C Diff Molecular

C Diff Molecular

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Reactive arthritis: an unusual presentation of acute Clostridioides difficile colitis
Reactive arthritis: an unusual presentation of acute Clostridioides difficile colitis
A 20-year-old Caucasian man with a history of psoriasis presented to the emergency department due to a 2-week history of severe polyarthralgia and a 3-week history of non-bloody diarrhoea. The initial workup 2 days prior in an urgent care clinic returned negative for all enteric pathogens including …
·pubmed.ncbi.nlm.nih.gov·
Reactive arthritis: an unusual presentation of acute Clostridioides difficile colitis
Systematic Evaluation of Parameters Important for Production of Native Toxin A and Toxin B from Clostridioides difficile
Systematic Evaluation of Parameters Important for Production of Native Toxin A and Toxin B from Clostridioides difficile
In the attempt to improve the purification yield of native toxin A (TcdA) and toxin B (TcdB) from Clostridioides difficile (C. difficile), we systematically evaluated culture parameters for their influence on toxin production. In this study, we showed that culturing C. difficile in a t …
·pubmed.ncbi.nlm.nih.gov·
Systematic Evaluation of Parameters Important for Production of Native Toxin A and Toxin B from Clostridioides difficile
In vitro and in vivo activities absorption tissue distribution and excretion studies of OBP-4 a potential anti-Clostridioides difficile agent
In vitro and in vivo activities absorption tissue distribution and excretion studies of OBP-4 a potential anti-Clostridioides difficile agent
Clostridioides* difficile infection (CDI) is considered to be a major concern of the healthcare system globally with an increasing need for alternative therapies. OBP-4, a new oxazolidinone-fluoroquinolone hybrid with excellent in vitro activities and good safety, shows promising featu …
·pubmed.ncbi.nlm.nih.gov·
In vitro and in vivo activities absorption tissue distribution and excretion studies of OBP-4 a potential anti-Clostridioides difficile agent
Clostridioides difficile Infection and Risk of Acute Graft-versus-Host Disease among Allogeneic Hematopoietic Stem Cell Transplantation Recipients
Clostridioides difficile Infection and Risk of Acute Graft-versus-Host Disease among Allogeneic Hematopoietic Stem Cell Transplantation Recipients
Clostridioides difficile infection (CDI) is a major cause of infectious diarrhea among allogeneic hematopoietic stem cell transplantation (allo-HSCT) recipients. The relationship between CDI and acute graft-versus-host disease (aGVHD) has been a topic of interest, as these 2 conditions may influence …
·pubmed.ncbi.nlm.nih.gov·
Clostridioides difficile Infection and Risk of Acute Graft-versus-Host Disease among Allogeneic Hematopoietic Stem Cell Transplantation Recipients
Mortality Following Clostridioides difficile Infection in Europe: A Retrospective Multicenter Case-Control Study
Mortality Following Clostridioides difficile Infection in Europe: A Retrospective Multicenter Case-Control Study
We aimed to describe the clinical presentation, treatment, outcome and report on factors associated with mortality over a 90-day period in Clostridioides difficile infection (CDI). Descriptive, univariate, and multivariate regression analyses were performed on data collected in a retrospectiv …
·pubmed.ncbi.nlm.nih.gov·
Mortality Following Clostridioides difficile Infection in Europe: A Retrospective Multicenter Case-Control Study
The selenophosphate synthetase selD is important for Clostridioides difficile physiology
The selenophosphate synthetase selD is important for Clostridioides difficile physiology
The endospore-forming pathogen, Clostridioides difficile, is the leading cause of antibiotic-associated diarrhea and is a significant burden on the community and healthcare. C. difficile, like all forms of life, incorporates selenium into proteins through a selenocysteine synthesis pat …
·pubmed.ncbi.nlm.nih.gov·
The selenophosphate synthetase selD is important for Clostridioides difficile physiology
Clostridioides difficile toxins enhanced the in vitro production of CXC chemokine ligand 2 and tumor necrosis factor-alpha via Toll-like receptors in macrophages
Clostridioides difficile toxins enhanced the in vitro production of CXC chemokine ligand 2 and tumor necrosis factor-alpha via Toll-like receptors in macrophages
