C Diff Molecular

C Diff Molecular

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The high prevalence of Clostridioides difficile among nursing home elders associates with a dysbiotic microbiome
The high prevalence of Clostridioides difficile among nursing home elders associates with a dysbiotic microbiome
Clostridioides difficile disproportionally affects the elderly living in nursing homes (NHs). Our objective was to explore the prevalence of C. difficile in NH elders, over time and to determine whether the microbiome or other clinical factors are associated with C. difficile co …
·pubmed.ncbi.nlm.nih.gov·
The high prevalence of Clostridioides difficile among nursing home elders associates with a dysbiotic microbiome
Fecal Mycobiota Combined with Host Immune Factors Distinguish Clostridioides difficile Infection from Asymptomatic Carriage
Fecal Mycobiota Combined with Host Immune Factors Distinguish Clostridioides difficile Infection from Asymptomatic Carriage
Our study provides specific markers of stool fungi combined with host immune factors to distinguish CDI patients from Carrier. It highlights the importance of gut mycobiome in CDI, which may have been underestimated. Further studies on the diagnostic applications and therapeutic potentials of these …
·pubmed.ncbi.nlm.nih.gov·
Fecal Mycobiota Combined with Host Immune Factors Distinguish Clostridioides difficile Infection from Asymptomatic Carriage
Contribution of Inhibitory Metabolites and Competition for Nutrients to Colonization Resistance against Clostridioides difficile by Commensal Clostridium
Contribution of Inhibitory Metabolites and Competition for Nutrients to Colonization Resistance against Clostridioides difficile by Commensal Clostridium
Clostridioides difficile is an anaerobic pathogen that causes significant morbidity and mortality. Understanding the mechanisms of colonization resistance against C. difficile is important for elucidating the mechanisms by which C. difficile is able to colonize the gut after ant …
·pubmed.ncbi.nlm.nih.gov·
Contribution of Inhibitory Metabolites and Competition for Nutrients to Colonization Resistance against Clostridioides difficile by Commensal Clostridium
A Point Mutation in the Transcriptional Repressor PerR Results in a Constitutive Oxidative Stress Response in Clostridioides difficile 630deltaerm
A Point Mutation in the Transcriptional Repressor PerR Results in a Constitutive Oxidative Stress Response in Clostridioides difficile 630deltaerm
The human pathogen Clostridioides difficile has evolved into the leading cause of nosocomial diarrhea. The bacterium is capable of spore formation, which even allows survival of antibiotic treatment. Although C. difficile features an anaerobic lifestyle, we determined a remarkably high …
·pubmed.ncbi.nlm.nih.gov·
A Point Mutation in the Transcriptional Repressor PerR Results in a Constitutive Oxidative Stress Response in Clostridioides difficile 630deltaerm
The State of Microbiome Science at the Intersection of Infectious Diseases and Antimicrobial Resistance
The State of Microbiome Science at the Intersection of Infectious Diseases and Antimicrobial Resistance
Along with the rise in modern chronic diseases, ranging from diabetes to asthma, lay the challenges posed by increasing antibiotic resistance resulting in difficult to treat infections, as well as sepsis. An emerging and unifying theme in the pathogenesis of these diverse public health threats is ch …
·pubmed.ncbi.nlm.nih.gov·
The State of Microbiome Science at the Intersection of Infectious Diseases and Antimicrobial Resistance
Predictive factors outcomes and molecular epidemiology of Clostridioides difficile diarrhea in Brazilian hospitals
Predictive factors outcomes and molecular epidemiology of Clostridioides difficile diarrhea in Brazilian hospitals
Little is known about the role of lineage of strains of Clostridioides difficile (CD) on the clinical presentation of CD infection (CDI) in Latin America, especially regarding the treatment response. We conducted a multicenter, prospective study to investigate the predictive factors and treatment ou …
·pubmed.ncbi.nlm.nih.gov·
Predictive factors outcomes and molecular epidemiology of Clostridioides difficile diarrhea in Brazilian hospitals
Novel risk factors and outcomes in inflammatory bowel disease patients with Clostridioides difficile infection
Novel risk factors and outcomes in inflammatory bowel disease patients with Clostridioides difficile infection
An overweight BMI and statin use were associated with severe or severe, complicated CDI in IBD patients. Further studies are needed to better understand how these factors impact management of patients with IBD to improve clinical outcomes and potentially reduce the risk of complications from CDI.
