C Diff Molecular

C Diff Molecular

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Characterization of Clostridioides difficile Persister Cells and Their Role in Antibiotic Tolerance - PubMed
Characterization of Clostridioides difficile Persister Cells and Their Role in Antibiotic Tolerance - PubMed
Clostridioides difficile is a Gram-positive pathogen known for its toxin production and spore formation. It is primarily responsible for most cases of antibiotic-associated diarrhea. Bacterial persisters are a small subset of the population that exhibits transient tolerance to bactericidal su …
·pubmed.ncbi.nlm.nih.gov·
Characterization of Clostridioides difficile Persister Cells and Their Role in Antibiotic Tolerance - PubMed
Genomic study of European Clostridioides difficile ribotype 002/sequence type 8 - PubMed
Genomic study of European Clostridioides difficile ribotype 002/sequence type 8 - PubMed
Clostridioides difficile has significant clinical importance as a leading cause of healthcare-associated infections, with symptoms ranging from mild diarrhoea to severe colitis, and possible life-threatening complications. C. difficile ribotype (RT) 002, mainly associated with MLST seq …
·pubmed.ncbi.nlm.nih.gov·
Genomic study of European Clostridioides difficile ribotype 002/sequence type 8 - PubMed
Antimicrobial susceptibilities, resistance mechanisms and molecular characteristics of toxigenic Clostridioides difficile isolates in a large teaching hospital in Chongqing, China - PubMed
Antimicrobial susceptibilities, resistance mechanisms and molecular characteristics of toxigenic Clostridioides difficile isolates in a large teaching hospital in Chongqing, China - PubMed
In contrast to prior studies, we found higher proportions of ST3 isolates with decreased tigecycline sensitivity, sharing similar resistance patterns and resistance genes. In the resistance process of tigecycline and tetracycline, the tetA(P) and tetB(P) genes may play a weak role.
·pubmed.ncbi.nlm.nih.gov·
Antimicrobial susceptibilities, resistance mechanisms and molecular characteristics of toxigenic Clostridioides difficile isolates in a large teaching hospital in Chongqing, China - PubMed
Spores of Clostridioides difficile are toxin delivery vehicles
Spores of Clostridioides difficile are toxin delivery vehicles
Communications Biology - This study shows that the genes coding for the two main toxins produced by Clostridioides difficile are expressed during sporulation and that the toxins associate with the...
·nature.com·
Spores of Clostridioides difficile are toxin delivery vehicles
Antimicrobial susceptibilities, resistance mechanisms and molecular characteristics of toxigenic Clostridioides difficile isolates in a large teaching hospital in Chongqing, China - PubMed
Antimicrobial susceptibilities, resistance mechanisms and molecular characteristics of toxigenic Clostridioides difficile isolates in a large teaching hospital in Chongqing, China - PubMed
In contrast to prior studies, we found higher proportions of ST3 isolates with decreased tigecycline sensitivity, sharing similar resistance patterns and resistance genes. In the resistance process of tigecycline and tetracycline, the tetA(P) and tetB(P) genes may play a weak role.
·pubmed.ncbi.nlm.nih.gov·
Antimicrobial susceptibilities, resistance mechanisms and molecular characteristics of toxigenic Clostridioides difficile isolates in a large teaching hospital in Chongqing, China - PubMed
Genomic study of European Clostridioides difficile ribotype 002/sequence type 8 - PubMed
Genomic study of European Clostridioides difficile ribotype 002/sequence type 8 - PubMed
Clostridioides difficile has significant clinical importance as a leading cause of healthcare-associated infections, with symptoms ranging from mild diarrhoea to severe colitis, and possible life-threatening complications. C. difficile ribotype (RT) 002, mainly associated with MLST seq …
·pubmed.ncbi.nlm.nih.gov·
Genomic study of European Clostridioides difficile ribotype 002/sequence type 8 - PubMed
Antimicrobial susceptibility in Clostridioides difficile varies according to European region and isolate source - PubMed
Antimicrobial susceptibility in Clostridioides difficile varies according to European region and isolate source - PubMed
Increased antimicrobial resistance was detected in eastern Europe and mostly associated with RT027 and related emerging RT181, while clinical isolates from northern and western Europe had the lowest general levels of resistance.
