C Diff Molecular

C Diff Molecular

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Functional characterization of Fur from the strict anaerobe Clostridioides difficile provides insight into its redox-driven regulatory capacity - PubMed
Functional characterization of Fur from the strict anaerobe Clostridioides difficile provides insight into its redox-driven regulatory capacity - PubMed
Clostridioides (formerly Clostridium) difficile is a leading cause of infectious diarrhea associated with antibiotic therapy. The ability of this anaerobic pathogen to acquire enough iron to proliferate under iron limitation conditions imposed by the host largely determines its pathogenicity. Howeve …
·pubmed.ncbi.nlm.nih.gov·
Functional characterization of Fur from the strict anaerobe Clostridioides difficile provides insight into its redox-driven regulatory capacity - PubMed
Gastrointestinal Conditions: Acute Infectious Gastroenteritis and Colitis - PubMed
Gastrointestinal Conditions: Acute Infectious Gastroenteritis and Colitis - PubMed
Gastroenteritis is inflammation of the stomach and intestines; colitis is inflammation of the colon. Viruses are the most common cause, followed by bacteria and parasites. Incidence of the various infections varies by age, sex, location, and vaccine availability; vaccination has reduced rotavirus in …
·pubmed.ncbi.nlm.nih.gov·
Gastrointestinal Conditions: Acute Infectious Gastroenteritis and Colitis - PubMed
Metagenome-assembled genomes (MAGs) suggest an acetate-driven protective role in gut microbiota disrupted by Clostridioides difficile - PubMed
Metagenome-assembled genomes (MAGs) suggest an acetate-driven protective role in gut microbiota disrupted by Clostridioides difficile - PubMed
Clostridioides difficile may have a negative impact on gut microbiota composition in terms of diversity and abundance, thereby triggering functional changes supported by the differential presence of genes involved in significant metabolic pathways, such as short-chain fatty acids (SCFA). This work h …
·pubmed.ncbi.nlm.nih.gov·
Metagenome-assembled genomes (MAGs) suggest an acetate-driven protective role in gut microbiota disrupted by Clostridioides difficile - PubMed
Protection against Clostridioides difficile disease by a naturally avirulent C. difficile strain - PubMed
Protection against Clostridioides difficile disease by a naturally avirulent C. difficile strain - PubMed
Clostridioides difficile infections (CDI) are prevalent in healthcare settings and are associated with high recurrence rates. Therapies to prevent CDI, including recent FDA-approved live biotherapeutic products, are costly and have not been used to prevent primary infections. While a nontoxig …
·pubmed.ncbi.nlm.nih.gov·
Protection against Clostridioides difficile disease by a naturally avirulent C. difficile strain - PubMed
Toxin genotypes, antibiotic resistance and their correlations in Clostridioides difficile isolated from hospitals in Xi'an, China - PubMed
Toxin genotypes, antibiotic resistance and their correlations in Clostridioides difficile isolated from hospitals in Xi'an, China - PubMed
Currently, the prevalence rate of C. difficile infection (CDI) in Xi'an is 12.67% (156/1231), with the major toxin genotype of the isolates being tcdA + tcdB + cdtA-/B-. Metronidazole and vancomycin were still effective drugs for the treatment of CDI, but we should pay attention to antibiotic manage …
·pubmed.ncbi.nlm.nih.gov·
Toxin genotypes, antibiotic resistance and their correlations in Clostridioides difficile isolated from hospitals in Xi'an, China - PubMed
Functional characterization of Fur from the strict anaerobe Clostridioides difficile provides insight into its redox-driven regulatory capacity - PubMed
Functional characterization of Fur from the strict anaerobe Clostridioides difficile provides insight into its redox-driven regulatory capacity - PubMed
Clostridioides (formerly Clostridium) difficile is a leading cause of infectious diarrhea associated with antibiotic therapy. The ability of this anaerobic pathogen to acquire enough iron to proliferate under iron limitation conditions imposed by the host largely determines its pathogenicity. Howeve …
·pubmed.ncbi.nlm.nih.gov·
Functional characterization of Fur from the strict anaerobe Clostridioides difficile provides insight into its redox-driven regulatory capacity - PubMed
