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The gut microbiome and dietary metabolites in the treatment of renal cell carcinoma - PubMed
The gut microbiome and dietary metabolites in the treatment of renal cell carcinoma - PubMed
The gut microbiome is interlinked with renal cell carcinoma (RCC) and its response to systemic treatment. Mounting data suggests that certain elements of the gut microbiome may correlate with improved outcomes. New generation sequencing techniques and advanced bioinformatic data curation are acceler …
·pubmed.ncbi.nlm.nih.gov·
The gut microbiome and dietary metabolites in the treatment of renal cell carcinoma - PubMed
β-resorcylic acid released by Limosilactobacillusreuteri protects against cisplatin-induced ovarian toxicity and infertility - PubMed
β-resorcylic acid released by Limosilactobacillusreuteri protects against cisplatin-induced ovarian toxicity and infertility - PubMed
Chemotherapy-induced premature ovarian insufficiency (CIPOI) triggers gonadotoxicity in women undergoing cancer treatment, leading to loss of ovarian reserves and subfertility, with no effective therapies available. In our study, fecal microbiota transplantation in a cisplatin-induced POI mouse mode …
·pubmed.ncbi.nlm.nih.gov·
β-resorcylic acid released by Limosilactobacillusreuteri protects against cisplatin-induced ovarian toxicity and infertility - PubMed
The influence of Akkermansia muciniphila on intestinal barrier function - PubMed
The influence of Akkermansia muciniphila on intestinal barrier function - PubMed
Intestinal barriers play a crucial role in human physiology, both in homeostatic and pathological conditions. Disruption of the intestinal barrier is a significant factor in the pathogenesis of gastrointestinal inflammatory diseases, such as inflammatory bowel disease. The profound influence of the …
·pubmed.ncbi.nlm.nih.gov·
The influence of Akkermansia muciniphila on intestinal barrier function - PubMed
Vonoprazan-associated Clostridioides difficile infection: an analysis of the Japanese Adverse Drug Event Report and the FDA Adverse Event Reporting System - PubMed
Vonoprazan-associated Clostridioides difficile infection: an analysis of the Japanese Adverse Drug Event Report and the FDA Adverse Event Reporting System - PubMed
While signal detection analysis based on the JADER and FAERS databases could not establish causality, our study demonstrated that both vonoprazan and PPIs were significantly associated with CDI. Vonoprazan showed a stronger association with CDI in both databases.
·pubmed.ncbi.nlm.nih.gov·
Vonoprazan-associated Clostridioides difficile infection: an analysis of the Japanese Adverse Drug Event Report and the FDA Adverse Event Reporting System - PubMed
Public health case for microbiome-sparing antibiotics and new opportunities for drug development - PubMed
Public health case for microbiome-sparing antibiotics and new opportunities for drug development - PubMed
Although antibiotics remain a cornerstone of modern medicine, the issues of widespread antibiotic resistance and collateral damage to the microbiome from antibiotic use are driving a need for drug developers to consider more tailored, patient-directed products to avoid antibiotic-induced perturbatio …
·pubmed.ncbi.nlm.nih.gov·
Public health case for microbiome-sparing antibiotics and new opportunities for drug development - PubMed
[Update in diagnosis and management of Clostridioides difficile] - PubMed
[Update in diagnosis and management of Clostridioides difficile] - PubMed
Clostridioides difficile (C. difficile) is one of the leading causes of infection associated with health care with high morbidity and mortality, especially among hospitalized older adults. The increase in the use of antibiotics has been associated with a higher number of cases and greater virulence. …
·pubmed.ncbi.nlm.nih.gov·
[Update in diagnosis and management of Clostridioides difficile] - PubMed
Clostridioides difficile Infection Risk Following Different Antibiotics: Insights from Multi-source Medical Data - PubMed
Clostridioides difficile Infection Risk Following Different Antibiotics: Insights from Multi-source Medical Data - PubMed
Our findings unveiled substantial diversity in CDI risk, both within and among antibiotic classes, providing valuable guidance for clinicians in antibiotic prescription decisions and for initiatives aimed at antibiotic stewardship.
·pubmed.ncbi.nlm.nih.gov·
Clostridioides difficile Infection Risk Following Different Antibiotics: Insights from Multi-source Medical Data - PubMed
Treatment and Management of Gastrointestinal Disorders - PubMed
Treatment and Management of Gastrointestinal Disorders - PubMed
This article reviews the evaluation and management of several gastrointestinal disorders that are commonly encountered by gastroenterologists and primary care physicians. With a focus on newer therapies, we discuss the management of chronic constipation, irritable bowel syndrome, Clostridioides diff …
·pubmed.ncbi.nlm.nih.gov·
Treatment and Management of Gastrointestinal Disorders - PubMed
Fructus Jujubae cooperated with water-expelling members in Shizao decoction alleviated intestinal injury and malignant ascites by modulating gut microbiota and metabolic homeostasis - PubMed
Fructus Jujubae cooperated with water-expelling members in Shizao decoction alleviated intestinal injury and malignant ascites by modulating gut microbiota and metabolic homeostasis - PubMed
FJ cooperated with WEM reduced intestinal injury and alleviated malignant ascites by modulating gut microbiota, short-chain fatty and tryptophan metabolism. These findings provide a scientific basis for the clinical application of FJ from SZD and the safe usage of SZD.
