Exposure to systemic antibiotics increased the risk of rehospitalization due to CDI, while post-discharge follow-up decreased the risk of rehospitalization due to CDI. Comprehensive transitions of care for hospitalized patients with C. difficile may reduce the risk of CDI-related rehospitaliz …

Conditions of transplant manufacturing, bowel cleansing, and a route of delivery tailored to the patient's characteristics are key factors in optimising FMT efficacy. FMT at first recurrence showed high success in real-life practice, whereas it had lower efficacy in severe CDI and non-severe refract …

This novel approach allows facilities to staff their IPC program based on individual factors. Future versions of the calculator will be optimized based on the findings. Future research will clarify the impact of staffing on patient outcomes and staff retention.

Our study found that C. difficile most of the ribotypes isolated from dogs are involved in cases of CDI in humans, and the prevalence was higher in dogs with diarrhea (p = 0.034). Although we could not confirm that diarrhea in these dogs was solely due to C. difficile, their colonization may represe …

In the present study, despite its small size, FMT through colonoscopy was shown to be a safe, effective, and lasting therapy in cases of recurrent CDI, concurring with results from larger studies.

Short-chain fatty acids (SCFAs) represent a cornerstone of gut health, serving as critical mediators of immune modulation and overall host homeostasis. Patients with dysbiosis caused by Clostridioides difficile infection (CDI) typically exhibit lower SCFAs levels compared to healthy stool don …

The portion of our nervous systems responsible for the 'fight or flight' response can shape the severity of potentially deadly C.

CHARLOTTESVILLE, Va. (CBS19 NEWS) -- New research from the UVA School of Medicine has unveiled a potential way to fight C. difficile, which has been described as "a deadly plague"

Researchers found the nervous system is a driving factor for C. Difficile cases.

In this emulated trial of adult patients with invasive GAS infections treated with β-lactam, linezolid appeared non-inferior to clindamycin suggesting linezolid as an alternative for adjunctive antitoxin therapy.

Gut Health: Initially used to combat recurring Clostridium difficile (C. diff) infections, FMT boasts a success rate of over 90 per cent. FMT has the potential to treat conditions such as inflammatory bowel disease (IBD), irritable bowel syndrome (IBS), alcoholic liver disease, alcohol use disorder, Parkinson’s disease, autism spectrum disorder, metabolic syndrome and obesity. FMT is being used in several countries. Australia was the first to research and publish extensively in this field. FDA approved the treatment in the US for recurrent Clostridium difficile infection in 2013.

The portion of our nervous systems responsible for the "fight or flight" response can shape the severity of potentially deadly C. difficile infections, new research from the University of Virginia School ...

Use this handout to explain the basics of why infection prevention and control and antimicrobial stewardship are essential and how the 2 fields must have a unified approach to patient and staff safety

In this exclusive article, Devin Jopp, the CEO of APIC, discusses the upcoming day-long virtual conference entitled “APIC AI Summit: The Impact of AI on IPC.”

Clostridioides difficile is traditionally isolated from healthcare facilities' inpatients, but it is increasingly being identified in people who have not recently been hospitalized and is more and more found in community settings. Investigators from Perelman School of Medicine at University of Pennsylvania developed an mRNA-LNP vaccine with promising results in preventing and controlling C. difficile infection.

A study by Loveleen Tina Joshi, PhD raised concerns about bleach-resistant C difficile strains, and Curtis J. Donskey, MD, and his team answered.

CHARLOTTESVILLE, Va. (CBS19 NEWS) -- New research from the UVA School of Medicine has unveiled a potential way to fight C. difficile, which has been described as "a deadly plague"

Peptidoglycan synthesis is an essential driver of bacterial growth and division. The final steps of this crucial process involve the activity of SEDS family glycosyltransferases that polymerize glycan strands and class B penicillin-binding protein (bPBP) transpeptidases that cross-link them. While m …

Recurrent C. difficile infection is an urgent public health threat, for which the last resort and lifesaving treatment is a fecal microbiota transplant. However, the exact mechanisms that mediate a successful FMT are not well-understood. Here, we show ...

Clostridioides difficile is the leading cause of antibiotic-associated infections worldwide. Within the host, C. difficile can transition from a sessile to a motile state by secreting PPEP-1, which releases the cells from the intestinal epithelium by cleaving adhesion proteins. PPEP-1 …

Since the publication of the recent North American and European guidelines on management of Clostridioides difficile infection (CDI), new evidence describing the epidemiology, testing and treatment of CDI has emerged. Despite all advances in infection control and antibiotic stewardship, the incidenc …

A group of bacteria that can alter the gut's microbiome may be key to successful fecal transplants.

Clinical care of patients with rCDI now includes Food and Drug Administration-approved therapeutics to address microbiome restoration. Clinical trial evidence supports use of VOS following antibiotics and importance of microbiome restoration in rCDI.

Clostridioides difficile RT027 strains cause infections that vary in severity from asymptomatic to lethal, but the molecular basis for this variability is poorly understood. Through comparative analyses of RT027 clinical isolates, we determined that isolates that exhibit greater variability i …

Dear Doctors: I was sick for months with debilitating pain, extreme weight loss, fatigue and loss of appetite. I was diagnosed with C. diff related to an abdominal surgery. I’m

Clostridioides difficile is the leading cause of antibiotic-associated infections worldwide. Within the host, C. difficile can transition from a sessile to a motile state by secreting PPEP-1, which releases the cells from the intestinal epithelium by cleaving adhesion proteins. PPEP-1 …

Metronidazole monotherapy is associated with increased risk of recurrent CDI in SOT recipients. Therapeutic strategies aimed to reduce the risk of recurrence should be implemented in this setting.

We investigated the effects of Clostridioides difficile toxin B (TcdB), a major virulence factor in C. difficile infection (CDI), on human neutrophils. TcdB inhibits neutrophil migration via loss of polarity of F-actin polymerization in response to interleukin-8. TcdB facilitates CDI by allowing C. …

Early treatment for CDI had shortened hospital stay. However, it did not affect clinical outcomes in adult patients.