C Diff Molecular

C Diff Molecular

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Pouchitis: pathophysiology and management - PubMed
Pouchitis: pathophysiology and management - PubMed
Pouchitis is an acute or chronic inflammatory disease of the ileal reservoir. It is common after restorative proctocolectomy with ileal pouch-anal anastomosis, and treatment of chronic antibiotic-refractory pouchitis has proven challenging. Most cases of acute pouchitis evolve into chronic pouchitis …
·pubmed.ncbi.nlm.nih.gov·
Pouchitis: pathophysiology and management - PubMed
Quinoline-based compounds can inhibit diverse enzymes that act on DNA - PubMed
Quinoline-based compounds can inhibit diverse enzymes that act on DNA - PubMed
Six of fifteen quinoline-based derivatives demonstrated comparable low micromolar inhibitory effects on human cytosine methyltransferase DNMT1, and the bacterial adenine methyltransferases Clostridioides difficile CamA and Caulobacter crescentus CcrM. Compounds 9 and 11 w …
·pubmed.ncbi.nlm.nih.gov·
Quinoline-based compounds can inhibit diverse enzymes that act on DNA - PubMed
Clostridioides difficile Colitis - PubMed
Clostridioides difficile Colitis - PubMed
Clostridioides difficile colitis is an important source of hospital-acquired diarrhea associated with antibiotic use. Symptoms are profuse watery diarrhea, typically following a course of antibiotics; however, some cases of fulminant disease may manifest with shock, ileus, or megacolon. Nonfulminant …
·pubmed.ncbi.nlm.nih.gov·
Clostridioides difficile Colitis - PubMed
Colorectal Disease and the Gut Microbiome: What a Surgeon Needs to Know - PubMed
Colorectal Disease and the Gut Microbiome: What a Surgeon Needs to Know - PubMed
The gut microbiome is defined as the microorganisms that reside within the gastrointestinal tract and produce a variety of metabolites that impact human health. These microbes play an intricate role in human health, and an imbalance in the gut microbiome, termed gut dysbiosis, has been implicated in …
·pubmed.ncbi.nlm.nih.gov·
Colorectal Disease and the Gut Microbiome: What a Surgeon Needs to Know - PubMed
Genotypic and phenotypic antimicrobial resistance of Irish Clostridioides difficile isolates, 2022 - PubMed
Genotypic and phenotypic antimicrobial resistance of Irish Clostridioides difficile isolates, 2022 - PubMed
Our results suggest that for moxifloxacin, tetracycline and clindamycin, phenotypic resistance in C. difficile can be predicted by genetic indicators and used for public health purposes. However, for the other five antibiotics, the model is not accurate and further development is necessary.
·pubmed.ncbi.nlm.nih.gov·
Genotypic and phenotypic antimicrobial resistance of Irish Clostridioides difficile isolates, 2022 - PubMed
Antimicrobial Effects of Some Natural Products on Adhesion and Biofilm Inhibition of Clostridioides difficile - PubMed
Antimicrobial Effects of Some Natural Products on Adhesion and Biofilm Inhibition of Clostridioides difficile - PubMed
Understanding the potential antimicrobial properties of natural compounds and their impacts on Clostridioides difficile virulence factors may aid in developing alternative strategies for preventing and treating C. difficile infections (CDI). In this study, we investigated the bacterici …
·pubmed.ncbi.nlm.nih.gov·
Antimicrobial Effects of Some Natural Products on Adhesion and Biofilm Inhibition of Clostridioides difficile - PubMed
Clostridioides difficile infection is associated with differences in transcriptionally active microbial communities - PubMed
Clostridioides difficile infection is associated with differences in transcriptionally active microbial communities - PubMed
Clostridioides difficile infection (CDI) is responsible for around 300,000 hospitalizations yearly in the United States, with the associated monetary cost being billions of dollars. Gut microbiome dysbiosis is known to be important to CDI. To the best of our knowledge, metatranscriptomics (MT …
·pubmed.ncbi.nlm.nih.gov·
Clostridioides difficile infection is associated with differences in transcriptionally active microbial communities - PubMed
Post-infectious ibs following Clostridioides difficile infection; role of microbiota and implications for treatment - PubMed
Post-infectious ibs following Clostridioides difficile infection; role of microbiota and implications for treatment - PubMed
Up to 25% of patients recovering from antibiotic-treated Clostridioides difficile infection (CDI) develop functional symptoms reminiscent of Post-Infectious Irritable Bowel Syndrome (PI-IBS). For patients with persistent symptoms following infection, a clinical dilemma arises as to whether to provid …
·pubmed.ncbi.nlm.nih.gov·
Post-infectious ibs following Clostridioides difficile infection; role of microbiota and implications for treatment - PubMed
The incidence of Clostridium difficile infection in children with and without inflammatory bowel diseases: A single-center study in Taiwan from 2006 to 2019 - PubMed
The incidence of Clostridium difficile infection in children with and without inflammatory bowel diseases: A single-center study in Taiwan from 2006 to 2019 - PubMed
Both CA-CDI and healthcare facility-onset CDI (HO-CDI) were increasing substantially in the pediatric population over the past decade in Taiwan. Compared to the general pediatric population, pediatric IBD patients had a much higher incidence of CDI.
