C Diff Molecular

C Diff Molecular

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Clostridioides difficile toxin B subverts germinal center and antibody recall responses by stimulating a drug-treatable CXCR4-dependent mechanism - PubMed
Clostridioides difficile toxin B subverts germinal center and antibody recall responses by stimulating a drug-treatable CXCR4-dependent mechanism - PubMed
Recurrent Clostridioides difficile infection (CDI) results in significant morbidity and mortality. We previously established that CDI in mice does not protect against reinfection and is associated with poor pathogen-specific B cell memory (Bmem), recapitulating our observations with human Bmem. Here …
·pubmed.ncbi.nlm.nih.gov·
Clostridioides difficile toxin B subverts germinal center and antibody recall responses by stimulating a drug-treatable CXCR4-dependent mechanism - PubMed
Positive pathogens in stool could predict the clinical outcomes of sepsis-associated acute kidney injury in critical ill patient - PubMed
Positive pathogens in stool could predict the clinical outcomes of sepsis-associated acute kidney injury in critical ill patient - PubMed
In this study, we sought to evaluate the influence of positive pathogens in stool (PPS) on clinical outcomes in critical ill patients with Sepsis-associated acute kidney injury (S-AKI) from intensive care unit. Our sample consisted of 7338 patients, of whom 752 (10.25%) had PPS. We found that the pr …
·pubmed.ncbi.nlm.nih.gov·
Positive pathogens in stool could predict the clinical outcomes of sepsis-associated acute kidney injury in critical ill patient - PubMed
Clostridioides difficile infection in patients with and without COVID-19 during the pandemic: a retrospective cohort study from a tertiary referral hospital - PubMed
Clostridioides difficile infection in patients with and without COVID-19 during the pandemic: a retrospective cohort study from a tertiary referral hospital - PubMed
Increased CDI prevalence and testing were observed compared to the beginning of the COVID-19 pandemic. Lower CDI-related CFR was observed in patients with COVID-19, which may be credited to the patients' significantly lower median age and CCI, as well as to the majority of deaths being due to respir …
·pubmed.ncbi.nlm.nih.gov·
Clostridioides difficile infection in patients with and without COVID-19 during the pandemic: a retrospective cohort study from a tertiary referral hospital - PubMed
KipOTIA detoxifies 5-oxoproline and promotes the growth of Clostridioides difficile - PubMed
KipOTIA detoxifies 5-oxoproline and promotes the growth of Clostridioides difficile - PubMed
Clostridioides difficile is an anaerobic enteric pathogen that disseminates in the environment as a dormant spore. For C. difficile and other sporulating bacteria, the initiation of sporulation is a regulated process that prevents spore formation under favorable growth conditions. In …
·pubmed.ncbi.nlm.nih.gov·
KipOTIA detoxifies 5-oxoproline and promotes the growth of Clostridioides difficile - PubMed
A conserved switch controls virulence, sporulation, and motility in C. difficile - PubMed
A conserved switch controls virulence, sporulation, and motility in C. difficile - PubMed
Spore formation is required for environmental survival and transmission of the human enteropathogenic Clostridioides difficile. In all bacterial spore formers, sporulation is regulated through activation of the master response regulator, Spo0A. However, the factors and mechanisms that directly regul …
·pubmed.ncbi.nlm.nih.gov·
A conserved switch controls virulence, sporulation, and motility in C. difficile - PubMed
Cu exposure induces liver inflammation via regulating gut microbiota/LPS/liver TLR4 signaling axis - PubMed
Cu exposure induces liver inflammation via regulating gut microbiota/LPS/liver TLR4 signaling axis - PubMed
