C Difficile

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A Double-Humanized Mouse Model for Studying Host Gut Microbiome-Immune Interactions in Gulf War Illness - PubMed
A Double-Humanized Mouse Model for Studying Host Gut Microbiome-Immune Interactions in Gulf War Illness - PubMed
Unraveling the multisymptomatic Gulf War Illness (GWI) pathology and finding an effective cure have eluded researchers for decades. The chronic symptom persistence and limitations for studying the etiologies in mouse models that differ significantly from those in humans pose challenges for drug disc …
·pubmed.ncbi.nlm.nih.gov·
A Double-Humanized Mouse Model for Studying Host Gut Microbiome-Immune Interactions in Gulf War Illness - PubMed
Alteration of Gut Microbiota Composition and Diversity in Acute and/or Chronic Graft-versus-Host Disease Following Hematopoietic Stem Cell Transplantation: A Prospective Cohort Study - PubMed
Alteration of Gut Microbiota Composition and Diversity in Acute and/or Chronic Graft-versus-Host Disease Following Hematopoietic Stem Cell Transplantation: A Prospective Cohort Study - PubMed
Changes in gut microbiome composition have been implicated in the pathogenesis of graft-versus-host disease (GvHD) after allogeneic hematopoietic stem cell transplantation (allo-HSCT). Our objective was to explore the microbial abundance in patients with GvHD after allo-HSCT. We conducted a single-c …
·pubmed.ncbi.nlm.nih.gov·
Alteration of Gut Microbiota Composition and Diversity in Acute and/or Chronic Graft-versus-Host Disease Following Hematopoietic Stem Cell Transplantation: A Prospective Cohort Study - PubMed
Changes in Fecal Short-Chain Fatty Acids in IBS Patients and Effects of Different Interventions: A Systematic Review and Meta-Analysis - PubMed
Changes in Fecal Short-Chain Fatty Acids in IBS Patients and Effects of Different Interventions: A Systematic Review and Meta-Analysis - PubMed
The results suggested that the fecal propionate concentration and acetate proportion could be used as biomarkers for IBS diagnosis. A low-FODMAP diet intervention could potentially serve as a treatment for IBS while FMT and probiotic administration need more robust trials.
·pubmed.ncbi.nlm.nih.gov·
Changes in Fecal Short-Chain Fatty Acids in IBS Patients and Effects of Different Interventions: A Systematic Review and Meta-Analysis - PubMed
Human Gut Microbiota for Diagnosis and Treatment of Depression - PubMed
Human Gut Microbiota for Diagnosis and Treatment of Depression - PubMed
Nowadays, depressive disorder is spreading rapidly all over the world. Therefore, attention to the studies of the pathogenesis of the disease in order to find novel ways of early diagnosis and treatment is increasing among the scientific and medical communities. Special attention is drawn to a bioma …
·pubmed.ncbi.nlm.nih.gov·
Human Gut Microbiota for Diagnosis and Treatment of Depression - PubMed
Insight into the Mechanism of Lysogeny Control of phiCDKH01 Bacteriophage Infecting Clinical Isolate of Clostridioides difficile - PubMed
Insight into the Mechanism of Lysogeny Control of phiCDKH01 Bacteriophage Infecting Clinical Isolate of Clostridioides difficile - PubMed
Clostridioides difficile is a causative agent of antibiotic-associated diarrhea as well as pseudomembranous colitis. So far, all known bacteriophages infecting these bacteria are temperate, which means that instead of prompt lysis of host cells, they can integrate into the host genome or repl …
·pubmed.ncbi.nlm.nih.gov·
Insight into the Mechanism of Lysogeny Control of phiCDKH01 Bacteriophage Infecting Clinical Isolate of Clostridioides difficile - PubMed
MUP1 mediates urolithin A alleviation of chronic alcohol-related liver disease via gut-microbiota-liver axis - PubMed
MUP1 mediates urolithin A alleviation of chronic alcohol-related liver disease via gut-microbiota-liver axis - PubMed
Alcohol-related liver disease (ALD) is recognized as a global health crisis, contributing to approximately 20% of liver cancer-associated fatalities. Dysbiosis of the gut microbiome is associated with the development of ALD, with the gut microbial metabolite urolithin A (UA) exhibiting a potential f …
·pubmed.ncbi.nlm.nih.gov·
MUP1 mediates urolithin A alleviation of chronic alcohol-related liver disease via gut-microbiota-liver axis - PubMed
Precision antibacterials to destroy antimicrobial-resistant bacteria in oncology
Precision antibacterials to destroy antimicrobial-resistant bacteria in oncology
Pylum Biosciences has built a technology platform to create antibacterials that target individual strains of bacteria without affecting the microbiota. Its lead preclinical programs target Clostridioides difficile for infectious disease and Fusobacterium nucleatum for colorectal cancer.