·pubmed.ncbi.nlm.nih.gov·
The incidence of Clostridium difficile infection in children with and without inflammatory bowel diseases: A single-center study in Taiwan from 2006 to 2019 - PubMed
Gut microbiome changes in mouse, Mongolian gerbil, and hamster models following Clostridioides difficile challenge - PubMed
Gut microbiome changes in mouse, Mongolian gerbil, and hamster models following Clostridioides difficile challenge - PubMed
Based on the observed responses to C. difficile challenge, we concluded for the first time that the Mongolian gerbil could be used as an animal model for CDI. Additionally, the taxa identified in this study may be used as biomarkers for further studies on CDI and to improve understanding rega …
·pubmed.ncbi.nlm.nih.gov·
Gut microbiome changes in mouse, Mongolian gerbil, and hamster models following Clostridioides difficile challenge - PubMed
Understanding the influence of the microbiome on childhood infections - PubMed
Understanding the influence of the microbiome on childhood infections - PubMed
Recent advances in sequencing technologies have led to an explosion of studies associating the human microbiome with the risk and severity of infectious diseases. As our knowledge of the extent to which the microbiome influences childhood infections continues to grow, microbiome-based diagnostics an …
·pubmed.ncbi.nlm.nih.gov·
Understanding the influence of the microbiome on childhood infections - PubMed
Genetic determinants of resistance to antimicrobial therapeutics are rare in publicly available Clostridioides difficile genome sequences - PubMed
Genetic determinants of resistance to antimicrobial therapeutics are rare in publicly available Clostridioides difficile genome sequences - PubMed
Genomic data suggested that resistance to therapeutic antimicrobial drugs is rare in C. difficile. Public antimicrobial resistance marker databases were not equipped to detect most of the genetic determinants relevant to antibiotic therapy of CDI.
·pubmed.ncbi.nlm.nih.gov·
Genetic determinants of resistance to antimicrobial therapeutics are rare in publicly available Clostridioides difficile genome sequences - PubMed
A commensal protozoan attenuates Clostridioides difficile pathogenesis in mice via arginine-ornithine metabolism and host intestinal immune response - PubMed
A commensal protozoan attenuates Clostridioides difficile pathogenesis in mice via arginine-ornithine metabolism and host intestinal immune response - PubMed
Antibiotic-induced dysbiosis is a major risk factor for Clostridioides difficile infection (CDI), and fecal microbiota transplantation (FMT) is recommended for treating CDI. However, the underlying mechanisms remain unclear. Here, we show that Tritrichomonas musculis (T.mu), an integral member of th …
·pubmed.ncbi.nlm.nih.gov·
A commensal protozoan attenuates Clostridioides difficile pathogenesis in mice via arginine-ornithine metabolism and host intestinal immune response - PubMed
Characteristics of Patients With Initial Clostridioides difficile Infection (CDI) That Are Associated With Increased Risk of Multiple CDI Recurrences - PubMed
Characteristics of Patients With Initial Clostridioides difficile Infection (CDI) That Are Associated With Increased Risk of Multiple CDI Recurrences - PubMed
Patients with iCDI who are older, on hemodialysis, or had recent hospitalization or nitrofurantoin use had increased risk of mrCDI and may benefit from early use of adjunctive therapy to prevent mrCDI. If confirmed, these findings could aid in clinical decision making and interventional study design …
·pubmed.ncbi.nlm.nih.gov·
Characteristics of Patients With Initial Clostridioides difficile Infection (CDI) That Are Associated With Increased Risk of Multiple CDI Recurrences - PubMed
Novel insights into phage biology of the pathogen Clostridioides difficile based on the active virome - PubMed
Novel insights into phage biology of the pathogen Clostridioides difficile based on the active virome - PubMed
The global pathogen Clostridioides difficile is a well-studied organism, and researchers work on unraveling its fundamental virulence mechanisms and biology. Prophages have been demonstrated to influence C. difficile toxin expression and contribute to the distribution of advantageous g …