Gastrointestinal Conditions: Acute Infectious Gastroenteritis and Colitis - PubMed
Gastrointestinal Conditions: Acute Infectious Gastroenteritis and Colitis - PubMed
Gastroenteritis is inflammation of the stomach and intestines; colitis is inflammation of the colon. Viruses are the most common cause, followed by bacteria and parasites. Incidence of the various infections varies by age, sex, location, and vaccine availability; vaccination has reduced rotavirus in …
·pubmed.ncbi.nlm.nih.gov·
Gastrointestinal Conditions: Acute Infectious Gastroenteritis and Colitis - PubMed
Progress on mechanisms of antibiotic resistance in Clostridioides difficile - PubMed
Progress on mechanisms of antibiotic resistance in Clostridioides difficile - PubMed
Clostridioides difficile (CD) is one of the most common pathogens causing health-care-associated infectious diarrhea and is listed by the U.S. Centers for Disease Control and Prevention as an urgent antibiotic resistance (AR) threat. Many resistance genes can be transferred between different CD stra …
·pubmed.ncbi.nlm.nih.gov·
Progress on mechanisms of antibiotic resistance in Clostridioides difficile - PubMed
Protection against Clostridioides difficile disease by a naturally avirulent C. difficile strain - PubMed
Protection against Clostridioides difficile disease by a naturally avirulent C. difficile strain - PubMed
Clostridioides difficile infections (CDI) are prevalent in healthcare settings and are associated with high recurrence rates. Therapies to prevent CDI, including recent FDA-approved live biotherapeutic products, are costly and have not been used to prevent primary infections. While a nontoxig …
·pubmed.ncbi.nlm.nih.gov·
Protection against Clostridioides difficile disease by a naturally avirulent C. difficile strain - PubMed
Metagenome-assembled genomes (MAGs) suggest an acetate-driven protective role in gut microbiota disrupted by Clostridioides difficile - PubMed
Metagenome-assembled genomes (MAGs) suggest an acetate-driven protective role in gut microbiota disrupted by Clostridioides difficile - PubMed
Clostridioides difficile may have a negative impact on gut microbiota composition in terms of diversity and abundance, thereby triggering functional changes supported by the differential presence of genes involved in significant metabolic pathways, such as short-chain fatty acids (SCFA). This work h …
·pubmed.ncbi.nlm.nih.gov·
Metagenome-assembled genomes (MAGs) suggest an acetate-driven protective role in gut microbiota disrupted by Clostridioides difficile - PubMed
Clostridioides difficile toxin B subverts germinal center and antibody recall responses by stimulating a drug-treatable CXCR4-dependent mechanism - PubMed
Clostridioides difficile toxin B subverts germinal center and antibody recall responses by stimulating a drug-treatable CXCR4-dependent mechanism - PubMed
Recurrent Clostridioides difficile infection (CDI) results in significant morbidity and mortality. We previously established that CDI in mice does not protect against reinfection and is associated with poor pathogen-specific B cell memory (Bmem), recapitulating our observations with human Bmem. Here …
·pubmed.ncbi.nlm.nih.gov·
Clostridioides difficile toxin B subverts germinal center and antibody recall responses by stimulating a drug-treatable CXCR4-dependent mechanism - PubMed
Positive pathogens in stool could predict the clinical outcomes of sepsis-associated acute kidney injury in critical ill patient - PubMed
Positive pathogens in stool could predict the clinical outcomes of sepsis-associated acute kidney injury in critical ill patient - PubMed
In this study, we sought to evaluate the influence of positive pathogens in stool (PPS) on clinical outcomes in critical ill patients with Sepsis-associated acute kidney injury (S-AKI) from intensive care unit. Our sample consisted of 7338 patients, of whom 752 (10.25%) had PPS. We found that the pr …
·pubmed.ncbi.nlm.nih.gov·
Positive pathogens in stool could predict the clinical outcomes of sepsis-associated acute kidney injury in critical ill patient - PubMed
Clostridioides difficile infection in patients with and without COVID-19 during the pandemic: a retrospective cohort study from a tertiary referral hospital - PubMed
Clostridioides difficile infection in patients with and without COVID-19 during the pandemic: a retrospective cohort study from a tertiary referral hospital - PubMed