·pubmed.ncbi.nlm.nih.gov·
Novel risk factors and outcomes in inflammatory bowel disease patients with Clostridioides difficile infection
Building blocks and blueprints for bacterial autolysins
Building blocks and blueprints for bacterial autolysins
Bacteria utilize a wide variety of endogenous cell wall hydrolases, or autolysins, to remodel their cell walls during processes including cell division, biofilm formation, and programmed death. We here systematically investigate the composition of these enzymes in order to gain insights into their a …
·pubmed.ncbi.nlm.nih.gov·
Building blocks and blueprints for bacterial autolysins
Ser/Thr Kinase-Dependent Phosphorylation of the Peptidoglycan Hydrolase CwlA Controls Its Export and Modulates Cell Division in Clostridioides difficile
Ser/Thr Kinase-Dependent Phosphorylation of the Peptidoglycan Hydrolase CwlA Controls Its Export and Modulates Cell Division in Clostridioides difficile
Cell growth and division require a balance between synthesis and hydrolysis of the peptidoglycan (PG). Inhibition of PG synthesis or uncontrolled PG hydrolysis can be lethal for the cells, making it imperative to control peptidoglycan hydrolase (PGH) activity. The synthesis or activity of several ke …
·pubmed.ncbi.nlm.nih.gov·
Ser/Thr Kinase-Dependent Phosphorylation of the Peptidoglycan Hydrolase CwlA Controls Its Export and Modulates Cell Division in Clostridioides difficile
Immune response against Clostridioides difficile and translation to therapy
Immune response against Clostridioides difficile and translation to therapy
The pathogenesis of Clostridioides difficile infection (CDI) has largely been attributed to the action of two major toxins - A and B. An enhanced systemic humoral immune response against these toxins has been shown to be protective against recurrent CDI. Over the years, fully human monoclonal …
·pubmed.ncbi.nlm.nih.gov·
Immune response against Clostridioides difficile and translation to therapy
Reactive arthritis: an unusual presentation of acute Clostridioides difficile colitis
Reactive arthritis: an unusual presentation of acute Clostridioides difficile colitis
A 20-year-old Caucasian man with a history of psoriasis presented to the emergency department due to a 2-week history of severe polyarthralgia and a 3-week history of non-bloody diarrhoea. The initial workup 2 days prior in an urgent care clinic returned negative for all enteric pathogens including …
·pubmed.ncbi.nlm.nih.gov·
Reactive arthritis: an unusual presentation of acute Clostridioides difficile colitis
Systematic Evaluation of Parameters Important for Production of Native Toxin A and Toxin B from Clostridioides difficile
Systematic Evaluation of Parameters Important for Production of Native Toxin A and Toxin B from Clostridioides difficile
In the attempt to improve the purification yield of native toxin A (TcdA) and toxin B (TcdB) from Clostridioides difficile (C. difficile), we systematically evaluated culture parameters for their influence on toxin production. In this study, we showed that culturing C. difficile in a t …
·pubmed.ncbi.nlm.nih.gov·
Systematic Evaluation of Parameters Important for Production of Native Toxin A and Toxin B from Clostridioides difficile
In vitro and in vivo activities absorption tissue distribution and excretion studies of OBP-4 a potential anti-Clostridioides difficile agent
In vitro and in vivo activities absorption tissue distribution and excretion studies of OBP-4 a potential anti-Clostridioides difficile agent
Clostridioides* difficile infection (CDI) is considered to be a major concern of the healthcare system globally with an increasing need for alternative therapies. OBP-4, a new oxazolidinone-fluoroquinolone hybrid with excellent in vitro activities and good safety, shows promising featu …
·pubmed.ncbi.nlm.nih.gov·
In vitro and in vivo activities absorption tissue distribution and excretion studies of OBP-4 a potential anti-Clostridioides difficile agent
Clostridioides difficile Infection and Risk of Acute Graft-versus-Host Disease among Allogeneic Hematopoietic Stem Cell Transplantation Recipients