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Precision antibacterials to destroy antimicrobial-resistant bacteria in oncology
A sequence invariable region in TcdB2 is required for toxin escape from Clostridioides difficile - PubMed
A sequence invariable region in TcdB2 is required for toxin escape from Clostridioides difficile - PubMed
Clostridioides difficile is a leading cause of antibiotic associated disease in the United States. The primary virulence factors produced by C. difficile are two large glucosylating toxins TcdA and TcdB. To date, several sequence variants of TcdB have been identified that differ in var …
·pubmed.ncbi.nlm.nih.gov·
A sequence invariable region in TcdB2 is required for toxin escape from Clostridioides difficile - PubMed
Identification of avaC from Human Gut Microbial Isolates that Converts 5AVA to 2-Piperidone - PubMed
Identification of avaC from Human Gut Microbial Isolates that Converts 5AVA to 2-Piperidone - PubMed
2-piperidone is a crucial industrial raw material of high-value nylon-5 and nylon-6,5. Currently, a major bottleneck in the biosynthesis of 2-piperidone is the identification of highly efficient 2-piperidone synthases. In this study, we aimed to identify specific strains among 51 human gut bacterial …
·pubmed.ncbi.nlm.nih.gov·
Identification of avaC from Human Gut Microbial Isolates that Converts 5AVA to 2-Piperidone - PubMed
Probiotic LB101 alleviates dry eye in mice by suppressing matrix metalloproteinase-9 expression through the regulation of gut microbiota-involved NF-κB signaling - PubMed
Probiotic LB101 alleviates dry eye in mice by suppressing matrix metalloproteinase-9 expression through the regulation of gut microbiota-involved NF-κB signaling - PubMed
Tear matrix metalloproteinase (MMP)-9 is an inflammatory signal in patients with dry eye (DE). In the present study, to understand the action mechanism of probiotic LB101 (Lactobacillus plantarum NK151 and Bifidobacterium bifidum NK175 [4:1] mix) against DE, we investigated its effect on tear amount …
·pubmed.ncbi.nlm.nih.gov·
Probiotic LB101 alleviates dry eye in mice by suppressing matrix metalloproteinase-9 expression through the regulation of gut microbiota-involved NF-κB signaling - PubMed
Therapeutic potential of probiotics in gut microbial homeostasis and Rheumatoid arthritis - PubMed
Therapeutic potential of probiotics in gut microbial homeostasis and Rheumatoid arthritis - PubMed
Rheumatoid arthritis (RA) is a chronic autoimmune disease characterized by inflammation and joint damage. Existing treatment options primarily focus on managing symptoms and slowing disease progression, often with side effects and limitations. The gut microbiome, a vast community of microorganisms p …
·pubmed.ncbi.nlm.nih.gov·
Therapeutic potential of probiotics in gut microbial homeostasis and Rheumatoid arthritis - PubMed
Role of gut microbiota in the pathogenesis of castration-resistant prostate cancer: a comprehensive study using sequencing and animal models - PubMed
Role of gut microbiota in the pathogenesis of castration-resistant prostate cancer: a comprehensive study using sequencing and animal models - PubMed
CRPC remains a significant challenge in prostate cancer research. We aimed to elucidate the role of gut microbiota and its specific mechanisms in CRPC using a multidisciplinary approach. We analyzed 16S rRNA sequencing data from mouse fecal samples, revealing substantial differences in gut microbiot …
·pubmed.ncbi.nlm.nih.gov·
Role of gut microbiota in the pathogenesis of castration-resistant prostate cancer: a comprehensive study using sequencing and animal models - PubMed
Live biotherapeutic products: a capstone for prevention of recurrent Clostridiodes difficile infection
Live biotherapeutic products: a capstone for prevention of recurrent Clostridiodes difficile infection
Clostridiodes difficile infection (CDI) continues to be one of the leading causes of healthcare-acquired diarrhea and infections, and recurrence is the biggest challenge in its management. As technology and research have led to a better understanding of the pathophysiology of C. difficile, we have come to appreciate the role that the gastrointestinal microbiota plays in infection onset and the prevention of recurrence. The gut microbiota is disrupted in those with CDI, which allows further propagation of the infection leading to recurrence, if the microbiota deficiency is unable to regrow itself. While antimicrobial therapy is necessary for treatment of any CDI, these therapeutics do not address the underlying disturbance of microbiota. Microbial remodulation therapies have been developed supplementing the microbiota deficiency that exists after the standard of care antimicrobial resulting in a reduction of recurrence. Fecal microbiota transplantation (FMT) was the initial attempt for this type of therapeutic and proved to be safe and effective, however never achieved FDA approval. In light of this, live biotherapeutic products (LBPs) were developed by pharmaceutical companies through a more standardized and regulated process. These products are safe and efficacious in reducing CDI recurrence when given after a standard of care antimicrobial, eventually leading to FDA approval of two products that can now be used widely in clinical practice.