·pubmed.ncbi.nlm.nih.gov·
Fructus Jujubae cooperated with water-expelling members in Shizao decoction alleviated intestinal injury and malignant ascites by modulating gut microbiota and metabolic homeostasis - PubMed
Efficacy of donor-recipient-matched faecal microbiota transplantation in patients with IBS-D: A single-centre, randomized, double-blind placebo-controlled study - PubMed
Efficacy of donor-recipient-matched faecal microbiota transplantation in patients with IBS-D: A single-centre, randomized, double-blind placebo-controlled study - PubMed
Donor-recipient-matched FMT significantly improved the clinical symptoms, quality of life, and anxiety scores of the patients with IBS-D than random-donor FMT.
·pubmed.ncbi.nlm.nih.gov·
Efficacy of donor-recipient-matched faecal microbiota transplantation in patients with IBS-D: A single-centre, randomized, double-blind placebo-controlled study - PubMed
Beyond the Gut: The intratumoral microbiome's influence on tumorigenesis and treatment response - PubMed
Beyond the Gut: The intratumoral microbiome's influence on tumorigenesis and treatment response - PubMed
The intratumoral microbiome (TM) refers to the microorganisms in the tumor tissues, including bacteria, fungi, viruses, and so on, and is distinct from the gut microbiome and circulating microbiota. TM is strongly associated with tumorigenesis, progression, metastasis, and response to therapy. This …
·pubmed.ncbi.nlm.nih.gov·
Beyond the Gut: The intratumoral microbiome's influence on tumorigenesis and treatment response - PubMed
Washed microbiota transplantation combined with biological agents promotes histological remission in refractory severe ulcerative colitis with recurrent intestinal infection: A case report - PubMed
Washed microbiota transplantation combined with biological agents promotes histological remission in refractory severe ulcerative colitis with recurrent intestinal infection: A case report - PubMed
Ulcerative colitis (UC) is a chronic non-specific colitis disease. In recent years, fecal microbiota transplantation (FMT), including improved washed microbiota transplantation (WMT), and biological agents have helped improve the prognosis of patients with UC. However, a significant number of patien …
·pubmed.ncbi.nlm.nih.gov·
Washed microbiota transplantation combined with biological agents promotes histological remission in refractory severe ulcerative colitis with recurrent intestinal infection: A case report - PubMed
Respiratory diseases and gut microbiota: relevance, pathogenesis, and treatment - PubMed
Respiratory diseases and gut microbiota: relevance, pathogenesis, and treatment - PubMed
Preclinical evidence has firmly established a bidirectional interaction among the lung, gut, and gut microbiome. There are many complex communication pathways between the lung and intestine, which affect each other's balance. Some metabolites produced by intestinal microorganisms, intestinal immune …
·pubmed.ncbi.nlm.nih.gov·
Respiratory diseases and gut microbiota: relevance, pathogenesis, and treatment - PubMed
Proteolytic activity of surface-exposed HtrA determines its expression level and is needed to survive acidic conditions in Clostridioides difficile - PubMed
Proteolytic activity of surface-exposed HtrA determines its expression level and is needed to survive acidic conditions in Clostridioides difficile - PubMed
To survive in the host, pathogenic bacteria need to be able to react to the unfavorable conditions that they encounter, like low pH, elevated temperatures, antimicrobial peptides and many more. These conditions may lead to unfolding of envelope proteins and this may be lethal. One of the mechanisms …
·pubmed.ncbi.nlm.nih.gov·
Proteolytic activity of surface-exposed HtrA determines its expression level and is needed to survive acidic conditions in Clostridioides difficile - PubMed
A Novel Truncated CHAP Modular Endolysin, CHAPSAP26-161, That Lyses Staphylococcus aureus, Acinetobacter baumannii, and Clostridioides difficile, and Exhibits Therapeutic Effects in a Mouse Model of A. baumannii Infection - PubMed
A Novel Truncated CHAP Modular Endolysin, CHAPSAP26-161, That Lyses Staphylococcus aureus, Acinetobacter baumannii, and Clostridioides difficile, and Exhibits Therapeutic Effects in a Mouse Model of A. baumannii Infection - PubMed
Development of novel antibacterial agents is imperative due to the increasing threat of antibioticresistant pathogens. This study aimed to develope the enhanced antibacterial activity and in-vivo efficacy of a novel truncated endolysin, CHAPSAP26-161, derived from the endolysin LysSAP26, …
·pubmed.ncbi.nlm.nih.gov·
A Novel Truncated CHAP Modular Endolysin, CHAPSAP26-161, That Lyses Staphylococcus aureus, Acinetobacter baumannii, and Clostridioides difficile, and Exhibits Therapeutic Effects in a Mouse Model of A. baumannii Infection - PubMed
Ganoderic Acid A Mitigates Inflammatory Bowel Disease through Modulation of AhR Activity by Microbial Tryptophan Metabolism - PubMed
Ganoderic Acid A Mitigates Inflammatory Bowel Disease through Modulation of AhR Activity by Microbial Tryptophan Metabolism - PubMed