Copper (Cu) serves as an essential cofactor in all organisms, yet excessive Cu exposure is widely recognized for its role in inducing liver inflammation. However, the precise mechanism by which Cu triggers liver inflammation in ducks, particularly in relation to the interplay in gut microbiota regul …
·pubmed.ncbi.nlm.nih.gov·
Cu exposure induces liver inflammation via regulating gut microbiota/LPS/liver TLR4 signaling axis - PubMed
Defining the phylogenetics and resistome of the major Clostridioides difficile ribotypes circulating in Australia - PubMed
Defining the phylogenetics and resistome of the major Clostridioides difficile ribotypes circulating in Australia - PubMed
Clostridioides difficile infection (CDI) remains a significant public health threat globally. New interventions to treat CDI rely on an understanding of the evolution and epidemiology of circulating strains. Here we provide longitudinal genomic data on strain diversity, transmission dynamics …
·pubmed.ncbi.nlm.nih.gov·
Defining the phylogenetics and resistome of the major Clostridioides difficile ribotypes circulating in Australia - PubMed
Revealing roles of S-layer protein (SlpA) in Clostridioides difficile pathogenicity by generating the first slpA gene deletion mutant - PubMed
Revealing roles of S-layer protein (SlpA) in Clostridioides difficile pathogenicity by generating the first slpA gene deletion mutant - PubMed
Clostridioides difficile infection (CDI) with high morbidity and high mortality is an urgent threat to public health, and C. difficile pathogenesis studies are eagerly required for CDI therapy. The major surface layer protein, SlpA, was supposed to play a key role in C. difficile …
·pubmed.ncbi.nlm.nih.gov·
Revealing roles of S-layer protein (SlpA) in Clostridioides difficile pathogenicity by generating the first slpA gene deletion mutant - PubMed
Clostridioides difficile in calves, cattle and humans from Dutch dairy farms: Predominance of PCR ribotype 695 (clade 5, sequence type 11) in cattle - PubMed
Clostridioides difficile in calves, cattle and humans from Dutch dairy farms: Predominance of PCR ribotype 695 (clade 5, sequence type 11) in cattle - PubMed
C. difficile was found in ∼20% of dairy farms with a predominance of the relatively unknown RT695. Isolates of RT695 belonged to the same clade and sequence type as RT078/126, which is recognized as an important zoonotic type.
·pubmed.ncbi.nlm.nih.gov·
Clostridioides difficile in calves, cattle and humans from Dutch dairy farms: Predominance of PCR ribotype 695 (clade 5, sequence type 11) in cattle - PubMed
Identification of a hemorrhagic determinant in Clostridioides difficile TcdA and Paeniclostridium sordellii TcsH - PubMed
Identification of a hemorrhagic determinant in Clostridioides difficile TcdA and Paeniclostridium sordellii TcsH - PubMed
Paeniclostridium sordellii and Clostridioides difficile infections often cause hemorrhage in the affected tissues and organs, which is mainly attributed to their hemorrhagic toxins, TcsH and TcdA. In this study, we demonstrate that TcsH and TcdA, but not other related toxins. including …
·pubmed.ncbi.nlm.nih.gov·
Identification of a hemorrhagic determinant in Clostridioides difficile TcdA and Paeniclostridium sordellii TcsH - PubMed
Effect of Leptin Receptor Q223R Polymorphism on Clostridioides difficile Infection-Induced Macrophage Migration Inhibitory Factor Production - PubMed
Effect of Leptin Receptor Q223R Polymorphism on Clostridioides difficile Infection-Induced Macrophage Migration Inhibitory Factor Production - PubMed
Proinflammatory cytokine levels and host genetic makeup are key determinants of Clostridioides difficile infection (CDI) outcomes. We previously reported that blocking the inflammatory cytokine macrophage migration inhibitory factor (MIF) ameliorates CDI. Here, we determined kinetics of MIF producti …
·pubmed.ncbi.nlm.nih.gov·
Effect of Leptin Receptor Q223R Polymorphism on Clostridioides difficile Infection-Induced Macrophage Migration Inhibitory Factor Production - PubMed