·pubmed.ncbi.nlm.nih.gov·
Novel insights into phage biology of the pathogen Clostridioides difficile based on the active virome - PubMed
[A case of disseminated tuberculosis presenting as a metastasizing tumor, complicated by toxic megacolon caused by Clostridium difficile: Difficulties in diagnosis] - PubMed
[A case of disseminated tuberculosis presenting as a metastasizing tumor, complicated by toxic megacolon caused by Clostridium difficile: Difficulties in diagnosis] - PubMed
A mára ritkán előforduló tuberkulózis (tbc) extrapulmonális manifesztációi előrehaladott rosszindulatú daganatok képét utánozhatják, jelentős diagnosztikus dilemmákat okozva. A tbc igazolása gyakorta bonyolult, komplex vizsgálatokat igényel. Egy fiatal vietnámi nőbeteg esetét ismertetjük, aki idült …
·pubmed.ncbi.nlm.nih.gov·
[A case of disseminated tuberculosis presenting as a metastasizing tumor, complicated by toxic megacolon caused by Clostridium difficile: Difficulties in diagnosis] - PubMed
A new toxin toolkit for C. diff
A new toxin toolkit for C. diff
Clostridioides difficile (C. diff) is a leading cause of diarrhea and healthcare-associated infections in the United States and recognized as an urgent threat by the Centers for Disease Control. Virulence of C. diff infections is believed to rely primarily on the production of two toxins: TcdA and TcdB. TcdA and TcdB are large homologous proteins...
·news.google.com·
A new toxin toolkit for C. diff
A commensal protozoan attenuates Clostridioides difficile pathogenesis in mice via arginine-ornithine metabolism and host intestinal immune response
A commensal protozoan attenuates Clostridioides difficile pathogenesis in mice via arginine-ornithine metabolism and host intestinal immune response
Nature Communications - Faecal microbiome transplant has been shown to be able to reduce Clostridioides difficile infection. Here the authors show that an intestinal commensal protozoan reduces C....
·news.google.com·
A commensal protozoan attenuates Clostridioides difficile pathogenesis in mice via arginine-ornithine metabolism and host intestinal immune response
Identification of a new family of peptidoglycan transpeptidases reveals atypical crosslinking is essential for viability in Clostridioides difficile - PubMed
Identification of a new family of peptidoglycan transpeptidases reveals atypical crosslinking is essential for viability in Clostridioides difficile - PubMed
Clostridioides difficile , the leading cause of antibiotic-associated diarrhea, relies primarily on 3-3 crosslinks created by L,D-transpeptidases (LDTs) to fortify its peptidoglycan (PG) cell wall. This is unusual, as in most bacteria the vast majority of PG crosslinks are 4-3 crosslinks, whi …
·pubmed.ncbi.nlm.nih.gov·
Identification of a new family of peptidoglycan transpeptidases reveals atypical crosslinking is essential for viability in Clostridioides difficile - PubMed
Microbiome bacterial influencers of host immunity and response to immunotherapy - PubMed
Microbiome bacterial influencers of host immunity and response to immunotherapy - PubMed
The gut microbiota influences anti-tumor immunity and can induce or inhibit response to immune checkpoint inhibitors (ICIs). Therefore, microbiome features are being studied as predictive/prognostic biomarkers of patient response to ICIs, and microbiome-based interventions are attractive adjuvant tr …
·pubmed.ncbi.nlm.nih.gov·
Microbiome bacterial influencers of host immunity and response to immunotherapy - PubMed
The impact of existing total anti-toxin B IgG immunity in outcomes of recurrent Clostridioides difficile infection - PubMed
The impact of existing total anti-toxin B IgG immunity in outcomes of recurrent Clostridioides difficile infection - PubMed
Late anti-toxin-B humoral immunity acquired after treatment is important for preventing recurrent Clostridioides difficile infection. We prospectively-measured anti-toxin-B IgG and neutralization titers at diagnosis as potential early predictors of recurrence. High anti-toxin-B-IgG/neutralizing anti …
·pubmed.ncbi.nlm.nih.gov·