Increased CDI prevalence and testing were observed compared to the beginning of the COVID-19 pandemic. Lower CDI-related CFR was observed in patients with COVID-19, which may be credited to the patients' significantly lower median age and CCI, as well as to the majority of deaths being due to respir …
·pubmed.ncbi.nlm.nih.gov·
Clostridioides difficile infection in patients with and without COVID-19 during the pandemic: a retrospective cohort study from a tertiary referral hospital - PubMed
KipOTIA detoxifies 5-oxoproline and promotes the growth of Clostridioides difficile - PubMed
KipOTIA detoxifies 5-oxoproline and promotes the growth of Clostridioides difficile - PubMed
Clostridioides difficile is an anaerobic enteric pathogen that disseminates in the environment as a dormant spore. For C. difficile and other sporulating bacteria, the initiation of sporulation is a regulated process that prevents spore formation under favorable growth conditions. In …
·pubmed.ncbi.nlm.nih.gov·
KipOTIA detoxifies 5-oxoproline and promotes the growth of Clostridioides difficile - PubMed
A conserved switch controls virulence, sporulation, and motility in C. difficile - PubMed
A conserved switch controls virulence, sporulation, and motility in C. difficile - PubMed
Spore formation is required for environmental survival and transmission of the human enteropathogenic Clostridioides difficile. In all bacterial spore formers, sporulation is regulated through activation of the master response regulator, Spo0A. However, the factors and mechanisms that directly regul …
·pubmed.ncbi.nlm.nih.gov·
A conserved switch controls virulence, sporulation, and motility in C. difficile - PubMed
Cu exposure induces liver inflammation via regulating gut microbiota/LPS/liver TLR4 signaling axis - PubMed
Cu exposure induces liver inflammation via regulating gut microbiota/LPS/liver TLR4 signaling axis - PubMed
Copper (Cu) serves as an essential cofactor in all organisms, yet excessive Cu exposure is widely recognized for its role in inducing liver inflammation. However, the precise mechanism by which Cu triggers liver inflammation in ducks, particularly in relation to the interplay in gut microbiota regul …
·pubmed.ncbi.nlm.nih.gov·
Cu exposure induces liver inflammation via regulating gut microbiota/LPS/liver TLR4 signaling axis - PubMed
Defining the phylogenetics and resistome of the major Clostridioides difficile ribotypes circulating in Australia - PubMed
Defining the phylogenetics and resistome of the major Clostridioides difficile ribotypes circulating in Australia - PubMed
Clostridioides difficile infection (CDI) remains a significant public health threat globally. New interventions to treat CDI rely on an understanding of the evolution and epidemiology of circulating strains. Here we provide longitudinal genomic data on strain diversity, transmission dynamics …
·pubmed.ncbi.nlm.nih.gov·
Defining the phylogenetics and resistome of the major Clostridioides difficile ribotypes circulating in Australia - PubMed
Revealing roles of S-layer protein (SlpA) in Clostridioides difficile pathogenicity by generating the first slpA gene deletion mutant - PubMed
Revealing roles of S-layer protein (SlpA) in Clostridioides difficile pathogenicity by generating the first slpA gene deletion mutant - PubMed
Clostridioides difficile infection (CDI) with high morbidity and high mortality is an urgent threat to public health, and C. difficile pathogenesis studies are eagerly required for CDI therapy. The major surface layer protein, SlpA, was supposed to play a key role in C. difficile …
·pubmed.ncbi.nlm.nih.gov·
Revealing roles of S-layer protein (SlpA) in Clostridioides difficile pathogenicity by generating the first slpA gene deletion mutant - PubMed
Clostridioides difficile in calves, cattle and humans from Dutch dairy farms: Predominance of PCR ribotype 695 (clade 5, sequence type 11) in cattle - PubMed
Clostridioides difficile in calves, cattle and humans from Dutch dairy farms: Predominance of PCR ribotype 695 (clade 5, sequence type 11) in cattle - PubMed
C. difficile was found in ∼20% of dairy farms with a predominance of the relatively unknown RT695. Isolates of RT695 belonged to the same clade and sequence type as RT078/126, which is recognized as an important zoonotic type.
