We report a comprehensive evaluation of the toxin B (TcdB) vaccine adjuvanted with a dual Toll-like receptor ligand liposome adjuvant for Clostridioides difficile infection (CDI). The vaccine completely protected mice from a lethal infection. Compared to alum adjuvanted TcdB, it generated fun …

The objective of this study was to determine the presence of C. difficile in seafood, to identify the ribotype of isolates, to reveal the distribution of their toxinogenic genes and to evaluate the antibiotic susceptibility of C. difficile strains. For this purpose, a total of 755 seafood samples we …

Fulminant iClostridium difficile/i colitis is a severe and potentially life-threatening form of iClostridium difficile-/iassociated bacterial disease leading to inflammation and damage to the colon. Complications such as toxic megacolon, sepsis, and multi-organ failure commonly occur in indi …

Recurrent iC. difficile/i infection (CDI) is a major health threat with significant mortality and financial costs. Fecal Microbiota Transplantation (FMT) is an effective therapy, however the mechanisms by which it acts, particularly on the host, are poorly understood. Here we enrolled a prospect …

Fecal Microbiota Transplantation in a Long-Standing Auto-Brewery Syndrome with Complex Symptomatology

Introduction The use of antibiotics such as oral clindamycin has been effective in treating bacterial infections. However, this medication often comes with significant side effects, particula...

Acurx prepares for Phase 3 trials in C. difficile treatment

The study also found that HSSPs minimize health costs and provide additional revenue for health systems.

Background Clostridium difficile infection (CDI) is a significant healthcare concern, marked by its rising prevalence and associated morbidity and mortality. However, there is limited data on...

The global antibiotic resistance market is anticipated to reach US$ 17.23 billion by 2030; growing at a CAGR of 7.1% during the forecast period, 2022 – 2030.

Clostridioides difficile is a gram-positive bacteria that causes disease in persons with dysbiosis of the gut microbiota and has been listed as an urgent threat due to the emergence of resistance.

WMT had significant short-term and medium-term clinical efficacy in MetS. There were differences in the structure of metabolites between Marked Response OMVs and Moderate Response OMVs. The level of 9-Carboxy methoxy methylguanine in Marked Response OMVs can be a good predictor of the efficacy of WM …

Trinity Guardion, a leader in hospital bed hygiene solutions, announced the completion of a $6 million financing, including new funding of $3.5 million in a Series B funding round. This investment is aimed at accelerating the production and commercialization of the innovative Soteria Bed Barrier System. Queen City Angels led this funding round, and other investors included Tamiami Angel Fund, Market Street Ventures, and RKCA.

Jacinda Abdul-Mutakabbir, PharmD, MPH, AAHIVP, discusses a study she conducted that highlights how social determinants of health exacerbate severity and increase rates of mortality from Clostridioides difficile infections in vulnerable communities.

An HIV- positive patient with Kaposi's sarcoma and undergoing chemotherapy, had been on antibiotic therapy for around 14 days with ceftriaxone and imipenem. He was admitted with a 5-day evolution of watery diarrhea followed by rectorrhagia. His CD4 level was 226 cells/ mm3. Colonoscopy was done with …

There continues to be significant interest from both clinicians and patients in using faecal transplantation, as the integral role of the gut microbiome is increasingly recognised in various disease conditions, both within and beyond the gut. This Clinical Perspectives article provides an overview o …

On November 20, 2024, the U.S. Environmental Protection Agency (EPA) announced the release of its draft guidance for public comment to support registration and evaluation of efficacy claims for pre-saturated antimicrobial towelettes on hard non-porous surfaces such as stainless steel, metal, glass, hard plastic, or sealed wood, commonly seen in the market as “disinfecting wipes,” using a recently approved standard test method.

(BPT) - Every year, nearly half a million people in the U.S. suffer from a serious and potentially deadly infection called Clostridioides difficile or C. diff.1,2 C. diff is a bacteria that can …

TEHRAN (ANA)- Iranian researchers from University of Tehran succeeded in developing and designing an electrochemical genosensor to identify different strains of the C. difficile bacteria with high sensitivity and accuracy.

Methylmercury (MeHg) can cause devastating neurotoxicity in animals and human beings. Gut microbiota dysbiosis has been found in MeHg-poisoned animals. Fecal microbiota transplantation (FMT) has been shown to improve clinical outcomes in a variety of diseases such as epilepsy, amyotrophic lateral sc …

Gut microbiota modulation: a novel mechanism in arb-mediated hypertension treatment

The online version contains supplementary material available at 10.1007/s13167-024-00381-5.

The role of nutrition during infection is gaining momentum, with key findings exploring the effect of some nutrients in limiting the severity of infections and helping the microbiota recover from antibiotic-induced dysbiosis. Although this field is in its infancy, these findings open the possibility …

WEDNESDAY, Dec. 4, 2024 (HealthDay News) -- Many general practitioners prescribe antibiotics for suspected community-acquired pneumonia (CAP) even when chest radiograph (CR) results are negative, according to a study published in the November/December issue of the Annals of Family Medicine. Juliette Pinot, M.D., from the Université Paris Cité and Université Sorbonne Paris Nord, and colleagues analyzed antibiotic

Physicians are voicing concerns about a lack of regulation and the risks of parents taking matters into their own hands.

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We see an increase in the number of people with colds and flu during the holiday season, as people get together more with others. Antibiotics are very important

The gut microbiota might perhaps one day become a routine tool for the early diagnosis of many diseases and to guide treatment, but at present there

The COVID-19 pandemic, instigated by SARS-CoV-2, has initiated a transformative shift in hospital and laboratory environments worldwide. Airborne precautions have become as crucial as universal blood and body fluid precautions, prompting the normalization of Personal Protective Equipment (PPE) usage, including surgical masks or N95FFR. However, this surge in demand has led to shortages among healthcare workers.

Adapting implementation approaches and strategies as technology spreads.