C Diff Molecular

C Diff Molecular

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Frontiers | Characterization of the gut microbiome of patients with Clostridioides difficile infection, patients with non–C. difficile diarrhea, and C. difficile–colonized patients
Frontiers | Characterization of the gut microbiome of patients with Clostridioides difficile infection, patients with non–C. difficile diarrhea, and C. difficile–colonized patients
IntroductionClostridioides difficile infection (CDI) is the main cause of nosocomial diarrhea in developed countries. A key challenge in CDI is the lack of o...
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Frontiers | Characterization of the gut microbiome of patients with Clostridioides difficile infection, patients with non–C. difficile diarrhea, and C. difficile–colonized patients
Inhibition of Clostridioides difficile toxins TcdA and TcdB by the amiodarone derivative dronedarone - PubMed
Inhibition of Clostridioides difficile toxins TcdA and TcdB by the amiodarone derivative dronedarone - PubMed
The dreaded nosocomial pathogen Clostridioides difficile causes diarrhea and severe inflammation of the colon, especially after the use of certain antibiotics. The bacterium releases two deleterious toxins, TcdA and TcdB, into the gut, which are mainly responsible for the symptoms of C. difficile-as …
·pubmed.ncbi.nlm.nih.gov·
Inhibition of Clostridioides difficile toxins TcdA and TcdB by the amiodarone derivative dronedarone - PubMed
Cleavage of an engulfment peptidoglycan hydrolase by a sporulation signature protease in Clostridioides difficile - PubMed
Cleavage of an engulfment peptidoglycan hydrolase by a sporulation signature protease in Clostridioides difficile - PubMed
In the model organism Bacillus subtilis, a signaling protease produced in the forespore, SpoIVB, is essential for the activation of the sigma factor σK, which is produced in the mother cell as an inactive pro-protein, pro-σK. SpoIVB has a second function essential to sporulatio …
·pubmed.ncbi.nlm.nih.gov·
Cleavage of an engulfment peptidoglycan hydrolase by a sporulation signature protease in Clostridioides difficile - PubMed
Clostridioides difficile Toxins: Host Cell Interactions and Their Role in Disease Pathogenesis - PubMed
Clostridioides difficile Toxins: Host Cell Interactions and Their Role in Disease Pathogenesis - PubMed
Clostridioides difficile, a Gram-positive anaerobic bacterium, is the leading cause of hospital-acquired antibiotic-associated diarrhea worldwide. The severity of C. difficile infection (CDI) varies, ranging from mild diarrhea to life-threatening conditions such as pseudomembranous col …
·pubmed.ncbi.nlm.nih.gov·
Clostridioides difficile Toxins: Host Cell Interactions and Their Role in Disease Pathogenesis - PubMed
Borrelia burgdorferi 0755, a Novel Cytotoxin with Unknown Function in Lyme Disease - PubMed
Borrelia burgdorferi 0755, a Novel Cytotoxin with Unknown Function in Lyme Disease - PubMed
The pathophysiology of Lyme disease, especially in its persistent form, remains to be determined. As many of the neurologic symptoms are similar to those seen in other toxin-associated disorders, a hypothesis was generated that B. burgdorferi, the causative agent of Lyme disease, may produce …
·pubmed.ncbi.nlm.nih.gov·
Borrelia burgdorferi 0755, a Novel Cytotoxin with Unknown Function in Lyme Disease - PubMed
Clostridioides difficile Toxins: Host Cell Interactions and Their Role in Disease Pathogenesis - PubMed
Clostridioides difficile Toxins: Host Cell Interactions and Their Role in Disease Pathogenesis - PubMed
Clostridioides difficile, a Gram-positive anaerobic bacterium, is the leading cause of hospital-acquired antibiotic-associated diarrhea worldwide. The severity of C. difficile infection (CDI) varies, ranging from mild diarrhea to life-threatening conditions such as pseudomembranous col …
·pubmed.ncbi.nlm.nih.gov·
Clostridioides difficile Toxins: Host Cell Interactions and Their Role in Disease Pathogenesis - PubMed
The impact of YabG mutations on C. difficile spore germination and processing of spore substrates - PubMed
The impact of YabG mutations on C. difficile spore germination and processing of spore substrates - PubMed
YabG is a sporulation-specific protease that is conserved among sporulating bacteria. C. difficile YabG processes cortex destined proteins preproSleC into proSleC and CspBA to CspB and CspA. YabG also affects synthesis of spore coat/exosporium proteins CotA and CdeM. In prior work that identi …
·pubmed.ncbi.nlm.nih.gov·
The impact of YabG mutations on C. difficile spore germination and processing of spore substrates - PubMed
The gut microbiota and diabetes: research, translation, and clinical applications - 2023 Diabetes, Diabetes Care, and Diabetologia Expert Forum - PubMed
The gut microbiota and diabetes: research, translation, and clinical applications - 2023 Diabetes, Diabetes Care, and Diabetologia Expert Forum - PubMed