·pubmed.ncbi.nlm.nih.gov·
Clostridioides difficile in calves, cattle and humans from Dutch dairy farms: Predominance of PCR ribotype 695 (clade 5, sequence type 11) in cattle - PubMed
Identification of a hemorrhagic determinant in Clostridioides difficile TcdA and Paeniclostridium sordellii TcsH - PubMed
Identification of a hemorrhagic determinant in Clostridioides difficile TcdA and Paeniclostridium sordellii TcsH - PubMed
Paeniclostridium sordellii and Clostridioides difficile infections often cause hemorrhage in the affected tissues and organs, which is mainly attributed to their hemorrhagic toxins, TcsH and TcdA. In this study, we demonstrate that TcsH and TcdA, but not other related toxins. including …
·pubmed.ncbi.nlm.nih.gov·
Identification of a hemorrhagic determinant in Clostridioides difficile TcdA and Paeniclostridium sordellii TcsH - PubMed
Effect of Leptin Receptor Q223R Polymorphism on Clostridioides difficile Infection-Induced Macrophage Migration Inhibitory Factor Production - PubMed
Effect of Leptin Receptor Q223R Polymorphism on Clostridioides difficile Infection-Induced Macrophage Migration Inhibitory Factor Production - PubMed
Proinflammatory cytokine levels and host genetic makeup are key determinants of Clostridioides difficile infection (CDI) outcomes. We previously reported that blocking the inflammatory cytokine macrophage migration inhibitory factor (MIF) ameliorates CDI. Here, we determined kinetics of MIF producti …
·pubmed.ncbi.nlm.nih.gov·
Effect of Leptin Receptor Q223R Polymorphism on Clostridioides difficile Infection-Induced Macrophage Migration Inhibitory Factor Production - PubMed
Deficiency of IL-22-binding protein enhances the ability of the gut microbiota to protect against enteric pathogens - PubMed
Deficiency of IL-22-binding protein enhances the ability of the gut microbiota to protect against enteric pathogens - PubMed
Interleukin 22 (IL-22) promotes intestinal barrier integrity, stimulating epithelial cells to enact defense mechanisms against enteric infections, including the production of antimicrobial peptides. IL-22 binding protein (IL-22BP) is a soluble decoy encoded by the Il22ra2 gene that decreases …
·pubmed.ncbi.nlm.nih.gov·
Deficiency of IL-22-binding protein enhances the ability of the gut microbiota to protect against enteric pathogens - PubMed
X-ray structure and mutagenesis analyses of Clostridioides difficile endolysin Ecd09610 glucosaminidase domain - PubMed
X-ray structure and mutagenesis analyses of Clostridioides difficile endolysin Ecd09610 glucosaminidase domain - PubMed
Clostridioides difficile endolysin (Ecd09610) consists of an unknown domain at its N terminus, followed by two catalytic domains, a glucosaminidase domain and endopeptidase domain. X-ray structure and mutagenesis analyses of the Ecd09610 catalytic domain with glucosaminidase activity (Ecd09610CD53) …
·pubmed.ncbi.nlm.nih.gov·
X-ray structure and mutagenesis analyses of Clostridioides difficile endolysin Ecd09610 glucosaminidase domain - PubMed
Clostridiodes difficile infection in inflammatory bowel disease: a clinical review - PubMed
Clostridiodes difficile infection in inflammatory bowel disease: a clinical review - PubMed
Available studies show that the prevalence of CDI-IBD is not optimistic. Currently, potential treatment options for CDI-IBD include a number of probiotics and novel antibiotics. This review updates the knowledge on the management of CDI in IBD patients, which is timely and important for GI doctors a …