Deficiency of IL-22-binding protein enhances the ability of the gut microbiota to protect against enteric pathogens - PubMed
Deficiency of IL-22-binding protein enhances the ability of the gut microbiota to protect against enteric pathogens - PubMed
Interleukin 22 (IL-22) promotes intestinal barrier integrity, stimulating epithelial cells to enact defense mechanisms against enteric infections, including the production of antimicrobial peptides. IL-22 binding protein (IL-22BP) is a soluble decoy encoded by the Il22ra2 gene that decreases …
·pubmed.ncbi.nlm.nih.gov·
Deficiency of IL-22-binding protein enhances the ability of the gut microbiota to protect against enteric pathogens - PubMed
X-ray structure and mutagenesis analyses of Clostridioides difficile endolysin Ecd09610 glucosaminidase domain - PubMed
X-ray structure and mutagenesis analyses of Clostridioides difficile endolysin Ecd09610 glucosaminidase domain - PubMed
Clostridioides difficile endolysin (Ecd09610) consists of an unknown domain at its N terminus, followed by two catalytic domains, a glucosaminidase domain and endopeptidase domain. X-ray structure and mutagenesis analyses of the Ecd09610 catalytic domain with glucosaminidase activity (Ecd09610CD53) …
·pubmed.ncbi.nlm.nih.gov·
X-ray structure and mutagenesis analyses of Clostridioides difficile endolysin Ecd09610 glucosaminidase domain - PubMed
Clostridiodes difficile infection in inflammatory bowel disease: a clinical review - PubMed
Clostridiodes difficile infection in inflammatory bowel disease: a clinical review - PubMed
Available studies show that the prevalence of CDI-IBD is not optimistic. Currently, potential treatment options for CDI-IBD include a number of probiotics and novel antibiotics. This review updates the knowledge on the management of CDI in IBD patients, which is timely and important for GI doctors a …
·pubmed.ncbi.nlm.nih.gov·
Clostridiodes difficile infection in inflammatory bowel disease: a clinical review - PubMed
Theophylline-based control of repA on a Clostridioides difficile plasmid for use in allelic exchange - PubMed
Theophylline-based control of repA on a Clostridioides difficile plasmid for use in allelic exchange - PubMed
Historically, mutagenesis in the non-model enteropathogenic bacterium Clostridioides difficile has been challenging. Developing a versatile and reliable method of generating targeted mutations in C. difficile is important to further our understanding of its pathogenesis. Some of the most common targ …
·pubmed.ncbi.nlm.nih.gov·
Theophylline-based control of repA on a Clostridioides difficile plasmid for use in allelic exchange - PubMed
Deficiency of IL-22-binding protein enhances the ability of the gut microbiota to protect against enteric pathogens - PubMed
Deficiency of IL-22-binding protein enhances the ability of the gut microbiota to protect against enteric pathogens - PubMed
Interleukin 22 (IL-22) promotes intestinal barrier integrity, stimulating epithelial cells to enact defense mechanisms against enteric infections, including the production of antimicrobial peptides. IL-22 binding protein (IL-22BP) is a soluble decoy encoded by the Il22ra2 gene that decreases …
·pubmed.ncbi.nlm.nih.gov·
Deficiency of IL-22-binding protein enhances the ability of the gut microbiota to protect against enteric pathogens - PubMed
Effect of Leptin Receptor Q223R Polymorphism on Clostridioides difficile Infection-Induced Macrophage Migration Inhibitory Factor Production - PubMed
Effect of Leptin Receptor Q223R Polymorphism on Clostridioides difficile Infection-Induced Macrophage Migration Inhibitory Factor Production - PubMed
Proinflammatory cytokine levels and host genetic makeup are key determinants of Clostridioides difficile infection (CDI) outcomes. We previously reported that blocking the inflammatory cytokine macrophage migration inhibitory factor (MIF) ameliorates CDI. Here, we determined kinetics of MIF producti …
·pubmed.ncbi.nlm.nih.gov·