Clostridioides difficile Infection and Risk of Acute Graft-versus-Host Disease among Allogeneic Hematopoietic Stem Cell Transplantation Recipients
Clostridioides difficile infection (CDI) is a major cause of infectious diarrhea among allogeneic hematopoietic stem cell transplantation (allo-HSCT) recipients. The relationship between CDI and acute graft-versus-host disease (aGVHD) has been a topic of interest, as these 2 conditions may influence …
·pubmed.ncbi.nlm.nih.gov·
Clostridioides difficile Infection and Risk of Acute Graft-versus-Host Disease among Allogeneic Hematopoietic Stem Cell Transplantation Recipients
Mortality Following Clostridioides difficile Infection in Europe: A Retrospective Multicenter Case-Control Study
Mortality Following Clostridioides difficile Infection in Europe: A Retrospective Multicenter Case-Control Study
We aimed to describe the clinical presentation, treatment, outcome and report on factors associated with mortality over a 90-day period in Clostridioides difficile infection (CDI). Descriptive, univariate, and multivariate regression analyses were performed on data collected in a retrospectiv …
·pubmed.ncbi.nlm.nih.gov·
Mortality Following Clostridioides difficile Infection in Europe: A Retrospective Multicenter Case-Control Study
The selenophosphate synthetase selD is important for Clostridioides difficile physiology
The selenophosphate synthetase selD is important for Clostridioides difficile physiology
The endospore-forming pathogen, Clostridioides difficile, is the leading cause of antibiotic-associated diarrhea and is a significant burden on the community and healthcare. C. difficile, like all forms of life, incorporates selenium into proteins through a selenocysteine synthesis pat …
·pubmed.ncbi.nlm.nih.gov·
The selenophosphate synthetase selD is important for Clostridioides difficile physiology
Clostridioides difficile toxins enhanced the in vitro production of CXC chemokine ligand 2 and tumor necrosis factor-alpha via Toll-like receptors in macrophages
Clostridioides difficile toxins enhanced the in vitro production of CXC chemokine ligand 2 and tumor necrosis factor-alpha via Toll-like receptors in macrophages
Introduction. Clostridioides difficile infection (CDI) causes toxin-mediated enteropathy, such as antibiotic-associated diarrhoea and pseudomembranous colitis. Rho-glucosylating toxin A (TcdA) and toxin B (TcdB) have been clearly implicated in pathogenesis, whereas the virulence of bin …
·pubmed.ncbi.nlm.nih.gov·
Clostridioides difficile toxins enhanced the in vitro production of CXC chemokine ligand 2 and tumor necrosis factor-alpha via Toll-like receptors in macrophages
Variants at the MHC Region Associate With Susceptibility to Clostridioides difficile Infection: A Genome-Wide Association Study Using Comprehensive Electronic Health Records
Variants at the MHC Region Associate With Susceptibility to Clostridioides difficile Infection: A Genome-Wide Association Study Using Comprehensive Electronic Health Records
Leveraging the EHR and genetic data, genome-wide association, and fine-mapping techniques, this study identified variants and genes associated with Clostridioides difficile infection, provided insights into host immune mechanisms, and described the potential for novel treatment strategies for …
·pubmed.ncbi.nlm.nih.gov·
Variants at the MHC Region Associate With Susceptibility to Clostridioides difficile Infection: A Genome-Wide Association Study Using Comprehensive Electronic Health Records
Fulminant Pseudomembranous Colitis Leading to Clostridium Paraputrificum Bacteremia
Fulminant Pseudomembranous Colitis Leading to Clostridium Paraputrificum Bacteremia
Clostridium species are spore-forming gram-positive anaerobic rod bacteria that cause a broad range of infections in humans, including intra-abdominal infections, myonecrosis, and bacteremia. Pseudomembranous colitis (PMC) is a severe form of infection caused by Clostridioides diffi …
·pubmed.ncbi.nlm.nih.gov·
Fulminant Pseudomembranous Colitis Leading to Clostridium Paraputrificum Bacteremia
CD25890 a conserved protein that modulates sporulation initiation in Clostridioides difficile
CD25890 a conserved protein that modulates sporulation initiation in Clostridioides difficile
