H5N1 Flu

1436 bookmarks
Newest
Rapid response: Preliminary guidance on human vaccination against avian influenza in a non-pandemic context as of December 2024 - Canada.ca
Rapid response: Preliminary guidance on human vaccination against avian influenza in a non-pandemic context as of December 2024 - Canada.ca
Valid as of February 19, 2025: The National Advisory Committee on Immunization's rapid response related to preliminary guidance on human vaccination against avian influenza in a non-pandemic context as of December 2024.
·canada.ca·
Rapid response: Preliminary guidance on human vaccination against avian influenza in a non-pandemic context as of December 2024 - Canada.ca
Comparative Mutational Analysis and the Glycosylation Patterns of a Peruvian Isolated Avian Influenza a Virus H5N1: Exploring Possible Viral Spillover Events Within One Health Approach
Comparative Mutational Analysis and the Glycosylation Patterns of a Peruvian Isolated Avian Influenza a Virus H5N1: Exploring Possible Viral Spillover Events Within One Health Approach
(1) Background: The emergence of H5N1 Influenza A viruses clade 2.3.3.4b since 2020, have caused the mortality of thousands of birds/mammals worldwide, through evolu-tionary changes have been associated with acquired mutations and posttranslational modifications. (2) Methods: This study aimed to compare the mutational profile of H5N1 avian Influenza virus isolated from a Peruvian natural reserve, with recent data from other related international studies made in human and different species of domestic and wild birds and mammals. Briefly, the near complete protein sequences of Influenza virus coming from a Calidris alba were analyzed in a multisegmented level, altogether with 55 samples collected between 2022-2024 in different countries. Moreover, the glycosylation patterns were also predicted in silico. (3) Results: A total of 603 amino acid changes were found among H5N1 viruses analyzed, underscoring the detection of critical mutations HA:143T, HA:156A, HA:208K, NA: 71S, NP:52H, PA:336M, PA:36T, PA:85A/N, PB1-F2:66S, PB2:199S, PB2:292V, PB2:559T, as well as PA:86I, PA:432I, PA:558L, HA:492D, NA:70D, NS1-83P, PB1:515A, PA-X:57Q, PB1-F2:22E, NS1-21Q, NEP:67G, among others, considered of importance under One Health perspective. Similarly, changes in the N-linked glycosylation sites (NLGs) predicted in both HA and NA proteins were found, highlighting the loss/acquisition or changes in some NLGs sites such as 209NNTN, 100 NPTT, 302NSSM (HA) and 70NNTN, 68NISS, 50NGSV (NA). (4) Conclu-sions: This study provides our understanding about the evolution of current Influenza A viruses H5N1 HPAIV circulating globally. These findings outline the importance of sur-veillance updating mutational profiles and glycosylation patterns of these highly evolved virus.
·preprints.org·
Comparative Mutational Analysis and the Glycosylation Patterns of a Peruvian Isolated Avian Influenza a Virus H5N1: Exploring Possible Viral Spillover Events Within One Health Approach
Dutch Field Studies Show Promise for Two Experimental Avian Flu H5N1 Vaccines
Dutch Field Studies Show Promise for Two Experimental Avian Flu H5N1 Vaccines
Field studies led by Wageningen University have demonstrated the efficacy of two vaccines in reducing mortality in poultry infected with the Highly Pathogenic Avian Influenza (HPAI) H1N1 virus, although it is too early to draw accurate conclusions about transmission.
·food-safety.com·
Dutch Field Studies Show Promise for Two Experimental Avian Flu H5N1 Vaccines
Epidemiologist analyzes Trump administration's strategies against bird flu
Epidemiologist analyzes Trump administration's strategies against bird flu
The Trump administration plans to roll out a new strategy against the bird flu. There are few details, but to bring egg prices down, the plan is aimed at trying to minimize the slaughter of chickens when the flu strikes a flock. More than 150 million poultry have been affected since 2022 and 58 people have been sickened by it. Geoff Bennett discussed more with epidemiologist Dr. Katelyn Jetelina.
·pbs.org·
Epidemiologist analyzes Trump administration's strategies against bird flu
Molecular determinants of cross-strain influenza A virus recognition by αβ T cell receptors - PubMed
Molecular determinants of cross-strain influenza A virus recognition by αβ T cell receptors - PubMed
Cross-reactive αβ T cell receptors (TCRs) recognizing multiple peptide variants can provide effective control of rapidly evolving viruses yet remain understudied. By screening 12 naturally occurring influenza-derived HLA-B*35:01-restricted nucleoprotein (NP)sub418-426/sub epitopes (B*35:01-NP …
·pubmed.ncbi.nlm.nih.gov·
Molecular determinants of cross-strain influenza A virus recognition by αβ T cell receptors - PubMed
Neuraminidase reassortment and oseltamivir resistance in clade 2.3.4.4b A(H5N1) viruses circulating among Canadian poultry, 2024 - PubMed
Neuraminidase reassortment and oseltamivir resistance in clade 2.3.4.4b A(H5N1) viruses circulating among Canadian poultry, 2024 - PubMed
We report the detection of a clade 2.3.4.4b A(H5N1) reassortant virus with a neuraminidase surface protein derived from a North American lineage low-pathogenic avian influenza virus. This virus caused a widespread and ongoing outbreak across 45 poultry farms in British Columbia, Canada. Isolates fro …
·pubmed.ncbi.nlm.nih.gov·
Neuraminidase reassortment and oseltamivir resistance in clade 2.3.4.4b A(H5N1) viruses circulating among Canadian poultry, 2024 - PubMed