Introduction. Clostridioides difficile infection (CDI) causes toxin-mediated enteropathy, such as antibiotic-associated diarrhoea and pseudomembranous colitis. Rho-glucosylating toxin A (TcdA) and toxin B (TcdB) have been clearly implicated in pathogenesis, whereas the virulence of bin …
·pubmed.ncbi.nlm.nih.gov·
Clostridioides difficile toxins enhanced the in vitro production of CXC chemokine ligand 2 and tumor necrosis factor-alpha via Toll-like receptors in macrophages
Variants at the MHC Region Associate With Susceptibility to Clostridioides difficile Infection: A Genome-Wide Association Study Using Comprehensive Electronic Health Records
Variants at the MHC Region Associate With Susceptibility to Clostridioides difficile Infection: A Genome-Wide Association Study Using Comprehensive Electronic Health Records
Leveraging the EHR and genetic data, genome-wide association, and fine-mapping techniques, this study identified variants and genes associated with Clostridioides difficile infection, provided insights into host immune mechanisms, and described the potential for novel treatment strategies for …
·pubmed.ncbi.nlm.nih.gov·
Variants at the MHC Region Associate With Susceptibility to Clostridioides difficile Infection: A Genome-Wide Association Study Using Comprehensive Electronic Health Records
Fulminant Pseudomembranous Colitis Leading to Clostridium Paraputrificum Bacteremia
Fulminant Pseudomembranous Colitis Leading to Clostridium Paraputrificum Bacteremia
Clostridium species are spore-forming gram-positive anaerobic rod bacteria that cause a broad range of infections in humans, including intra-abdominal infections, myonecrosis, and bacteremia. Pseudomembranous colitis (PMC) is a severe form of infection caused by Clostridioides diffi …
·pubmed.ncbi.nlm.nih.gov·
Fulminant Pseudomembranous Colitis Leading to Clostridium Paraputrificum Bacteremia
CD25890 a conserved protein that modulates sporulation initiation in Clostridioides difficile
CD25890 a conserved protein that modulates sporulation initiation in Clostridioides difficile
Bacteria that reside in the gastrointestinal tract of healthy humans are essential for our health, sustenance and well-being. About 50-60% of those bacteria have the ability to produce resilient spores that are important for the life cycle in the gut and for host-to-host transmission. A genomic sign …
·pubmed.ncbi.nlm.nih.gov·
CD25890 a conserved protein that modulates sporulation initiation in Clostridioides difficile
NAFLD and Infection, a Nuanced Relationship
NAFLD and Infection, a Nuanced Relationship
In this narrative review, we synthetize current knowledge on several infections including urinary tract infection, pneumonia, Helicobacter pylori, coronavirus disease 2019, and Clostridioides difficile as they relate to NAFLD
·pubmed.ncbi.nlm.nih.gov·
NAFLD and Infection, a Nuanced Relationship
Frequency of toxin genes and antibiotic resistance pattern of Clostridioides difficile isolates in diarrheal samples among hospitalized patients in Hamadan Iran
Frequency of toxin genes and antibiotic resistance pattern of Clostridioides difficile isolates in diarrheal samples among hospitalized patients in Hamadan Iran
The results of this study showed toxigenic C. difficile with tcdA + /tcdB + profile is a major cause of nosocomial diarrhea in Hamadan, and clinical laboratories should routinely perform C. difficile diagnostic testing on diarrheal specimens of hospi …
·pubmed.ncbi.nlm.nih.gov·
Frequency of toxin genes and antibiotic resistance pattern of Clostridioides difficile isolates in diarrheal samples among hospitalized patients in Hamadan Iran
Seres Therapeutics to Present Key Data on Investigational Microbiome Therapeutics for Recurrent C. difficile Infection and Ulcerative Colitis at the Digestive Disease Week (DDW) Annual Meeting - Yahoo Finance
Seres Therapeutics to Present Key Data on Investigational Microbiome Therapeutics for Recurrent C. difficile Infection and Ulcerative Colitis at the Digestive Disease Week (DDW) Annual Meeting - Yahoo Finance
Seres Therapeutics, Inc. (Nasdaq: MCRB), a leading microbiome therapeutics company, today announced that it will present recent research findings from its microbiome drug development portfolio at Digestive Disease Week® (DDW), which is taking place virtually from May 21-23, 2021. With two oral presentations and two posters of distinction, Seres will demonstrate the potential of microbiome-based therapies for patients with serious diseases like recurrent Clostridioides difficile infection (CDI) and ulcerative colitis (UC).
