C Difficile

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Gut microbiome-based therapies for alleviating cognitive impairment: state of the field, limitations, and future perspectives - PubMed
Gut microbiome-based therapies for alleviating cognitive impairment: state of the field, limitations, and future perspectives - PubMed
Cognitive impairment (CI) is a multifaceted neurological condition that can trigger negative emotions and a range of concurrent symptoms, imposing significant public health and economic burdens on society. Therefore, it is imperative to discover a remedy for CI. Nevertheless, the mechanisms behind t …
·pubmed.ncbi.nlm.nih.gov·
Gut microbiome-based therapies for alleviating cognitive impairment: state of the field, limitations, and future perspectives - PubMed
Gut dysbiosis aggravates cognitive deficits, amyloid pathology and lipid metabolism dysregulation in a transgenic mouse model of Alzheimer's disease - PubMed
Gut dysbiosis aggravates cognitive deficits, amyloid pathology and lipid metabolism dysregulation in a transgenic mouse model of Alzheimer's disease - PubMed
Gut dysbiosis, a well-known risk factor to triggers the progression of Alzheimer's disease (AD), is strongly associated with metabolic disturbance. Trimethylamine N-oxide (TMAO), produced in the dietary choline metabolism, has been found to accelerate neurodegeneration in AD pathology. In thi …
·pubmed.ncbi.nlm.nih.gov·
Gut dysbiosis aggravates cognitive deficits, amyloid pathology and lipid metabolism dysregulation in a transgenic mouse model of Alzheimer's disease - PubMed
Prevalence of antimicrobial-resistant organisms in smaller Canadian hospitals: Community, Rural, and Northern Acute Care Point Prevalence (CNAPP-19) Survey, 2019 - PubMed
Prevalence of antimicrobial-resistant organisms in smaller Canadian hospitals: Community, Rural, and Northern Acute Care Point Prevalence (CNAPP-19) Survey, 2019 - PubMed
Antimicrobial-resistant organisms remain a serious threat to public health in Canada. The results of this survey warrant further investigation into AROs in smaller Canadian hospitals as a potential reservoir of antimicrobial resistance.
·pubmed.ncbi.nlm.nih.gov·
Prevalence of antimicrobial-resistant organisms in smaller Canadian hospitals: Community, Rural, and Northern Acute Care Point Prevalence (CNAPP-19) Survey, 2019 - PubMed
Evaluation of an Automated, Pharmacist-Driven, Antimicrobial Patient Acuity Scoring System for Hospitalized Bacteremic Patients - PubMed
Evaluation of an Automated, Pharmacist-Driven, Antimicrobial Patient Acuity Scoring System for Hospitalized Bacteremic Patients - PubMed
Purpose: The implementation of an automated, pharmacist-driven, scoring system within the EMR has been shown to improve patient care in patients with Staphylococcus aureus bacteremia by increasing the adherence to disease specific quality-of-care measures. However, there are a lack of …
·pubmed.ncbi.nlm.nih.gov·
Evaluation of an Automated, Pharmacist-Driven, Antimicrobial Patient Acuity Scoring System for Hospitalized Bacteremic Patients - PubMed
Generalisability of predictive models for Clostridioides difficile infection, severity, and recurrence at an urban safety-net hospital - PubMed
Generalisability of predictive models for Clostridioides difficile infection, severity, and recurrence at an urban safety-net hospital - PubMed
The performance of our models after weighting did not change drastically suggesting that our model predicting C. difficile infection, severity, and recurrence may not be impacted by patient selection factors; however, other researchers may want to consider addressing these catchment forces using IPW …
·pubmed.ncbi.nlm.nih.gov·
Generalisability of predictive models for Clostridioides difficile infection, severity, and recurrence at an urban safety-net hospital - PubMed
The anti-inflammatory and anti-apoptotic effects of Achillea millefolium L. extracts on Clostridioides difficile ribotype 001 in human intestinal epithelial cells - PubMed
The anti-inflammatory and anti-apoptotic effects of Achillea millefolium L. extracts on Clostridioides difficile ribotype 001 in human intestinal epithelial cells - PubMed
The results of the present study for the first time demonstrate the antimicrobial activity and protective effects of A. millefolium extracts on inflammatory response and apoptosis induced by Tox-S from C. difficile RT001 clinical strain in vitro. Further research is needed to evaluate the potential …
·pubmed.ncbi.nlm.nih.gov·