The impact of existing total anti-toxin B IgG immunity in outcomes of recurrent Clostridioides difficile infection - PubMed
Porcine Monocyte DNA Traps Formed during Infection with Pathogenic Clostridioides difficile Strains - PubMed
Porcine Monocyte DNA Traps Formed during Infection with Pathogenic Clostridioides difficile Strains - PubMed
Clostridioides (Clostridium) difficile is an enteric pathogen of several mammalian species including man, frequently involving nosocomial resurgence, following oral administration of broad-spectrum antibiotics, but also with human-to-human infection occurring, and neonatal pigs …
·pubmed.ncbi.nlm.nih.gov·
Porcine Monocyte DNA Traps Formed during Infection with Pathogenic Clostridioides difficile Strains - PubMed
Transplant of microbiota from Crohn's disease patients to germ-free mice results in colitis - PubMed
Transplant of microbiota from Crohn's disease patients to germ-free mice results in colitis - PubMed
Although the role of the intestinal microbiota in the pathogenesis of inflammatory bowel disease (IBD) is beyond debate, attempts to verify the causative role of IBD-associated dysbiosis have been limited to reports of promoting the disease in genetically susceptible mice or in chemically induced co …
·pubmed.ncbi.nlm.nih.gov·
Transplant of microbiota from Crohn's disease patients to germ-free mice results in colitis - PubMed
Clostridium difficile Infection Prior to Total Hip Arthroplasty Independently Increases the Risk of Periprosthetic Joint Infection - PubMed
Clostridium difficile Infection Prior to Total Hip Arthroplasty Independently Increases the Risk of Periprosthetic Joint Infection - PubMed
A C. difficile infection prior to THA is an independent risk factor for PJI. Proximity of C. difficile infection is associated with increased risk of PJI. Future investigations should evaluate how to adequately optimize patients prior to THA and pursue strategies to determine appropriate timing for …
·pubmed.ncbi.nlm.nih.gov·
Clostridium difficile Infection Prior to Total Hip Arthroplasty Independently Increases the Risk of Periprosthetic Joint Infection - PubMed
Incidence of Colorectal Cancer After Intestinal Infection Due to Clostridioides difficile - PubMed
Incidence of Colorectal Cancer After Intestinal Infection Due to Clostridioides difficile - PubMed
This study shows a statistically significant correlation between CDI and decreased incidence of CRC. Additionally, there is a statistically significant correlation between obese patients with CDI and an increased incidence of CRC. Further research is needed to explore the mechanism of this striking …
·pubmed.ncbi.nlm.nih.gov·
Incidence of Colorectal Cancer After Intestinal Infection Due to Clostridioides difficile - PubMed
Clostridioides difficile infection promotes gastrointestinal dysfunction in human and mice post-acute phase of the disease - PubMed
Clostridioides difficile infection promotes gastrointestinal dysfunction in human and mice post-acute phase of the disease - PubMed
In conclusion, post-infection intestinal dysfunction occurs in humans and mice post-CDI. Importantly, we have validated in the mouse model that CDI causes abnormal GI transit in the recovery phase of the disease, indicating the potential utility of the model in exploring the underlying mechanisms of …
·pubmed.ncbi.nlm.nih.gov·
Clostridioides difficile infection promotes gastrointestinal dysfunction in human and mice post-acute phase of the disease - PubMed
Clostridioides difficile infection promotes gastrointestinal dysfunction in human and mice post-acute phase of the disease - PubMed
Clostridioides difficile infection promotes gastrointestinal dysfunction in human and mice post-acute phase of the disease - PubMed
In conclusion, post-infection intestinal dysfunction occurs in humans and mice post-CDI. Importantly, we have validated in the mouse model that CDI causes abnormal GI transit in the recovery phase of the disease, indicating the potential utility of the model in exploring the underlying mechanisms of …
·pubmed.ncbi.nlm.nih.gov·
Clostridioides difficile infection promotes gastrointestinal dysfunction in human and mice post-acute phase of the disease - PubMed