·pubmed.ncbi.nlm.nih.gov·
Antimicrobial susceptibility in Clostridioides difficile varies according to European region and isolate source - PubMed
RelQ-mediated alarmone signalling regulates growth, stress-induced biofilm formation and spore accumulation in Clostridioides difficile - PubMed
RelQ-mediated alarmone signalling regulates growth, stress-induced biofilm formation and spore accumulation in Clostridioides difficile - PubMed
The bacterial stringent response (SR) is a conserved transcriptional reprogramming pathway mediated by the nucleotide signalling alarmones, (pp)pGpp. The SR has been implicated in antibiotic survival in Clostridioides difficile, a biofilm- and spore-forming pathogen that causes resilient, hig …
·pubmed.ncbi.nlm.nih.gov·
RelQ-mediated alarmone signalling regulates growth, stress-induced biofilm formation and spore accumulation in Clostridioides difficile - PubMed
Commensal-pathogen dynamics structure disease outcomes during Clostridioides difficile colonization - PubMed
Commensal-pathogen dynamics structure disease outcomes during Clostridioides difficile colonization - PubMed
Gastrointestinal colonization by Clostridioides difficile is common in healthcare settings and ranges in clinical presentation from asymptomatic carriage to lethal C. difficile infection (CDI). We used a systems biology approach to investigate why patients colonized with C. difficil …
·pubmed.ncbi.nlm.nih.gov·
Commensal-pathogen dynamics structure disease outcomes during Clostridioides difficile colonization - PubMed
Commensal-pathogen dynamics structure disease outcomes during Clostridioides difficile colonization - PubMed
Commensal-pathogen dynamics structure disease outcomes during Clostridioides difficile colonization - PubMed
Gastrointestinal colonization by Clostridioides difficile is common in healthcare settings and ranges in clinical presentation from asymptomatic carriage to lethal C. difficile infection (CDI). We used a systems biology approach to investigate why patients colonized with C. difficil …
·pubmed.ncbi.nlm.nih.gov·
Commensal-pathogen dynamics structure disease outcomes during Clostridioides difficile colonization - PubMed
The state of play of rodent models for the study of Clostridioides difficile infection - PubMed
The state of play of rodent models for the study of Clostridioides difficile infection - PubMed
Clostridioides difficile is the most common cause of nosocomial antibiotic-associated diarrhoea and is responsible for a spectrum of diseases characterized by high levels of recurrence and morbidity. In some cases, complications can lead to death. Currently, several types of animal models hav …
·pubmed.ncbi.nlm.nih.gov·
The state of play of rodent models for the study of Clostridioides difficile infection - PubMed
RelQ-mediated alarmone signalling regulates growth, stress-induced biofilm formation and spore accumulation in Clostridioides difficile - PubMed
RelQ-mediated alarmone signalling regulates growth, stress-induced biofilm formation and spore accumulation in Clostridioides difficile - PubMed
The bacterial stringent response (SR) is a conserved transcriptional reprogramming pathway mediated by the nucleotide signalling alarmones, (pp)pGpp. The SR has been implicated in antibiotic survival in Clostridioides difficile, a biofilm- and spore-forming pathogen that causes resilient, hig …
·pubmed.ncbi.nlm.nih.gov·
RelQ-mediated alarmone signalling regulates growth, stress-induced biofilm formation and spore accumulation in Clostridioides difficile - PubMed
Ultrastructure Variability of the Exosporium Layer of Clostridium difficile Spores from Sporulating Cultures and Biofilms | Applied and Environmental Microbiology
Ultrastructure Variability of the Exosporium Layer of Clostridium difficile Spores from Sporulating Cultures and Biofilms | Applied and Environmental Microbiology
ABSTRACT The anaerobic sporeformer Clostridium difficile is the leading cause of nosocomial antibiotic-associated diarrhea in developed and developing countries. The metabolically dormant spore form is considered the morphotype responsible for ...
·news.google.com·
Ultrastructure Variability of the Exosporium Layer of Clostridium difficile Spores from Sporulating Cultures and Biofilms | Applied and Environmental Microbiology
Comparative genome analyses of clinical and non-clinical Clostridioides difficile strains - PubMed
Comparative genome analyses of clinical and non-clinical Clostridioides difficile strains - PubMed
The pathogenic bacterium Clostridioides difficile is a worldwide health burden with increasing morbidity, mortality and antibiotic resistances. Therefore, extensive research efforts are made to unravel its virulence and dissemination. One crucial aspect for C. difficile is its mobilome …
·pubmed.ncbi.nlm.nih.gov·
Comparative genome analyses of clinical and non-clinical Clostridioides difficile strains - PubMed
PhosphoLipidome Alteration Induced by Clostridioides difficile Toxin B in Enteric Glial Cells - PubMed
PhosphoLipidome Alteration Induced by Clostridioides difficile Toxin B in Enteric Glial Cells - PubMed
Clostridioides difficile (C. difficile) is responsible for a spectrum of nosocomial/antibiotic-associated gastrointestinal diseases that are increasing in global incidence and mortality rates. The C. difficile pathogenesis is due to toxin A and B (TcdA/TcdB), both causing cytopa …
·pubmed.ncbi.nlm.nih.gov·
PhosphoLipidome Alteration Induced by Clostridioides difficile Toxin B in Enteric Glial Cells - PubMed
Spores of Clostridioides difficile are toxin delivery vehicles - PubMed
Spores of Clostridioides difficile are toxin delivery vehicles - PubMed
Clostridioides difficile causes a wide range of intestinal diseases through the action of two main cytotoxins, TcdA and TcdB. Ingested spores germinate in the intestine establishing a population of cells that produce toxins and spores. The pathogenicity locus, PaLoc, comprises several genes, includi …
·pubmed.ncbi.nlm.nih.gov·
Spores of Clostridioides difficile are toxin delivery vehicles - PubMed
Fecal microbiota composition is a better predictor of recurrent Clostridioides difficile infection than clinical factors in a prospective, multicentre cohort study - PubMed
Fecal microbiota composition is a better predictor of recurrent Clostridioides difficile infection than clinical factors in a prospective, multicentre cohort study - PubMed
Early microbiota response to CDI treatment is a better predictor of reCDI than clinical prognostic factors, but not yet sufficient enough to predict reCDI in daily practice.