·news.google.com·
Live biotherapeutic products: a capstone for prevention of recurrent Clostridiodes difficile infection
Study of Highly Efficient Au/Pt Nanoparticles for Rapid Screening of Clostridium difficile - PubMed
Study of Highly Efficient Au/Pt Nanoparticles for Rapid Screening of Clostridium difficile - PubMed
This study synthesized core/shell gold-platinum nanoparticles and characterized their colorimetric properties; ultraviolet-visible spectroscopy revealed that the synthesized nanoparticles exhibited distinct colors from conventional gold nanoparticles. Furthermore, the nanoparticles were subjected to …
·pubmed.ncbi.nlm.nih.gov·
Study of Highly Efficient Au/Pt Nanoparticles for Rapid Screening of Clostridium difficile - PubMed
PRM1201 effectively inhibits colorectal cancer metastasis via shaping gut microbiota and short- chain fatty acids - PubMed
PRM1201 effectively inhibits colorectal cancer metastasis via shaping gut microbiota and short- chain fatty acids - PubMed
In summary, PRM1201 exerts its anti-metastatic effects by modulating SCFA-producing bacteria and enhancing the production of SCFAs. Furthermore, the prebiotic-like actions of PRM1201, along with the PRM1201-treated bacteria, function as inhibitors of histone deacetylases (DHACs) thereby effectively …
·pubmed.ncbi.nlm.nih.gov·
PRM1201 effectively inhibits colorectal cancer metastasis via shaping gut microbiota and short- chain fatty acids - PubMed
Clinical improvement effect of regulating gut microbiota on metabolic dysfunction-associated steatotic liver disease: systematic review and meta-analysis of randomized controlled trials - PubMed
Clinical improvement effect of regulating gut microbiota on metabolic dysfunction-associated steatotic liver disease: systematic review and meta-analysis of randomized controlled trials - PubMed
This meta-analysis supported the modulation of gut microbiota with synbiotics in the management of MASLD.
·pubmed.ncbi.nlm.nih.gov·
Clinical improvement effect of regulating gut microbiota on metabolic dysfunction-associated steatotic liver disease: systematic review and meta-analysis of randomized controlled trials - PubMed
Gut microbiota-derived acetate attenuates lung injury induced by influenza infection via protecting airway tight junctions - PubMed
Gut microbiota-derived acetate attenuates lung injury induced by influenza infection via protecting airway tight junctions - PubMed
Collectively, our results demonstrated that GM protected airway TJs by modulating GPR43-AMPK signaling in IAV-induced lung injury. Therefore, improving GM dysbiosis may be a potential therapeutic target for patients with IAV infection.
·pubmed.ncbi.nlm.nih.gov·
Gut microbiota-derived acetate attenuates lung injury induced by influenza infection via protecting airway tight junctions - PubMed
The evolving facets of vaginal microbiota transplantation: reinvigorating the unexplored frontier amid complex challenges - PubMed
The evolving facets of vaginal microbiota transplantation: reinvigorating the unexplored frontier amid complex challenges - PubMed
In an age of cutting-edge sequencing methods and worldwide endeavors such as The Human Microbiome Project and MetaHIT, the human microbiome stands as a complex and diverse community of microorganisms. A central theme in current scientific inquiry revolves around reinstating a balanced microbial comp …
·pubmed.ncbi.nlm.nih.gov·
The evolving facets of vaginal microbiota transplantation: reinvigorating the unexplored frontier amid complex challenges - PubMed