C Difficile

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Impact of oral vancomycin treatment duration on rate of Clostridioides difficile recurrence in patients requiring concurrent systemic antibiotics - PubMed
Impact of oral vancomycin treatment duration on rate of Clostridioides difficile recurrence in patients requiring concurrent systemic antibiotics - PubMed
Oral vancomycin prescribing relative to the systemic antibiotic end date may affect CDI recurrence to a greater extent than total vancomycin duration alone. Further studies are needed to confirm these findings.
·pubmed.ncbi.nlm.nih.gov·
Impact of oral vancomycin treatment duration on rate of Clostridioides difficile recurrence in patients requiring concurrent systemic antibiotics - PubMed
Exogenous butyrate inhibits butyrogenic metabolism and alters virulence phenotypes in Clostridioides difficile - PubMed
Exogenous butyrate inhibits butyrogenic metabolism and alters virulence phenotypes in Clostridioides difficile - PubMed
The gut microbiome engenders colonization resistance against the diarrheal pathogen Clostridioides difficile, but the molecular basis of this colonization resistance is incompletely understood. A prominent class of gut microbiome-produced metabolites important for colonization resistance agai …
·pubmed.ncbi.nlm.nih.gov·
Exogenous butyrate inhibits butyrogenic metabolism and alters virulence phenotypes in Clostridioides difficile - PubMed
Anti-S-layer monoclonal antibodies impact Clostridioides difficile physiology - PubMed
Anti-S-layer monoclonal antibodies impact Clostridioides difficile physiology - PubMed
Clostridioides difficile (C. difficile), a gram-positive anaerobic and spore-forming bacterium, is the leading cause of nosocomial antibiotic-associated diarrhea in adults which is characterized by high levels of recurrence and mortality. Surface (S)-layer Protein A (SlpA), the most ab …
·pubmed.ncbi.nlm.nih.gov·
Anti-S-layer monoclonal antibodies impact Clostridioides difficile physiology - PubMed
The Gut Microbiota and Major Depressive Disorder: Current Understanding and Novel Therapeutic Strategies - PubMed
The Gut Microbiota and Major Depressive Disorder: Current Understanding and Novel Therapeutic Strategies - PubMed
Major depressive disorder (MDD) is a common neuropsychiatric challenge that primarily targets young females. MDD as a global disorder has a multifactorial etiology related to the environment and genetic background. A balanced gut microbiota is one of the most important environmental factors involved …
·pubmed.ncbi.nlm.nih.gov·
The Gut Microbiota and Major Depressive Disorder: Current Understanding and Novel Therapeutic Strategies - PubMed
Gut-targeted therapies for type 2 diabetes mellitus: A review - PubMed
Gut-targeted therapies for type 2 diabetes mellitus: A review - PubMed
Type 2 diabetes mellitus (T2DM) is a chronic metabolic disorder characterized by hyperglycemia and insulin resistance. The global prevalence of T2DM has reached epidemic proportions, affecting approximately 463 million adults worldwide in 2019. Current treatments for T2DM include lifestyle modificat …
·pubmed.ncbi.nlm.nih.gov·
Gut-targeted therapies for type 2 diabetes mellitus: A review - PubMed
Antimicrobial Resistance of Clostridioides difficile in Children from a Tertiary Pediatric Hospital in Shanghai, China - PubMed
Antimicrobial Resistance of Clostridioides difficile in Children from a Tertiary Pediatric Hospital in Shanghai, China - PubMed
C. difficile isolates from children with reduced susceptibility to metronidazole and vancomycin are emerging in pediatric CDI in China. The lack of pCD-METRO plasmid and vanA/B associated with reduced antibiotic susceptibility suggests there are additional mechanisms of resistance.
·pubmed.ncbi.nlm.nih.gov·
Antimicrobial Resistance of Clostridioides difficile in Children from a Tertiary Pediatric Hospital in Shanghai, China - PubMed
Case Report: Fecal Microbiota Transplantation for the Treatment of Generalized Eczema Occurring After COVID-19 Vaccination - PubMed
Case Report: Fecal Microbiota Transplantation for the Treatment of Generalized Eczema Occurring After COVID-19 Vaccination - PubMed
Adverse skin reactions caused by the COVID-19 vaccine have attracted considerable attention. As we all know, the development mechanism of some skin diseases is related to the gut and skin microbiome. A 78-year-old male patient who received the COVID-19 vaccine developed generalized eczema with multi …
·pubmed.ncbi.nlm.nih.gov·
Case Report: Fecal Microbiota Transplantation for the Treatment of Generalized Eczema Occurring After COVID-19 Vaccination - PubMed
Gut-targeted therapies for type 2 diabetes mellitus: A review - PubMed
Gut-targeted therapies for type 2 diabetes mellitus: A review - PubMed
Type 2 diabetes mellitus (T2DM) is a chronic metabolic disorder characterized by hyperglycemia and insulin resistance. The global prevalence of T2DM has reached epidemic proportions, affecting approximately 463 million adults worldwide in 2019. Current treatments for T2DM include lifestyle modificat …
·pubmed.ncbi.nlm.nih.gov·
Gut-targeted therapies for type 2 diabetes mellitus: A review - PubMed
Fecal Microbiota Transplantation Alleviates Allergic Rhinitis via CD4+ T Cell Modulation Through Gut Microbiota Restoration - PubMed
Fecal Microbiota Transplantation Alleviates Allergic Rhinitis via CD4+ T Cell Modulation Through Gut Microbiota Restoration - PubMed
Allergic rhinitis (AR) is an allergic condition of the upper respiratory tract with a complex pathogenesis, including epithelial barrier disruption, immune regulation, and gut microbiota, which is not yet fully understood. Gut microbiota is closely linked to allergic diseases, including AR. Fecal mi …
·pubmed.ncbi.nlm.nih.gov·
Fecal Microbiota Transplantation Alleviates Allergic Rhinitis via CD4+ T Cell Modulation Through Gut Microbiota Restoration - PubMed
Pfizer's New C. difficile Awareness Initiative Explained | Pfizer
Pfizer's New C. difficile Awareness Initiative Explained | Pfizer
Pfizer recently convened experts representing a cross-section of healthcare professionals and patient organizations for a panel titled, “Clostridioides difficile: A public health threat in plain sight.” They first met during a panel discussion that coincided with Infectious Disease (ID) Week in late-2019 and served as a launchpad for the C.