·pubmed.ncbi.nlm.nih.gov·
Clostridiodes difficile infection in inflammatory bowel disease: a clinical review - PubMed
Theophylline-based control of repA on a Clostridioides difficile plasmid for use in allelic exchange - PubMed
Theophylline-based control of repA on a Clostridioides difficile plasmid for use in allelic exchange - PubMed
Historically, mutagenesis in the non-model enteropathogenic bacterium Clostridioides difficile has been challenging. Developing a versatile and reliable method of generating targeted mutations in C. difficile is important to further our understanding of its pathogenesis. Some of the most common targ …
·pubmed.ncbi.nlm.nih.gov·
Theophylline-based control of repA on a Clostridioides difficile plasmid for use in allelic exchange - PubMed
Deficiency of IL-22-binding protein enhances the ability of the gut microbiota to protect against enteric pathogens - PubMed
Deficiency of IL-22-binding protein enhances the ability of the gut microbiota to protect against enteric pathogens - PubMed
Interleukin 22 (IL-22) promotes intestinal barrier integrity, stimulating epithelial cells to enact defense mechanisms against enteric infections, including the production of antimicrobial peptides. IL-22 binding protein (IL-22BP) is a soluble decoy encoded by the Il22ra2 gene that decreases …
·pubmed.ncbi.nlm.nih.gov·
Deficiency of IL-22-binding protein enhances the ability of the gut microbiota to protect against enteric pathogens - PubMed
Effect of Leptin Receptor Q223R Polymorphism on Clostridioides difficile Infection-Induced Macrophage Migration Inhibitory Factor Production - PubMed
Effect of Leptin Receptor Q223R Polymorphism on Clostridioides difficile Infection-Induced Macrophage Migration Inhibitory Factor Production - PubMed
Proinflammatory cytokine levels and host genetic makeup are key determinants of Clostridioides difficile infection (CDI) outcomes. We previously reported that blocking the inflammatory cytokine macrophage migration inhibitory factor (MIF) ameliorates CDI. Here, we determined kinetics of MIF producti …
·pubmed.ncbi.nlm.nih.gov·
Effect of Leptin Receptor Q223R Polymorphism on Clostridioides difficile Infection-Induced Macrophage Migration Inhibitory Factor Production - PubMed
Effects of supplementing direct-fed microbials on health and growth of pre-weaning Gyr × Holstein dairy calves - PubMed
Effects of supplementing direct-fed microbials on health and growth of pre-weaning Gyr × Holstein dairy calves - PubMed
This study aimed to evaluate the effects of direct-fed microbials (DFM) on health and growth responses of pre-weaning Bos indicus × B. taurus (Gyr × Holstein) crossbred calves. Ninety newborn heifer calves [initial body weight (BW) 35 ± 4.0 kg] were used. At birth, calves were ranked by initial BW a …
·pubmed.ncbi.nlm.nih.gov·
Effects of supplementing direct-fed microbials on health and growth of pre-weaning Gyr × Holstein dairy calves - PubMed
Advancements in understanding bacterial enteritis pathogenesis through organoids - PubMed
Advancements in understanding bacterial enteritis pathogenesis through organoids - PubMed
Bacterial enteritis has a substantial role in contributing to a large portion of the global disease burden and serves as a major cause of newborn mortality. Despite advancements gained from current animal and cell models in improving our understanding of pathogens, their widespread application is hi …
·pubmed.ncbi.nlm.nih.gov·
Advancements in understanding bacterial enteritis pathogenesis through organoids - PubMed