The anti-inflammatory and anti-apoptotic effects of Achillea millefolium L. extracts on Clostridioides difficile ribotype 001 in human intestinal epithelial cells - PubMed
Bacteroides and related species: The keystone taxa of the human gut microbiota - PubMed
Bacteroides and related species: The keystone taxa of the human gut microbiota - PubMed
Microbial communities play a significant role in maintaining ecosystems in a healthy homeostasis. Presently, in the human gastrointestinal tract, there are certain taxonomic groups of importance, though there is no single species that plays a keystone role. Bacteroides spp. are known to be major pla …
·pubmed.ncbi.nlm.nih.gov·
Bacteroides and related species: The keystone taxa of the human gut microbiota - PubMed
Another iron in C. difficile's fire - PubMed
Another iron in C. difficile's fire - PubMed
Iron is arguably the most important nutrient in the ongoing battle between hosts and bacteria. Recently in Nature, a unique iron storage organelle, the ferrosome, was discovered in the human pathogen Clostridioides difficile.1 But what is the role of ferrosomes and how do they affect bact …
·pubmed.ncbi.nlm.nih.gov·
Another iron in C. difficile's fire - PubMed
Fecal microbiota transplantation in capsules for the treatment of steroid refractory and steroid dependent acute graft vs. host disease: a pilot study - PubMed
Fecal microbiota transplantation in capsules for the treatment of steroid refractory and steroid dependent acute graft vs. host disease: a pilot study - PubMed
Acute graft-versus-host disease (aGvHD) is a serious complication of allogeneic hematopoietic stem-cell transplantation with limited treatment options. The gut microbiome plays a critical role in aGvHD pathogenesis. Fecal microbiota transplantation (FMT) has emerged as a potential therapeutic approa …
·pubmed.ncbi.nlm.nih.gov·
Fecal microbiota transplantation in capsules for the treatment of steroid refractory and steroid dependent acute graft vs. host disease: a pilot study - PubMed
Identification of Muscle Strength-Related Gut Microbes through Human Fecal Microbiome Transplantation - PubMed
Identification of Muscle Strength-Related Gut Microbes through Human Fecal Microbiome Transplantation - PubMed
The gut microbiome is well known for its influence on human physiology and aging. Therefore, we speculate that the gut microbiome may affect muscle strength in the same way as the host's own genes. To demonstrate candidates for gut microbes affecting muscle strength, we remodeled the original gut mi …
·pubmed.ncbi.nlm.nih.gov·
Identification of Muscle Strength-Related Gut Microbes through Human Fecal Microbiome Transplantation - PubMed
The combination of gut microbiota-depleted treatment and fecal microbiota transplantation is an important strategy to verify the efficacy of Traditional Chinese Medicine though modulation of gut dysbiosis - PubMed
The combination of gut microbiota-depleted treatment and fecal microbiota transplantation is an important strategy to verify the efficacy of Traditional Chinese Medicine though modulation of gut dysbiosis - PubMed
The combination of gut microbiota-depleted treatment and fecal microbiota transplantation is an important strategy to verify the efficacy of Traditional Chinese Medicine though modulation of gut dysbiosis
·pubmed.ncbi.nlm.nih.gov·
The combination of gut microbiota-depleted treatment and fecal microbiota transplantation is an important strategy to verify the efficacy of Traditional Chinese Medicine though modulation of gut dysbiosis - PubMed
A Rare Case of Polymerase Chain Reaction-Negative Severe Clostridioides difficile Infection - PubMed
A Rare Case of Polymerase Chain Reaction-Negative Severe Clostridioides difficile Infection - PubMed
Accurately diagnosing Clostridioides difficile infection (CDI) is crucial for effective patient management. A misdiagnosis poses risks to patients, leads to treatment delays, and contributes to infection transmission in healthcare settings. While using polymerase chain reaction (PCR) to ampli …
·pubmed.ncbi.nlm.nih.gov·
A Rare Case of Polymerase Chain Reaction-Negative Severe Clostridioides difficile Infection - PubMed
Microbiota and mucosal gene expression of fecal microbiota transplantation or placebo treated patients with chronic pouchitis - PubMed
Microbiota and mucosal gene expression of fecal microbiota transplantation or placebo treated patients with chronic pouchitis - PubMed