·finance.yahoo.com·
Seres Therapeutics to Present Key Data on Investigational Microbiome Therapeutics for Recurrent C. difficile Infection and Ulcerative Colitis at the Digestive Disease Week (DDW) Annual Meeting - Yahoo Finance
Colocutaneous fistula following Clostridioides difficile infection managed as an 'autocolostomy': a novel approach to a recognised complication
Colocutaneous fistula following Clostridioides difficile infection managed as an 'autocolostomy': a novel approach to a recognised complication
Colocutaneous fistula is a rare entity in colorectal disease. We present a case of colocutaneous fistula in a patient whose postoperative course following a laparoscopic anterior resection for sigmoid cancer was complicated by Clostridioides difficile colitis. During the follow-up period, it …
·pubmed.ncbi.nlm.nih.gov·
Colocutaneous fistula following Clostridioides difficile infection managed as an 'autocolostomy': a novel approach to a recognised complication
Characterizing risk factors for Clostridioides difficile among hospitalized patients with community-acquired pneumonia
Characterizing risk factors for Clostridioides difficile among hospitalized patients with community-acquired pneumonia
Objective: Hospitalized patients with community-acquired pneumonia (CAP) are at risk of developing Clostridioides difficile infection (CDI). We developed and tested clinical decision-rules for identifying CDI risk in this patient population.Methods: The study was a single-center …
·pubmed.ncbi.nlm.nih.gov·
Characterizing risk factors for Clostridioides difficile among hospitalized patients with community-acquired pneumonia
Long-Term Infectious Complications of Kidney Transplantation
Long-Term Infectious Complications of Kidney Transplantation
Infections remain a common complication of solid-organ transplantation. Most infections in the first month after transplant are typically health care-associated infections, whereas late infections, beyond 6-12 months, are community-acquired infections. Opportunistic infections most frequently presen …
·pubmed.ncbi.nlm.nih.gov·
Long-Term Infectious Complications of Kidney Transplantation
Antimicrobial resistance surveillance of Clostridioides difficile in Australia 2015-18
Antimicrobial resistance surveillance of Clostridioides difficile in Australia 2015-18
The majority of C. difficile isolated in Australia did not show reduced susceptibility to antimicrobials recommended for treatment of CDI (vancomycin, metronidazole and fidaxomicin). Resistance to carbapenems and fluoroquinolones was low and MDR was uncommon; however, clindamycin resistance was freq …
·pubmed.ncbi.nlm.nih.gov·
Antimicrobial resistance surveillance of Clostridioides difficile in Australia 2015-18
In situ analysis of antibiotic resistance genes in anaerobically digested dairy manure and its subsequent disposal facilities
In situ analysis of antibiotic resistance genes in anaerobically digested dairy manure and its subsequent disposal facilities
The metagenomic and quantitative polymerase chain reaction approaches were combined to evaluate the profiles of ARGs and plasmids in anaerobically digested dairy manure in situ and reveal the persistence and elevation of typical ARGs and plasmids in its subsequent disposal facilities in CAFOs, respe …
·pubmed.ncbi.nlm.nih.gov·
In situ analysis of antibiotic resistance genes in anaerobically digested dairy manure and its subsequent disposal facilities
Cwl0971 a novel peptidoglycan hydrolase plays pleiotropic roles in Clostridioides difficile R20291
Cwl0971 a novel peptidoglycan hydrolase plays pleiotropic roles in Clostridioides difficile R20291
Clostridioides difficile is a Gram-positive, spore-forming, toxin-producing anaerobe that can cause nosocomial antibiotic-associated intestinal disease. Although the production of toxin A (TcdA) and toxin B (TcdB) contribute to the main pathogenesis of C. difficile, the mechanism of TcdA and TcdB re …
·pubmed.ncbi.nlm.nih.gov·
Cwl0971 a novel peptidoglycan hydrolase plays pleiotropic roles in Clostridioides difficile R20291
S-layers: The Proteinaceous Multifunctional Armors of Gram-Positive Pathogens
S-layers: The Proteinaceous Multifunctional Armors of Gram-Positive Pathogens
S-layers are self-assembled crystalline 2D lattices enclosing the cell envelopes of several bacteria and archaea. Despite their abundance, the landscape of S-layer structure and function remains a land of wonder. By virtue of their location, bacterial S-layers have been hypothesized to add structura …
·pubmed.ncbi.nlm.nih.gov·
S-layers: The Proteinaceous Multifunctional Armors of Gram-Positive Pathogens
Estimation of Risk of Death Attributable to Acute Gastroenteritis Not Caused by Clostridioides difficile Infection Among Hospitalized Adults in England
Estimation of Risk of Death Attributable to Acute Gastroenteritis Not Caused by Clostridioides difficile Infection Among Hospitalized Adults in England
Approximately 5000 of the 276,000 deaths that occur annually among hospitalized adults in England can be attributed to AGE not caused by CDI, which is higher than previously estimated.
·pubmed.ncbi.nlm.nih.gov·
Estimation of Risk of Death Attributable to Acute Gastroenteritis Not Caused by Clostridioides difficile Infection Among Hospitalized Adults in England