Inflammatory bowel disease (IBD), including Crohn's disease and ulcerative colitis, is a complex gastrointestinal condition influenced by genetic, microbial, and environmental factors, among which the gut microbiota plays a crucial role and has emerged as a potential therapeutic target. Ganoderic ac …
·pubmed.ncbi.nlm.nih.gov·
Ganoderic Acid A Mitigates Inflammatory Bowel Disease through Modulation of AhR Activity by Microbial Tryptophan Metabolism - PubMed
MS-20 enhances the gut microbiota-associated antitumor effects of anti-PD1 antibody - PubMed
MS-20 enhances the gut microbiota-associated antitumor effects of anti-PD1 antibody - PubMed
Cancer immunotherapy has been regarded as a promising strategy for cancer therapy by blocking immune checkpoints and evoking immunity to fight cancer, but its efficacy seems to be heterogeneous among patients. Manipulating the gut microbiota is a potential strategy for enhancing the efficacy of immu …
·pubmed.ncbi.nlm.nih.gov·
MS-20 enhances the gut microbiota-associated antitumor effects of anti-PD1 antibody - PubMed
Escape Velocity-the Launch of Microbiome Therapies - PubMed
Escape Velocity-the Launch of Microbiome Therapies - PubMed
Food and Drug Administration approval of the first microbiome therapies represents a true expansion the treatment paradigm for Clostridioides difficile but raises new questions about the future role of fecal microbiota transplantation. The authors outline the advances in microbiome therapeutic devel …
·pubmed.ncbi.nlm.nih.gov·
Escape Velocity-the Launch of Microbiome Therapies - PubMed
Washed microbiota transplantation via colonic transendoscopic enteral tube rescues severe acute pancreatitis: A case series - PubMed
Washed microbiota transplantation via colonic transendoscopic enteral tube rescues severe acute pancreatitis: A case series - PubMed
WMT via colonic TET played a critical therapeutic role in rescuing severe AP cases. This is the first report providing direct evidence for the clinical value of targeting microbiota through colonic TET in rescuing severe AP.
·pubmed.ncbi.nlm.nih.gov·
Washed microbiota transplantation via colonic transendoscopic enteral tube rescues severe acute pancreatitis: A case series - PubMed
Efficacy and safety of fecal microbiota transplantation for treatment of ulcerative colitis: A post-consensus systematic review and meta-analysis - PubMed
Efficacy and safety of fecal microbiota transplantation for treatment of ulcerative colitis: A post-consensus systematic review and meta-analysis - PubMed
FMT demonstrates favorable performance and safety; however, well-designed randomized clinical trials are still needed before the widespread use of FMT can be recommended. Furthermore, standardizing the FMT process is urgently needed for improved safety and efficacy.
·pubmed.ncbi.nlm.nih.gov·
Efficacy and safety of fecal microbiota transplantation for treatment of ulcerative colitis: A post-consensus systematic review and meta-analysis - PubMed
Human gut microbiota interactions shape the long-term growth dynamics and evolutionary adaptations of Clostridioides difficile - PubMed
Human gut microbiota interactions shape the long-term growth dynamics and evolutionary adaptations of Clostridioides difficile - PubMed
Clostridioides difficile can transiently or persistently colonize the human gut, posing a risk factor for infections. This colonization is influenced by complex molecular and ecological interactions with human gut microbiota. By investigating C. difficile dynamics in human gut communit …
·pubmed.ncbi.nlm.nih.gov·
Human gut microbiota interactions shape the long-term growth dynamics and evolutionary adaptations of Clostridioides difficile - PubMed
Clostridioides difficile colonization is not mediated by bile salts and requires Stickland fermentation of proline in an in vitro model of infection - PubMed
Clostridioides difficile colonization is not mediated by bile salts and requires Stickland fermentation of proline in an in vitro model of infection - PubMed
C. difficile is one of the leading causes of hospital-acquired infections and antibiotic-associated diarrhea. Several potential mechanisms through which the microbiota can limit C. difficile infection have been identified and are potential targets for new therapeutics. However, it is u …
·pubmed.ncbi.nlm.nih.gov·
Clostridioides difficile colonization is not mediated by bile salts and requires Stickland fermentation of proline in an in vitro model of infection - PubMed
A case of community-acquired Clostridioides difficile infection causing intussusception, severe pneumonia, and severe hypokalemia - PubMed
A case of community-acquired Clostridioides difficile infection causing intussusception, severe pneumonia, and severe hypokalemia - PubMed
This case report highlights a binary toxin-producing C. difficile that caused intussusception. The consideration of community-acquired C. difficile in the differential diagnosis of severe enteritis is necessary, even in Japan.
·pubmed.ncbi.nlm.nih.gov·
A case of community-acquired Clostridioides difficile infection causing intussusception, severe pneumonia, and severe hypokalemia - PubMed