Altered microbiota and impaired host immune function have been linked to the pathogenesis of pouchitis. We used 16S rRNA gene sequencing and RNA sequencing data from a previous randomized clinical trial (RCT) on fecal microbiota transplantation (FMT) therapy in 26 chronic pouchitis patients with one …
·pubmed.ncbi.nlm.nih.gov·
Microbiota and mucosal gene expression of fecal microbiota transplantation or placebo treated patients with chronic pouchitis - PubMed
Clostridioides difficile Infection in Hospitalized Patients-A Retrospective Epidemiological Study - PubMed
Clostridioides difficile Infection in Hospitalized Patients-A Retrospective Epidemiological Study - PubMed
Clostridioides difficile infection (CDI) is the main source of healthcare and antibiotic-associated diarrhea in hospital context and long-term care units, showing significant morbidity and mortality. This study aimed to analyze the epidemiological context, describing the severity and outcomes …
·pubmed.ncbi.nlm.nih.gov·
Clostridioides difficile Infection in Hospitalized Patients-A Retrospective Epidemiological Study - PubMed
Prophage Carriage and Genetic Diversity within Environmental Isolates of Clostridioides difficile - PubMed
Prophage Carriage and Genetic Diversity within Environmental Isolates of Clostridioides difficile - PubMed
Clostridioides difficile is an important human pathogen causing antibiotic-associated diarrhoea worldwide. Besides using antibiotics for treatment, the interest in bacteriophages as an alternative therapeutic option has increased. Prophage abundance and genetic diversity are well-documented i …
·pubmed.ncbi.nlm.nih.gov·
Prophage Carriage and Genetic Diversity within Environmental Isolates of Clostridioides difficile - PubMed
Comparative Effectiveness of Fidaxomicin vs Vancomycin in Populations With Immunocompromising Conditions for the Treatment of Clostridioides difficile Infection: A Single-Center Study - PubMed
Comparative Effectiveness of Fidaxomicin vs Vancomycin in Populations With Immunocompromising Conditions for the Treatment of Clostridioides difficile Infection: A Single-Center Study - PubMed
The findings of this study suggest that the use of fidaxomicin for treatment of CDI reduces poor outcomes in patients who are immunocompromised.
·pubmed.ncbi.nlm.nih.gov·
Comparative Effectiveness of Fidaxomicin vs Vancomycin in Populations With Immunocompromising Conditions for the Treatment of Clostridioides difficile Infection: A Single-Center Study - PubMed
The Effect of Cross-Sex Fecal Microbiota Transplantation on Metabolism and Hormonal Status in Adult Rats - PubMed
The Effect of Cross-Sex Fecal Microbiota Transplantation on Metabolism and Hormonal Status in Adult Rats - PubMed
Increasing evidence of sexual dimorphism in the pathophysiology of metabolic complications caused by sex steroids is under investigation. The gut microbiota represents a complex microbial ecosystem involved in energy metabolism, immune response, nutrition acquisition, and the health of host organism …
·pubmed.ncbi.nlm.nih.gov·
The Effect of Cross-Sex Fecal Microbiota Transplantation on Metabolism and Hormonal Status in Adult Rats - PubMed
Fecal microbiota transplantation revealed the function of folic acid on reducing abdominal fat deposition in broiler chickens mediated by gut microbiota - PubMed
Fecal microbiota transplantation revealed the function of folic acid on reducing abdominal fat deposition in broiler chickens mediated by gut microbiota - PubMed
Excess abdominal fat reduces carcass yield and feed conversion ratio, thereby resulting in significant economic losses in the poultry industry. Our previous study demonstrated that dietary addition of folic acid reduced fat deposition and changed gut microbiota and short-chain fatty acid. However, w …
·pubmed.ncbi.nlm.nih.gov·
Fecal microbiota transplantation revealed the function of folic acid on reducing abdominal fat deposition in broiler chickens mediated by gut microbiota - PubMed
Dissecting mechanisms of fecal microbiota transplantation efficacy in disease - PubMed
Dissecting mechanisms of fecal microbiota transplantation efficacy in disease - PubMed
Fecal microbiota transplantation (FMT) has emerged as an alternative or adjunct experimental therapy for microbiome-associated diseases following its success in the treatment of recurrent Clostridioides difficile infections (rCDIs). However, the mechanisms of action involved remain relatively unknow …
·pubmed.ncbi.nlm.nih.gov·
Dissecting mechanisms of fecal microbiota transplantation efficacy in disease - PubMed
Quality of life among older patients receiving faecal microbiota transplant for Clostridioides difficile infection - PubMed