Bacteria that reside in the gastrointestinal tract of healthy humans are essential for our health, sustenance and well-being. About 50-60% of those bacteria have the ability to produce resilient spores that are important for the life cycle in the gut and for host-to-host transmission. A genomic sign …
·pubmed.ncbi.nlm.nih.gov·
CD25890 a conserved protein that modulates sporulation initiation in Clostridioides difficile
NAFLD and Infection, a Nuanced Relationship
NAFLD and Infection, a Nuanced Relationship
In this narrative review, we synthetize current knowledge on several infections including urinary tract infection, pneumonia, Helicobacter pylori, coronavirus disease 2019, and Clostridioides difficile as they relate to NAFLD
·pubmed.ncbi.nlm.nih.gov·
NAFLD and Infection, a Nuanced Relationship
Frequency of toxin genes and antibiotic resistance pattern of Clostridioides difficile isolates in diarrheal samples among hospitalized patients in Hamadan Iran
Frequency of toxin genes and antibiotic resistance pattern of Clostridioides difficile isolates in diarrheal samples among hospitalized patients in Hamadan Iran
The results of this study showed toxigenic C. difficile with tcdA + /tcdB + profile is a major cause of nosocomial diarrhea in Hamadan, and clinical laboratories should routinely perform C. difficile diagnostic testing on diarrheal specimens of hospi …
·pubmed.ncbi.nlm.nih.gov·
Frequency of toxin genes and antibiotic resistance pattern of Clostridioides difficile isolates in diarrheal samples among hospitalized patients in Hamadan Iran
Seres Therapeutics to Present Key Data on Investigational Microbiome Therapeutics for Recurrent C. difficile Infection and Ulcerative Colitis at the Digestive Disease Week (DDW) Annual Meeting - Yahoo Finance
Seres Therapeutics to Present Key Data on Investigational Microbiome Therapeutics for Recurrent C. difficile Infection and Ulcerative Colitis at the Digestive Disease Week (DDW) Annual Meeting - Yahoo Finance
Seres Therapeutics, Inc. (Nasdaq: MCRB), a leading microbiome therapeutics company, today announced that it will present recent research findings from its microbiome drug development portfolio at Digestive Disease Week® (DDW), which is taking place virtually from May 21-23, 2021. With two oral presentations and two posters of distinction, Seres will demonstrate the potential of microbiome-based therapies for patients with serious diseases like recurrent Clostridioides difficile infection (CDI) and ulcerative colitis (UC).
·finance.yahoo.com·
Seres Therapeutics to Present Key Data on Investigational Microbiome Therapeutics for Recurrent C. difficile Infection and Ulcerative Colitis at the Digestive Disease Week (DDW) Annual Meeting - Yahoo Finance
Colocutaneous fistula following Clostridioides difficile infection managed as an 'autocolostomy': a novel approach to a recognised complication
Colocutaneous fistula following Clostridioides difficile infection managed as an 'autocolostomy': a novel approach to a recognised complication
Colocutaneous fistula is a rare entity in colorectal disease. We present a case of colocutaneous fistula in a patient whose postoperative course following a laparoscopic anterior resection for sigmoid cancer was complicated by Clostridioides difficile colitis. During the follow-up period, it …
·pubmed.ncbi.nlm.nih.gov·
Colocutaneous fistula following Clostridioides difficile infection managed as an 'autocolostomy': a novel approach to a recognised complication
Characterizing risk factors for Clostridioides difficile among hospitalized patients with community-acquired pneumonia
Characterizing risk factors for Clostridioides difficile among hospitalized patients with community-acquired pneumonia
Objective: Hospitalized patients with community-acquired pneumonia (CAP) are at risk of developing Clostridioides difficile infection (CDI). We developed and tested clinical decision-rules for identifying CDI risk in this patient population.Methods: The study was a single-center …
·pubmed.ncbi.nlm.nih.gov·
Characterizing risk factors for Clostridioides difficile among hospitalized patients with community-acquired pneumonia