This article summarises the state of the science on the role of the gut microbiota (GM) in diabetes from a recent international expert forum organised by Diabetes, Diabetes Care, and Diabetologia, which was held at the European Association for the Study of Diabetes 2023 Annual Meeting in Hamburg, Ge …
·pubmed.ncbi.nlm.nih.gov·
The gut microbiota and diabetes: research, translation, and clinical applications - 2023 Diabetes, Diabetes Care, and Diabetologia Expert Forum - PubMed
Island biogeography theory provides a plausible explanation for why larger vertebrates and taller humans have more diverse gut microbiomes - PubMed
Island biogeography theory provides a plausible explanation for why larger vertebrates and taller humans have more diverse gut microbiomes - PubMed
Prior work has shown a positive scaling relationship between vertebrate body size, human height, and gut microbiome alpha diversity. This observation mirrors commonly observed species area relationships (SAR) in many other ecosystems. Here, we expand these observations to several large data sets, sh …
·pubmed.ncbi.nlm.nih.gov·
Island biogeography theory provides a plausible explanation for why larger vertebrates and taller humans have more diverse gut microbiomes - PubMed
Understanding host immune responses in Clostridioides difficile infection: Implications for pathogenesis and immunotherapy - PubMed
Understanding host immune responses in Clostridioides difficile infection: Implications for pathogenesis and immunotherapy - PubMed
Clostridioides difficile (C. difficile) is the predominant causative agent of nosocomial diarrhea worldwide. Infection with C. difficile occurs due to the secretion of large glycosylating toxin proteins, which can lead to toxic megacolon or mortality in susceptible hosts. A crit …
·pubmed.ncbi.nlm.nih.gov·
Understanding host immune responses in Clostridioides difficile infection: Implications for pathogenesis and immunotherapy - PubMed
Insight into the Mechanism of Lysogeny Control of phiCDKH01 Bacteriophage Infecting Clinical Isolate of Clostridioides difficile - PubMed
Insight into the Mechanism of Lysogeny Control of phiCDKH01 Bacteriophage Infecting Clinical Isolate of Clostridioides difficile - PubMed
Clostridioides difficile is a causative agent of antibiotic-associated diarrhea as well as pseudomembranous colitis. So far, all known bacteriophages infecting these bacteria are temperate, which means that instead of prompt lysis of host cells, they can integrate into the host genome or repl …
·pubmed.ncbi.nlm.nih.gov·
Insight into the Mechanism of Lysogeny Control of phiCDKH01 Bacteriophage Infecting Clinical Isolate of Clostridioides difficile - PubMed
Implications of Microbiota and Immune System in Development and Progression of Metabolic Dysfunction-Associated Steatotic Liver Disease - PubMed
Implications of Microbiota and Immune System in Development and Progression of Metabolic Dysfunction-Associated Steatotic Liver Disease - PubMed
Metabolic dysfunction-associated steatotic liver disease (MASLD) is the most prevalent type of liver disease worldwide. The exact pathophysiology behind MASLD remains unclear; however, it is thought that a combination of factors or "hits" act as precipitants for disease onset and progression. Abunda …
·pubmed.ncbi.nlm.nih.gov·
Implications of Microbiota and Immune System in Development and Progression of Metabolic Dysfunction-Associated Steatotic Liver Disease - PubMed
Alteration of Gut Microbiota Composition and Diversity in Acute and/or Chronic Graft-versus-Host Disease Following Hematopoietic Stem Cell Transplantation: A Prospective Cohort Study - PubMed
Alteration of Gut Microbiota Composition and Diversity in Acute and/or Chronic Graft-versus-Host Disease Following Hematopoietic Stem Cell Transplantation: A Prospective Cohort Study - PubMed
Changes in gut microbiome composition have been implicated in the pathogenesis of graft-versus-host disease (GvHD) after allogeneic hematopoietic stem cell transplantation (allo-HSCT). Our objective was to explore the microbial abundance in patients with GvHD after allo-HSCT. We conducted a single-c …
·pubmed.ncbi.nlm.nih.gov·
Alteration of Gut Microbiota Composition and Diversity in Acute and/or Chronic Graft-versus-Host Disease Following Hematopoietic Stem Cell Transplantation: A Prospective Cohort Study - PubMed
Metabolic Disease Research Grant - NRVNews
Metabolic Disease Research Grant - NRVNews
The U.S. Department of Health and Human Services (HHS) has awarded Virginia Tech a $300,000 grant for allergy, immunology and transplantation research related
·news.google.com·
Metabolic Disease Research Grant - NRVNews
Insight into the Mechanism of Lysogeny Control of phiCDKH01 Bacteriophage Infecting Clinical Isolate of Clostridioides difficile - PubMed
Insight into the Mechanism of Lysogeny Control of phiCDKH01 Bacteriophage Infecting Clinical Isolate of Clostridioides difficile - PubMed