·pfizer.com·
Pfizer's New C. difficile Awareness Initiative Explained | Pfizer
C difficile—a rose by any other name…
C difficile—a rose by any other name…
The twists and turns of bacterial taxonomy occasionally throw up complications for the infectious diseases community. Long established and familiar organisms are, from the perspective of many medical practitioners, suddenly renamed for what might seem to be arcane reasons that have little relevance to the management of disease. However, if a name change is hastily adopted by medical practitioners there is the potential for unintended consequences. For this reason, and a strong conservative instinct, taxonomic changes can take a while to filter through to medical practice.
·thelancet.com·
C difficile—a rose by any other name…
Entry door for deadly C. difficile toxin suggests new mode of protection - Boston Children's Answers A new target for fighting Clostridium difficile
Entry door for deadly C. difficile toxin suggests new mode of protection - Boston Children's Answers A new target for fighting Clostridium difficile
Researchers report a key target in fighting Clostridium difficile -- a receptor called Frizzled, through which C. diff’s most potent toxin gets into cells.
·answers.childrenshospital.org·
Entry door for deadly C. difficile toxin suggests new mode of protection - Boston Children's Answers A new target for fighting Clostridium difficile
Defined microbial communities and their soluble products protect mice from Clostridioides difficile infection - PubMed
Defined microbial communities and their soluble products protect mice from Clostridioides difficile infection - PubMed
Clostridioides difficile is the leading cause of antibiotic-associated infectious diarrhea. The development of C.difficile infection is tied to perturbations of the bacterial community in the gastrointestinal tract, called the gastrointestinal microbiota. Repairing the gastrointestinal microbiota by …
·pubmed.ncbi.nlm.nih.gov·
Defined microbial communities and their soluble products protect mice from Clostridioides difficile infection - PubMed
Starvation helps transition to abundance - a ferrosome story - PubMed
Starvation helps transition to abundance - a ferrosome story - PubMed
Iron is an essential nutrient for bacterial pathogenesis. In their study, Skaar and colleagues (Pi et al.) discovered and determined the detailed structure of ferrosomes within Clostridioides difficile, the iron-storage organelles that form under iron-limited conditions in anticipation of future iro …
·pubmed.ncbi.nlm.nih.gov·
Starvation helps transition to abundance - a ferrosome story - PubMed
Approaching pathogenic Clostridia from a One Health perspective - PubMed
Approaching pathogenic Clostridia from a One Health perspective - PubMed
Spore-forming pathogens have a unique capacity to thrive in diverse environments, and with temporal persistence afforded through their ability to sporulate. These behaviors require a One Health approach to identify critical reservoirs and outbreak-associated transmission chains, given their capacity …
·pubmed.ncbi.nlm.nih.gov·
Approaching pathogenic Clostridia from a One Health perspective - PubMed
Clostridioides difficile Infection: A Clinical Review of Pathogenesis, Clinical Considerations, and Treatment Strategies - PubMed
Clostridioides difficile Infection: A Clinical Review of Pathogenesis, Clinical Considerations, and Treatment Strategies - PubMed
Prevention of CDI can be achieved by proper hygiene, vaccinations, and detecting the infection early. Proper hygiene is indeed noted to be one of the best ways to prevent CDI in the hospital setting. Overprescribing antibiotics is also another huge reason why CDI occurs. Proper prescription of antib …
·pubmed.ncbi.nlm.nih.gov·
Clostridioides difficile Infection: A Clinical Review of Pathogenesis, Clinical Considerations, and Treatment Strategies - PubMed
Fecal microbiota transplantation alleviates intestinal inflammatory diarrhea caused by oxidative stress and pyroptosis via reducing gut microbiota-derived lipopolysaccharides - PubMed
Fecal microbiota transplantation alleviates intestinal inflammatory diarrhea caused by oxidative stress and pyroptosis via reducing gut microbiota-derived lipopolysaccharides - PubMed
Infancy is a critical period in the maturation of the gut microbiota and a phase of susceptibility to gut microbiota dysbiosis. Early disturbances in the gut microbiota can have long-lasting effects on host physiology, including intestinal injury and diarrhea. Fecal microbiota transplantation (FMT) …
·pubmed.ncbi.nlm.nih.gov·
Fecal microbiota transplantation alleviates intestinal inflammatory diarrhea caused by oxidative stress and pyroptosis via reducing gut microbiota-derived lipopolysaccharides - PubMed
Phase variation of flagella and toxins in Clostridioides difficile is mediated by selective Rho-dependent termination - PubMed
Phase variation of flagella and toxins in Clostridioides difficile is mediated by selective Rho-dependent termination - PubMed
Clostridioides difficile is an intestinal pathogen that exhibits phase variation of flagella and toxins though inversion of the flagellar (flg) switch controlling flagellar and toxin gene expression. The transcription termination factor Rho preferentially inhibits swimming motility of bacteria with …
·pubmed.ncbi.nlm.nih.gov·
Phase variation of flagella and toxins in Clostridioides difficile is mediated by selective Rho-dependent termination - PubMed