·pubmed.ncbi.nlm.nih.gov·
Fecal microbiota composition is a better predictor of recurrent Clostridioides difficile infection than clinical factors in a prospective, multicentre cohort study - PubMed
Exploring YabG's Role in C difficile Spore Biology
Exploring YabG's Role in C difficile Spore Biology
Mutations in YabG affect spore germination and substrate processing, offering insights into its essential functions in the lifecycle of C diff.
·news.google.com·
Exploring YabG's Role in C difficile Spore Biology
Formation of the pyruvoyl-dependent proline reductase Prd from Clostridioides difficile requires the maturation enzyme PrdH - PubMed
Formation of the pyruvoyl-dependent proline reductase Prd from Clostridioides difficile requires the maturation enzyme PrdH - PubMed
Stickland fermentation, the coupled oxidation and reduction of amino acid pairs, is a major pathway for obtaining energy in the nosocomial bacterium Clostridioides difficile. D-proline is the preferred substrate for the reductive path, making it not only a key component of the general metabol …
·pubmed.ncbi.nlm.nih.gov·
Formation of the pyruvoyl-dependent proline reductase Prd from Clostridioides difficile requires the maturation enzyme PrdH - PubMed
Human intestinal microbiome: Role in health and disease - PubMed
Human intestinal microbiome: Role in health and disease - PubMed
The study of the microbiota and the microbiome, and specifically the intestinal one, has determined great interest due to the possible association of their alterations with numerous diseases. These include entities as diverse as Crohn's disease, autism, diabetes, cancer or situations as prevalent to …
·pubmed.ncbi.nlm.nih.gov·
Human intestinal microbiome: Role in health and disease - PubMed
Frontiers | Characterization of the gut microbiome of patients with Clostridioides difficile infection, patients with non–C. difficile diarrhea, and C. difficile–colonized patients
Frontiers | Characterization of the gut microbiome of patients with Clostridioides difficile infection, patients with non–C. difficile diarrhea, and C. difficile–colonized patients
IntroductionClostridioides difficile infection (CDI) is the main cause of nosocomial diarrhea in developed countries. A key challenge in CDI is the lack of o...
·news.google.com·
Frontiers | Characterization of the gut microbiome of patients with Clostridioides difficile infection, patients with non–C. difficile diarrhea, and C. difficile–colonized patients
Removal of mobile genetic elements from the genome of Clostridioides difficile and the implications for the organism's biology - PubMed
Removal of mobile genetic elements from the genome of Clostridioides difficile and the implications for the organism's biology - PubMed
Clostridioides difficile is an emerging pathogen of One Health significance. Its highly variable genome contains mobile genetic elements (MGEs) such as transposons and prophages that influence its biology. Systematic deletion of each genetic element is required to determine their precise role …
·pubmed.ncbi.nlm.nih.gov·
Removal of mobile genetic elements from the genome of Clostridioides difficile and the implications for the organism's biology - PubMed
The impact of YabG mutations on C. difficile spore germination and processing of spore substrates - PubMed
The impact of YabG mutations on C. difficile spore germination and processing of spore substrates - PubMed
YabG is a sporulation-specific protease that is conserved among sporulating bacteria. C. difficile YabG processes cortex destined proteins preproSleC into proSleC and CspBA to CspB and CspA. YabG also affects synthesis of spore coat/exosporium proteins CotA and CdeM. In prior work that identi …
·pubmed.ncbi.nlm.nih.gov·
The impact of YabG mutations on C. difficile spore germination and processing of spore substrates - PubMed
Clostridioides difficile superoxide reductase mitigates oxygen sensitivity - PubMed
Clostridioides difficile superoxide reductase mitigates oxygen sensitivity - PubMed
Clostridioides difficile causes a serious diarrheal disease and is a common healthcare-associated bacterial pathogen. Although it has a major impact on human health, the mechanistic details of C. difficile intestinal colonization remain undefined. C. difficile is highly sensitiv …
·pubmed.ncbi.nlm.nih.gov·
Clostridioides difficile superoxide reductase mitigates oxygen sensitivity - PubMed
Clostridioides difficile superoxide reductase mitigates oxygen sensitivity - PubMed
Clostridioides difficile superoxide reductase mitigates oxygen sensitivity - PubMed
Clostridioides difficile causes a serious diarrheal disease and is a common healthcare-associated bacterial pathogen. Although it has a major impact on human health, the mechanistic details of C. difficile intestinal colonization remain undefined. C. difficile is highly sensitiv …
·pubmed.ncbi.nlm.nih.gov·
Clostridioides difficile superoxide reductase mitigates oxygen sensitivity - PubMed