H5N1 Flu

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Mechanisms of miR-18a-5p Target NEDD9-Mediated Suppression of H5N1 Influenza Virus in Mammalian and Avian Hosts
Mechanisms of miR-18a-5p Target NEDD9-Mediated Suppression of H5N1 Influenza Virus in Mammalian and Avian Hosts
MicroRNAs (miRNAs) are key regulators of gene expression, exerting post-translational control through mRNA silencing or degradation. These molecules play pivotal roles in host–pathogen interactions, particularly in modulating antiviral immune responses. The global public health threat posed by the H5N1 Highly Pathogenic Avian Influenza (HPAI) virus necessitates urgent exploration of novel therapeutic strategies. Our investigation revealed significant dysregulation of miR-18a-5p following influenza virus infection, observed consistently across both in vitro and in vivo models. Experimental evidence demonstrated that miR-18a-5p overexpression effectively inhibits H5N1 virus propagation through multiple mechanisms: (1) in vitro studies using A549 cells transfected with miR-18a-5p mimics showed a substantial reduction in viral replication; (2) animal models (mice and chickens) with elevated miR-18a-5p expression exhibited markedly suppressed AIV replication, reduced pathogenicity, and improved survival rates. The therapeutic potential of miR-18a-5p was particularly evident in its ability to significantly decrease mortality rates in H5N1-infected animals. Furthermore, this miRNA demonstrated robust protective effects against virus-induced lung damage, suggesting its dual role in both preventing and treating H5N1 infections. These findings position miR-18a-5p as a promising candidate for the development of broad-spectrum antiviral interventions, offering a novel strategic approach to combat this serious public health challenge.
·mdpi.com·
Mechanisms of miR-18a-5p Target NEDD9-Mediated Suppression of H5N1 Influenza Virus in Mammalian and Avian Hosts
India News Today highlights on February 28, 2025 : India ramps up H5N1 containment after outbreak in Madhya Pradesh
India News Today highlights on February 28, 2025 : India ramps up H5N1 containment after outbreak in Madhya Pradesh
India News Today highlights on February 28, 2025: Get the latest updates on the most important stories from across the nation. From political developments and economic trends to cultural events and social issues, stay informed about what's happening in India right now. Stay connected with real-time news that matters to you.
·livemint.com·
India News Today highlights on February 28, 2025 : India ramps up H5N1 containment after outbreak in Madhya Pradesh
Bird Flu Outbreak In Bihar’s Jehanabad: H5N1 Virus Confirmed In Dead Crows, Officials Issue Alert | Health News | Zee News
Bird Flu Outbreak In Bihar’s Jehanabad: H5N1 Virus Confirmed In Dead Crows, Officials Issue Alert | Health News | Zee News
The district administration in Bihars Jehanabad has confirmed that the recent deaths of several crows on February 18 were caused by Avian Influenza (H5N1), commonly known as bird flu, officials said. Brajesh Kumar, Additional District Magistrate (ADM) of Jehanabad, said that the test reports from RD
·zeenews.india.com·
Bird Flu Outbreak In Bihar’s Jehanabad: H5N1 Virus Confirmed In Dead Crows, Officials Issue Alert | Health News | Zee News
How bird flu spreads between humans and cats
How bird flu spreads between humans and cats
New research reveals cats can contract bird flu from infected humans. Learn about transmission pathways, symptoms to watch for and how to protect your companion
·rollingout.com·
How bird flu spreads between humans and cats
Piedmont-Triad Farmers Implementing Stricter Measures to Combat Bird Flu Spread - YouTube
Piedmont-Triad Farmers Implementing Stricter Measures to Combat Bird Flu Spread - YouTube
The US Department of Agriculture says North Carolina has the third highest bird flu outbreak. Subscribe to WXII on YouTube now for more: http://bit.ly/1mVq5um Get more Winston-Salem news: http://www.wxii12.com Like us: http://www.facebook.com/wxii12news Follow us: http://twitter.com/WXII Instagram: https://www.instagram.com/wxii12news/
·m.youtube.com·
Piedmont-Triad Farmers Implementing Stricter Measures to Combat Bird Flu Spread - YouTube
Avian Flu: How Scientists and Farmers are Working to Adapt
Avian Flu: How Scientists and Farmers are Working to Adapt
Matt Koci, a virus expert and professor with NC State University’s Prestage Department of Poultry Science, sheds light on what's driving the current outbreak of Avian flu and how scientists are working around the clock to find solutions.
·cals.ncsu.edu·
Avian Flu: How Scientists and Farmers are Working to Adapt
State Veterinarian Kyle Shipman Responds to Bird Flu Misinformation
State Veterinarian Kyle Shipman Responds to Bird Flu Misinformation
More than a dozen major commercial poultry production facilities all across Indiana have been hit with Bird Flu since the beginning of the year. Not only are State Health Officials trying to battle the virus, but they’re
·hoosieragtoday.com·
State Veterinarian Kyle Shipman Responds to Bird Flu Misinformation
2 indoor cats contract bird flu in WA
2 indoor cats contract bird flu in WA
Washington officials report some indoor cats in the state have tested positive for bird flu and offer ways to keep your pets safe.
·fox13seattle.com·
2 indoor cats contract bird flu in WA
RFK Team's Moves on Vaccines, Bird Flu Stoke Health Worries (1)
RFK Team's Moves on Vaccines, Bird Flu Stoke Health Worries (1)
The latest actions by federal health authorities overseen by Robert F. Kennedy Jr. on vaccine development and evaluation are raising alarms among public health experts about the nation’s ability to handle a major health crisis like bird flu.
·news.bloomberglaw.com·
RFK Team's Moves on Vaccines, Bird Flu Stoke Health Worries (1)
Avian influenza research at University of Minnesota expands to study wildlife species | WTIP
Avian influenza research at University of Minnesota expands to study wildlife species | WTIP
With the growing expansiveness of the highly pathogenic avian influenza, also known as “bird flu,” researchers at the University of Minnesota are launching a collaborative effort to study its impact on wildlife species. The highly pathogenic avian influenza (HPAI) has made headlines for its devastating impact on free-ranging birds, mammals, and the poultry industry for...
·wtip.org·
Avian influenza research at University of Minnesota expands to study wildlife species | WTIP