Clostridioides difficile is a causative agent of antibiotic-associated diarrhea as well as pseudomembranous colitis. So far, all known bacteriophages infecting these bacteria are temperate, which means that instead of prompt lysis of host cells, they can integrate into the host genome or repl …
·pubmed.ncbi.nlm.nih.gov·
Insight into the Mechanism of Lysogeny Control of phiCDKH01 Bacteriophage Infecting Clinical Isolate of Clostridioides difficile - PubMed
A sequence invariable region in TcdB2 is required for toxin escape from Clostridioides difficile - PubMed
A sequence invariable region in TcdB2 is required for toxin escape from Clostridioides difficile - PubMed
Clostridioides difficile is a leading cause of antibiotic associated disease in the United States. The primary virulence factors produced by C. difficile are two large glucosylating toxins TcdA and TcdB. To date, several sequence variants of TcdB have been identified that differ in var …
·pubmed.ncbi.nlm.nih.gov·
A sequence invariable region in TcdB2 is required for toxin escape from Clostridioides difficile - PubMed
Identification of avaC from Human Gut Microbial Isolates that Converts 5AVA to 2-Piperidone - PubMed
Identification of avaC from Human Gut Microbial Isolates that Converts 5AVA to 2-Piperidone - PubMed
2-piperidone is a crucial industrial raw material of high-value nylon-5 and nylon-6,5. Currently, a major bottleneck in the biosynthesis of 2-piperidone is the identification of highly efficient 2-piperidone synthases. In this study, we aimed to identify specific strains among 51 human gut bacterial …
·pubmed.ncbi.nlm.nih.gov·
Identification of avaC from Human Gut Microbial Isolates that Converts 5AVA to 2-Piperidone - PubMed
The complete catalog of antimicrobial resistance secondary active transporters in Clostridioides difficile: evolution and drug resistance perspective - PubMed
The complete catalog of antimicrobial resistance secondary active transporters in Clostridioides difficile: evolution and drug resistance perspective - PubMed
Secondary active transporters shuttle substrates across eukaryotic and prokaryotic membranes, utilizing different electrochemical gradients. They are recognized as one of the antimicrobial efflux pumps among pathogens. While primary active transporters within the genome of C. difficile 630 ha …
·pubmed.ncbi.nlm.nih.gov·
The complete catalog of antimicrobial resistance secondary active transporters in Clostridioides difficile: evolution and drug resistance perspective - PubMed
Decoding the role of immune T cells: A new territory for improvement of metabolic-associated fatty liver disease - PubMed
Decoding the role of immune T cells: A new territory for improvement of metabolic-associated fatty liver disease - PubMed
Metabolic-associated fatty liver disease (MAFLD) is a new emerging concept and is associated with metabolic dysfunction, generally replacing the name of nonalcoholic fatty liver disease (NAFLD) due to heterogeneous liver condition and inaccuracies in definition. The prevalence of MAFLD is rising by …
·pubmed.ncbi.nlm.nih.gov·
Decoding the role of immune T cells: A new territory for improvement of metabolic-associated fatty liver disease - PubMed
Genomic and phenotypic studies among Clostridioides difficile isolates show a high prevalence of clade 2 and great diversity in clinical isolates from Mexican adults and children with healthcare-associated diarrhea - PubMed
Genomic and phenotypic studies among Clostridioides difficile isolates show a high prevalence of clade 2 and great diversity in clinical isolates from Mexican adults and children with healthcare-associated diarrhea - PubMed
Clostridioides difficile is a toxin-producing bacterial pathogen recognized as the most common cause of diarrhea acquired primarily in healthcare settings. This bacterial species is diverse; its global population has been divided into five different clades using multilocus sequence typing, an …
·pubmed.ncbi.nlm.nih.gov·
Genomic and phenotypic studies among Clostridioides difficile isolates show a high prevalence of clade 2 and great diversity in clinical isolates from Mexican adults and children with healthcare-associated diarrhea - PubMed
Characterization and dynamics of intestinal microbiota in patients with Clostridioides difficile colonization and infection - PubMed
Characterization and dynamics of intestinal microbiota in patients with Clostridioides difficile colonization and infection - PubMed
Gut microbiota dysbiosis increases the susceptibility to Clostridioides difficile infection (CDI). In this study, we monitored C. difficile colonization (CDC) patients from no CDC status (CDN) to CDC status (CDCp) and CDI patients from asymptomatic status before CDI (PRECDI), CDI status (ONCDI), to …
·pubmed.ncbi.nlm.nih.gov·
Characterization and dynamics of intestinal microbiota in patients with Clostridioides difficile colonization and infection - PubMed