Effect of Leptin Receptor Q223R Polymorphism on Clostridioides difficile Infection-Induced Macrophage Migration Inhibitory Factor Production - PubMed
Effects of supplementing direct-fed microbials on health and growth of pre-weaning Gyr × Holstein dairy calves - PubMed
Effects of supplementing direct-fed microbials on health and growth of pre-weaning Gyr × Holstein dairy calves - PubMed
This study aimed to evaluate the effects of direct-fed microbials (DFM) on health and growth responses of pre-weaning Bos indicus × B. taurus (Gyr × Holstein) crossbred calves. Ninety newborn heifer calves [initial body weight (BW) 35 ± 4.0 kg] were used. At birth, calves were ranked by initial BW a …
·pubmed.ncbi.nlm.nih.gov·
Effects of supplementing direct-fed microbials on health and growth of pre-weaning Gyr × Holstein dairy calves - PubMed
Advancements in understanding bacterial enteritis pathogenesis through organoids - PubMed
Advancements in understanding bacterial enteritis pathogenesis through organoids - PubMed
Bacterial enteritis has a substantial role in contributing to a large portion of the global disease burden and serves as a major cause of newborn mortality. Despite advancements gained from current animal and cell models in improving our understanding of pathogens, their widespread application is hi …
·pubmed.ncbi.nlm.nih.gov·
Advancements in understanding bacterial enteritis pathogenesis through organoids - PubMed
Pouchitis: pathophysiology and management - PubMed
Pouchitis: pathophysiology and management - PubMed
Pouchitis is an acute or chronic inflammatory disease of the ileal reservoir. It is common after restorative proctocolectomy with ileal pouch-anal anastomosis, and treatment of chronic antibiotic-refractory pouchitis has proven challenging. Most cases of acute pouchitis evolve into chronic pouchitis …
·pubmed.ncbi.nlm.nih.gov·
Pouchitis: pathophysiology and management - PubMed
Quinoline-based compounds can inhibit diverse enzymes that act on DNA - PubMed
Quinoline-based compounds can inhibit diverse enzymes that act on DNA - PubMed
Six of fifteen quinoline-based derivatives demonstrated comparable low micromolar inhibitory effects on human cytosine methyltransferase DNMT1, and the bacterial adenine methyltransferases Clostridioides difficile CamA and Caulobacter crescentus CcrM. Compounds 9 and 11 w …
·pubmed.ncbi.nlm.nih.gov·
Quinoline-based compounds can inhibit diverse enzymes that act on DNA - PubMed
Clostridioides difficile Colitis - PubMed
Clostridioides difficile Colitis - PubMed
Clostridioides difficile colitis is an important source of hospital-acquired diarrhea associated with antibiotic use. Symptoms are profuse watery diarrhea, typically following a course of antibiotics; however, some cases of fulminant disease may manifest with shock, ileus, or megacolon. Nonfulminant …
·pubmed.ncbi.nlm.nih.gov·
Clostridioides difficile Colitis - PubMed
Colorectal Disease and the Gut Microbiome: What a Surgeon Needs to Know - PubMed
Colorectal Disease and the Gut Microbiome: What a Surgeon Needs to Know - PubMed
The gut microbiome is defined as the microorganisms that reside within the gastrointestinal tract and produce a variety of metabolites that impact human health. These microbes play an intricate role in human health, and an imbalance in the gut microbiome, termed gut dysbiosis, has been implicated in …
·pubmed.ncbi.nlm.nih.gov·
Colorectal Disease and the Gut Microbiome: What a Surgeon Needs to Know - PubMed
Genotypic and phenotypic antimicrobial resistance of Irish Clostridioides difficile isolates, 2022 - PubMed
Genotypic and phenotypic antimicrobial resistance of Irish Clostridioides difficile isolates, 2022 - PubMed
Our results suggest that for moxifloxacin, tetracycline and clindamycin, phenotypic resistance in C. difficile can be predicted by genetic indicators and used for public health purposes. However, for the other five antibiotics, the model is not accurate and further development is necessary.
