictate the health of their host by strengthening the natural defenses of the gut epithelium or cause disease by exacerbating underlying conditions. Biofilm communities can also block the establishment of pathogens and prevent infectious diseases. Although these biofilms are important for colonization resistance, new data provide evidence that gut biofilms can act as a reservoir for pathogens such as Clostridioides difficile. In this review, we will look at the biofilms of the intestinal tract, their contribution to health and disease, and the factors influencing their formation. We will then focus on the factors contributing to biofilm formation in C. difficile, how these biofilms are formed, and their properties. In the last section, we will look at how the gut microbiota and the gut biofilm influence C. difficile biofilm formation, persistence, and transmission.
·mdpi.com·
Microorganisms | Free Full-Text | Wolf in Sheep’s Clothing: Clostridioides difficile Biofilm as a Reservoir for Recurrent Infections