Quality of life among older patients receiving faecal microbiota transplant for Clostridioides difficile infection - PubMed
This study highlights the importance of considering the psychological, social and physical wellbeing of patients when assessing the efficacy of FMT as a treatment option for patients with CDI. It further emphasises the importance of health professionals identifying patients' individual ways of handl …
·pubmed.ncbi.nlm.nih.gov·
Quality of life among older patients receiving faecal microbiota transplant for Clostridioides difficile infection - PubMed
The microbial metabolite urolithin A reduces Clostridioides difficile toxin expression and toxin-induced epithelial damage - PubMed
The microbial metabolite urolithin A reduces Clostridioides difficile toxin expression and toxin-induced epithelial damage - PubMed
Therapy for Clostridioides difficile infections includes the use of antibiotics, immunosuppressors, and fecal microbiota transplantation. However, these treatments have several drawbacks, including the loss of colonization resistance, the promotion of autoimmune disorders, and the potential f …
·pubmed.ncbi.nlm.nih.gov·
The microbial metabolite urolithin A reduces Clostridioides difficile toxin expression and toxin-induced epithelial damage - PubMed
The microbial-derived bile acid lithocholate and its epimers inhibit Clostridioides difficile growth and pathogenicity while sparing members of the gut microbiota | Journal of Bacteriology
The microbial-derived bile acid lithocholate and its epimers inhibit Clostridioides difficile growth and pathogenicity while sparing members of the gut microbiota | Journal of Bacteriology
In the search for a novel therapeutic that targets Clostridioides difficile, bile acids have become a viable solution. Epimers of bile acids are particularly attractive as they may provide protection against C. difficile while leaving the indigenous gut ...
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The microbial-derived bile acid lithocholate and its epimers inhibit Clostridioides difficile growth and pathogenicity while sparing members of the gut microbiota | Journal of Bacteriology
Flagellin is essential for initial attachment to mucosal surfaces by Clostridioides difficile | Microbiology Spectrum
Flagellin is essential for initial attachment to mucosal surfaces by Clostridioides difficile | Microbiology Spectrum
Clostridioides difficile is one of the leading causes of hospital-acquired infections worldwide and presents challenges in treatment due to recurrent gastrointestinal disease after treatment with antimicrobials. The mechanisms by which C. difficile ...
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Flagellin is essential for initial attachment to mucosal surfaces by Clostridioides difficile | Microbiology Spectrum
Durability and outcomes of fecal microbiota transplantation for recurrent Clostridioides difficile infection in patients with moderate to severe inflammatory bowel disease - PubMed
Durability and outcomes of fecal microbiota transplantation for recurrent Clostridioides difficile infection in patients with moderate to severe inflammatory bowel disease - PubMed
Durability and outcomes of fecal microbiota transplantation for recurrent Clostridioides difficile infection in patients with moderate to severe inflammatory bowel disease
·pubmed.ncbi.nlm.nih.gov·
Durability and outcomes of fecal microbiota transplantation for recurrent Clostridioides difficile infection in patients with moderate to severe inflammatory bowel disease - PubMed
Multimodal vaccination targeting the receptor binding domains of Clostridioides difficile toxins A and B with an attenuated Salmonella Typhimurium vector (YS1646) protects mice from lethal challenge - PubMed
Multimodal vaccination targeting the receptor binding domains of Clostridioides difficile toxins A and B with an attenuated Salmonella Typhimurium vector (YS1646) protects mice from lethal challenge - PubMed
Clostridioides difficile remains a major public health threat, and new approaches are needed to develop an effective vaccine. To date, the industry has focused on intramuscular vaccination targeting the C. difficile toxins. Multiple disappointing results in phase III trials have largel …
·pubmed.ncbi.nlm.nih.gov·
Multimodal vaccination targeting the receptor binding domains of Clostridioides difficile toxins A and B with an attenuated Salmonella Typhimurium vector (YS1646) protects mice from lethal challenge - PubMed