·pubmed.ncbi.nlm.nih.gov·
Genotypic and phenotypic antimicrobial resistance of Irish Clostridioides difficile isolates, 2022 - PubMed
Antimicrobial Effects of Some Natural Products on Adhesion and Biofilm Inhibition of Clostridioides difficile - PubMed
Antimicrobial Effects of Some Natural Products on Adhesion and Biofilm Inhibition of Clostridioides difficile - PubMed
Understanding the potential antimicrobial properties of natural compounds and their impacts on Clostridioides difficile virulence factors may aid in developing alternative strategies for preventing and treating C. difficile infections (CDI). In this study, we investigated the bacterici …
·pubmed.ncbi.nlm.nih.gov·
Antimicrobial Effects of Some Natural Products on Adhesion and Biofilm Inhibition of Clostridioides difficile - PubMed
Clostridioides difficile infection is associated with differences in transcriptionally active microbial communities - PubMed
Clostridioides difficile infection is associated with differences in transcriptionally active microbial communities - PubMed
Clostridioides difficile infection (CDI) is responsible for around 300,000 hospitalizations yearly in the United States, with the associated monetary cost being billions of dollars. Gut microbiome dysbiosis is known to be important to CDI. To the best of our knowledge, metatranscriptomics (MT …
·pubmed.ncbi.nlm.nih.gov·
Clostridioides difficile infection is associated with differences in transcriptionally active microbial communities - PubMed
Post-infectious ibs following Clostridioides difficile infection; role of microbiota and implications for treatment - PubMed
Post-infectious ibs following Clostridioides difficile infection; role of microbiota and implications for treatment - PubMed
Up to 25% of patients recovering from antibiotic-treated Clostridioides difficile infection (CDI) develop functional symptoms reminiscent of Post-Infectious Irritable Bowel Syndrome (PI-IBS). For patients with persistent symptoms following infection, a clinical dilemma arises as to whether to provid …
·pubmed.ncbi.nlm.nih.gov·
Post-infectious ibs following Clostridioides difficile infection; role of microbiota and implications for treatment - PubMed
The incidence of Clostridium difficile infection in children with and without inflammatory bowel diseases: A single-center study in Taiwan from 2006 to 2019 - PubMed
The incidence of Clostridium difficile infection in children with and without inflammatory bowel diseases: A single-center study in Taiwan from 2006 to 2019 - PubMed
Both CA-CDI and healthcare facility-onset CDI (HO-CDI) were increasing substantially in the pediatric population over the past decade in Taiwan. Compared to the general pediatric population, pediatric IBD patients had a much higher incidence of CDI.
·pubmed.ncbi.nlm.nih.gov·
The incidence of Clostridium difficile infection in children with and without inflammatory bowel diseases: A single-center study in Taiwan from 2006 to 2019 - PubMed
Gut microbiome changes in mouse, Mongolian gerbil, and hamster models following Clostridioides difficile challenge - PubMed
Gut microbiome changes in mouse, Mongolian gerbil, and hamster models following Clostridioides difficile challenge - PubMed
Based on the observed responses to C. difficile challenge, we concluded for the first time that the Mongolian gerbil could be used as an animal model for CDI. Additionally, the taxa identified in this study may be used as biomarkers for further studies on CDI and to improve understanding rega …
·pubmed.ncbi.nlm.nih.gov·
Gut microbiome changes in mouse, Mongolian gerbil, and hamster models following Clostridioides difficile challenge - PubMed
Understanding the influence of the microbiome on childhood infections - PubMed
Understanding the influence of the microbiome on childhood infections - PubMed
Recent advances in sequencing technologies have led to an explosion of studies associating the human microbiome with the risk and severity of infectious diseases. As our knowledge of the extent to which the microbiome influences childhood infections continues to grow, microbiome-based diagnostics an …
·pubmed.ncbi.nlm.nih.gov·
Understanding the influence of the microbiome on childhood infections - PubMed